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Novel Therapeutic Target to Promoting Cardiomyocyte Proliferation and Enhance Cardiac Regeneration for Myocardial Injury and Disease

Advantages: Identification of MRPS5 as a Therapeutic Target: Reduction of MRPS5 expression stimulates cardiomyocyte proliferation and enhances heart function Discovery of the MRPS5 signaling axis: Decreased MRPS5 enhances ATF4 and Knl1, which promote cardiomyocyte, boosting cardiac recovery after myocardial injury Improved Survival and Cardiac...

Published: 11/22/2024 | Inventor(s): Da-Zhi Wang, John Mably

Keywords(s): Biotechnology, Cardiological Diseases Treatment, Cell & Tissue Culture & Engineering, Medical Diagnostics, Pharmaceuticals

Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Cell & Tissue Engineering, Technology Classifications > Medical > Pharmaceuticals

3D Printed Swab for Diagnostic Testing

Advantages: 3D-printed swab comprising a shaft and a plurality of protrusions, that can be manufactured at high capacity with low potential for contamination. 3D-printed swabs can be manufactured with various tip shapes and stem lengths to help optimize sample collections from different targeted locations. 3D printing allows tip diameters...

Published: 7/30/2024 | Inventor(s): Summer Decker, Jonathan Ford, Michael Teng, Kami Kim, Todd Hazelton, John Sinnott, Todd Goldstein

Keywords(s): Medical Devices, Medical Diagnostics

Category(s): Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Medical Devices

AI-Driven Magnetic Respiratory Sensor for Real-Time Monitoring of Respiratory Diseases Like COVID-19

Advantages: An AI-assisted contactless device that measures a patient’s breathing pattern and provides early and rapid detection of COVID-19 respiratory symptoms, in under 5 minutes. The ultrahigh sensitivity enables real-time monitoring of abnormal variations in a patient’s breath across multiple stages of disease. The portable...

Published: 7/15/2024 | Inventor(s): Manh-Huong Phan, Kee Young Hwang, Valery Ortiz Jimenez, Baleeswaraiah Muchharla

Keywords(s): Artificial Intelligence, Medical Diagnostics, Respiratory Diseases

Category(s): Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Respiratory

Object-Detecting Deep Learning for Multi-Event Electrochemical Data (Case No. 2024-088)

Summary: UCLA researchers in the Department of Chemistry and Biochemistry developed a custom-designed deep learning architecture for object detection and mechanisms classification to streamline the experimental design of cyclic voltammograms. Background: Cyclic voltammetry, a widely used electrochemical test, serves as a crucial tool in understanding...

Published: 8/23/2024 | Inventor(s): Chong Liu, Quanquan Gu, Benjamin Hoar, Weitong Zhang, Yuanzhou Chen

Keywords(s): 2D ultrasound imaging, Artifical Intelligence (Machine Learning, Data Mining), artificial electromagnetic materials, bioelectronics, Biomaterial, electrochemical sensors, Electronics & Semiconductors, Lithium Battery, Lithium-Ion Battery, Machine Learning, Materials, Medical Devices and Materials, Medical diagnostics, Pharmaceutical Drug, Pharmaceutical testing, Rechargeable Battery, zzenergy storage

Category(s): Electrical > Electronics & Semiconductors, Energy & Environment > Energy Efficiency, Energy & Environment > Energy Storage, Energy & Environment > Water Monitoring & Treatment, Software & Algorithms > Image Processing, Software & Algorithms > Artificial Intelligence & Machine Learning, Electrical > Signal Processing

Field-Effect Transistor Biosensors Integrated With Porous Media (Case No. 2023-093)

Summary: UCLA researchers in the Department of Electrical and Computer Engineering in collaboration with the University of Chicago have developed a new diagnostic biosensor by combining field-effect transistors with porous media. Background: Point-of-care (POC) and self-testing tools rely on the real-time monitoring of biomarkers in bodily fluids....

Published: 4/1/2024 | Inventor(s): Aydogan Ozcan, Hyou-Arm Joung, Hyun-June Jang, Junhong Chen

Keywords(s): Biomarker, biomarkers, Biomaterial, Biosensor, Computer-Aided Diagnosis, Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Diagnostic Test, Electrical, Electrical Engineering, electrically-mediated sensing, electrochemical sensors, enzyme functionalization, Medical diagnostics, multiplexed analysis, Point Of Care, point-of-care, porous media, sample matrix effects, transistors

Category(s): Electrical, Electrical > Sensors, Medical Devices, Medical Devices > Monitoring And Recording Systems, Diagnostic Markers, Diagnostic Markers > Targets And Assays, Platforms, Platforms > Diagnostic Platform Technologies

Frequency Domain Diffuse Correlation Spectroscopy

Advantages: Robust simultaneous quantitative measurement of tissue blood flow and absorption, ensuring reliability and enabling easy cross-subject comparisons for versatility. Single source source-detector separation measurement, reducing the size of the optical probe significantly for portability. Simplifies electronics by eliminating the...

Published: 3/6/2024 | Inventor(s): Ashwin Parthasarathy, Sadhu Moka, Abdul Mohaimen Safi

Keywords(s): Biotechnology, Medical Diagnostics, Spectroscopy

Category(s): Technology Classifications > Medical > Cell & Tissue Engineering, Technology Classifications > Medical > Medical Imaging, Technology Classifications > Medical > Medical Devices, Technology Classifications > Electronics > Spectroscopy

Swabseq Agnostic Diagnostic Platform (Case No. 2023-293)

Summary: UCLA researchers in the Departments of Computer Science and Anatomic Pathology have developed an untargeted NGS diagnostic tool capable of detecting all known and emerging respiratory RNA viruses in a single test, enhancing our capacity to rapidly address public health crises through improved diagnostics. Background: Most clinical diagnostic...

Published: 9/17/2024 | Inventor(s): Eleazar Eskin, Valerie Arboleda

Keywords(s): agnostic detection, Bioinformatics, bioinformatics pipeline, Computer-Aided Diagnosis, Diagnostic Markers & Platforms, Diagnostic Test, DNA Sequencing, Medical diagnostics, metagenomic diagnostic platform, meta-genomics, next generation sequencing (NGS), Pathogen, Pathogenesis, Sequencing

Category(s): Platforms, Platforms > Diagnostic Platform Technologies, Life Science Research Tools, Life Science Research Tools > Research Methods, Diagnostic Markers > Targets And Assays, Software & Algorithms, Software & Algorithms > Digital Health, Software & Algorithms > Bioinformatics

Core-Shell Hydrogel Particles With Tunable Porosity for Digital Nucleic Acid Assays (Case No. 2023-058)

Summary: UCLA researchers in the Department of Bioengineering have developed a novel method to perform ultra-high sensitivity, low-cost nucleic acid amplification assays utilizing porous microdroplets. Background: Nucleic acid concentration measurement is essential in biological research and diagnostics. The 2020 pandemic underscored the importance...

Published: 8/30/2023 | Inventor(s): Dino Di Carlo, Michael Thomas Alesse Bogumil

Keywords(s): Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Diagnostic Test, Flow Cytometry, Medical diagnostics

Category(s): Diagnostic Markers > Cancer, Diagnostic Markers > Targets And Assays, Chemical > Emulsions, Life Science Research Tools > Microfluidics And Mems, Life Science Research Tools > Research Methods, Platforms > Diagnostic Platform Technologies

UBE3A Gene Therapy for the Treatment of Tauopathies

Advantages: Reduction in Pathology Improved Memory and Cognitive Function Targeted Delivery and Brain-wide Distribution Business Summary: Alzheimer’s disease (AD) is a neurodegenerative disease that involves the accumulation of A-Beta proteins and Tau proteins within the brain and leads to cognitive impairments. The accumulation of these...

Published: 9/26/2023 | Inventor(s): Jazmin Pena, Kevin Nash

Keywords(s): Medical Diagnostics, Neurodegenerative Diseases, Neuroscience, Therapeutics

Category(s): Technology Classifications > Medical, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Therapeutics

Countering Fragile X Syndrome with Reelin

Advantages: Precision Targeting Minimized Side Effects Durability Business Summary: Reelin in Fragile X Syndrome presents a novel and innovative strategy for addressing Fragile X Syndrome (FXS), a common inherited intellectual disability. This study is distinguished by its meticulous analysis of the distinctions between pre- and post-synaptic...

Published: 8/22/2024 | Inventor(s): Nicole Morrill, Kevin Nash

Keywords(s): Biotechnology, Genetics, Health Tech, Medical Diagnostics

Category(s): Technology Classifications > Medical, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Medical Diagnostics

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