Search Results - inflammation

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Intranasally-Delivered Therapy For The Treatment Of Depression And Dementia

Intranasal nasal dantrolene nanoparticles alone, or in combination with lithium, can provide protection against depression and dementia with minimal or no side effects. Problem: Major depression disorder (MDD) affects 350 million patients in the world and about 16% of the population in USA. In addition, up to 50% of Alzheimer’s disease (AD)...

Published: 3/12/2025 | Inventor(s): Huafeng Wei

Keywords(s): Aging, Immunology, Immunoncology, Infectious Disease, Inflammation, Neurodegenerative Diseases

Category(s): Technology Classifications > Therapeutics

Nanotherapy to Treat Intestinal Inflammation

NU 2015-160 PRIMARY INVENTOR Arun Sharma SHORT DESCRIPTION Potent anti-inflammatory nanomolecules to treat chronic intestinal inflammation (ileitis) that is detrimental to tissue function BACKGROUND Clinical complications of inflammatory bowel disease (IBD) such as Crohn’s disease (CD) can be observed throughout the digestive tract as tissue...

Published: 4/4/2025 | Inventor(s):

Keywords(s): Gastrointestinal and Hepatic disease, Inflammation, Small molecule, Therapeutics

Category(s): Life Sciences > Therapeutics

Nanoparticles for Precise & Targeted Treatment of Neurological Conditions

Problem: Acute ischemic stroke (AIS) is the second leading cause of death worldwide, affecting around 600,000 Americans annually. However, pharmacological treatment of AIS is difficult due to ineffective and nonspecific targeting to blood brain barrier epitopes via intravenous administration. Over 100 drugs have been tried and failed in clinical trials...

Published: 2/20/2025 | Inventor(s): Oscar Marcos Contreras, Jacob Brenner, Vladimir Muzykantov, Jia Nong, Patrick Glassman, Drew Weissman, Sahiley Reyes-Esteves

Keywords(s): Drug Delivery, Inflammation, Nanotechnology, Neurology

Category(s): Technology Classifications > Therapeutics

Macrophage-Targeting Lipid Nanoparticles (MacLNPs) Deliver siRNA Intranasally to Treat Viral Pneumonia

siRNA-LNP knock-down of TAK1 delivered intranasally and to macrophages specifically prevents inflammation-induced pathology in a mouse model Problem: Macrophages are an important component of the innate immune system, but can mediate excessive inflammation and cause severe pathology if left unchecked. This poses a challenge for the treatment of acute...

Published: 12/19/2024 | Inventor(s): Michael Mitchell, Lulu Xue, Andrew Vaughan, Gan Zhao

Keywords(s): Bioengineering, Drug Delivery, Gene Therapy, Immunology, Infectious Disease, Inflammation, Nanotechnology, Platform Technology

Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Materials, Technology Classifications > Therapeutics, Technology Classifications > Vaccines

Improving Diagnosis and Treatment of Sarcoidosis

Using a blood or tissue biomarker to improve diagnosis and identification of a new targeted treatment. Problem: Sarcoidosis is an inflammatory disease that can affect any organ, predominantly the lung, skin, and the lymphatic system. Symptoms include difficulty breathing, extreme fatigue, skin inflammation, and joint pain. Sarcoidosis compromises patients’...

Published: 12/5/2024 | Inventor(s): Thomas Hin-Chai Leung, Satish Sati, Misha Rosenbach

Keywords(s): Dermatology, Immunology, Inflammation, Ophthalmology, Pulmonary

Category(s): Technology Classifications > Diagnostics

Inflammation sensitive bacteria can detect flares of IBD

NU 2023-131 INVENTORS Jonathan Xia Arthur Prindle* BACKGROUND The prevalence of Inflammatory Bowel Disease (IBD), a spectrum of chronic autoimmune inflammatory disorders of the gastrointestinal tract, has steadily increased from 3.7 million in 1990 to 6.8 million in 2017. The spectrum of diseases are characterized by a relapsing and remitting...

Published: 3/3/2025 | Inventor(s):

Keywords(s): Diagnostics, Gastrointestinal and Hepatic disease, Inflammation

Category(s): Life Sciences > Biomarkers & Biomedical Research Tools

Nisin-Based Formulations for Oral and Systemic Conditions (UCLA Case Nos. 2023-133 and 2022-306)

UCLA researchers in the Department of Dentistry have found a novel use for nisin alone, and in formulations, for use in the treatment of Alzheimer’s disease, and multiple inflammation states such as brain inflammation, joint inflammation, oral inflammation, systemic inflammation, inflammatory bowel diseases, and non-alcoholic fatty liver disease...

Published: 2/14/2025 | Inventor(s): Yvonne Kapila

Keywords(s): Alzheimers disease, Antibacterial, gut inflammation, Inflammation, microbiome, nanoparticle delivery system, Nanoparticles, nisin, oral inflammation, periodontal disease, periodontal inflammation, periodontal regeneration

Category(s): Therapeutics > CNS and Neurology

Novel GalNAc-siRNA Conjugates as a Treatment for High Blood Triglycerides and Fatty Liver Disease

H&E staining of mice liver sections showing protection against high blood triglyceride and MASLD induced by a high-fat diet in knockout mice. Invention Summary: Diabetes and obesity are the major contributors to the pathological accumulation of triglyceride (TAG) in the blood and liver, resulting in metabolic syndrome, myocardial infarction,...

Published: 8/9/2024 | Inventor(s): Fredric Wondisford, Sally Radovick

Keywords(s): Inflammation

Category(s): Technology Classifications > Healthcare & Life Sciences

Therapy for acute kidney injury

NU 2022-202 INVENTORS Pinelopi Kapitsinou* Ratnakar Tiwari SHORT DESCRIPTION Inhibition of MCT4 slows the progression of acute kidney inury to chronic kidney disease BACKGROUND Acute kidney inury (AKI) is a sudden onset of kidney dysfunction, often caused by factors such as ischemia, toxins, or infections, leading to impaired filtration and accumulation...

Published: 4/4/2025 | Inventor(s):

Keywords(s): Inflammation, Renal Disease, Therapeutics

Category(s): Life Sciences > Therapeutics

Quercetin as substrate for antiviral treatment against Hepatitis C virus infection (UCLA Case No. 2023-003)

UCLA researchers in the Department of Pathology and Hematology have developed a novel antiviral treatment for Hepatitis C virus based on the metabolic modulating properties of dietary compound Quercetin. BACKGROUND: Hepatitis C virus (HCV) is responsible for 180 million infections worldwide and over 12,000 deaths in the U.S. each year. Despite most...

Published: 2/14/2025 | Inventor(s): Nu Lu

Keywords(s): antivirals, hepatitis, immune metabolism, Inflammation, liver disease

Category(s): Therapeutics > Infectious Diseases, Therapeutics > Inflammation And Inflammatory Diseases

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