Search Results - inflammation

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Macrophage-Targeting Lipid Nanoparticles (MacLNPs) Deliver siRNA Intranasally to Treat Viral Pneumonia
siRNA-LNP knock-down of TAK1 delivered intranasally and to macrophages specifically prevents inflammation-induced pathology in a mouse model Problem: Macrophages are an important component of the innate immune system, but can mediate excessive inflammation and cause severe pathology if left unchecked. This poses a challenge for the treatment of acute...
Published: 12/19/2024   |   Inventor(s): Michael Mitchell, Lulu Xue, Andrew Vaughan, Gan Zhao
Keywords(s): Bioengineering, Drug Delivery, Gene Therapy, Immunology, Infectious Disease, Inflammation, Nanotechnology, Platform Technology
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Materials, Technology Classifications > Therapeutics, Technology Classifications > Vaccines
Improving Diagnosis and Treatment of Sarcoidosis
Using a blood or tissue biomarker to improve diagnosis and identification of a new targeted treatment. Problem: Sarcoidosis is an inflammatory disease that can affect any organ, predominantly the lung, skin, and the lymphatic system. Symptoms include difficulty breathing, extreme fatigue, skin inflammation, and joint pain. Sarcoidosis compromises patients’...
Published: 12/5/2024   |   Inventor(s): Thomas Hin-Chai Leung, Satish Sati, Misha Rosenbach
Keywords(s): Dermatology, Immunology, Inflammation, Ophthalmology, Pulmonary
Category(s): Technology Classifications > Diagnostics
Nisin-Based Formulations for Oral and Systemic Conditions (UCLA Case Nos. 2023-133 and 2022-306)
UCLA researchers in the Department of Dentistry have found a novel use for nisin alone, and in formulations, for use in the treatment of Alzheimer’s disease, and multiple inflammation states such as brain inflammation, joint inflammation, oral inflammation, systemic inflammation, inflammatory bowel diseases, and non-alcoholic fatty liver disease...
Published: 9/19/2024   |   Inventor(s): Yvonne Kapila
Keywords(s): Alzheimers disease, Antibacterial, gut inflammation, Inflammation, microbiome, nanoparticle delivery system, Nanoparticles, nisin, oral inflammation, periodontal disease, periodontal inflammation, periodontal regeneration
Category(s): Therapeutics > CNS and Neurology
Novel GalNAc-siRNA Conjugates as a Treatment for High Blood Triglycerides and Fatty Liver Disease
​ H&E staining of mice liver sections showing protection against high blood triglyceride and MASLD induced by a high-fat diet in knockout mice. Invention Summary: Diabetes and obesity are the major contributors to the pathological accumulation of triglyceride (TAG) in the blood and liver, resulting in metabolic syndrome, myocardial infarction,...
Published: 8/9/2024   |   Inventor(s): Fredric Wondisford, Sally Radovick
Keywords(s): Inflammation
Category(s): Technology Classifications > Healthcare & Life Sciences
Therapy for acute kidney injury
NU 2022-202 INVENTORS Pinelopi Kapitsinou* Ratnakar Tiwari SHORT DESCRIPTION Inhibition of MCT4 slows the progression of acute kidney inury to chronic kidney disease BACKGROUND Acute kidney inury (AKI) is a sudden onset of kidney dysfunction, often caused by factors such as ischemia, toxins, or infections, leading to impaired filtration and accumulation...
Published: 8/26/2024   |   Inventor(s):  
Keywords(s): Inflammation, Renal Disease, Therapeutics
Category(s): Life Sciences > Therapeutics
Quercetin as substrate for antiviral treatment against Hepatitis C virus infection (UCLA Case No. 2023-003)
UCLA researchers in the Department of Pathology and Hematology have developed a novel antiviral treatment for Hepatitis C virus based on the metabolic modulating properties of dietary compound Quercetin. BACKGROUND: Hepatitis C virus (HCV) is responsible for 180 million infections worldwide and over 12,000 deaths in the U.S. each year. Despite most...
Published: 5/16/2024   |   Inventor(s): Nu Lu
Keywords(s): antivirals, hepatitis, immune metabolism, Inflammation, liver disease
Category(s): Therapeutics > Infectious Diseases, Therapeutics > Inflammation And Inflammatory Diseases
Methods for the Treatment of Inflammation
­Advantages: Exceptional precision in addressing inflammation, minimizing potential side effects. Unique COX-2 interaction reduces the risk of adverse reactions. Versatile effectiveness across various inflammatory disorders, providing relief to a wide range of patients. Summary: This technology addresses a significant healthcare challenge...
Published: 11/7/2024   |   Inventor(s): Bill Baker, Sofia Kokkaliari, James Leahy, Wayne Williams
Keywords(s): Inflammation, Pain Relief / Management
Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Oncology
Therapeutics for Neurodegenerative Disorders and Cancer Using Lenalidomide Analogs
Abstract: Inflammatory processes associated with the over-production of tumor necrosis-alpha (TNF-alpha), a potent activator of the immune system accompany numerous neurodegenerative diseases. TNF-alpha has been validated as a drug target with the development of the inhibitors Enbrel and Remicade (fusion antibodies) as prescription medications. Both,...
Published: 10/4/2024   |   Inventor(s): Nigel Greig, Weiming Luo, David Tweedie, Harold Holloway, Qian-sheng Yu, Edward Goetzl
Keywords(s): CNS, Holloway, Immunomodulatory Agents, Inflammation, Lenalidomide, National Institute on Aging, Neurodegenerative Disorders, NIA, THALIDOMIDE, TNF-alpha, Tumor Necrosis-alpha
Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology
New Insect Sf9-ET Cell Line for Determining Baculovirus Titers
Abstract: The baculovirus-based protein expression system has gained increased prominence as a method for expressing recombinant proteins that are used in a wide range of biomedical applications. An important step in the use of this system is the ability to determine the virus infectious titer, i.e., the number of active baculovirus particles produced...
Published: 12/6/2024   |   Inventor(s): Ralph (Butch) Hopkins, Dominic Esposito
Keywords(s): Baculovirus, Baculovirus Titer, Esposito, IMMUNE, Inflammation, Insect Cell Line, Protein Expression Sf9-ET
Category(s): TherapeuticArea > Infectious Disease, TherapeuticArea > Cardiology, Collaboration Sought > Licensing, TherapeuticArea > Reproductive Health, TherapeuticArea > Nephrology, Application > Research Materials, TherapeuticArea > Gastroenterology, TherapeuticArea > Endocrinology, TherapeuticArea > Dermatology, TherapeuticArea > Immunology, TherapeuticArea > Oncology, TherapeuticArea > Ear, Nose, & Throat, TherapeuticArea > Ophthalmology
Murine metastatic pancreatic adenocarcinoma cell lines
Abstract: Researchers at the National Cancer Institute (NCI) have developed orthotopic allograft models for pancreatic cancer that utilize low passage primary pancreatic adenocarcinoma cells or tumor fragments implanted into the cancer-free pancreata of recipient syngeneic immunocompetent mice. Tumor development in these models is more synchronized,...
Published: 4/8/2024   |   Inventor(s): Serguei Kozlov, Ludmila Szabova, Melanie Gordon, Myhaymin Kamal, Jerome Schlomer, Theresa Guerin, Theresa O'Sullivan, Terry Van Dyke
Keywords(s): ADENOCARCINOMA, CANCER, GEM-Derived Allograft, Inflammation, Kozlov, Mouse Models, Pancreatic
Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Oncology, Collaboration Sought > Licensing, Application > Research Materials
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