Search Results - b+cell

4 Results Sort By:
Multi-Particle System for Capture and Detection of Cellular and Molecular Analytes (Case No. 2025-267)
Summary: UCLA researchers in the Department of Bioengineering have developed a novel multi-particle system that selectively confines cells and molecular reactions within cavities formed by interacting particles. Background: Screening and selecting cells with specific, beneficial traits has become a vital process in using cell-derived products...
Published: 7/29/2025   |   Inventor(s): Dino Di Carlo, Alyssa Arnheim, Michael Mellody, Yuta Nakagawa, Lily Shang
Keywords(s): Assay, B Cell, barcode, Bioassay, biological assays, Biomarker, biomarkers, Biomaterial, capping particles, CAR-T cell platform, CAR-T cell therapy, cavities, cavity-containing particles, Cell and tissue culture, cell encapsulation, cell engineering, cell imaging, cell mapping, cell sorting, cell type identification, cell-based therapy, centrifugation, confinement, Diagnostic Platform Technologies (E.G. Microfluidics), Digital Microfluidics, Drug, Drug Delivery, Drug Discovery, drug screening, high throughput, high throughput assays, high throughput testing, high-throughput analysis, High-Throughput Screening, Immunoassay, Immunoassay Sense (Molecular Biology), Microfluidics, Microfluidics And Mem's, Microfluidics Nanosphere, microparticles, moieties, Nanoparticle, single cell analysis, single cell analysis and testing, Single cell data, single-cell resolution, single-cell trapping
Category(s): Life Science Research Tools, Life Science Research Tools > Cell Counting And Imaging, Life Science Research Tools > Lab Equipment, Life Science Research Tools > Microscopy And Imaging, Life Science Research Tools > Microfluidics And Mems, Medical Devices, Platforms
Targeted Lentiviral Transduction of B-Cells With Desired B-Cell Receptor Specificity (UCLA Case No. 2023-237)
UCLA researchers in the Division of Hematology and Oncology in the Department of Medicine, have discovered novel lentiviral vectors that can be used for gene delivery to B-cells and for the development of neutralizing antibodies against viruses. BACKGROUND: Microbial tropism is a microbiology term that describes the types of animals (including human),...
Published: 7/17/2025   |   Inventor(s): Koki Morizono
Keywords(s): B Cell, cell receptor, COVID-19, VIral entry, Virus
Category(s): Therapeutics > Immunology And Immunotherapy
Improved CD22 Binders for Effective Immunotherapy Against Relapsed or Refractory Acute Lymphoblastic Leukemia (ALL)
Abstract: Targeting the CD22 receptor of B-cells with chimeric antigen receptor (CAR)-T cells has been a promising new therapy to treat B-cell malignancies in clinical trials, inducing remission in 70% of patients with relapsed acute lymphoblastic leukemia (ALL). However, diminished CD22 expression on B-cell surface can lead to relapse and decreased...
Published: 4/22/2025   |   Inventor(s): Dimiter Dimitrov, Zhongyu Zhu, Terry Fry, Sneha Ramakrishna
Keywords(s): Acute Lymphoblastic Leukemia, ALL, B Cell, CAR, CAR-T, CD22, chimeric antigen receptor, Dimitrov, T cell
Category(s): Application > Therapeutics, TherapeuticArea > Oncology, Collaboration Sought > Licensing
2021-309-METHODS OF USING SHAPED PARTICLES IN FLOW CYTOMETERS FOR ASSAYS ON B CELLS AND T CELLS
Summary: UCLA researchers in the Department of Bioengineering have developed a platform to sort single cells based on their secreted product at high throughput using commonly accessible lab infrastructure, i.e., flow cytometers. Background: Techniques to sort single cells based on secreted products have the potential to accelerate the development...
Published: 7/17/2025   |   Inventor(s): Dino Di Carlo, Joseph de Rutte, Robert Dimatteo, Maani Archang, Robert Damoiseaux, Doyeon Koo
Keywords(s): Antibody, B Cell, Bioassay, Cell Counting/Imaging, Cellular Differentiation, Cytometry, Flow Cytometry, Fluorescence, Hybridoma Technology, Secretory Component, T Cell, Targets And Assays
Category(s): Life Science Research Tools, Life Science Research Tools > Antibodies, Life Science Research Tools > Cell Lines, Life Science Research Tools > Research Methods, Life Science Research Tools > Other Reagents, Diagnostic Markers, Diagnostic Markers > Targets And Assays, Platforms > Diagnostic Platform Technologies