Search Results - animal+model

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STING Agonist 8803 for Blood-Brain Barrier Opening in Glioblastoma Treatment
SHORT DESCRIPTION Chemical compound that opens the blood-brain barrier to enhance delivery of therapeutics for treating glioblastoma. INVENTORS Amy Heimberger* Northwestern University Feinberg School of Medicine, Department of Neurological Surgery * Principal Investigator NU 2025-212 IP STATUS US...
Published: 4/27/2026   |   Updated: 4/27/2026   |   Inventor(s):  
Keywords(s): AD - Alzheimer’s Disease, Adjunct therapy, ALS - Amyotrophic Lateral Sclerosis, Animal Model, Autoimmune disease, Cancer/Oncology, CNS - Central Nervous System, Drug delivery, Immunology, Immunotherapy, MS - Multiple Sclerosis, Neurodegenerative disease, Neurologic disease, PD - Parkinson's Disease, Repurposed Drugs, Research tool, Small molecule, Targeted therapy, TBI - Traumatic brain injury
Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools
A Rat Model of IgA Nephropathy
NU 2019-196 INVENTORS Jing Jin* Xinfang Xie SHORT DESCRIPTION A novel rat model of IgA nephropathy (IgAN, also known as Berger's disease), enabling reproducible kidney mesangial deposits characteristic of the human disease for therapeutic and diagnostic evaluation. BACKGROUND IgAN, the most common glomerulonephritis worldwide, results...
Published: 4/13/2026   |   Updated: 2/26/2026   |   Inventor(s):  
Keywords(s): Animal Model, Antibody, Drug screening, Immunology, Inflammation, Renal Disease, Research tool
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
Cell Line for Generating Nonhuman Primate T Cells
Application Cell line for efficient in vitro differentiation of rhesus macaque-specific T cells from hematopoietic stem and progenitor cells. Key Benefits Replaces need for primary rhesus macaque thymus tissue. Improves differentiation efficiency and reduces media requirements compared to existing methods. Yields CD4+ and CD8+ T cells, double-positive...
Published: 1/20/2026   |   Updated: 11/3/2025   |   Inventor(s): Sheikh Rahman
Keywords(s): 3D in vitro Models, Animal Model, Cell Lines and Organoids, Immunology and Inflammation Treatments
Category(s): TechPub Algolia > Research Tools
A GALT-null Rat Model for Studies of Classic Galactosemia
Application Pre-clinical rodent model to study classic galactosemia disease. Key Benefits Identify striking differences in GALT-independent galactose metabolism among tissues and across post-natal time points. Study the relationship between galactose metabolite levels in blood and other tissues. Study the impact of rigorous galactose restriction...
Published: 1/20/2026   |   Updated: 7/2/2024   |   Inventor(s): Judith Fridovich-Keil
Keywords(s): Animal Model, Rare and Orphan Disease Treatments
Category(s): TechPub Algolia > Research Tools
Mouse Model for Specific Proteomic Labeling
Application Proteomic labeling (labeling of proteins). Key Benefits Method can be used to express TurboID in any cell type. The mouse line can be crossed with any existing Cre line and can be extended to any organ/tissue system. Detection of labeled biomarkers can be identified in biofluids as biomarkers of cell specific disease mechanisms. Can...
Published: 2/13/2025   |   Updated: 12/1/2023   |   Inventor(s): Srikant Rangaraju, Nicholas (Nick) Seyfried, Sruti Rayaprolu
Keywords(s): Animal Model, Biomarkers
Category(s): TechPub Algolia > Research Tools
Pig Lentiviral-Induced Spinal Cord Glioblastoma
Application Porcine model of spinal cord glioblastoma for the development and testing of pre-clinical therapeutic for spinal cord tumors. Key Benefits Novel lentiviral gene transfer offers a viable pathway to modeling glioblastoma in higher order species. The existing model is the first reproducible immunocompetent large animal model of spinal...
Published: 2/13/2025   |   Updated: 11/27/2023   |   Inventor(s): Muhibullah (Mohib) Tora, Pavlos Texakalidis, Thais Buchman, Nicholas Boulis
Keywords(s): Animal Model
Category(s): TechPub Algolia > Research Tools
SMAD3 Reporter Mouse for Assessing TGF-ß/Activin Pathway Activation
Description of Technology: The Transforming Growth Factor Beta (TGF-ß) ligands (i.e., TGF-ß1, -ß2, -ß3) are key regulatory proteins in animal physiology. Disruption of normal TGF-ß signaling is associated with many diseases from cancer to fibrosis. In mice and humans, TGF-ß activates TGF-ß receptors (e.g.,...
Published: 4/24/2026   |   Updated: 8/2/2023   |   Inventor(s): Lalage Wakefield, Yu-an Yang, Sushil Rane, Caroline Hill
Keywords(s): Animal Model, CANCER, EGFP, Fibrosis, Wakefield, mothers against decapentaplegic homolog 3, Oncology, Reporter Mouse, SMAD3, TGF-ß, Transforming Growth Factor Beta
Category(s): TherapeuticArea > Endocrinology, TherapeuticArea > Oncology, Application > Research Materials, Collaboration Sought > Licensing, TherapeuticArea > Cardiology, TherapeuticArea > Immunology, TherapeuticArea > Neurology
Whole-Animal Genetic Model to Mimic Aspects of the Patient Phenotype of Classic Galactosemia
­ Application An animal model for studying the underlying causes of galactosemia and screening for novel drugs to treat the condition. Key Benefits The first animal model for elucidating the underlying causes of galactosemia in infants. Animals with galactosemia causing genetic knockout exhibit similar disease phenotypes and complications...
Published: 7/30/2024   |   Updated: 2/8/2023   |   Inventor(s): Judith Fridovich-Keil
Keywords(s): Animal Model, Enzyme/Protein, Genetic Disorders, Metabolic Diseases, Rare/Orphan Diseases
Category(s): TechPub Algolia > Research Tools
Improved Acoustic Plethysmograph System for Noninvasive Measurement of Pulmonary Function
CDC researchers have developed a novel acoustic whole body plethysmograph (AWBP) that allows measurement of tidal volume in lab animals, independent of gas compression in the lung. This system provides particular advantages over the traditional whole body plethysmograph (WBP) when measuring model animals with increased gas compression due to increased...
Published: 4/18/2025   |   Updated: 12/6/2022   |   Inventor(s): David Frazer, Jeffrey Reynolds
Keywords(s): AA2XXX, AA5XXX, AAXXXX, AC1XXX, AC2XXX, AC3XXX, AC6XXX, Acoustic, ACXXXX, ADXXXX, AE1BXX, AE1XXX, AE3XXX, AE4XXX, AEXXXX, ANIMAL, Animal Model, ANIMAL welfare, ASTHMA, Breath, BREATHING, CDC Docket Import, CDC Docket Import CDC Prosecuting, DDXXXX, DEVICE, DEXXXX, DXXXXX, FUNCTION, IA3XXX, IA5XXX, ICXXXX, IDXXXX, LUNG, lung cancer, Lung Disease, LUNGS, Lung-Targeted, Measuring, NIOSH, NIOSH-HELD, Plethysmograph, Pulmonary, Pulmonary edema, PULMONARY FIBROSIS, research, RESEARCH TOOL, RESPIRABLE, Respiration, respiratory, Respiratory Diseases, respiratory INFECTION, Tool, VBXXXX, VJXXXX, VKXXXX, VLXXXX, VOXXXX, VPXXXX, WAXXXX, WBXXXX, WCXXXX, WGXXXX, WIXXXX, WMXXXX, XDXXXX, XHXXXX, XIXXXX, XJXXXX, YCXXXX, YEXXXX, YFXXXX
Category(s): Collaboration Sought > Licensing, Application > Software / Apps, Application > Medical Devices, Application > Diagnostics, TherapeuticArea > Pulmonology, TherapeuticArea > Immunology, Application > Research Materials, ResearchProducts > Research Equipment, TherapeuticArea > Cardiology, Application > Non-Medical Devices, TherapeuticArea > Ophthalmology, Application > Vaccines, Application > Therapeutics, Application > Occupational Safety and Health, TherapeuticArea > Infectious Disease, Application > Consumer Products, TherapeuticArea > Dental, TherapeuticArea > Endocrinology, ResearchProducts > Computational models/software, TherapeuticArea > Oncology
A Mouse with a Targeted Mutation in the Uncoupling Protein-3 (upc3) Gene
The NIH announces the development of a transgenic mouse with a targeted mutation in the ucp3 gene. The ucp3 gene is implicated I the function of regulating energy metabolism. This regulatory function is thought to be accomplished by changing metabolic efficiency (causing energy expended as heat rather than used for ADP/ATP conversion) and/or by participating...
Published: 5/7/2025   |   Updated: 12/6/2022   |   Inventor(s): Marc Reitman, Dawei Gong
Keywords(s): AC5XXX, ACXXXX, Animal Model, AXXXXX, BAXXXX, Gene, Mouse, MUTATION, Protein-3, Q fever, Targeted, UCP3, Uncoupling
Category(s): Collaboration Sought > Licensing, ResearchProducts > Animal Models
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