Search Results - platforms

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Multi-Particle System for Capture and Detection of Cellular and Molecular Analytes (Case No. 2025-267)
Summary: UCLA researchers in the Department of Bioengineering have developed a novel multi-particle system that selectively confines cells and molecular reactions within cavities formed by interacting particles. Background: Screening and selecting cells with specific, beneficial traits has become a vital process in using cell-derived products...
Published: 7/29/2025   |   Inventor(s): Dino Di Carlo, Alyssa Arnheim, Michael Mellody, Yuta Nakagawa, Lily Shang
Keywords(s): Assay, B Cell, barcode, Bioassay, biological assays, Biomarker, biomarkers, Biomaterial, capping particles, CAR-T cell platform, CAR-T cell therapy, cavities, cavity-containing particles, Cell and tissue culture, cell encapsulation, cell engineering, cell imaging, cell mapping, cell sorting, cell type identification, cell-based therapy, centrifugation, confinement, Diagnostic Platform Technologies (E.G. Microfluidics), Digital Microfluidics, Drug, Drug Delivery, Drug Discovery, drug screening, high throughput, high throughput assays, high throughput testing, high-throughput analysis, High-Throughput Screening, Immunoassay, Immunoassay Sense (Molecular Biology), Microfluidics, Microfluidics And Mem's, Microfluidics Nanosphere, microparticles, moieties, Nanoparticle, single cell analysis, single cell analysis and testing, Single cell data, single-cell resolution, single-cell trapping
Category(s): Life Science Research Tools, Life Science Research Tools > Cell Counting And Imaging, Life Science Research Tools > Lab Equipment, Life Science Research Tools > Microscopy And Imaging, Life Science Research Tools > Microfluidics And Mems, Medical Devices, Platforms
Subgraph Matching for High-Throughput DNA-Aptamer Secondary Structure Classification and Machine Learning Interpretability (Case No. 2025-104)
Intro Sentence: UCLA researchers in the Department of Mathematics have developed machine learning methods to rapidly identify novel aptamer sequences for target binding to accelerate highly-accurate diagnostic and therapeutic development. Background: Aptamers are single-stranded nucleotide polymers that bind with high affinity to targets such as...
Published: 7/22/2025   |   Inventor(s): Andrea Bertozzi, Anne Andrews, Matthew Tyler, Paolo Climaco, Noelle Mitchell
Keywords(s): Advanced Computing / AI, advanced computing methods, Aptamers, Artifical Intelligence (Machine Learning, Data Mining), artificial intelligence/machine learning models, bioinformatics pipeline, cancer target, clustering, computational efficiency, computational efficiency and analysis, design software, DNA clustering, DNA oligomer, DNA Sequencing, Drug, Drug Delivery, Drug Development, Drug Discovery, drug screening, high throughput, high throughput assays, high throughput testing, high-throughput analysis, High-Throughput Screening, interpretability, pipeline, large-scale parallelization, Machine Learning, machine learning modeling, motif structures, open source, open source code, OpenAI, Pharmaceutical Drug, protein classification, secondary structure, SELEX, sequences of interest, single strand DNA sequences, Software, Software & Algorithms, Software Development Tools, Software-enabled learning, subgraph matching, target binding, target detection, Targeted Therapy, Targets And Assays, tissue targeting accuracy
Category(s): Software & Algorithms, Software & Algorithms > AI Algorithms, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Data Analytics, Life Science Research Tools, Life Science Research Tools > Research Methods, Life Science Research Tools > Screening Libraries, Platforms, Platforms > Drug Delivery, Diagnostic Markers > Targets And Assays, Diagnostic Markers, Software & Algorithms > Bioinformatics
A Ventilated Artificial Human Lung Exposure System to Analyze and Test Human Exposures to Inhaled Substances (Case No. 2023-306)
Summary: UCLA researchers in the Department of Medicine and Environmental Health Sciences have developed a ventilated human lung system for laboratory testing of inhaled substances. Background: Measuring the toxicology of inhaled air, aerosols and other substances is challenging due to the complexity of human studies and limitations in existing...
Published: 7/28/2025   |   Inventor(s): Michael Roth, Airi Harui, Yifang Zhu, Haoxuan Chen
Keywords(s): aerosol, Angiogenesis Acute Lung Injury, bioaerosol, cardiopulmonary illness, Cellular Respiration, consumer goods and products, Lung, Lung Pulmonology, non-small cell lung cancer, Preclinical model development, Preclinical surgical innovation, pulmonary arterial pressure (PAP), pulmonary failure, Pulmonary fibrosis, Respiratory & Pulmonary, respiratory failure, right atrial to pulmonary canula, Simulation & Modeling, simulation model, small cell lung cancer
Category(s): Platforms, Platforms > Drug Delivery, Life Science Research Tools, Life Science Research Tools > Research Methods, Therapeutics, Therapeutics > Respiratory And Pulmonary, Mechanical, Mechanical > Sensors
A Fabrication Method for High-Precision, Large-Area Acoustic Single-Cell Trapping Devices (Case No. 2025-115)
Summary: UCLA researchers from the Department of Mechanical and Aerospace Engineering have developed a novel fabrication method for single-cell trapping devices. Background: Single-cell analysis is critical to personalized medicine, diagnostics, and biomedical research, as it allows researchers to identify, isolate, and expand desired cell subpopulations....
Published: 3/20/2025   |   Inventor(s): Pei-Yu Chiou, Jacob Smith
Keywords(s): acoustic manipulation, acoustics, air cavity formation, cell sorting, compliant membrane acoustic patterning (CMAP), Diagnostic Platform Technologies (E.G. Microfluidics), Digital Microfluidics, high-throughput analysis, large-area arrays, MEMS, Microfluidics, Microfluidics And Mem's, Microfluidics Dielectrophoresis, Microfluidics Multi-Band Device, Microfluidics Nanosphere, near-infrared (NIR) pulsed laser, PDMS, PDMS membranes, single cell analysis, Single cell data, single-cell resolution, single-cell trapping
Category(s): Materials, Materials > Membranes, Life Science Research Tools, Life Science Research Tools > Microfluidics And Mems, Life Science Research Tools > Cell Counting And Imaging, Platforms
Compound Drug Delivery System (Case No. 2024-015)
Summary: Researchers in UCLA’s Department of Orthopaedic Surgery have developed novel multi-drug delivery system that is compatible with standard syringe-based administration routes. Background: Drug compounding is the process of combining two or more medications to meet the needs of individual patients. Surgeons may mix different anesthetics...
Published: 3/20/2025   |   Inventor(s): Fabrizio Billi, Mauricio Silva, Aaron Kavanaugh
Keywords(s):  
Category(s): Therapeutics, Platforms, Platforms > Drug Delivery, Medical Devices
A Bistable Deformable Tactile Responsive Material and Device (Case No. 2024-202)
Summary: UCLA researchers in the Department of Materials Science and Engineering have developed a novel electroactive polymer membrane composition for interactive tactile interfaces. Background: Interactive tactile interfaces are soft actuators with diverse applications in medical and surgical training, actively deformable apparel, refreshable Braille...
Published: 2/14/2025   |   Inventor(s): Qibing Pei, Jinsung Kim, HyeonJi Hong
Keywords(s): bistable electroactive polymer, Braille, BSEP, deformable geometries, diaphragms, elastomers, hybrid electrodes, joule heating, MCRB, multi-cell refreshable Braille, phase change materials, shape memory, soft actuator, Stretchable electrodes
Category(s): Materials, Materials > Functional Materials, Medical Devices, Platforms, Platforms > Drug Delivery
Discovering Permanent Fluidic Magnets for Liquid Bioelectronics (Case No. 2024-083)
Summary: UCLA researchers from the Department of Bioengineering have developed a permanent fluidic magnet that maintains stable colloids for application in a variety of fields, including physiological monitoring and bioelectronics. Background: Colloid suspensions are comprised of dispersed small solid particles in fluids. The stability of a colloid...
Published: 7/17/2025   |   Inventor(s): Jun Chen
Keywords(s):  
Category(s): Materials, Materials > Functional Materials, Materials > Membranes, Electrical, Electrical > Mems, Materials > Nanotechnology, Platforms, Platforms > Drug Delivery
Deep Learning-Enhanced Paper-Based Vertical Flow Assay for High-Sensitivity Troponin Detection Using Nanoparticle Amplification (Case No. 2024-179)
Summary: UCLA researchers from the Departments of Electrical and Computer Engineering and Bioengineering have developed a novel assay for point-of-care testing for acute myocardial infarction. Background: Cardiovascular diseases are responsible for a substantial number of deaths and economic burdens. Acute myocardial infarction (AMI) is an event...
Published: 2/14/2025   |   Inventor(s): Aydogan Ozcan, Gyeo-Re Han, Artem Goncharov, Hyouarm Joung, Dino Di Carlo
Keywords(s): acute myocardial infarction, Assay, Bioassay, biological assays, cardiometabolic disease, cardiopulmonary illness, Cardiovascular, Cardiovascular Disease, Cardiovascular Disease Nephropathy, cardiovascular diseases, cardiovascular modeling, cardiovascular prediction, cardiovascular therapeutic solution, deep-learning analysis algorithms, Flow Device, heart disease mitigation, high-sensitivity cardiac troponin I, Immunoassay, Laminar flow, nanoparticle amplification chemistry, point-of-care testing, Targets And Assays, vertical flow assay
Category(s): Medical Devices, Medical Devices > Monitoring And Recording Systems, Platforms, Platforms > Diagnostic Platform Technologies, Diagnostic Markers, Diagnostic Markers > Targets And Assays
Detection of Dicrotic Notch in Arterial Pressure and Photoplethysmography Signals Using Iterative Envelope Mean Filter (Case No. 2024-034)
Summary: UCLA Researchers in the Department of Anesthesiology have developed an iterative envelope mean (IEM) method for the detection of specific features in arterial pressure monitoring applications. Background: The cardiac cycle consists of the distinct systolic and diastolic phases. The transition from the contracted, systolic phase to the...
Published: 3/26/2025   |   Inventor(s): Maxime Cannesson, Ravi Pal, Akos Rudas, Jeffrey Chiang, Sungsoo Kim
Keywords(s): arrhythmia, arterial blood pressure (ABP), cardiac cycle, Cardiac Electrophysiology, Cardiac failure, Cardiac Magnetic Resonance Imaging, cardiometabolic disease, cardiopulmonary illness, Cardiovascular, Cardiovascular Disease, Cardiovascular Disease Nephropathy, cardiovascular modeling, cardiovascular prediction, cardiovascular therapeutic solution, diastolic, diastolic phase peak, dicrotic notch, feature extraction tool, iterative envelope method (IEM), Medical Device, medical device cardiac monitoring, Medical Device Poly(Methyl Methacrylate), Medical Devices and Materials, non-invasive cardiac monitoring, photoplethysmography (PPG), Smart medical device, systolic, tachycardia, wearable medical device, wearable medical devices
Category(s): Medical Devices, Medical Devices > Monitoring And Recording Systems, Platforms, Platforms > Diagnostic Platform Technologies, Software & Algorithms, Diagnostic Markers > Targets And Assays, Diagnostic Markers
Universal Linear Intensity Transformations Using Spatially-Incoherent Diffractive Processors (Case No. 2023-192)
Summary: UCLA researchers in the Department of Electrical and Computer Engineering have developed a novel platform technology to facilitate the design of all-optical visual processors, which can be used to perform advanced computational tasks at the speed of light. Background: Information processing via light is a cutting-edge field among optics...
Published: 6/9/2025   |   Inventor(s): Aydogan Ozcan, MD Sadman Sakib Rahman, Xilin Yang
Keywords(s): Adaptive Optics, Algorithm Optical Coherence Tomography, all-optical diffractive computing, all-optical transformation, Artifical Intelligence (Machine Learning, Data Mining), Artificial Intelligence, Atomic Force Microscopy Optical Tweezers, computational imaging, deep diffractive network, Deep Learning, Deep learning-based sensing, diffractive processor, Dispersion (Optics), Electron Microscope, Electro-Optics, fluorescence microscopy, Focus (Optics), Infrared Electromagnetic Spectrum Dispersion (Optics), interference processor, large language model (LLNMs), linear optics, linear transformations, Machine Learning, Microscope, Microscopy, Microscopy And Imaging, Near-Field Scanning Optical Microscope, neural networks, Nonlinear Optics, non-linear optics, Optical Coherence , Optical Communication , Optical computing, Optical Fiber Copper Wire And Cable, optical implementation, Optical Microscope, Optical networks, optical processor, optical transmission, Optics Parabolic Reflector Curved Mirror, phase-only diffractive network, reverse engineered optical system, Software, Software & Algorithms, Software Development Tools, spatially-incoherent light, start to end optics design, Surgical Instrument Optical Coherence Tomography, three dimensional imaging, visual computing, Waferscale Processors
Category(s): Optics & Photonics, Optics & Photonics > Microscopy, Platforms, Software & Algorithms > Image Processing, Electrical, Electrical > Signal Processing, Electrical > Computing Hardware
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