Search Results - therapeutics

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Methioninase Inducing Virus for Anti-Cancer Therapy

Application A set of viral constructs that induce regulatable expression of methionine degrading enzyme for treatment of brain tumors. Key Benefits Built-in Tet-responsive element ensures precise regulation, preventing unwanted enzyme activity. IL-2 signal directs the enzyme for secretion, optimizing its therapeutic impact. Specific delivery...

Published: 12/9/2025 | Inventor(s): Timothy R. Gershon, Leon McSwain, Andrey Tikunov

Keywords(s): Drug Discovery, Enzyme and Protein Research, Oncology Treatments, Therapeutics

Category(s): TechPub Algolia, TechPub Algolia > Therapeutics

The Use of Annexins in Preventing and Treating Muscle Membrane Injury

NU 2018-119 INVENTORS Elizabeth McNally* Alexis Demonbreun SHORT DESCRIPTION An annexin-based biological therapeutic that enhances the body's natural cell membrane repair process to reduce muscle cell death and preserve tissue function. BACKGROUND Cell membrane integrity is critical for survival, especially in tissues under constant mechanical...

Published: 12/9/2025 | Inventor(s):

Keywords(s): Neurodegenerative disease, Therapeutics

Category(s): Life Sciences > Therapeutics

New Therapeutic Approach for the Treatment of Acute Myeloid Leukemia

NU 2017-214 Inventors Ali Shilatifard* Zibo Zhao Short Description A new therapeutic approach for the treatment of acute myeloid leukemia using casein kinase inhibitors. Background Leukemia is a group of cancers that affects the bone marrow and results in the overproduction of dysfunctional white blood cells (WBCs). The mixed lineage leukemia...

Published: 11/18/2025 | Inventor(s):

Keywords(s): Cancer/Oncology, Therapeutics

Category(s): Life Sciences > Therapeutics

Novel 2-Imidazolyl-Pyrimidine Inhibitors for Neurodegenerative Disease Therapeutics

NU 2014-101 INVENTORS Richard Silverman* Paramita Mukherjee SHORT DESCRIPTION This invention introduces novel 2-imidazolyl-pyrimidine scaffolds that inhibit neuronal nitric oxide synthase. It offers potential for drug development targeting Parkinson’s and other neurodegenerative diseases. BACKGROUND Neurodegenerative disorders such as...

Published: 12/3/2025 | Inventor(s):

Keywords(s): Biomedical, Materials, Neurodegenerative disease, Neurologic disease, Neurology, Small molecule, Therapeutics

Category(s): Physical Sciences > Materials and Industrial Processes

Arylazanylpyrazolone Inhibition of Mutant SOD1 Mediated Cytotoxicity and Application to the Treatment of ALS

✅ Feedback form for Tech ID 2012-178 PROPOSED TITLE: Arylazanylpyrazolone Inhibition of Mutant SOD1 Cytotoxicity for ALS Treatment NU 2012-178 INVENTORS Richard Silverman* Yinan Zhang SHORT DESCRIPTION Compounds based on arylazanylpyrazolone derivatives inhibit mutant SOD1-mediated cytotoxicity, offering a promising approach for ALS treatment. BACKGROUND Amyotrophic...

Published: 11/18/2025 | Inventor(s):

Keywords(s): Therapeutics

Category(s): Life Sciences > Therapeutics

2-(Pyridin-3-yl)quinazoline compounds as glucocerebrosidase modulators

✅ Feedback form for Tech ID 2015-064 PROPOSED TITLE: 2-(Pyridin-3-yl) quinazoline Compounds as Glucocerebrosidase Modulators NU 2015-064 INVENTORS Richard Silverman* Dimitri Krainc Jianbin Zheng SHORT DESCRIPTION Novel substituted quinazoline compounds that modulate glucocerebrosidase activity, offering a promising therapeutic approach for...

Published: 11/18/2025 | Inventor(s):

Keywords(s): Neurodegenerative disease, Neurologic disease, PD - Parkinson's Disease, Research tool, Therapeutics

Category(s): Life Sciences > Therapeutics

Development of Therapeutics for Amyotrophic Lateral Sclerosis (ALS)

NU 2008-163 and NU2009-098 Inventors Richard B. Silverman* Richard Morimoto P. Hande Ozdinler Short Description Three series of New Chemical Entities (NCEs) that exhibit efficacy in an ALS animal model Background ALS causes muscle weakness and atrophy due to the degeneration of the upper and lower motor neurons. This disease is both genetic...

Published: 11/18/2025 | Inventor(s):

Keywords(s): Neurodegenerative disease, Neurologic disease, Therapeutics

Category(s): Life Sciences > Therapeutics

Pyrimidine-2,4,6-Trione Derivatives Preparation and Their Use for the Treatment of Amyotrophic Lateral Sclerosis (ALS) ALS Therapy

NU 2009-072 INVENTORS Richard Morimoto* Richard Silverman* Gavin Guoyao Xia SHORT DESCRIPTION This invention discloses novel pyrimidine-2,4,6-trione derivatives (PYT compounds) that prevent abnormal protein aggregation associated with ALS, offering a promising new therapeutic approach for neurodegenerative diseases. BACKGROUND Amyotrophic...

Published: 11/18/2025 | Inventor(s):

Keywords(s): ALS - Amyotrophic Lateral Sclerosis, Neurodegenerative disease, Therapeutics

Category(s): Life Sciences > Therapeutics

ACE2+ Exosomes for COVID-19 Decoy Therapy

PROPOSED TITLE: ACE2+ Exosomes for COVID-19 Decoy Therapy NU NUMBER NU 2020-145 INVENTORS Deyu Fang* Huiping Liu* Andrew Hoffmann Emma June Schuster Lamiaa El-Shennawy Nurmaa Dashzeveg SHORT DESCRIPTION This invention provides exosomes loaded with ACE2 protein or viral antigen-specific IgGs for treatment of COVID-19. BACKGROUND The COVID-19...

Published: 11/17/2025 | Inventor(s):

Keywords(s): COVID-19, Drug delivery, Infectious disease, Therapeutics

Category(s): Life Sciences > Therapeutics

Small Molecule Inhibitors Targeting OTUD4-CD73 Interaction for Immune-Cold Tumors

Application This technology introduces small molecule inhibitors, ST80 and Z22, to disrupt the protein-protein interaction (PPI) between OTUD4 and CD73. These inhibitors enhance tumor immunogenicity by reducing CD73 stabilization, improving the immune response in triple-negative breast cancer (TNBC) and other immune-cold tumors. Key Benefits ST80...

Published: 12/9/2025 | Inventor(s): Yong Wan, Yueming Zhu, Ivet Bahar, Anupam Banerjee, Jiyoung Lee

Keywords(s): Drug Target Identification, Immunotherapy, Oncology Treatments, Small Molecule, Therapeutics

Category(s): TechPub Algolia > Drug Discovery

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