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Search Results - therapeutics
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A CSF-derived therapy for psychiatric disorders
NU2023-196 INVENTORS Peter Penzes* Marc Dos Santos BACKGROUND Currently, there is a lack of treatments which address the negative and cognitive symptoms of psychiatric disorders such as schizophrenia. Northwestern researchers have designed a recombinant form of ⍺2d-1 protein, a subunit of the voltage-gated calcium channel, to restore protein...
Published: 10/17/2024
|
Inventor(s):
Keywords(s):
Biologic
,
Psychiatric disease
,
Therapeutics
Category(s):
Life Sciences >
Therapeutics
Small molecule disruption of the super elongation complex as
therapeutics
for cancer and HIV infection
NU 2018-018 INVENTORS Ali Shilatifard* Kaiwei Liang Edwin R. Smith Gary E. Schiltz BACKGROUND The Super Elongation Complex (SEC) is a multiprotein complex that promotes productive elongation by RNA Polymerase II (Pol II), driving high rates of transcription that is implicated in multiple forms of Myc and MLL-driven cancers, as well as...
Published: 10/17/2024
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Inventor(s):
Keywords(s):
Therapeutics
Category(s):
Life Sciences >
Therapeutics
Targeting mTOR-Related Autophagy Dysfunction to Treat Age-Related Hearing Loss with Rapamycin and Its Derivatives
Advantages: Novel Application of FDA approved drugs, rapamycin and its derivatives, for treating age-related hearing loss (ARHL). Targeting mTOR alleviates oxidative stress and inflammation in the cochlea, enhancing cellular health and resilience to age-related damage. Potential to Reverse or Delay Age-related hearing loss (ARHL) in patients. Summary: Age-related...
Published: 11/5/2024
|
Inventor(s):
Robert Frisina
,
Xiaohua Zhu
,
Bo Ding
,
Xiaoxia Zhu
Keywords(s):
Pharmaceuticals
,
Therapeutics
Category(s):
Technology Classifications > Medical >
Therapeutics
,
Technology Classifications > Medical > Pharmaceuticals
,
Technology Classifications > Medical > Biotechnology
,
Technology Classifications > Medical > Biomedical Engineering
,
Technology Classifications > Medical > Medical Devices
Malaria transmission blocking using ELQ-infused bed nets
Summary Insecticide-treated mosquito bed nets reduce the transmission of malaria, but mosquitos have developed resistance to insecticides leading to reduced efficacy. Our new technology is a chemical solution for mosquito nets that kills malaria, is less prone to drug-resistance and is not toxic to humans. Technology Overview Insecticide-treated...
Published: 10/15/2024
|
Inventor(s):
Michael Riscoe
,
Aaron Nilsen
,
Joseph (Stone) Doggett
,
Flaminia Catteruccia
,
Douglas (Doug) Paton
Keywords(s):
Therapeutics
,
Therapeutics
- Infectious Diseases
,
Therapeutics
- Other
Category(s):
Therapeutics
,
Device
,
Chemical
Self-Manageable Abnormal Scar Treatment with Spherical Nucleic Acids (SNAs) Technology
NU 2018-071 INVENTORS Chad Mirkin* Anthony Sprangers Adam Ponedal SHORT DESCRIPTION Self-manageable abnormal scar treatment with spherical nucleic acid technology. BACKGROUND Despite advances in understanding molecular mechanisms of scar formation and decades of development of scar care development, an effective self-manageable scar treatment...
Published: 10/17/2024
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Inventor(s):
Keywords(s):
Therapeutics
Category(s):
Life Sciences >
Therapeutics
New Lipiodol Formulation for Treating Hepatocellular Carcinoma with Transarterial Chemoimmunoembolization
NU 2021-148 INVENTORS Dong Hyun Kim* Heegon Kim SHORT DESCRIPTION A new Lipiodol formulation designed to improve the efficacy and safety of transarterial chemoembolization in combination with immunotherapy. BACKGROUND Transarterial chemoembolization...
Published: 11/27/2024
|
Inventor(s):
Keywords(s):
Cancer/Oncology
,
Drug delivery
,
Gastrointestinal and Hepatic disease
,
Immunotherapy
,
Therapeutics
Category(s):
Life Sciences >
Therapeutics
Novel
Therapeutics
for Pediatric Embryonal Tumors Using PLK4 inhibitors
LU 2017-124 INVENTORS Simone T. Sredni* Tadanori Tomita SHORT DESCRIPTION Embryonal tumors such as malignant rhabdoid tumors (MRTs) are aggressive and frequently metastatic embryonal tumors of infancy. However, available therapies often elicit modest anti-tumor response leading to poor survival, or induce highly toxicity in patients of young...
Published: 8/26/2024
|
Inventor(s):
Keywords(s):
Therapeutics
Category(s):
Life Sciences >
Therapeutics
Combination therapy for the treatment of triple negative breast cancer
Summary Researchers at OHSU have discovered a novel combination therapy for triple negative breast cancer, which increases immune responses, causes tumor regression and improves survival in animal models. Technology Overview Triple negative breast cancer (TNBC) represents one of the most aggressive forms of all breast cancer subtypes with a very...
Published: 9/17/2024
|
Inventor(s):
Sanjay Malhotra
,
Lisa Coussens
,
Dhanir Tailor
,
Sushil Kumar
,
Arpit Dheeraj
Keywords(s):
Therapeutics
,
Therapeutics
- Cancer
Category(s):
Therapeutics
Functional Enrichment and Purification of a Therapeutically Superior Population of Cells (Case No. 2024-024)
Summary: UCLA researchers in the Departments of Bioengineering and Biological Chemistry have developed a method for identifying and enriching therapeutically useful cell sub-populations based on their secretions (SEC-seq). Background: Cell function is defined by a myriad of biomolecules that they secrete; over 3 thousand proteins are estimated to...
Published: 9/11/2024
|
Inventor(s):
Dino Di Carlo
,
Kathrin Plath
,
Shreya Udani
,
Justin Langerman
Keywords(s):
Cell Surface Receptor
,
Cytometry
,
Flow Cytometry
,
Functional Genomics
,
High-Throughput Screening
,
hydrogel
,
Microfluidics
,
single cell analysis
,
Therapeutics
Category(s):
Therapeutics
> Immunology And Immunotherapy
,
Therapeutics
,
Therapeutics
> Oncology > Oncology Immunotherapy
,
Life Science Research Tools
,
Life Science Research Tools > Research Methods
,
Diagnostic Markers > Targets And Assays
,
Therapeutics
> Cell Therapy
Peptide Amphiphiles for Sonic Hedgehog Regulation of Pelvic Nerves for Treatment of Stress Urinary Incontinence and Erectile Dysfunction
NU 2018-075, 2018-076, 2018-077 INVENTORS Caroline Podlasek Kevin McVary Daniel Harrington Samuel Stupp* SHORT DESCRIPTION Novel peptide amphiphile (PA) nanofiber hydrogel is used to deliver sonic hedgehog (SHH) protein to nerves of the major pelvic ganglia and the rhabdospincter as a treatment for erectile dysfunction and urinary incontinence. BACKGROUND Urinary...
Published: 7/11/2024
|
Inventor(s):
Keywords(s):
Materials
,
Therapeutics
Category(s):
Life Sciences >
Therapeutics
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