Search Results - therapeutics

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A new therapy to restore brain function and improve CADASIL-associated cognitive function. Background: CADASIL is a genetic disease that can lead to stroke and dementia. Caused by a gene mutation in nearly four out of every thousand people, this condition mainly affects young and middle-aged adults. It damages small blood vessels in the brain,...

Published: 4/1/2025 | Inventor(s): Li-Ru Zhao, Suning Ping

Keywords(s): therapeutics

Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines

Targeting Calcium Channels to treat Early-Stage Parkinson’s Disease

NU 2024-179 INVENTORS Dalton J. Surmeier Jr* Jack Nguyen SHORT DESCRIPTION Novel compounds to inhibit Cav1.3 calcium channels and slow the progression of Parkinson's Disease. BACKGROUND Parkinson’s Disease (PD) is the second most common age-related neurodegenerative disease after Alzheimer’s Disease, affecting nearly one million...

Published: 4/4/2025 | Inventor(s):

Keywords(s): Neurodegenerative disease, Small molecule, Therapeutics

Category(s): Life Sciences > Therapeutics

Brain Cancer: Novel Prognostic Method and Therapeutic Target for Glioblastoma

Advantages: A precision-guided method for identifying glioblastoma-related genes that improves assessment of the current prognostic biomarker Enables the identification of potential novel therapeutic targets: GLP1R agonists, which are already used for managing obesity and type 2 diabetes, could be explored as treatments for GBM Broader Applications:...

Published: 3/24/2025 | Inventor(s): George Blanck, Teresa Thomas

Keywords(s): Cancer Diagnostics, Medical Diagnostics, Oncology, Therapeutics

Category(s): Technology Classifications > Cancer > Cancer Diagnostics, Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Oncology, Technology Classifications > Medical > Therapeutics

Small Molecule for Bladder Repair

NU 2021-153 INVENTORS Arun Sharma* Matthew Bury Natalie Fuller SHORT DESCRIPTION A small molecule to improve the regenerative outcomes of injured or diseased urinary bladder tissue ABSTRACT Northwestern researchers have identified a small molecule that facilitates the repair and restoration of damaged urinary bladder tissue following loss of...

Published: 4/4/2025 | Inventor(s):

Keywords(s): Drug discovery, Small molecule, Therapeutics, Urology

Category(s): Life Sciences > Therapeutics

Nanotherapy to Treat Intestinal Inflammation

NU 2015-160 PRIMARY INVENTOR Arun Sharma SHORT DESCRIPTION Potent anti-inflammatory nanomolecules to treat chronic intestinal inflammation (ileitis) that is detrimental to tissue function BACKGROUND Clinical complications of inflammatory bowel disease (IBD) such as Crohn’s disease (CD) can be observed throughout the digestive tract as tissue...

Published: 4/4/2025 | Inventor(s):

Keywords(s): Gastrointestinal and Hepatic disease, Inflammation, Small molecule, Therapeutics

Category(s): Life Sciences > Therapeutics

Simple Formulation of Anaerobic Bacteria to Treat Solid Tumors

NU 2022-219 INVENTORS Dong-Hyun Kim* Hyunjun Choi Bongseo Choi SHORT DESCRIPTION A formulation of anaerobic bacteria embedded in embolic material, delivered through transcatheter intra-arterial infusion for treating solid tumors. BACKGROUND Non-pathogenic Clostridium novyi (C. novyi-NT) is an anaerobic bacterium capable of selective germination...

Published: 4/4/2025 | Inventor(s):

Keywords(s): Cancer/Oncology, Materials, Therapeutics

Category(s): Life Sciences > Therapeutics

Therapeutic Intervention for ALS and Dementia

NU 2021-058 INVENTORS Evangelos Kiskinis* Juan Alberto Ortega Cano Marco Boccitto SHORT DESCRIPTION Design of an RNA-based oligonucleotide that protects from dipeptide repeat protein toxicity for the treatment of ALS and FTD. BACKGROUND Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are devastating neurodegenerative diseases...

Published: 3/3/2025 | Inventor(s):

Keywords(s): Neurodegenerative disease, Therapeutics

Category(s): Life Sciences > Therapeutics

Novel Anti- Aggregation Therapeutic Targets Against Cystic Fibrosis Caused by Pseudomonas Aeruginosa

Advantages: Therapeutic Targets: Identified essential genes in Pa aggregate formation that can be potentially targeted with therapeutics Improved Infection Model: use of synthetic CF sputum media that closely mimics the physical and nutritional environment of CF sputum Potential for Broader Applications: can be extended to other bacterial species...

Published: 2/21/2025 | Inventor(s): Sophie Darch

Keywords(s): Medical Devices, Medical Diagnostics, Therapeutics

Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Medical Diagnostics

A CSF-derived therapy for psychiatric disorders

NU2023-196 INVENTORS Peter Penzes* Marc Dos Santos BACKGROUND Currently, there is a lack of treatments which address the negative and cognitive symptoms of psychiatric disorders such as schizophrenia. Northwestern researchers have designed a recombinant form of ⍺2d-1 protein, a subunit of the voltage-gated calcium channel, to restore protein...

Published: 10/17/2024 | Inventor(s):

Keywords(s): Biologic, Psychiatric disease, Therapeutics

Category(s): Life Sciences > Therapeutics

Small molecule disruption of the super elongation complex as therapeutics for cancer and HIV infection

NU 2018-018 INVENTORS Ali Shilatifard* Kaiwei Liang Edwin R. Smith Gary E. Schiltz BACKGROUND The Super Elongation Complex (SEC) is a multiprotein complex that promotes productive elongation by RNA Polymerase II (Pol II), driving high rates of transcription that is implicated in multiple forms of Myc and MLL-driven cancers, as well as...

Published: 3/3/2025 | Inventor(s):

Keywords(s): Therapeutics

Category(s): Life Sciences > Therapeutics

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