Search Results - colon+cancer

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Novel Aminotransferase Inhibitor Platform for the Treatment of Cancer and Neurological Disorders

SHORT DESCRIPTION Novel Aminotransferase Mechanism-Based Inhibitor (MBI) Platform Targeting OAT and GABA-AT as Novel Treatments for Cancer and Neurological Disorders. INVENTORS Richard Silverman* Weinberg College of Arts and Sciences, Department of Chemistry * Principal Investigator DEVELOPMENT...

Published: 6/1/2026 | Updated: 6/1/2026 | Inventor(s):

Keywords(s): AD - Alzheimer’s Disease, Cancer/Oncology, CNS - Central Nervous System, Colon cancer, Epilepsy, Gastric cancer, Liver cancer, Lung cancer, Neurodegenerative disease, Neurologic disease, Neurology, Pancreatic cancer, PD - Parkinson's Disease, Psychiatric disorder, Small molecule, Targeted therapy, Therapeutics

Category(s): Life Sciences > Therapeutics

Fatty-Acid Modified Cytotoxins and Peptides for Improved Efficacy, Safety, and Dosing Flexibility

SHORT DESCRIPTION A suite of four complementary technologies for a long-chain fatty‑acid–guided drug delivery platform to achieve superior therapeutic outcomes with reduced toxicity across both oncology and critical care applications. INVENTORS Nathan Gianneschi*, and others Weinberg College of Arts and Sciences,...

Published: 6/2/2026 | Updated: 6/1/2026 | Inventor(s):

Keywords(s): Adjunct therapy, BIO2026, Biologic, Breast cancer, Cancer/Oncology, Chemotherapy, Colon cancer, Lung cancer, Ovarian cancer, Pancreatic cancer, Small molecule, Targeted therapy, Therapeutics

Category(s): Life Sciences > Therapeutics

Small Molecule Inhibitors of Pleckstrin-2 for Treating Myeloproliferative Neoplasms

SHORT DESCRIPTION Small molecule inhibitors of Pleckstrin-2 (Plek2) for treating cell proliferative diseases and disorders, particularly myeloproliferative neoplasms (MPNs). NU Tech IDs: NU 2018-169, NU 2021-005 PRINCIPAL INVESTIGATOR Peng Ji Northwestern University Feinberg School of Medicine, Department of Pathology IP...

Published: 5/27/2026 | Updated: 5/27/2026 | Inventor(s):

Keywords(s): Breast cancer, Cancer/Oncology, Colon cancer, Leukemia, Lung cancer, Pancreatic cancer, Small molecule, Therapeutics

Category(s): Life Sciences > Therapeutics

Inhibitors of MNK Kinase for Targeted Cancer and CNS Therapeutics

NU 2015-098 (NU 2015-098, NU 2018-036, NU 2025-036) INVENTORS Gary Schiltz (Weinberg College of Arts and Sciences, Department of Chemistry)* SHORT DESCRIPTION MNK kinase inhibitors that reduce cancer cell viability and proliferation and penetrates the brain for potential treatment of glioblastoma and CNS disorders. BACKGROUND Leukemia and brain...

Published: 5/13/2026 | Updated: 4/29/2026 | Inventor(s):

Keywords(s): AD - Alzheimer’s Disease, AML - Acute myeloid leukemia, ASD - Autism Spectrum Disorder, Bladder cancer, Brain cancer, Breast cancer, Cancer/Oncology, CNS - Central Nervous System, Colon cancer, Lung cancer, Neurodegenerative disease, Pancreatic cancer, Prostate cancer, Small molecule, Targeted protein degradation, Targeted therapy, Therapeutics

Category(s): Life Sciences > Therapeutics

Use of Nucleotide Synthesis Inhibitors for Targeted Therapy in MLL3/4 COMPASS Mutant Cancer

NU 2022-053 INVENTORS Ali Shilatifard (Feinberg School of Medicine, Department of Biochemistry and Molecular Genetics)* Zibo Zhao (Feinberg School of Medicine, Department of Biochemistry and Molecular Genetics)* SHORT DESCRIPTION A therapeutic platform that targets MLL3/4 COMPASS mutant cancers by using nucleotide synthesis inhibitors to disrupt...

Published: 5/26/2026 | Updated: 4/29/2026 | Inventor(s):

Keywords(s): Bladder cancer, Breast cancer, Cancer/Oncology, Colon cancer, Gastric cancer, Leukemia, Lung cancer, Lymphoma, Prostate cancer, Targeted therapy, Therapeutics

Category(s): Life Sciences > Therapeutics

STING Agonist 8803 for Blood-Brain Barrier Opening in Glioblastoma Treatment

SHORT DESCRIPTION Chemical compound that opens the blood-brain barrier to enhance delivery of therapeutics for treating glioblastoma. INVENTORS Amy Heimberger* Northwestern University Feinberg School of Medicine, Department of Neurological Surgery * Principal Investigator NU Tech ID: NU 2025-212 IP...

Published: 5/7/2026 | Updated: 4/27/2026 | Inventor(s):

Keywords(s): AD - Alzheimer’s Disease, Adjunct therapy, ALS - Amyotrophic Lateral Sclerosis, Animal Model, Autoimmune disease, Bladder cancer, Brain cancer, Breast cancer, Cancer Treatment, Cancer/Oncology, Cervical cancer, CNS - Central Nervous System, Colon cancer, Drug delivery, Endometrial cancer, Gastric cancer, GBM - Glioblastoma, Head and neck cancer, Immunology, Immunotherapy, Liver cancer, Lung cancer, MS - Multiple Sclerosis, Neurodegenerative disease, Neurologic disease, Ovarian cancer, Pancreatic cancer, PD - Parkinson's Disease, Prostate cancer, Repurposed Drugs, Research tool, Small molecule, Targeted therapy, TBI - Traumatic brain injury, Therapeutics

Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools

Nanocytological and Molecular Analysis of Fecal Colonocytes for Colon Cancer Screening

NU 2010-131 INVENTORS Vadim Backman* Dhwanil Damania Dhananjay Kunte Hariharan Subramanian Hemant Roy Mart De La Cruz SHORT DESCRIPTION This technology offers a novel fecal test that detects nanoarchitectural and molecular markers in colonocytes. It delivers a minimally invasive screening method for early detection of colon cancer. BACKGROUND Colorectal...

Published: 12/9/2025 | Updated: 10/10/2025 | Inventor(s):

Keywords(s): Cancer/Oncology, Colon cancer, Diagnostics, Drug screening, Imaging, Research tool

Category(s): Life Sciences > Biomarkers & Biomedical Research Tools

Anti-CD73 Monoclonal Antibody for Enhanced Cancer Immunotherapy

NU 2020-207 INVENTORS Bin Zhang* Siqi Chen Jie Fan SHORT DESCRIPTION This invention comprises novel anti-CD73 monoclonal antibody compositions that recognize and inhibit mouse and human CD73. BACKGROUND CD73, an ecto-enzyme associated with adenosine metabolism, is an emerging immune checkpoint that promotes tumor progression...

Published: 5/26/2026 | Updated: 1/30/2025 | Inventor(s):

Keywords(s): Brain cancer, Breast cancer, Cancer/Oncology, Colon cancer, Gastric cancer, Immunotherapy, Lung cancer, Ovarian cancer, Pancreatic cancer, Therapeutics

Category(s): Life Sciences > Therapeutics

Human T Cell Receptors for Treating Cancer

Abstract: T cell receptors (TCRs) are proteins that recognize antigens in the context of infected or transformed cells and activate T cells to mediate an immune response and destroy abnormal cells. TCRs consist of two domains, one variable domain that recognizes the antigen and one constant region that helps the TCR anchor to the membrane and transmit...

Published: 4/22/2025 | Updated: 8/2/2023 | Inventor(s): Richard Morgan, Nachimuthu Chinnasamy, Steven Rosenberg

Keywords(s): COLON CANCER, Hepatocellular cancer, MELANOMA, PROSTATE CANCER, SSX

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics

High Affinity Nanobodies Targeting B7-H3 (CD276) for Treating Solid Tumors

Summary: The NCI seeks licensing and/or co-development research collaborations for CD276-targeting camel nanobodies. Description of Technology: CD276 (also called B7-H3) is a pan-cancer antigen expressed in multiple solid tumors and an emerging cancer target. CD276 protein is overexpressed in pancreatic cancer, prostate cancer, breast cancer, colon...

Published: 4/24/2026 | Updated: 8/2/2023 | Inventor(s): Mitchell Ho, Brad St. Croix, Ruixue Wang, Dan Li

Keywords(s): ADC, Antibody-drug Conjugate, B7-H3, BREAST CANCER, CAR, CD276, chimeric antigen receptor, COLON CANCER, Glioma, HO, lung cancer, Nanobodies, Neuroblastoma, OVARIAN CANCER, Pancreatic Cancer, solid tumors

Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology

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