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Search Results - targeted+therapy
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Covalent PRC2 Inhibitors for Advanced Cancer Therapeutics
SHORT DESCRIPTION Covalent inhibitors and proteolysis-targeting chimera (PROTAC) degraders targeting components of the PRC2 complex (EZH and EED) to block both enzymatic and non-enzymatic functions, offering robust anti-tumor efficacy. INVENTORS Gary Schiltz (Weinberg College of Arts and Sciences, Department of Chemistry)* Jindan...
Published: 3/5/2026
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Inventor(s):
Keywords(s):
AUTM26C1
,
BIAUTM1
,
Bladder cancer
,
Breast cancer
,
Cancer/Oncology
,
Covalent inhibitor
,
Lymphoma
,
Melanoma
,
PreSeed/Seed
,
Prostate cancer
,
PROTAC
,
Small molecule
,
Targeted protein degradation
,
Targeted therapy
,
Therapeutics
Category(s):
Life Sciences > Therapeutics
Inhibition of BACH1 for pulmonary arterial hypertension therapy
LU 2024-222 INVENTORS Youyang Zhao* SHORT DESCRIPTION This invention identifies a protein called BACH1 as a key driver of pulmonary arterial hypertension (PAH). By targeting and inhibiting BACH1, particularly in the pulmonary endothelium, this technology provides methods for preventing or reversing the abnormal thickening of pulmonary vasculature,...
Published: 3/5/2026
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Inventor(s):
Keywords(s):
Cardio-Pulmonary
,
Pulmonary disease
,
Targeted therapy
,
Therapeutics
Category(s):
Life Sciences > Therapeutics
Antibodies for treatment of coronavirus disease
NU 2023-247 INVENTORS Huiping Liu* Deyu Fang* Hannah Mubarak Andrew Hoffmann Nurmaa Dashzeveg Lamiaa El-Shennawy Juncheng Wei Wuwei Tan Yang Shen SHORT DESCRIPTION Computationally redesigned antibodies targeting SARS-CoV-2 for treating COVID-19. BACKGROUND The continuous evolution of SARS-CoV-2 has allowed the virus to escape most therapeutic...
Published: 2/26/2026
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Inventor(s):
Keywords(s):
Antibody
,
Artificial Intelligence & Machine Learning
,
Biologic
,
Infectious disease
,
Research tool
,
Targeted therapy
,
Therapeutics
Category(s):
Life Sciences > Therapeutics
Netrin-1 mimetic peptide amphiphiles
Netrin-1 Mimetic Peptide Amphiphile Assemblies NU 2024-174 INVENTORS Samuel Stupp* Cara Smith Zaida Alvarez Pinto SHORT DESCRIPTION Nanofiber-shaped supramolecular assemblies that mimic netrin-1 bioactivity to stimulate neurite growth and synaptic maturation for enhanced CNS regeneration. BACKGROUND Neurotrophic factors are essential for...
Published: 2/20/2026
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Inventor(s):
Keywords(s):
AD - Alzheimer’s Disease
,
CNS - Central Nervous System
,
CVA - Cerebrovascular Accident
,
Nanomaterials
,
Nanotechnology
,
Neurodegenerative disease
,
Regenerative medicine
,
SCI - Spinal cord injury
,
Targeted therapy
,
Therapeutics
Category(s):
Life Sciences > Therapeutics
Neuronal nitric oxide synthase (nNOS) inhibitors for
targeted therapy
of melanoma and neurodegenerative disorders
NU 2025-113 (NU 2018-176, NU 2024-250, NU 2025-038) INVENTORS Richard Silverman (Weinberg College of Arts and Sciences, Department of Chemistry) SHORT DESCRIPTION Novel highly selective neuronal nitric oxide synthase (nNOS) inhibitors for
targeted therapy
of melanoma and other cancers with high expression of nNOS (e.g., gliomas, ovarian cancer)...
Published: 3/4/2026
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Inventor(s):
Keywords(s):
AUTM26C1
,
BIAUTM1
,
Cancer/Oncology
,
Immunotherapy
,
Melanoma
,
Small molecule
,
Targeted therapy
,
Therapeutics
Category(s):
Life Sciences > Therapeutics
Selective DOT1L Protein Degraders for Precision Cancer Therapy
NU 2022-081 INVENTORS Sarki Abdulkadir (PI)* Gary Schiltz (PI)* SHORT DESCRIPTION A small molecule PROTAC technology that degrades DOT1L protein for targeted treatment of leukemia and prostate cancer. BACKGROUND Current cancer treatments, especially for MLL-rearranged leukemia and prostate cancer, face challenges of off-target effects and...
Published: 2/6/2026
|
Inventor(s):
Keywords(s):
AUTM26C1
,
BIAUTM1
,
Cancer/Oncology
,
Leukemia
,
Prostate cancer
,
PROTAC
,
Small molecule
,
Targeted protein degradation
,
Targeted therapy
,
Therapeutics
Category(s):
Life Sciences > Therapeutics
Subgraph Matching for High-Throughput DNA-Aptamer Secondary Structure Classification and Machine Learning Interpretability (Case No. 2025-104)
Intro Sentence: UCLA researchers in the Department of Mathematics have developed machine learning methods to rapidly identify novel aptamer sequences for target binding to accelerate highly-accurate diagnostic and therapeutic development. Background: Aptamers are single-stranded nucleotide polymers that bind with high affinity to targets such as...
Published: 8/19/2025
|
Inventor(s):
Andrea Bertozzi
,
Anne Andrews
,
Matthew Tyler
,
Paolo Climaco
,
Noelle Mitchell
Keywords(s):
Advanced Computing / AI
,
advanced computing methods
,
Aptamers
,
Artifical Intelligence (Machine Learning, Data Mining)
,
artificial intelligence/machine learning models
,
bioinformatics pipeline
,
cancer target
,
clustering
,
computational efficiency
,
computational efficiency and analysis
,
design software
,
DNA clustering
,
DNA oligomer
,
DNA Sequencing
,
Drug
,
Drug Delivery
,
Drug Development
,
Drug Discovery
,
drug screening
,
high throughput
,
high throughput assays
,
high throughput testing
,
high-throughput analysis
,
High-Throughput Screening
,
interpretability, pipeline
,
large-scale parallelization
,
Machine Learning
,
machine learning modeling
,
motif structures
,
open source
,
open source code
,
OpenAI
,
Pharmaceutical Drug
,
protein classification
,
secondary structure
,
SELEX
,
sequences of interest
,
single strand DNA sequences
,
Software
,
Software & Algorithms
,
Software Development Tools
,
Software-enabled learning
,
subgraph matching
,
target binding
,
target detection
,
Targeted Therapy
,
Targets And Assays
,
tissue targeting accuracy
Category(s):
Software & Algorithms
,
Software & Algorithms > AI Algorithms
,
Software & Algorithms > Artificial Intelligence & Machine Learning
,
Software & Algorithms > Data Analytics
,
Life Science Research Tools
,
Life Science Research Tools > Research Methods
,
Life Science Research Tools > Screening Libraries
,
Platforms
,
Platforms > Drug Delivery
,
Diagnostic Markers > Targets And Assays
,
Diagnostic Markers
,
Software & Algorithms > Bioinformatics
Cell-type specific disruption of M1 muscarinic acetylcholine receptor expression to alleviate Parkinson's disease
NU 2024-244 INVENTORS Dalton J. Surmeier Jr* Tatiana Tkatch Shenyu Zhai SHORT DESCRIPTION Gene therapy targeting M1 muscarinic receptor expression in striatal spiny projection neurons to enhance levodopa response and slow Parkinson’s Disease progression. BACKGROUND Parkinson’s Disease (PD) is the second most common age-related...
Published: 1/5/2026
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Inventor(s):
Keywords(s):
CNS - Central Nervous System
,
Gene therapy
,
Neurodegenerative disease
,
Neurologic disease
,
Neurology
,
PD - Parkinson's Disease
,
Targeted therapy
,
Therapeutics
Category(s):
Life Sciences > Therapeutics
Gene therapy for levodopa-induced dyskinesia
NU 2024-086 INVENTORS Dalton J. Surmeier Jr* Weixing Shen Shenyu Zhai Tatiana Tkatch Qiaoling Cui Zhong Xie SHORT DESCRIPTION Gene therapy targeting GRIN2B in striatal spiny projection neurons to treat levodopa-induced dyskinesia. BACKGROUND Parkinson’s Disease (PD) is the second most common age-related neurodegenerative disease...
Published: 1/5/2026
|
Inventor(s):
Keywords(s):
CNS - Central Nervous System
,
Dyskinesis
,
Neurodegenerative disease
,
Neurologic disease
,
Neurology
,
PD - Parkinson's Disease
,
Targeted therapy
,
Therapeutics
Category(s):
Life Sciences > Therapeutics
Therapeutic Intervention for ALS and Dementia
NU 2021-058 INVENTORS Evangelos Kiskinis* Juan Alberto Ortega Cano Marco Boccitto SHORT DESCRIPTION Design of an RNA-based oligonucleotide that protects from dipeptide repeat protein toxicity for the treatment of ALS and FTD. BACKGROUND Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are devastating neurodegenerative diseases...
Published: 12/18/2025
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Inventor(s):
Keywords(s):
ALS - Amyotrophic Lateral Sclerosis
,
CNS - Central Nervous System
,
DPR - Dipeptide Repeat Proteins
,
FTD - Frontotemporal Dementia
,
Neurodegenerative disease
,
Neurology
,
RNA - Ribonucleic Acid
,
Targeted therapy
,
Therapeutics
Category(s):
Life Sciences > Therapeutics
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