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Search Results - immunology
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Orthogonal Cytokine Enhanced CAR T Cells Generated Through Gene Editing
Brief Description: The present disclosure provides methods of producing a modified immune cell responsive to orthogonal cytokine signaling and a modified immune cell produced by said method. The present disclosure further provides a modified immune cell responsive to orthogonal cytokine signaling and methods for treating cancer comprising the modified...
Published: 8/21/2025
|
Inventor(s):
K. Christopher Garcia
,
Michael Milone
,
Qian Zhang
Keywords(s):
Cell Therapy
,
Immunology
,
Immunoncology
,
Immunotherapy
,
Oncology
,
Platform Technology
Category(s):
Technology Classifications > Therapeutics
Peptides For Solid Cancer Tumor Immunotherapy Treatment
Short, multivalent peptide antagonists to block macrophage immune-receptor SIRPα, promoting cancer cell phagocytosis. Problem: Modern cancer cell immunotherapies incorporate immune checkpoint blockade mechanisms, where prominent therapies target functionally suppressed immune cells in tumor microenvironments. Relieving this suppression allows...
Published: 8/11/2025
|
Inventor(s):
Dennis Discher
,
AbdelAziz Jalil
Keywords(s):
Cell Therapy
,
Immunology
,
Oncology
Category(s):
Technology Classifications > Chemical Processes and Synthesis
,
Technology Classifications > Therapeutics
,
Technology Classifications > Vaccines
Restoration of motor function through delayed intraspinal delivery of mRNA-encoded IL-10 after spinal cord injury
Brief Description: Disclosed herein is a composition including a nucleoside-modified mRNA encapsulated in a lipid nanoparticle wherein the nucleoside-modified mRNA encodes IL10, IL-6, MIP1a, GDNF (glial cell line-derived neurotrophic factor), or a combination thereof. A method of treated spinal cord injury is also described. Image: Caption: Reference...
Published: 7/9/2025
|
Inventor(s):
Norbert Pardi
,
Drew Weissman
Keywords(s):
Bioengineering
,
Drug Delivery
,
Gene Therapy
,
Immunology
,
Neurology
,
Regenerative Medicine
Category(s):
Technology Classifications > Therapeutics
,
Technology Classifications > Vaccines
Binding Between TREM2 and Heparan Sulfate Delineates the Role of Microglia in AD and Reveals Novel Treatment Strategies
Advantages: Discovered novel structural interactions between HS and TREM2, associated with neurodegeneration High-affinity binding: TREM2 specifically interacts with Heparan Sulfate (HS) modified with 6-O-sulfation and iduronic acid, enabling precise microglial modulation compared to broad-spectrum anti-inflammatory strategies Defined structural...
Published: 8/12/2025
|
Inventor(s):
Lianchun Wang
,
Ilayda McMillan
Keywords(s):
Immunology
,
Neurodegenerative Diseases
,
Neuroscience
Category(s):
zzNeurodegenerative Diseases Treatment
,
Technology Classifications > Medical > Neuroscience
,
Technology Classifications > Medical > Therapeutics
Reducing The Adverse Side Effects Of Using Native T-Cells To Destroy Cancer Cells
A Switchable Bispecific T-Cell Nanoengager (sBiTNE) to link T cells with cancer cells that can be reversed if off-tumor toxicity is detected. Problem: Compounds which link native T-cells with the surface antigens found on cancer cells have emerged as an effective treatment for blood malignancies and are currently being developed for solid tumors....
Published: 4/16/2025
|
Inventor(s):
Michael Mitchell
,
Ningqiang Gong
Keywords(s):
Bioengineering
,
Immunology
,
Immunoncology
,
Immunotherapy
,
Oncology
,
Platform Technology
,
Protein/Peptide (Non-Antibody)
,
Small Molecule
Category(s):
Technology Classifications > Therapeutics
Methods and Sequences for mRNA and Other HIV Vaccine Development
Unique sequences eliciting broadly neutralizing antibodies (bNAbs) against human immunodeficiency virus (HIV) that could be used to develop effective mRNA-based and other types of HIV vaccine. Problem: Despite decades of research, there is currently no vaccine to prevent HIV infection. A major goal of HIV vaccine programs is to generate bNAbs, which...
Published: 8/1/2025
|
Inventor(s):
George Shaw
,
Edward (Ted) Kreider
,
Beatrice Hahn
,
Ashwin Skelly
,
Hui Li
,
Drew Weissman
Keywords(s):
Bioengineering
,
HIV/AIDS
,
Immunology
,
Infectious Disease
,
Protein/Peptide (Non-Antibody)
Category(s):
Technology Classifications > Vaccines
Intranasally-Delivered Therapy For The Treatment Of Depression And Dementia
Intranasal nasal dantrolene nanoparticles alone, or in combination with lithium, can provide protection against depression and dementia with minimal or no side effects. Problem: Major depression disorder (MDD) affects 350 million patients in the world and about 16% of the population in USA. In addition, up to 50% of Alzheimer’s disease (AD)...
Published: 8/1/2025
|
Inventor(s):
Huafeng Wei
Keywords(s):
Aging
,
Immunology
,
Immunoncology
,
Infectious Disease
,
Inflammation
,
Neurodegenerative Diseases
Category(s):
Technology Classifications > Therapeutics
Anticancer IgG Against Multiple Epitopes on Live Tumors Upon Disruption of ‘Self’ Signaling by CD47
A method to combine two or three monoclonal antibodies (mABs) into one treatment to successfully bind to multiple cancer cell surface epitopes and promote targeted degradation by phagocytosis. Problem: Phagocytosis of ‘self’ cells is generally inhibited by a key macrophage checkpoint interaction between SIRPα on the macrophage and...
Published: 2/27/2025
|
Inventor(s):
Dennis Discher
,
Jason Andrechak
,
Lawrence Dooling
Keywords(s):
Antibody
,
Bioengineering
,
Cell Therapy
,
Drug Target
,
Immunology
,
Immunoncology
,
Immunotherapy
,
Oncology
,
Platform Technology
Category(s):
Technology Classifications > Therapeutics
Gene Therapy for DOCK8 Deficiency (UCLA Case No. 2023-178)
UCLA researchers in the Department of Pediatrics Allergy and
Immunology
have developed a gene therapy method to express the full-length DOCK8 protein in cells, aimed at treating DOCK8 deficiency. These method allows for safe and effective DOCK8 expression in hematopoietic stem cells without the need for an HLA-matched donor, enabling patients to undergo...
Published: 7/17/2025
|
Inventor(s):
Caroline Kuo
Keywords(s):
bone marrow
,
bone marrow transplants
,
DOCK8
,
DOCK8 deficiency
,
Gene Editing Systems
,
Gene Therapy
,
hematopoietic stem cells
,
Immune System
,
immunodeficiency
,
Immunology
,
intein splicing
Category(s):
Therapeutics >
Immunology
And Immunotherapy
,
Therapeutics > Gene Therapy And Editing
,
Therapeutics > Stem Cells And Regenerative Medicine
,
Life Science Research Tools > Plasmids/Vectors
Antibody-based HPV detection
NU 2023-157 INVENTORS Laimonis Laimins* Conor Templeton SHORT DESCRIPTION High-risk human papillomaviruses (HPV) are a primary cause of genital and oropharyngeal cancers. Nucleic acid amplification tests (NAATs) are the current standard in the field for robust identification and genotyping of HPV infections. For more simplistic staining,...
Published: 8/5/2025
|
Inventor(s):
Keywords(s):
Immunology
Category(s):
Life Sciences > Therapeutics
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