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Search Results - animal+model
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A GALT-null Rat Model for Studies of Classic Galactosemia
Application Pre-clinical rodent model to study classic galactosemia disease. Key Benefits Identify striking differences in GALT-independent galactose metabolism among tissues and across post-natal time points. Study the relationship between galactose metabolite levels in blood and other tissues. Study the impact of rigorous galactose restriction...
Published: 7/30/2024
|
Inventor(s):
Judith Fridovich-Keil
Keywords(s):
Animal Model
,
Genetic Disorders
Category(s):
TechPub Algolia > Research Tools
Mouse Model for Specific Proteomic Labeling
Application Proteomic labeling (labeling of proteins). Key Benefits Method can be used to express TurboID in any cell type. The mouse line can be crossed with any existing Cre line and can be extended to any organ/tissue system. Detection of labeled biomarkers can be identified in biofluids as biomarkers of cell specific disease mechanisms. Can...
Published: 7/30/2024
|
Inventor(s):
Srikant Rangaraju
,
Nicholas Seyfried
,
Sruti Rayaprolu
Keywords(s):
Animal Model
,
Biomarker
Category(s):
TechPub Algolia > Research Tools
Pig Lentiviral-Induced Spinal Cord Glioblastoma
Application Porcine model of spinal cord glioblastoma for the development and testing of pre-clinical therapeutic for spinal cord tumors. Key Benefits Novel lentiviral gene transfer offers a viable pathway to modeling glioblastoma in higher order species. The existing model is the first reproducible immunocompetent large
animal model
of spinal...
Published: 7/30/2024
|
Inventor(s):
Muhibullah (Mohib) Tora
,
Pavlos Texakalidis
,
Thais Buchman
,
Nicholas Boulis
Keywords(s):
Animal Model
,
Oncology
Category(s):
TechPub Algolia > Research Tools
SMAD3 Reporter Mouse for Assessing TGF-ß/Activin Pathway Activation
Abstract: The Transforming Growth Factor Beta (TGF-ß) ligands (i.e., TGF-ß1, -ß2, -ß3) are key regulatory proteins in animal physiology. Disruption of normal TGF-ß signaling is associated with many diseases from cancer to fibrosis. In mice and humans, TGF-ß activates TGF-ß receptors (e.g., TGFBR1), which activates SMAD proteins that alter gene expression...
Published: 5/23/2024
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Inventor(s):
Lalage Wakefield
,
Yu-an Yang
,
Sushil Rane
,
Caroline Hill
Keywords(s):
Animal Model
,
CANCER
,
EGFP
,
Fibrosis, Wakefield
,
mothers against decapentaplegic homolog 3
,
Oncology
,
Reporter Mouse
,
SMAD3
,
TGF-ß
,
Transforming Growth Factor Beta
Category(s):
TherapeuticArea > Endocrinology
,
TherapeuticArea > Oncology
,
Application > Research Materials
,
Collaboration Sought > Licensing
,
TherapeuticArea > Cardiology
,
TherapeuticArea > Immunology
,
TherapeuticArea > Neurology
Whole-Animal Genetic Model to Mimic Aspects of the Patient Phenotype of Classic Galactosemia
Application An
animal model
for studying the underlying causes of galactosemia and screening for novel drugs to treat the condition. Key Benefits The first animal model for elucidating the underlying causes of galactosemia in infants. Animals with galactosemia causing genetic knockout exhibit similar disease phenotypes and complications...
Published: 7/30/2024
|
Inventor(s):
Judith Fridovich-Keil
Keywords(s):
Animal Model
,
Enzyme/Protein
,
Genetic Disorders
,
Metabolic Diseases
,
Rare/Orphan Diseases
Category(s):
TechPub Algolia > Research Tools
Improved Acoustic Plethysmograph System for Noninvasive Measurement of Pulmonary Function
CDC researchers have developed a novel acoustic whole body plethysmograph (AWBP) that allows measurement of tidal volume in lab animals, independent of gas compression in the lung. This system provides particular advantages over the traditional whole body plethysmograph (WBP) when measuring model animals with increased gas compression due to increased...
Published: 7/25/2024
|
Inventor(s):
David Frazer
,
Jeffrey Reynolds
Keywords(s):
AA2XXX
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AA5XXX
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AAXXXX
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AC1XXX
,
AC2XXX
,
AC3XXX
,
AC6XXX
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Acoustic
,
ACXXXX
,
ADXXXX
,
AE1BXX
,
AE1XXX
,
AE3XXX
,
AE4XXX
,
AEXXXX
,
ANIMAL
,
Animal Model
,
ANIMAL welfare
,
ASTHMA
,
Breath
,
BREATHING
,
CDC Docket Import
,
CDC Docket Import CDC Prosecuting
,
DDXXXX
,
DEVICE
,
DEXXXX
,
DXXXXX
,
FUNCTION
,
IA3XXX
,
IA5XXX
,
ICXXXX
,
IDXXXX
,
LUNG
,
lung cancer
,
Lung Disease
,
LUNGS
,
Lung-Targeted
,
Measuring
,
NIOSH
,
NIOSH-HELD
,
Plethysmograph
,
Pulmonary
,
Pulmonary edema
,
PULMONARY FIBROSIS
,
research
,
RESEARCH TOOL
,
RESPIRABLE
,
Respiration
,
respiratory
,
Respiratory Diseases
,
respiratory INFECTION
,
Tool
,
VBXXXX
,
VJXXXX
,
VKXXXX
,
VLXXXX
,
VOXXXX
,
VPXXXX
,
WAXXXX
,
WBXXXX
,
WCXXXX
,
WGXXXX
,
WIXXXX
,
WMXXXX
,
XDXXXX
,
XHXXXX
,
XIXXXX
,
XJXXXX
,
YCXXXX
,
YEXXXX
,
YFXXXX
Category(s):
Collaboration Sought > Licensing
,
Application > Software / Apps
,
Application > Medical Devices
,
Application > Diagnostics
,
TherapeuticArea > Pulmonology
,
TherapeuticArea > Immunology
,
Application > Research Materials
,
ResearchProducts > Research Equipment
,
TherapeuticArea > Cardiology
,
Application > Non-Medical Devices
,
TherapeuticArea > Ophthalmology
,
Application > Vaccines
,
Application > Therapeutics
,
Application > Occupational Safety and Health
,
TherapeuticArea > Infectious Disease
,
Application > Consumer Products
,
TherapeuticArea > Dental
,
TherapeuticArea > Endocrinology
,
ResearchProducts > Computational models/software
,
TherapeuticArea > Oncology
A Mouse with a Targeted Mutation in the Uncoupling Protein-3 (upc3) Gene
The NIH announces the development of a transgenic mouse with a targeted mutation in the ucp3 gene. The ucp3 gene is implicated I the function of regulating energy metabolism. This regulatory function is thought to be accomplished by changing metabolic efficiency (causing energy expended as heat rather than used for ADP/ATP conversion) and/or by participating...
Published: 4/8/2024
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Inventor(s):
Keywords(s):
AC5XXX
,
ACXXXX
,
Animal Model
,
AXXXXX
,
BAXXXX
,
Gene
,
Mouse
,
MUTATION
,
Protein-3
,
Q fever
,
Targeted
,
UCP3
,
Uncoupling
Category(s):
Collaboration Sought > Licensing
,
ResearchProducts >
Animal Model
s
Tyrosinase Viral Vectors for the Generation of Rodents Exhibiting Time -Dependent Production and Intracellular Accumulation of Human-Like Neuromelanin
Application Improved study of neurodegenerative diseases on mice. Key Benefits Ability to study neuromelanin’s association with neurodegenerative diseases with mice. Researchers can analyze overexpression of tyrosinase on specific cell types. Market Summary Neurodegenerative diseases such as Alzheimer’s and Parkinson’s...
Published: 7/30/2024
|
Inventor(s):
David Weinshenker
,
Alexa Iannitelli
Keywords(s):
Animal Model
Category(s):
TechPub Algolia > Research Tools
Novel Methods to Upcycle Wear-Resistance Nanocomposites
NU 2020-149 INVENTORS John Torkelson* Tong Wei ABSTRACT Low density polyethylene (LDPE) is one of the most produced and consumed polymers worldwide. However, due to the poor wear and abrasion resistance, the application of LDPE under continuous friction is limited. This Northwestern technology improves the wear resistance of LDPE by incorporating...
Published: 7/3/2024
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Inventor(s):
Keywords(s):
Adhesive
,
Allergy
,
Analysis
,
Animal Model
,
Manufacturing/Processing
Category(s):
Physical Sciences > Materials and Industrial Processes
3D-Printed Mouse Headplates for Implantation of EEG, EMG and Depth Electrodes
Application Tool to precisely and reproducibly implant electrode and other instrumentation into the mouse brain for neurophysiology studies. Key Benefits Inexpensive, rapid and efficient reproduction of headplates. Allows consistent and quick surgical implantation. Capable of recording or stimulating multiple sites in the mouse brain. Market...
Published: 7/30/2024
|
Inventor(s):
Nigel Pedersen
,
Lauren Aiani
Keywords(s):
Animal Model
,
Neuroscience/Pain
Category(s):
TechPub Algolia > Research Tools
,
TechPub Algolia > Medical Device
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