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Method to Determine Quality of Mitochondrial Cargo in Extracellular Vesicles
A novel method that measures mitochondrial membrane potential in extracellular vesicles, providing a direct readout of mitochondrial quality and utility. Background: Studies have shown that EV-mediated intercellular communication is influenced, at least in part, by the mitochondrial cargo contained within EVs. This highlights the importance of rigorous...
Published: 1/29/2026   |   Inventor(s): Barbara Alevriadou, Zahid Manzar, Hans Minderman
Keywords(s): Biotechnology, Diagnostic, Healthcare, Pharmaceutical, Research Tool, Technologies, Therapeutic and Vaccines
Category(s): Campus > University at Buffalo, Technology Classifications > Research Tools and Reagents, Technology Classifications > Screens and Assays
The use of complex or fusion protein of soluble MIC (Smic) and antibody to treat MIC-negative cancer
NU 2019-146 INVENTORS Jennifer Wu* SHORT DESCRIPTION A fusion protein complex comprising soluble MIC and a non-blocking sMIC-neutralizing antibody that effectively activates CD8 T cells for the treatment of MIC-negative cancer. BACKGROUND Effective T cell co-stimulation is critical for durable tumor control, yet many current immunotherapies...
Published: 12/9/2025   |   Inventor(s):  
Keywords(s): Antibody, Cancer/Oncology, Research tool
Category(s): Life Sciences > Therapeutics
2-(Pyridin-3-yl)quinazoline compounds as glucocerebrosidase modulators
✅ Feedback form for Tech ID 2015-064 PROPOSED TITLE: 2-(Pyridin-3-yl) quinazoline Compounds as Glucocerebrosidase Modulators NU 2015-064 INVENTORS Richard Silverman* Dimitri Krainc Jianbin Zheng SHORT DESCRIPTION Novel substituted quinazoline compounds that modulate glucocerebrosidase activity, offering a promising therapeutic approach for...
Published: 11/18/2025   |   Inventor(s):  
Keywords(s): Neurodegenerative disease, Neurologic disease, PD - Parkinson's Disease, Research tool, Therapeutics
Category(s): Life Sciences > Therapeutics
Projected Beam Pen Lithography for Benchtop High Resolution Maskless Photolithography of Large Areas
NU 2012-090 INVENTORS Chad Mirkin (Northwestern University, Department of Chemistry)* Keith Brown Shu He Guoliang Liu Xing Liao Wooyoung Shim Abrin Schmucker SHORT DESCRIPTION This lithography system uses a projected beam pen method to directly pattern surfaces. It produces sub-100nm features quickly without the need for expensive masks. BACKGROUND Current...
Published: 12/9/2025   |   Inventor(s):  
Keywords(s): Lithography, Nanomaterials, Nanotechnology, Research tool
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
A Biological Marker for Concussion
NU 2016-016 INVENTORS Nina Kraus* Trent Nicol Travis White-Schwoch SHORT DESCRIPTION This technology provides a method for objectively identifying non-penetrating brain injuries by analyzing the brain’s frequency following response (FFR) to an acoustic stimulus. It offers a non-invasive alternative that improves diagnostic precision and...
Published: 12/9/2025   |   Inventor(s):  
Keywords(s): Biomarker, Brain injury, Devices, Diagnostics, Electrophysiology, Health IT, Medical device, Neurologic disease, Research tool
Category(s): Life Sciences > Healthcare Devices, Tools & IT, Life Sciences > Biomarkers & Biomedical Research Tools
A platform for mapping reactive cysteines within the immunopeptidome
NU 2024-044 INVENTORS Xiaoyu Zhang* Chenlu Zhang Chen Zhou SHORT DESCRIPTION This invention provides novel chemical probes for mapping reactive cysteine residues within the major histocompatibility complex class I (MHC-I) immunopeptidome. BACKGROUND The immune system's recognition of infected or malignant cells hinges on the presentation...
Published: 12/11/2025   |   Inventor(s):  
Keywords(s): Biomarker, Immunology, Research reagent, Research tool
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
TauSeeK: Disease Specific Tau Protein Fibrils & Seeding Proteins
NU 2024-154 INVENTORS Songi Han* Austin Dubose Michael Vigers Andrew Longhini Vishnu Vijayan Kenneth Kosik Samuel Lobo Peter C. Ryffel Lokeswara Rao Potnuru Karen Tsay Chung-Ta Han SHORT DESCRIPTION Compositions, kits, and methods for generating synthetic miniature tau peptides and fibrils, and synthetic full-length pathogenic tau...
Published: 1/14/2026   |   Inventor(s):  
Keywords(s): AD - Alzheimer’s Disease, HD - Huntington's Disease, Neurodegenerative disease, Neurology, PD - Parkinson's Disease, Research tool
Category(s): Life Sciences > Therapeutics
Flexible Nanophotonic Cavity-Enhanced Infrared Photodetectors Employing Double Quantum Wells
Double-quantum-well infrared photodetectors (DQWIPs) integrated with nanophotonic cavities enable highly responsive mid-infrared detection through enhanced intersubband absorption in the thin semiconductor heterostructure. Additionally, the technology is compatible with flexible substrates. Background: Quantum Well Infrared Photodetectors (QWIPs)...
Published: 1/30/2026   |   Inventor(s): Peter Liu, Puspita Paul
Keywords(s): Featured, Imaging: Medical Imaging, Instrumentation, Night vision and thermal imaging, Optics, Research Tool, Sensors, Surveillance, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Electronics, Technology Classifications > Engineering, Technology Classifications > Semiconductor Devices and Manufacturing, Technology Classifications > Quantum Computing
Nanocytological and Molecular Analysis of Fecal Colonocytes for Colon Cancer Screening
NU 2010-131 INVENTORS Vadim Backman* Dhwanil Damania Dhananjay Kunte Hariharan Subramanian Hemant Roy Mart De La Cruz SHORT DESCRIPTION This technology offers a novel fecal test that detects nanoarchitectural and molecular markers in colonocytes. It delivers a minimally invasive screening method for early detection of colon cancer. BACKGROUND Colorectal...
Published: 12/9/2025   |   Inventor(s):  
Keywords(s): Cancer/Oncology, Colon cancer, Diagnostics, Drug screening, Imaging, Research tool
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
Artificial Extracellular Matrix for Enhanced Maturation of Human iPSCs-derived Neurons
Artificial Extracellular Matrix for Enhanced Maturation of Human iPSCs-derived Neurons NU 2018-157 Peptide amphiphile nanofibers enhance neuron maturation by promoting high mobility while reducing cell aggregation. INVENTORS Samuel I. Stupp Zaida Alvarez Pinto Juan Alberto Ortega Cano Kohei Sato Evangelos Kiskinis SHORT DESCRIPTION A...
Published: 11/6/2025   |   Inventor(s):  
Keywords(s): Neurology, Research tool
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
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