Search Results - therapeutics

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Clinical Bacterial Isolate Engineered as Prostate Cancer Immunotherapy
NU 2015-087 INVENTORS Praveen Thumbikat* Anthony Schaeffer Jonathan Anker Sarki Abdulkadir SHORT DESCRIPTION This technology uses a genetically modified CP1 E. coli as an immunotherapeutic agent for prostate cancer. It offers a non-invasive treatment option designed to stimulate an immune response in both early stage and advanced disease. BACKGROUND Existing...
Published: 10/10/2025   |   Inventor(s):  
Keywords(s): Cancer/Oncology, Therapeutics
Category(s): Life Sciences > Therapeutics
A Novel Combination Therapy for Parkinson’s Disease
NU 2013-149 INVENTORS Dalton Surmeier Jr (Northwestern University, Feinberg School of Medicine, Chair of the Department of Neuroscience)* Daniel Galtieri Ema Ilijic Enrico Zampese Jaime Guzman-Lucero Javier Sanchez SHORT DESCRIPTION This technology uses a low-dose combination of two FDA-approved compounds to reduce oxidative stress in neurons...
Published: 10/9/2025   |   Inventor(s):  
Keywords(s): Biomedical, Drug delivery, Neurodegenerative disease, Neurologic disease, PD - Parkinson's Disease, Therapeutics
Category(s): Life Sciences > Therapeutics
Protein Biomarkers of Rett Syndrome
Application Quantifiable protein biomarkers for Rett syndrome. Key Benefits Critical protein biomarkers of Rett syndrome identified in brain and cerebrospinal fluid. Quantifiable biochemical biomarkers of gene therapy effectiveness. Market Summary Rett syndrome is a progressive neurodevelopmental disorder that affects approximately one in 10,000...
Published: 10/3/2025   |   Inventor(s): Victor Faundez, Stephanie Zlatic
Keywords(s): Biomarkers, Gene Therapy and Editing, Rare and Orphan Disease Treatments, Therapeutics
Category(s): TechPub Algolia > Diagnostics
Novel Heart Failure Therapy: Farnesyltransferase Inhibition Targets Protein Aggregation in Cardiomyocytes
Advantages First-in-Class Mechanism: Targets a novel pathway—protein farnesylation—for heart failure treatment. Broad Therapeutic Potential: Effective in both HFrEF and HFpEF, addressing a major unmet need. Tested in multiple preclinical models: Danon disease cardiomyopathy (genetic model); HFpEF (diet-induced and hypertensive models);...
Published: 9/11/2025   |   Inventor(s): Kunhua Song, Congwu Chi, Amanda Conniff
Keywords(s): Cardiovascular Diseases, Drug Repurpose, Medical Pharmaceuticals, Therapeutics
Category(s): Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Biotechnology, Technology Classifications > Chemistry
Antibody based reagents that specifically recognize toxic oligomeric forms of beta-amyloid
Neurodegenerative diseases such as Alzheimer’s are affecting an increasing number, with annual new diagnoses approaching one-half million; and total cost, $150 billion. Early diagnosis and treatment are important for optimal outcomes, yet there is currently no test to detect such diseases in their early, asymptomatic stages. Active immuniza-tion...
Published: 8/27/2025   |   Inventor(s): Michael Sierks, Srinath Kasturirangan
Keywords(s): Bio-Technology, Therapeutics
Category(s): Life Science (All LS Techs), Diagnostic Assays/Devices, Neurodegenerative Disease Technologies, Non-Cancer Therapeutics, Proteomic Assays/Reagents/Tools, Medical Diagnostics/Sensors
Reagents Targeting Neurodegenerative Diseases and Traumatic Brain Injury
Misfolding and aggregation of proteins, such as beta-amyloid (Aß), alpha-synuclein (a-syn), tau and TAR DNA-binding protein 43 (TDP-43), have been strongly correlated with early onset of neurodegenerative diseases such as Alzheimer's Disease (AD), Parkinson's Disease (PD), Frontotemporal Dementia (FTD), amyotrophic lateral sclerosis (ALS) and...
Published: 8/27/2025   |   Inventor(s): Michael Sierks, Stephanie Williams, Lalitha Venkataraman
Keywords(s): AFM, Antibody Therapeutics, Antigen-specific Therapies, Bioassay, Bio-Technology, CNS Therapeutics, Therapeutics
Category(s): Life Science (All LS Techs), Neurodegenerative Disease Technologies, Non-Cancer Therapeutics, Proteomic Assays/Reagents/Tools, Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices
Spatiotemporal Drug Control in Autoimmune and Inflammatory Diseases: Photoswitchable JAK2 Inhibitors for Reversible Kinase Modulation
Advantages Precise spatiotemporal control and reversible modulation of kinase activity Reduced systemic toxicity and off-target effects Superior binding affinity and isomer selectivity than traditional Jak 2 inhibitor Summary Janus kinase 2 (JAK2), a key player in hematologic cancers and autoimmune diseases, is a particularly challenging target...
Published: 9/11/2025   |   Inventor(s): Shelby Kell, Chavdar Slavov
Keywords(s): Autoimmune Diseases, Inflammatory Diseases, Small Molecules, Therapeutics
Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals
M4 Foldamer Peptidomimetic: Targeting Amyloid-beta (Aβ) Aggregation to Restore Neuronal Function in Alzheimer’s Disease
Adantages Enhanced Blood-Brain Barrier (BBB) Penetration allows for efficient therapeutic targeting Superior serum stability enables a longer therapeutic window compared to conventional peptide therapeutics Multimodal therapeutic mechanism simultaneously addresses multiple pathological hallmarks of Alzheimer’s Disease (AD) Summary Alzheimer’s...
Published: 9/29/2025   |   Inventor(s): Jianfeng Cai, Heng Liu, Donghui Zhu, Firoz Akhter
Keywords(s): Alzheimer's Disease, Neurodegenerative Diseases, Therapeutics
Category(s): zzNeurodegenerative Diseases Treatment, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Therapeutics
Regenerative Extracellular Vesicle (EV) Therapy for Sarcopenia: A Cell-Free Solution for Muscle Aging
Advantages Rejuvenates aged muscle tissue: restoring to youthful state while enhancing muscle mass and strength. Reduces muscle fiber degeneration and inflammation: healthier and more effective muscle regeneration. Effectively reverses age-associated alterations in muscle stem cells (MuSCs), outperforming PBS treatment in aged mice models. Summary Sarcopenia...
Published: 9/11/2025   |   Inventor(s): Wanling Xuan
Keywords(s): Drug Discovery, Medical Pharmaceuticals, Therapeutics
Category(s): Technology Classifications > Medical, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals
Targeted Therapy for Glioblastoma via Purine Metabolism Modulation
NU 2019-086 INVENTORS Atique Ahmed* Cheol Park Jack Shireman SHORT DESCRIPTION This technology introduces a targeted approach for glioblastoma treatment that modulates purine biosynthesis by targeting the ARL13B-IMPDH2 interaction using repurposed FDA-approved and internationally-used drugs. BACKGROUND Glioblastoma is an incurable, aggressive...
Published: 10/3/2025   |   Inventor(s):  
Keywords(s): Cancer/Oncology, Repurposed Drugs, Therapeutics
Category(s): Life Sciences > Therapeutics
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