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Search Results - therapeutics
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New Therapeutic Approach for the Treatment of Acute Myeloid Leukemia
NU 2017-214 Inventors Ali Shilatifard* Zibo Zhao Short Description A new therapeutic approach for the treatment of acute myeloid leukemia using casein kinase inhibitors. Background Leukemia is a group of cancers that affects the bone marrow and results in the overproduction of dysfunctional white blood cells (WBCs). The mixed lineage leukemia...
Published: 11/18/2025
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Inventor(s):
Keywords(s):
Cancer/Oncology
,
Therapeutics
Category(s):
Life Sciences >
Therapeutics
Novel 2-Imidazolyl-Pyrimidine Inhibitors for Neurodegenerative Disease
Therapeutics
PROPOSED TITLE: Novel 2-Imidazolyl-Pyrimidine Inhibitors for Neurodegenerative Disease
Therapeutics
NU 2014-101 INVENTORS Richard Silverman* Paramita Mukherjee SHORT DESCRIPTION This invention introduces novel 2-imidazolyl-pyrimidine scaffolds that inhibit neuronal nitric oxide synthase. It offers potential for drug development targeting Parkinson’s...
Published: 11/18/2025
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Inventor(s):
Keywords(s):
Biomedical
,
Materials
,
Neurodegenerative disease
,
Neurologic disease
,
Neurology
,
Small molecule
,
Therapeutics
Category(s):
Physical Sciences > Materials and Industrial Processes
Arylazanylpyrazolone Inhibition of Mutant SOD1 Mediated Cytotoxicity and Application to the Treatment of ALS
✅ Feedback form for Tech ID 2012-178 PROPOSED TITLE: Arylazanylpyrazolone Inhibition of Mutant SOD1 Cytotoxicity for ALS Treatment NU 2012-178 INVENTORS Richard Silverman* Yinan Zhang SHORT DESCRIPTION Compounds based on arylazanylpyrazolone derivatives inhibit mutant SOD1-mediated cytotoxicity, offering a promising approach for ALS treatment. BACKGROUND Amyotrophic...
Published: 11/18/2025
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Inventor(s):
Keywords(s):
Therapeutics
Category(s):
Life Sciences >
Therapeutics
2-(Pyridin-3-yl)quinazoline compounds as glucocerebrosidase modulators
✅ Feedback form for Tech ID 2015-064 PROPOSED TITLE: 2-(Pyridin-3-yl) quinazoline Compounds as Glucocerebrosidase Modulators NU 2015-064 INVENTORS Richard Silverman* Dimitri Krainc Jianbin Zheng SHORT DESCRIPTION Novel substituted quinazoline compounds that modulate glucocerebrosidase activity, offering a promising therapeutic approach for...
Published: 11/18/2025
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Inventor(s):
Keywords(s):
Neurodegenerative disease
,
Neurologic disease
,
PD - Parkinson's Disease
,
Research tool
,
Therapeutics
Category(s):
Life Sciences >
Therapeutics
Development of
Therapeutics
for Amyotrophic Lateral Sclerosis (ALS)
NU 2008-163 and NU2009-098 Inventors Richard B. Silverman* Richard Morimoto P. Hande Ozdinler Short Description Three series of New Chemical Entities (NCEs) that exhibit efficacy in an ALS animal model Background ALS causes muscle weakness and atrophy due to the degeneration of the upper and lower motor neurons. This disease is both genetic...
Published: 11/18/2025
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Inventor(s):
Keywords(s):
Neurodegenerative disease
,
Neurologic disease
,
Therapeutics
Category(s):
Life Sciences >
Therapeutics
Pyrimidine-2,4,6-Trione Derivatives Preparation and Their Use for the Treatment of Amyotrophic Lateral Sclerosis (ALS) ALS Therapy
NU 2009-072 INVENTORS Richard Morimoto* Richard Silverman* Gavin Guoyao Xia SHORT DESCRIPTION This invention discloses novel pyrimidine-2,4,6-trione derivatives (PYT compounds) that prevent abnormal protein aggregation associated with ALS, offering a promising new therapeutic approach for neurodegenerative diseases. BACKGROUND Amyotrophic...
Published: 11/18/2025
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Inventor(s):
Keywords(s):
ALS - Amyotrophic Lateral Sclerosis
,
Neurodegenerative disease
,
Therapeutics
Category(s):
Life Sciences >
Therapeutics
ACE2+ Exosomes for COVID-19 Decoy Therapy
PROPOSED TITLE: ACE2+ Exosomes for COVID-19 Decoy Therapy NU NUMBER NU 2020-145 INVENTORS Deyu Fang* Huiping Liu* Andrew Hoffmann Emma June Schuster Lamiaa El-Shennawy Nurmaa Dashzeveg SHORT DESCRIPTION This invention provides exosomes loaded with ACE2 protein or viral antigen-specific IgGs for treatment of COVID-19. BACKGROUND The COVID-19...
Published: 11/17/2025
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Inventor(s):
Keywords(s):
COVID-19
,
Drug delivery
,
Infectious disease
,
Therapeutics
Category(s):
Life Sciences >
Therapeutics
Small Molecule Inhibitors Targeting OTUD4-CD73 Interaction for Immune-Cold Tumors
Application This technology introduces small molecule inhibitors, ST80 and Z22, to disrupt the protein-protein interaction (PPI) between OTUD4 and CD73. These inhibitors enhance tumor immunogenicity by reducing CD73 stabilization, improving the immune response in triple-negative breast cancer (TNBC) and other immune-cold tumors. Key Benefits ST80...
Published: 11/13/2025
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Inventor(s):
Yong Wan
,
Yueming Zhu
,
Ivet Bahar
,
Anupam Banerjee
,
Jiyoung Lee
Keywords(s):
Drug Target Identification
,
Immunotherapy
,
Oncology Treatments
,
Small Molecule
,
Therapeutics
Category(s):
TechPub Algolia > Drug Discovery
Spherical Nucleic Acids with Sheddable PEG Layers for Enhanced Tumor Targeting
NU 2017-169 INVENTORS Chad Mirkin* (Northwestern University, Weinberg College of Arts and Sciences, Department of Chemistry, Director of the International Institute for Nanotechnology (IIN)) Brian Meckes Wuliang Zhang SHORT DESCRIPTION For oncology applications, this invention offers spherical nucleic acids with an enzyme-cleavable PEG layer...
Published: 11/7/2025
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Inventor(s):
Keywords(s):
Biologic
,
Biomarker
,
Biomedical
,
Cancer/Oncology
,
Chemicals
,
Diagnostics
,
Drug delivery
,
Nanoparticle
,
Nanotechnology
,
Personalized medicine
,
Therapeutics
Category(s):
Life Sciences >
Therapeutics
,
Life Sciences > Healthcare Devices, Tools & IT
,
Life Sciences > Biomarkers & Biomedical Research Tools
Fungal Natural Product Discovery Using FAC-MS Technology
NU 2016-068 INVENTORS Neil Kelleher* Kenneth Clevenger Paul Thomas SHORT DESCRIPTION This platform uses fungal artificial chromosomes and ultra‐high mass accuracy LC-MS to profile secondary metabolites. It offers a rapid, scalable approach for natural product discovery in drug and agricultural research. BACKGROUND Current natural product...
Published: 11/6/2025
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Inventor(s):
Keywords(s):
Therapeutics
Category(s):
Life Sciences >
Therapeutics
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