Search Results - pharmaceuticals

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ASC-Targeted Nanoparticles for Browning White Adipose Tissue and Combatting Obesity and Metabolic Diseases
Invention Description Obesity and related metabolic diseases are increasing in prevalence in the US and worldwide. They are difficult to treat with traditional therapies such as lifestyle intervention, pharmacotherapy, and various surgical procedures because of low compliance, low efficacy, high side effects and cost. One promising new approach focuses...
Published: 1/12/2026   |   Inventor(s): Shu Wang, Aysegul Kartal Acet, Fang Zhou
Keywords(s):  
Category(s): Biological Nanotechnology, Non-Cancer Therapeutics, Nucleic Acid/Peptide/Protein Therapies, Pharmaceuticals
Multiomic Approaches to Pediatric Inflammatory Bowel Disease
Invention Description Pediatric Inflammatory Bowel Disease (IBD), encompassing Crohn’s Disease and Ulcerative Colitis, presents significant clinical challenges due to its complex and heterogeneous nature, often leading to lifelong health complications. Current diagnostic and therapeutic strategies are limited by an incomplete understanding of...
Published: 1/17/2026   |   Inventor(s): Todd Sandrin, Peter Jurutka, Haiwei Gu, Brad Pasternak
Keywords(s):  
Category(s): Applied Technologies, Diagnostic Assays/Devices, Life Science (All LS Techs), Pharmaceuticals, Proteomic Assays/Reagents/Tools, Artificial Intelligence/Machine Learning
Unified Model of Alzheimer’s Disease Pathobiology
Invention Description Understanding of the pathobiology of Alzheimer’s disease (AD) has long been fragmented, with much research centered around biological mechanisms including amyloid β or tau proteins, inflammation, cell death pathways, glia, mitochondria and more. While these all deal with real facets in the biology of AD, they are limited...
Published: 1/6/2026   |   Inventor(s): Carol Huseby, Elaine Delvaux, Paul Coleman
Keywords(s):  
Category(s): Diagnostic Assays/Devices, Life Science (All LS Techs), Medical Diagnostics/Sensors, Neurodegenerative Disease Technologies, Pharmaceuticals
Switchable mRNA Expression Platform
Invention Description While recent advances have made RNA therapeutics and vaccines more mainstream, they still suffer from drawbacks including high-dosing requirements and the inability for conditional and targeted expression. Further, they can experience off-target gene expression and related side effects as well as challenges in tissue- or cell-specific...
Published: 10/2/2025   |   Inventor(s): Petr Sulc, Mark Knappenberger, Archana Kikla, Matthew Sample, Karen Anderson
Keywords(s):  
Category(s): Vaccines/Antimicrobials, Non-Cancer Therapeutics, Pharmaceuticals, Life Science (All LS Techs), Genomic Assays/Reagents/Tools
Brain-Targeted Nanoparticles for Delivering Agents to the Brain
The blood brain barrier (BBB) is a highly selective semipermeable complex, and only about 2% of small molecules in the blood can penetrate it. Because of this, drug delivery to the brain is fairly ineffective. Research into receptors expressed on the BBB is promising, however, many receptors (glucose transporter 1, transferrin receptor, LDL-receptor...
Published: 8/27/2025   |   Inventor(s): Shu Wang, Zhaoyang Fan
Keywords(s):  
Category(s): Biological Nanotechnology, Diagnostic Assays/Devices, Imaging, Life Science (All LS Techs), Pharmaceuticals, Medical Imaging, Non-Cancer Therapeutics
Compounds to Modulate Retinoid X Receptors
The human retinoid X receptors (RXRs) function as transcriptional regulators, often in partnership with members of a larger nuclear receptor family of transcription factors. RXR agonists have been shown to modulate RXR transcription and activate or repress various biological pathways and effect therapeutic results for various conditions. There are a...
Published: 8/27/2025   |   Inventor(s): Carl Wagner, Peter Jurutka, Pamela Marshall, Arjan Van Der Vaart
Keywords(s): Bio-Technology, Drug Screening
Category(s): Life Science (All LS Techs), Cancer Therapeutics, Pharmaceuticals, Neurodegenerative Disease Technologies, Non-Cancer Therapeutics
Modulating the Production of Neuroactive Molecules by Gut Microbes
Inhibitory neurotransmitters, such as y-aminobutyric acid (GABA), taurine, taurine analogs and β-alanine, have been associated with neurological disorders such as epilepsy, schizophrenia, dementia, autism, Alzheimer’s disease (AD) and more. Additionally, gut microbiome dysbiosis has also been linked to many neurological disorders, with modulations...
Published: 8/27/2025   |   Inventor(s): Dhara Shah, Pavani Dadi
Keywords(s):  
Category(s): Proteomic Assays/Reagents/Tools, Pharmaceuticals, Neurodegenerative Disease Technologies, Non-Cancer Therapeutics, Microbiome, Life Science (All LS Techs)
A novel Scaffold for Mode-Selective Inhibition of TRPV1
Pain is estimated to affect about 30% of the world’s population and treatment is challenging because of issues with addiction and withdrawal which accompany many current analgesics. Human TRPV1 is a widely expressed nociceptor and is a desirable target to modulate diverse human pathophysiologies, including pain, obesity, and diabetes, among others....
Published: 10/24/2025   |   Inventor(s): Wade Van Horn, Pankaj J. Pasricha
Keywords(s):  
Category(s): Life Science (All LS Techs), Non-Cancer Therapeutics, Pharmaceuticals, Advanced Materials/Nanotechnology, Artificial Intelligence/Machine Learning, Biomaterials
Enhanced Combinatorial Oncolytic Virotherapy
Oncolytic viruses (OVs) are able to selectively infect and kill cancer cells without damaging normal cells. They can be used as a monotherapy, or they can be combined with existing cancer therapeutics for increased potency. While much progress has been made around OVs, one of their biggest limitations is their inability to successfully replicate, spread,...
Published: 3/31/2025   |   Inventor(s): Mohammed Masmudur Rahman
Keywords(s):  
Category(s): Cancer, Cancer Therapeutics, Life Science (All LS Techs), Pharmaceuticals
Metabolic Reprogramming of Immune for Autoimmune Disorders Prevention/Reversal
Antigen-specific immune suppression or tolerance is a highly attractive strategy to prevent inflammation-induced tissue damage in rheumatoid arthritis (RA). Although there is insufficient knowledge about autoantigens in human RA, generating and expanding synovium-specific regulatory T cells, and suppressing synovium-specific follicular T-helper cells,...
Published: 2/19/2025   |   Inventor(s): Abhinav Acharya, Joslyn Mangal
Keywords(s):  
Category(s): Advanced Materials/Nanotechnology, Biomaterials, Life Science (All LS Techs), Non-Cancer Therapeutics, Nucleic Acid/Peptide/Protein Therapies, Pharmaceuticals
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