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Novel Human C3 Derivatives for Therapeutic Complement Depletion
The complement system is part of the immune system and is important in both innate and adaptive immunity. However, the complement system can also be a pathogenetic factor in many diseases including, rheumatoid arthritis, reperfusion injury, myasthenia gravis, and more. Complement has also been shown to be important for the development of antibodies...
Published: 9/23/2024   |   Inventor(s): Carl-Wilhelm Vogel, Paul Finnegan, Julie Rayes, Sebastien Lacroix-Desmazes
Keywords(s):  
Category(s): Cancer Therapeutics, Life Science (All LS Techs), Non-Cancer Therapeutics, Pharmaceuticals
Mapping Targets of Antibody Binding
The use of monoclonal antibodies (mAbs) in research, diagnostics and therapeutics is ubiquitous, particularly because of their ability to simultaneously achieve high affinity and specificity. mAbs binding typically involves interactions between it and 5-8 amino acids in a specific spatial arrangement. These interactions at defined positions is what...
Published: 8/13/2024   |   Inventor(s): Neal Woodbury, Laimonas Kelbauskas, Akanksha Singh, Pritha Bisarad
Keywords(s):  
Category(s): Applied Technologies, Bioanalytical Assays, Chemistries & Devices, Computing & Information Technology, Life Science (All LS Techs), Proteomic Assays/Reagents/Tools, Pharmaceuticals
Inflammation Targeting Contrast Agent for MR Imaging
Atherosclerosis is characterized by the formation of fatty plaque deposits within the vasculature. With increasing plaque buildup, the affected arteries may harden and narrow leading to complications such as heart attack, stroke, aneurysm and other cardiovascular events. The complex nature of plaque makes lesion-targeting imaging, and subsequently early...
Published: 7/25/2024   |   Inventor(s): Joshua Rousseau, Kuei-Chun Wang, Ting-Yun Wang
Keywords(s):  
Category(s): Advanced Materials/Nanotechnology, Biomaterials, Imaging, Medical Imaging, Life Science (All LS Techs), Non-Cancer Therapeutics, Pharmaceuticals
Multifunctional Radical Quenchers for Mitochondrial Diseases
Mitochondrial diseases are a group of disorders associated with dysfunctional mitochondria, often caused by genetic mutations to mitochondrial DNA. Mitochondrial defects are damaging, particularly to tissues with high energy demands such as neural and muscle tissues. Energy effecting defects have been implicated in forms of movement disorders, cardiomyopathy,...
Published: 1/25/2024   |   Inventor(s): Sidney Hecht, Arnaud Chevalier, Omar Khdour
Keywords(s):  
Category(s): Life Science (All LS Techs), Pharmaceuticals, Non-Cancer Therapeutics
Methylene Blue and Methylene Violet Analogs as Mitochondrial Therapeutic Agents
Mitochondrial dysfunction has been implicated in a number of diseases, including Alzheimer’s disease (AD), movement disorders, diseases of the cardiovascular system, cancer, diabetes, blindness and deafness. Mitochondrial defects are damaging, particularly to tissues with high energy demands such as neural and muscle tissues. Membrane-penetrating...
Published: 1/25/2024   |   Inventor(s): Sidney Hecht, Omar Khdour, Sandipan Roy Chowdhury, Nishant Visavadiya
Keywords(s): Alzheimer's Disease, Diabetes, Genetic Disorders, Metabolic Disorders, Mitochondrial medicine
Category(s): Life Science (All LS Techs), Non-Cancer Therapeutics, Pharmaceuticals
Methylene Blue and Methylene Violet Analogs as Mitochondrial Therapeutic Agents
Mitochondrial dysfunction has been implicated in a number of diseases, including Alzheimer’s disease (AD), movement disorders, diseases of the cardiovascular system, cancer, diabetes, blindness and deafness. Mitochondrial defects are damaging, particularly to tissues with high energy demands such as neural and muscle tissues. Membrane-penetrating...
Published: 1/25/2024   |   Inventor(s): Sidney Hecht, Omar Khdour, Sandipan Roy Chowdhury, Indrajit Bandyopadhyay
Keywords(s): Alzheimer's Disease, Diabetes, Genetic Disorders, Metabolic Disorders, Mitochondrial medicine, Neurodegenerative Disorders, Parkinson's Disease, Pharmaceutical
Category(s): Life Science (All LS Techs), Non-Cancer Therapeutics, Pharmaceuticals
Multifunctional Radical Quenchers for Mitochondrial Diseases
Mitochondrial diseases are a group of disorders associated with dysfunctional mitochondria, often caused by genetic mutations to mitochondrial DNA. Mitochondrial defects are damaging, particularly to tissues with high energy demands such as neural and muscle tissues. Energy effecting defects have been implicated in forms of movement disorders, cardiomyopathy,...
Published: 1/25/2024   |   Inventor(s): Sidney Hecht, Omar Khdour, Mohammad Alam, Sriloy Dey, Yana Chen, Arnaud Chevalier
Keywords(s): Alzheimer's Disease, Drug Discovery, Mitochondrial medicine, Neurodegenerative Disorders
Category(s): Life Science (All LS Techs), Pharmaceuticals, Non-Cancer Therapeutics
Alkylaminoquinones as Multifunctional Radical Quenchers
Mitochondrial diseases are a group of disorders associated with dysfunctional mitochondria, often caused by genetic mutations to mitochondrial DNA. Mitochondrial defects are damaging, particularly to tissues with high energy demands such as neural and muscle tissues. Energetic defects have been implicated in forms of movement disorders, cardiomyopathy,...
Published: 1/25/2024   |   Inventor(s): Sidney Hecht, Manikandadas Mathilakathu Madathil, Omar Khdour
Keywords(s): Alzheimer's Disease, CNS Therapeutics, Drug, Mitochondrial medicine, Neurodegenerative Disorders, Neurological Disorders, Pharmaceutical, Therapeutics
Category(s): Life Science (All LS Techs), Non-Cancer Therapeutics, Pharmaceuticals
Multifunctional Radical Quenchers and Simplified Synthesis Routes
Mitochondrial diseases are a group of disorders associated with dysfunctional mitochondria, often caused by genetic mutations to mitochondrial DNA. Mitochondrial defects are damaging, particularly to tissues with high energy demands such as neural and muscle tissues. Energetic defects have been implicated in forms of movement disorders, cardiomyopathy,...
Published: 1/25/2024   |   Inventor(s): Sidney Hecht, Xiaoqing Cai, Omar Khdour
Keywords(s): Mitochondrial medicine, Therapeutics
Category(s): Life Science (All LS Techs), Pharmaceuticals, Non-Cancer Therapeutics
Multifunctional Radical Quenchers and Simplified Synthesis Routes
Mitochondrial diseases are a group of disorders associated with dysfunctional mitochondria, often caused by genetic mutations to mitochondrial DNA. Mitochondrial defects are damaging, particularly to tissues with high energy demands such as neural and muscle tissues. Energetic defects have been implicated in forms of movement disorders, cardiomyopathy,...
Published: 1/25/2024   |   Inventor(s): Sidney Hecht, Omar Khdour, Sandipan Roy Chowdhury, Poulami Talukder
Keywords(s): Therapeutics
Category(s): Life Science (All LS Techs), Pharmaceuticals, Non-Cancer Therapeutics
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