Search Results - bio-technology

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Antibody based reagents that specifically recognize toxic oligomeric forms of beta-amyloid
Neurodegenerative diseases such as Alzheimer’s are affecting an increasing number, with annual new diagnoses approaching one-half million; and total cost, $150 billion. Early diagnosis and treatment are important for optimal outcomes, yet there is currently no test to detect such diseases in their early, asymptomatic stages. Active immuniza-tion...
Published: 8/27/2025   |   Inventor(s): Michael Sierks, Srinath Kasturirangan
Keywords(s): Bio-Technology, Therapeutics
Category(s): Life Science (All LS Techs), Diagnostic Assays/Devices, Neurodegenerative Disease Technologies, Non-Cancer Therapeutics, Proteomic Assays/Reagents/Tools, Medical Diagnostics/Sensors
Compounds to Modulate Retinoid X Receptors
The human retinoid X receptors (RXRs) function as transcriptional regulators, often in partnership with members of a larger nuclear receptor family of transcription factors. RXR agonists have been shown to modulate RXR transcription and activate or repress various biological pathways and effect therapeutic results for various conditions. There are a...
Published: 8/27/2025   |   Inventor(s): Carl Wagner, Peter Jurutka, Pamela Marshall, Arjan Van Der Vaart
Keywords(s): Bio-Technology, Drug Screening
Category(s): Life Science (All LS Techs), Cancer Therapeutics, Pharmaceuticals, Neurodegenerative Disease Technologies, Non-Cancer Therapeutics
Reagents Targeting Neurodegenerative Diseases and Traumatic Brain Injury
Misfolding and aggregation of proteins, such as beta-amyloid (Aß), alpha-synuclein (a-syn), tau and TAR DNA-binding protein 43 (TDP-43), have been strongly correlated with early onset of neurodegenerative diseases such as Alzheimer's Disease (AD), Parkinson's Disease (PD), Frontotemporal Dementia (FTD), amyotrophic lateral sclerosis (ALS) and...
Published: 8/27/2025   |   Inventor(s): Michael Sierks, Stephanie Williams, Lalitha Venkataraman
Keywords(s): AFM, Antibody Therapeutics, Antigen-specific Therapies, Bioassay, Bio-Technology, CNS Therapeutics, Therapeutics
Category(s): Life Science (All LS Techs), Neurodegenerative Disease Technologies, Non-Cancer Therapeutics, Proteomic Assays/Reagents/Tools, Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices
System and Circuit of Compute-in-Memory Design for Genome Alignment
Next-generation sequencing (NGS) technologies have revolutionized genomics research because they enable faster, cheaper and accurate decoding of nucleotide sequences. This has resulted in breakthroughs in diagnostics, disease risk assessment, personalized medicines, screening and more. However, despite all the NGS-related advancements that have been...
Published: 5/1/2025   |   Inventor(s): Deliang Fan, Fan Zhang
Keywords(s): Bio-Technology, Computational Machine, Computing Architecture, Gene, Memory, Personalized medicine
Category(s): Artificial Intelligence/Machine Learning, Genomic Assays/Reagents/Tools, Life Science (All LS Techs), Manufacturing/Construction/Mechanical, Semiconductor Devices, Semiconductors, Materials & Processes
Controlled Tunnel Gap Device for Sequencing Polymers
To reduce costs and increase the availability of personalized genomics new approaches to DNA sequencing are required. Nanopore sequencing is one proposed technique. In nanopore sequencing, DNA molecules are forced through a tiny aperture by electrophoresis. As the individual bases transit the nanopore, their identity can be determined, in theory, by...
Published: 2/13/2025   |   Inventor(s): Stuart Lindsay, Shuai Chang, Jin He, Peiming Zhang, Shuo Huang
Keywords(s): Bio-Technology
Category(s): Life Science (All LS Techs)
Enhancing Strength of EICP-Treated Sand Using a Protein-Based Additive
Background Effective ground improvement methods are essential for optimal utilization of land, whether they be roads, embankments, dunes, or slopes. Conventional methods using compaction, pile insertion, and cement-soil mixing provide adequate stability but have several major drawbacks. They are often expensive, time-consuming, require specialized...
Published: 6/2/2025   |   Inventor(s): Edward Kavazanjian, Nasser Hamdan, Hamed Khodadadi Tirkolaei, Abdullah Almajed
Keywords(s): Bio-Technology, Engineering, Materials and Electronics
Category(s): Physical Science, Manufacturing/Construction/Mechanical, Environmental Remediation/Wastewater Treatment, Environmental
SulfCo
Background Recent research in the asphalt industry has focused on promoting sustainability through reducing mixing and compaction temperatures. Sulfur-extended asphalt has been studied extensively for this purpose because of the reduction in price of asphalt concrete that sulfur offers, as well as reducing the mixing and compaction temperatures. However,...
Published: 2/13/2025   |   Inventor(s): Elham Fini, Albert Hung
Keywords(s): Bio-Technology, Environmental, Materials and Electronics
Category(s): Alternative Energy/Biofuels/Bioplastics/Algae, Environmental, Manufacturing/Construction/Mechanical, Physical Science
Single Cell In-Situ Extraction with Intact 3D Morphology from Formalin Fixed Paraffin Embedded (FFPE) Tissues
FFPE is a well-established and widely used method for preservation and histological analysis of tissue samples. DNA/RNA/and Proteins can be extracted from FFPE samples, but generally lack single cell resolution and completely lack 3D spatial resolution. Enabling 3D resolution allows the correlation of morphology to information like gene expression,...
Published: 2/13/2025   |   Inventor(s): David Richardson, Thai Tran, Dmitry Derkach, Colleen Ziegler
Keywords(s): Bioanalysis, Biological Cell Manipulation, Bio-Technology, Cancer, Device, Diagnostics, Gene Expression, Genomics, Proteomics, In situ, Molecular Diagnostics, Single-cell analysis
Category(s): Bioanalytical Assays, Chemistries & Devices, Genomic Assays/Reagents/Tools, Life Science (All LS Techs), Proteomic Assays/Reagents/Tools
Methods to Increase Genetic Transformation in Cyanobacterium
Cyanobacteria are model species for studying photosynthesis and recently have been gaining increased attention for their ability to produce renewable fuels and chemicals by harvesting solar energy and recycling carbon dioxide. Unfortunately, despite all the recent research and exciting achievements made regarding cyanobacteria, genetic transformation...
Published: 2/13/2025   |   Inventor(s): Bo Wang, Weiwen Zhang, Deirdre Meldrum
Keywords(s): Algae, Microalgae, Cyanobacteria, Biofuels Production, Bio-Technology, Plasmid, Vectors, Constructs
Category(s): Life Science (All LS Techs), Vectors/Constructs/Plasmids, Alternative Energy/Biofuels/Bioplastics/Algae
Bi-specific Antibodies as a Therapeutic for Alzheimer’s Disease
Alzheimer’s disease (AD) is one of the most prominent and feared neurodegenerative diseases associated with aging. A hallmark of this disease is the formation of extra-cellular amyloid plaques in the brain. The principle component of these extracellular plaques is amyloid-ß protein (Aß). Though the mechanisms underlying Alzheimer’s...
Published: 2/13/2025   |   Inventor(s): Michael Sierks, Shanta Boddapati, Srinath Kasturirangan
Keywords(s): Bio-Technology, Therapeutics
Category(s): Life Science (All LS Techs), Neurodegenerative Disease Technologies, Non-Cancer Therapeutics, Pharmaceuticals
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