Search Results - immunology

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Tumor Suppression by Retinoic Acid Pathway Inhibition
­Targeting retinoic acid (RA) synthesizing enzymes or RA receptors with small molecules boosts the immune system towards a tumor rejection response Problem: Hepatocellular carcinoma (HCC) is the most common liver cancer globally. In the US alone, 33 000 patients are diagnosed yearly, 27 000 of which will die. Once metastasized, HCC shows...
Published: 6/21/2024   |   Inventor(s): Malay Haldar, Ganesha Rai Bantukallu
Keywords(s): Cell Therapy, Drug Target, Immunology, Immunoncology, Oncology, Small Molecule
Category(s): Technology Classifications > Therapeutics
Immune Modulator Encoded Lipid Nanoparticle Formulation Improves T Cell Response to Vaccines
Researchers developed an LNP-mRNA-based vaccine that encodes different cytokine mRNAs, as a method to enhance CD8+ T cell responses and memory formation. Problem: Lipid nanoparticles (LNPs) are an emerging technique to deliver mRNA in vivo more efficiently. While recent progress in mRNA technology has allowed the rapid development of SARS-COV2 vaccines,...
Published: 7/2/2024   |   Inventor(s): Christopher Hunter, Drew Weissman, Mohamad Alameh, Emily Aunins, Anthony Phan
Keywords(s): Bioengineering, Drug Delivery, Immunology, Immunoncology, Immunotherapy, Infectious Disease, Nanotechnology
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Vaccines
Topical Treatment for Autoimmune Disorders
Treatment method for autoimmune diseases such as diabetes, multiple sclerosis, atherosclerosis, and rheumatoid arthritis using skin application of a vitamin D analog where topical treatment leads to systemic immunoregulation. Problem: Immunomodulatory drugs are typically administered systemically and often lead to severe side effects. Moreover,...
Published: 6/5/2024   |   Inventor(s): Taku Kambayashi
Keywords(s): Immunology, Obesity, Metabolic Disease and Diabetes
Category(s): Technology Classifications > Therapeutics
Novel FOXO1 Inhibitor for the Restoration of Lymphatic Valve Growth in Congenital Lymphedema
­Advantages: Foxo1 inhibitor increased the expression levels of valve-forming genes in vitro and valves in vivo MOA: Foxo1 inhibition increases β-catenin and activates downstream genes FOXO1 inhibition can be a viable strategy to rescue valve defects in congenital lymphedema Summary: Mutations in many genes that regulate lymphatic...
Published: 9/3/2024   |   Inventor(s): Ying Yang
Keywords(s): Genetics, Immunology, Medical Therapeutics Gene Therapy
Category(s): Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Biotechnology
Anti-CD133 Monoclonal Antibodies as Cancer Therapeutics
Abstract: Most early work on CD133 was carried out using one of two monoclonal antibodies (mAbs), AC133 and AC141, which recognize an undefined glycosylated epitope of CD 133. Researchers from NCI's Pharmacodynamic Assay Development and Implementation Section generated novel anti-human CD133 monoclonal antibodies from large extracellular domain loops...
Published: 4/8/2024   |   Inventor(s): Thomas Pfister, Robert Kinders, Allison Marrero
Keywords(s): Anti-CD133, Biomarker, CANCER, Diagnostic Tool, Immunology, Rabbit Monoclonal Antibodies, screening
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Immunology, Application > Therapeutics, TherapeuticArea > Oncology
y-AApeptide-based long-acting pan-coronavirus fusion inhibitor with dual targets in spike protein and oral bioavailability
­Advantages: S-20-1 demonstrates potent inhibitory action, this broad-spectrum activity suggests that S-20-1 could be effective against a wide range of coronaviruses, making it a valuable candidate for pandemic preparedness and management. The research provides insights into the mechanism of action of S-20-1, demonstrating its ability to bind...
Published: 9/25/2023   |   Inventor(s): Jianfeng Cai, Shibo JIANG, Lu LU, Songyi XUE, Xinling WANG, Lei WANG, Wei XU, Shuai XIA
Keywords(s): Drug Discovery, Immunology
Category(s): Technology Classifications > Medical > Biotechnology
Non-Toxic, Potent Antimicrobial Peptides Derived From Wasp Venom For Use Against Antimicrobial Resistant (AMR) Pathogens
Synthetic antimicrobial peptides derived from wasp venom to treat antibiotic-resistant infections. Problem: Antibiotics have transformed modern medicine as they are just one of the most effective drugs in history. However, the rise of antimicrobial resistance (AMR) currently threatens to undermine these achievements, posing a major threat to public...
Published: 10/16/2023   |   Inventor(s): Cesar de la Fuente-Nunez, Lucía Ageitos Castiñeiras, Marcelo Der Torossian Torres, Andreia Boaro
Keywords(s): Bioengineering, Immunology, Infectious Disease, Protein/Peptide (Non-Antibody)
Category(s): Technology Classifications > Therapeutics
Methods for Cryopreservation of Cells for Improved Commercial Manufacture of NK Cell Therapies
A method that maintains the viability and function of NK cells following cryopreservation, enabling the production, storage, and transportation of therapeutic doses of NK cells to treatment centers. Problem: There is a growing interest in using NK cells as immunotherapies for diseases such as cancer. Making commercially viable NK cell therapies requires...
Published: 10/16/2023   |   Inventor(s): Neil Sheppard, Abdulla Berjis
Keywords(s): Cell Therapy, Immunology, Immunoncology, Oncology
Category(s): Technology Classifications > Therapeutics
Cholesterol Analogues Incorporated Into LNPs For Enhanced mRNA Delivery
Hydroxycholesterols are used to formulate lipid nanoparticles (LNPs) for enhanced mRNA delivery into T cells. Problem: In recent times, the delivery of mRNA has become a major focus for therapeutics. Intracellular delivery is the major challenge. Intracellular delivery requires ionizable lipids for mRNA delivery. In addition to this, these constituents...
Published: 2/6/2024   |   Inventor(s): Michael Mitchell, Margaret Billingsley, Savan Patel, Xuexiang Han, Hanwen Zhang
Keywords(s): Bioengineering, Cell Therapy, Drug Delivery, Gene Editing, Gene Therapy, Genetic Disorders, Immunology, Immunoncology, Immunotherapy, Inflammation, Nanotechnology, Platform Technology
Category(s): Technology Classifications > Therapeutics
Neuroprotection in TBI/Concussion via Dietary Supplement
A dietary supplement that protects brain cells from the effects of TBI and concussion Problem: Traumatic brain injury (TBI) is a major cause of death and disability. Mild TBIs (such as concussion) are particularly common for athletes and warfighters and can produce disabilities without immediate brain cell death. This may be due to damage to...
Published: 6/24/2024   |   Inventor(s): Daniel Kacy Cullen, Carolyn Keating, Kevin Browne
Keywords(s): Antibody, Cell Therapy, Immunology, Immunoncology, Oncology
Category(s): Technology Classifications > Therapeutics
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