Search Results - therapeutics

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Spatiotemporal Drug Control in Autoimmune and Inflammatory Diseases: Photoswitchable JAK2 Inhibitors for Reversible Kinase Modulation
Advantages Precise spatiotemporal control and reversible modulation of kinase activity Reduced systemic toxicity and off-target effects Superior binding affinity and isomer selectivity than traditional Jak 2 inhibitor Summary Janus kinase 2 (JAK2), a key player in hematologic cancers and autoimmune diseases, is a particularly challenging target...
Published: 8/18/2025   |   Inventor(s): Shelby Kell, Chavdar Slavov
Keywords(s): Autoimmune Diseases, Inflammatory Diseases, Small Molecules, Therapeutics
Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals
M4 Foldamer Peptidomimetic: Targeting Amyloid-beta (Aβ) Aggregation to Restore Neuronal Function in Alzheimer’s Disease
Adantages Enhanced Blood-Brain Barrier (BBB) Penetration allows for efficient therapeutic targeting Superior serum stability enables a longer therapeutic window compared to conventional peptide therapeutics Multimodal therapeutic mechanism simultaneously addresses multiple pathological hallmarks of Alzheimer’s Disease (AD) Summary Alzheimer’s...
Published: 8/22/2025   |   Inventor(s): Jianfeng Cai, Heng Liu, Donghui Zhu, Firoz Akhter
Keywords(s): Alzheimer's Disease, Neurodegenerative Diseases, Therapeutics
Category(s): zzNeurodegenerative Diseases Treatment, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Therapeutics
Regenerative Extracellular Vesicle (EV) Therapy for Sarcopenia: A Cell-Free Solution for Muscle Aging
Advantages Rejuvenates aged muscle tissue: restoring to youthful state while enhancing muscle mass and strength. Reduces muscle fiber degeneration and inflammation: healthier and more effective muscle regeneration. Effectively reverses age-associated alterations in muscle stem cells (MuSCs), outperforming PBS treatment in aged mice models. Summary Sarcopenia...
Published: 7/23/2025   |   Inventor(s): Wanling Xuan
Keywords(s): Drug Discovery, Medical Pharmaceuticals, Therapeutics
Category(s): Technology Classifications > Medical, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals
Targeted Therapy for Glioblastoma via Purine Metabolism Modulation
NU 2019-086 INVENTORS Atique Ahmed* Cheol Park Jack Shireman SHORT DESCRIPTION This technology introduces a targeted approach for glioblastoma treatment that modulates purine biosynthesis by targeting the ARL13B-IMPDH2 interaction using repurposed FDA-approved and internationally-used drugs. BACKGROUND Glioblastoma is an incurable, aggressive...
Published: 8/5/2025   |   Inventor(s):  
Keywords(s): Cancer/Oncology, Repurposed Drugs, Therapeutics
Category(s): Life Sciences > Therapeutics
A targeted and localizing anticoagulation therapy
NU 2016-126 INVENTORS Guillermo Ameer* Yunxiao Zhu SHORT DESCRIPTION This technology employs a novel conjugation method that attaches a fibrin binding peptide (CREKA) to heparin, ensuring targeted localization and maintained anticoagulant activity for medical devices. BACKGROUND Current anticoagulation strategies typically...
Published: 8/5/2025   |   Inventor(s):  
Keywords(s): Therapeutics
Category(s): Life Sciences > Therapeutics
Computerized Cognitive Training for Insomnia (COGMUSE)
Advantages Gamified cognitive training that is aimed at adults with both autism and insomnia Flexibility in terms of the ability to incorporate user feedback Summary Older adults with insomnia as well as autistic adults with co-occurring insomnia often struggle with persistent cognitive and sleep disturbances. These issues are only marginally...
Published: 7/17/2025   |   Inventor(s): Ashley Curtis
Keywords(s): Biotechnology, Computer Science, Computers Software and Information Technology, Health Tech, Human Computer Interfaces, Neuroscience, Psychiatry / Mental Health, Therapeutics
Category(s): Technology Classifications > Computer Science > Computers Software & Information Technology, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Therapeutics, Technology Classifications > Engineering > Computer Engineering
Development of an Innovative AI-Enhanced Music-Based Magnetic Respiratory Therapy System
Advantages Uses magnetic sensors to monitor breathing without wires or chest straps AI adapts music in real time to regulate and stabilize respiration Designed for stress relief, respiratory therapy, and sleep quality improvement Comfortable, low-cost, and easy to use for home or clinical settings Summary Patients with respiratory issues whether...
Published: 5/20/2025   |   Inventor(s): Manh-Huong Phan, Dang Nguyen, Kee Young Hwang
Keywords(s): Therapeutics
Category(s): Technology Classifications > Medical > Therapeutics
Bone-Promoting Thermoresponsive Macromolecules
PROPOSED TITLE Bone-Promoting Thermoresponsive Macromolecules NU 2016-201 INVENTORS Guillermo Ameer* Simona Morochnik SHORT DESCRIPTION Injectable, thermoresponsive PPCN-based hydrogels that are liquid at room temperature and gel at body temperature to provide controlled release of therapeutic agents and promote bone repair and formation. BACKGROUND The...
Published: 8/5/2025   |   Inventor(s):  
Keywords(s): Therapeutics
Category(s): Life Sciences > Therapeutics
A New Approach for Treating CADASIL
A new therapy to restore brain function and improve CADASIL-associated cognitive function. Background: CADASIL is a genetic disease that can lead to stroke and dementia. Caused by a gene mutation in nearly four out of every thousand people, this condition mainly affects young and middle-aged adults. It damages small blood vessels in the brain,...
Published: 5/13/2025   |   Inventor(s): Li-Ru Zhao, Suning Ping
Keywords(s): therapeutics
Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines
Self-powered, bioresorbable drug release systems
NU 2023-045 INVENTORS John Rogers* Colin Franz* Yamin Zhang SHORT DESCRIPTION Northwestern and Shirley Ryan AbilityLab researchers have developed a novel, self-powered, bioresorbable drug delivery system that enables light-controlled, targeted drug release without the need for surgical removal post-treatment. BACKGROUND Current drug delivery systems...
Published: 8/5/2025   |   Inventor(s):  
Keywords(s): Biomaterials, Cancer/Oncology, Drug delivery, Infectious disease, Medical device, Therapeutics
Category(s): Life Sciences > Healthcare Devices, Tools & IT
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