Search Results - car-t+cell+therapy

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Multi-Particle System for Capture and Detection of Cellular and Molecular Analytes (Case No. 2025-267)
Summary: UCLA researchers in the Department of Bioengineering have developed a novel multi-particle system that selectively confines cells and molecular reactions within cavities formed by interacting particles. Background: Screening and selecting cells with specific, beneficial traits has become a vital process in using cell-derived products...
Published: 7/29/2025   |   Inventor(s): Dino Di Carlo, Alyssa Arnheim, Michael Mellody, Yuta Nakagawa, Lily Shang
Keywords(s): Assay, B Cell, barcode, Bioassay, biological assays, Biomarker, biomarkers, Biomaterial, capping particles, CAR-T cell platform, CAR-T cell therapy, cavities, cavity-containing particles, Cell and tissue culture, cell encapsulation, cell engineering, cell imaging, cell mapping, cell sorting, cell type identification, cell-based therapy, centrifugation, confinement, Diagnostic Platform Technologies (E.G. Microfluidics), Digital Microfluidics, Drug, Drug Delivery, Drug Discovery, drug screening, high throughput, high throughput assays, high throughput testing, high-throughput analysis, High-Throughput Screening, Immunoassay, Immunoassay Sense (Molecular Biology), Microfluidics, Microfluidics And Mem's, Microfluidics Nanosphere, microparticles, moieties, Nanoparticle, single cell analysis, single cell analysis and testing, Single cell data, single-cell resolution, single-cell trapping
Category(s): Life Science Research Tools, Life Science Research Tools > Cell Counting And Imaging, Life Science Research Tools > Lab Equipment, Life Science Research Tools > Microscopy And Imaging, Life Science Research Tools > Microfluidics And Mems, Medical Devices, Platforms
Gene Modifications to Enhance the Function of PSC-Derived T Cells and NK Cells (UCLA Case No. 2023-129)
UCLA researchers in the Department of Medicine have generated novel pluripotent stem cell derived T cells that exhibit improved survival, expansion, and anti-tumor efficacy for use in cell therapy treatments. BACKGROUND: The Food and Drug Administration has approved several chimeric antigen receptor-T (CAR-T) cell therapies since 2017 to combat lymphoma...
Published: 7/17/2025   |   Inventor(s): Christopher Seet
Keywords(s): CAR-T cell therapy, Immunotherapy, pluripotent stem cell (PSC), T-cell engineering
Category(s): Therapeutics > Immunology And Immunotherapy, Therapeutics > Gene Therapy And Editing
Affinity and Functional Based Screening of T Cell Receptor Repertoire Using Nanovials (Case No. 2024-042)
Summary: Researchers in the Department of Bioengineering at UCLA have developed a hydrogel platform that measures single T cell secretions, aiding in the definition of T cell receptor repertoires for functional immunotherapy applications. Background: T cell immunotherapies, namely T cell receptor (TCR) therapies, have emerged as promising candidates...
Published: 4/14/2025   |   Inventor(s): Dino Di Carlo, Owen Witte, Doyeon Koo, Zhiyuan Mao
Keywords(s): Cancer Immunotherapy, CAR-T cell therapy, Flow Cytometry, hydrogel, Immunooncology, Immunotherapy, Peptide, single cell analysis, T Cell, T cell based therapy
Category(s): Diagnostic Markers > Immunology, Life Science Research Tools > Screening Libraries, Therapeutics > Immunology And Immunotherapy
Engineered T Cells Capable of Simultaneous Tumor Targeting and Alteration of Tumor Microenvironment Through Vasculature Normalization (UCLA Case No. 2023-264)
UCLA researchers in the Department of Microbiology, Immunology and Molecular Genetics have built a series of chimeric antigen receptor (CAR)-T cells that target different antigens and secrete different anti-angiogenic proteins. Additionally, researchers also constructed bispecific CARs that respond to tumor antigen and pro-angiogenic molecules. BACKGROUND:...
Published: 7/17/2025   |   Inventor(s): Yvonne Chen
Keywords(s): Cancer, Cancer Immunotherapy, CAR-T cell therapy, immunosuppression, Immunosuppressive Drug, Immunotherapy, solid tumors, Tumor microenvironment, tumor vasculature, VEGF
Category(s): Therapeutics > Oncology
Inhibitory Chimeric Antigen Receptors That Reduce Car-T Cell “On-Target, Off-Tumor” Toxicity (UCLA Case No. 2022-186)
­SUMMARY: UCLA researchers in the Department of Microbiology, Immunology and Molecular Genetics, and the Department of Molecular and Medical Pharmacology have recently developed a novel approach which improves the kinetics and specificity of CAR T-cell therapy. BACKGROUND: Chimeric antigen receptor (CAR) T-cell therapy makes use of reengineered...
Published: 7/17/2025   |   Inventor(s): Owen Witte
Keywords(s): blood cancers, CAR-T cell therapy
Category(s): Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology, Therapeutics > Oncology > Oncology Immunotherapy, Therapeutics
Novel Anti-mesothelin CAR for Use in Engineered Cell Therapies (UCLA Case No. 2023-281)
UCLA researchers in the Department of Microbiology Immunology and Molecular Genetics have developed a nanobody-based CAR T cell platform with increased stability and cross-immunogenicity between human and mouse antigens. BACKGROUND: Chimeric antigen receptor (CAR) T-cell therapy makes use of reengineered T cells to target and clear cancer cells....
Published: 7/17/2025   |   Inventor(s): Yvonne Chen
Keywords(s): Cancer, CAR-T cell platform, CAR-T cell therapy, cell engineering, Immunotherapy, Mesothelin, nanobody, Nanoparticle
Category(s): Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy
Synthetic Viscoelastic Activating Cells (SynVACs) for T cell engineering (UCLA Case No. 2023-190)
UCLA researchers in the Department of Bioengineering have developed a novel microfluidic device that produces synthetic viscoelastic cells for efficacious therapeutic T cell activation. BACKGROUND: T cell-based therapies, such as the chimeric antigen receptor (CAR) T cell therapy, represents a significant advancement in cancer treatment, particularly...
Published: 7/17/2025   |   Inventor(s): Zeyang Liu, Song Li, Lili Yang, Yanruide Li
Keywords(s): CAR-T cell therapy, Synthetic antigen presenting cells (SynVACs), T Cell, T cell based therapy, T-cell activation, T-cell engineering, t-cells
Category(s): Therapeutics > Oncology