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Search Results - therapeutics
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Self-Manageable Abnormal Scar Treatment with Spherical Nucleic Acids (SNAs) Technology
NU 2018-071 INVENTORS Anthony Sprangers Shengshuang Zhu Adam Ponedal Chad Mirkin* ABSTRACT A self-administrable scar treatment based on spherical nucleic acids (SNAs) that penetrates skin and suppressed TGFβ1 expression to prevent abnormal scar formation. Non-invasive and offers patients an accessible, painless solution for scar care...
Published: 9/10/2024
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Inventor(s):
Keywords(s):
Therapeutics
Category(s):
Life Sciences >
Therapeutics
New Lipiodol Formulation for Treating Hepatocellular Carcinoma with Transarterial Chemoimmunoembolization
NU 2021-148 INVENTORS Dong Hyun Kim* Heegon Kim SHORT DESCRIPTION A new Lipiodol formulation designed to improve the efficacy and safety of transarterial chemoembolization in combination with immunotherapy. BACKGROUND Transarterial chemoembolization...
Published: 9/4/2024
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Inventor(s):
Keywords(s):
Cancer/Oncology
,
Drug delivery
,
Gastrointestinal and Hepatic disease
,
Immunotherapy
,
Therapeutics
Category(s):
Life Sciences >
Therapeutics
Novel
Therapeutics
for Pediatric Embryonal Tumors Using PLK4 inhibitors
LU 2017-124 INVENTORS Simone T. Sredni* Tadanori Tomita SHORT DESCRIPTION Embryonal tumors such as malignant rhabdoid tumors (MRTs) are aggressive and frequently metastatic embryonal tumors of infancy. However, available therapies often elicit modest anti-tumor response leading to poor survival, or induce highly toxicity in patients of young...
Published: 8/26/2024
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Inventor(s):
Keywords(s):
Therapeutics
Category(s):
Life Sciences >
Therapeutics
Combination therapy for the treatment of triple negative breast cancer
Summary Researchers at OHSU have discovered a novel combination therapy for triple negative breast cancer, which increases immune responses, causes tumor regression and improves survival in animal models. Technology Overview Triple negative breast cancer (TNBC) represents one of the most aggressive forms of all breast cancer subtypes with a very...
Published: 9/17/2024
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Inventor(s):
Sanjay Malhotra
,
Lisa Coussens
,
Dhanir Tailor
,
Sushil Kumar
,
Arpit Dheeraj
Keywords(s):
Therapeutics
,
Therapeutics
- Cancer
Category(s):
Therapeutics
Functional Enrichment and Purification of a Therapeutically Superior Population of Cells (Case No. 2024-024)
Summary: UCLA researchers in the Departments of Bioengineering and Biological Chemistry have developed a method for identifying and enriching therapeutically useful cell sub-populations based on their secretions (SEC-seq). Background: Cell function is defined by a myriad of biomolecules that they secrete; over 3 thousand proteins are estimated to...
Published: 9/11/2024
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Inventor(s):
Dino Di Carlo
,
Kathrin Plath
,
Shreya Udani
,
Justin Langerman
Keywords(s):
Cell Surface Receptor
,
Cytometry
,
Flow Cytometry
,
Functional Genomics
,
High-Throughput Screening
,
hydrogel
,
Microfluidics
,
single cell analysis
,
Therapeutics
Category(s):
Therapeutics
> Immunology And Immunotherapy
,
Therapeutics
,
Therapeutics
> Oncology > Oncology Immunotherapy
,
Life Science Research Tools
,
Life Science Research Tools > Research Methods
,
Diagnostic Markers > Targets And Assays
,
Therapeutics
> Cell Therapy
Peptide Amphiphiles for Sonic Hedgehog Regulation of Pelvic Nerves for Treatment of Stress Urinary Incontinence and Erectile Dysfunction
NU 2018-075, 2018-076, 2018-077 INVENTORS Caroline Podlasek Kevin McVary Daniel Harrington Samuel Stupp* SHORT DESCRIPTION Novel peptide amphiphile (PA) nanofiber hydrogel is used to deliver sonic hedgehog (SHH) protein to nerves of the major pelvic ganglia and the rhabdospincter as a treatment for erectile dysfunction and urinary incontinence. BACKGROUND Urinary...
Published: 7/11/2024
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Inventor(s):
Keywords(s):
Materials
,
Therapeutics
Category(s):
Life Sciences >
Therapeutics
Multi-Phasic Therapeutic Delivery System (UCLA Case No. 2020-396)
Researchers in the Department of Radiological Sciences at UCLA have conceived a new methodology to overcome obstacles arising after the treatment of tumors by accessing their vascular supply by 1) targeting tumor vessels 2) delivering antineoplastic agents (e.g., chemotherapy or immunotherapy) and 3) delivering anti-angiogenic therapy to reduce blood...
Published: 7/10/2024
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Inventor(s):
Antoinette Gomes
Keywords(s):
Anti-Angiogenics
,
Multiphasic and Multitemporal
,
Oncology
,
Therapeutics
,
Vascular therapy
Category(s):
Therapeutics
> Oncology
,
Medical Devices
Therapy for acute kidney injury
NU 2022-202 INVENTORS Pinelopi Kapitsinou* Ratnakar Tiwari SHORT DESCRIPTION Inhibition of MCT4 slows the progression of acute kidney inury to chronic kidney disease BACKGROUND Acute kidney inury (AKI) is a sudden onset of kidney dysfunction, often caused by factors such as ischemia, toxins, or infections, leading to impaired filtration and accumulation...
Published: 8/26/2024
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Inventor(s):
Keywords(s):
Inflammation
,
Renal Disease
,
Therapeutics
Category(s):
Life Sciences >
Therapeutics
Nanopatterning for control of cell cytoskeleton
NU 2018-027 INVENTORS Chad Mirkin* Milan Mrksich* Brian Meckes Maria Cabezas SHORT DESCRIPTION Polymer pen lithography (PPL) to spatially define locations where cells can adhere to a substrate in aniosotropic patterns. BACKGROUND Cells have unique shapes that play significant roles in their function; cell shape influences cellular processes...
Published: 7/3/2024
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Inventor(s):
Keywords(s):
Therapeutics
Category(s):
Life Sciences >
Therapeutics
TranquiDome™ healing pod integrated with multisensory features
Unmet Need: A comfortable regenerative pod to reduce the stress among blood donors and enhance their blood donation experience. The United States is experiencing an increasing demand of about 2-3% per year for blood supply, to address medical treatments, natural disasters, and emergencies. Blood centers face a critical need to provide a comfortable...
Published: 6/12/2024
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Inventor(s):
Minyoung Cerruti
,
Ruben Estrada
,
Dakota Witte
,
Naeem Shook
Keywords(s):
Adaptive Healthcare Technologies
,
Clinics and hospitals
,
Healing Pod
,
Therapeutics
Category(s):
Technologies > Health & Well-being > Community Health & Safety
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