Search Results - drug+screening

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Compounds and Methods for Treating Cancer by Destroying Cancer Stem Cells (UCLA Case No. 2021-286)
Researchers from UCLA’s Department of Chemistry and Biochemistry and the Department of Radiation Oncology have synthesized a set of compounds for the eradication of cancer stem cells. These compounds are predicted to cross the blood brain barrier and show promise as effective interventions for glioblastoma in both in vitro and in vivo assays. BACKGROUND:...
Published: 7/11/2024   |   Inventor(s): Michael Jung, Frank Pajonk
Keywords(s): blood-brain barrier, Brain, Cancer, Cancer stem cells, drug screening, GBM, Glioblastoma, Glioma, new chemical entity
Category(s): Therapeutics > Oncology, Therapeutics > CNS and Neurology, Therapeutics > Stem Cells And Regenerative Medicine
Analytical Device for Sorting Single Cells Based on Secreted Products
NU 2023-084 INVENTORS Shana O. Kelley* Zongjie Wang Mahmoud A. M. Labib SHORT DESCRIPTION A high-throughput, cost-effective device for sorting of single cells in a culture and analysis of their secreted products. BACKGROUND The demand for cost-effective cell analysis methods is expanding due to the increasing urge for the early detection,...
Published: 7/3/2024   |   Inventor(s):  
Keywords(s): Autoimmune disease, Biomedical, Devices, Diagnostics, Drug screening, Personalized medicine
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
Human Synovial Sarcoma Cell Line A2243
Abstract: Synovial sarcoma is a cancer affecting mesenchymal cells in connective tissues. This rare cancer is typically linked to genetic abnormalities or exposure to radiation. Metastatic growth throughout the body can occur primarily through blood circulation. More than 90% of synovial sarcomas show a characteristic t(X;18)(p11;q11) translocation...
Published: 7/25/2024   |   Inventor(s): Stuart Aaronson, Nelson Ellmore
Keywords(s): A2243, Aaronson, Chromosomal Translocation, CONNECTIVE TISSUE, Drug Screening, Human Cell Line, Mesenchymal Cells, Rare Cancer, SSX, Synovial sarcoma, SYT, tumor formation
Category(s): TherapeuticArea > Oncology, Collaboration Sought > Licensing, Application > Research Materials
Tumor-Targeted Killing with Aptamer-Nucleic Acid Nanostructures
Despite decades of research, cancer remains one of today’s most pressing health concerns. Traditional treatment approaches such as radiation therapy and chemotherapy can cause systemic toxicity and become ineffective when resistant tumors emerge. Recently, anticancer strategies have focused on drugs which specifically target tumor-related biological...
Published: 4/14/2023   |   Inventor(s): Yung Chang, Hao Yan
Keywords(s): Bio-Technology, Drug Screening, Therapeutics
Category(s): Life Science (All LS Techs), Cancer Therapeutics, Genomic Assays/Reagents/Tools
Autodock Vina Software Process for Efficient Large-Scale Cognate Ligand Screening
The invention pertains to software processes, additions, and docking approaches to Autodock Vina that speeds the rate and efficiency of analyzing ligand interactions with a receptor by cognate ligands and rewards conformations in the scoring algorithm for residue interactions that are based on the biological data. The score is multiplied by a weighting...
Published: 4/8/2024   |   Inventor(s): Umesh Padia, Elizabeth Geras-Raaka, Marvin Gershengorn
Keywords(s): AD3XXX, ADXXXX, Autodock, COGNATE, Cognate Ligand, Drug Screening, drug screening tool, LIGAND-BINDING, Vina, WIXXXX, WMXXXX, XJXXXX, YBXXXX
Category(s): Collaboration Sought > Collaboration, ResearchProducts > Computational models/software, Application > Consumer Products, Application > Software / Apps, Application > Research Materials
Cotranslational Protein Expression System for High-throughput Screening
Reporter gene-based assays are used extensively in high-throughput screening (HTS) to identify chemical modulators of cellular pathways for drug discovery and development. However, such screening frequently results in a large number of false “hits” due to interactions of screened compounds with reporter proteins, producing confounding results. Thus,...
Published: 7/25/2024   |   Inventor(s): Chih-Chien (Ken) Cheng, Samuel Hasson, James Inglese
Keywords(s): AC4XXX, ACXXXX, AXXXXX, Coincidence, drug discovery, Drug Screening, High-throughput, High-throughput screen, HTS, REPORTER, reporter gene
Category(s): Collaboration Sought > Collaboration
Encapsulation Strategy for Creating Engineered 3D Cellular Models
Cell culture is a fundamental research tool for countless biological applications from drug discovery to cancer research and regenerative medicine. While two-dimensional (2D) cell culture is ubiquitous in research settings, it fails to adequately consider the natural three-dimensional (3D) microenvironment of cells. As newer and better 3D cell culture...
Published: 2/23/2023   |   Inventor(s): Rajeshwar Nitiyanandan, Tanya Nanda, Kaushal Rege
Keywords(s): Drug Screening, Regenerative Medicine
Category(s): Advanced Materials/Nanotechnology, Biomaterials, Cancer Therapeutics, Life Science (All LS Techs), Medical Devices, Non-Cancer Therapeutics, Pharmaceuticals
High-throughput screening platform for skin penetration and permeability for dermal drugs and skin care products
Description The skin is one of the most readily accessible tissues for delivery of drugs and therapeutics. Improving skin permeation and retention is a major focus for new drugs and skin care products. In the development stage of transdermal drugs, it’s important to probe permeability and test delivery methods in a high-throughput, cost-effective,...
Published: 11/1/2023   |   Inventor(s): Hugh Smyth, Patricia Martins
Keywords(s): Drug development, Drug screening
Category(s): Life sciences > Research tools > Tool/assay/screening platform, Life sciences > Therapeutics > Drug screening
Multi-material 3D bioprinter for use in drug testing/screening supporting cancer drug discovery.
Cancer testing/screening procedures used in developing new drug therapies take years and are founded on the use of 2D cell cultures and animal models prior to human trials. This pathway is not always representative of how a drug will perform in humans since 2D technology cannot print multi-material bio-cell structures for evaluating new drug performance....
Published: 7/29/2024   |   Inventor(s): Amir Miri Ramsheh
Keywords(s): 3D, Cancer, Drug Screening, Hydrogels, Medical Devices
Category(s): Human Health Care > Biomarkers, Diagnosis and Detection, Research Tools
Biocompatible gel formulation
Single-cell and cell cluster optical tomography, or Cell-CT, has found increasing application in life sciences basic research. Two limitations to its use in this area are that it can image only fixed cells, and the lack of thixotropic gels that can support live cells and also satisfy refractive index constraints. Researchers at the Biodesign Institute...
Published: 2/23/2023   |   Inventor(s): Roger Johnson, Fengyu Su, Laimonas Kelbauskas, Vivek Nandakumar, Yanqing Tian, Deirdre Meldrum
Keywords(s): Bio-Technology, Drug Screening, Materials, Medical Devices and Imaging, Therapeutics
Category(s): Biomaterials, Life Science (All LS Techs), Medical Imaging
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