Search Results - drug+development

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Induced Pluripotent Stem Cells Derived from Patients with CEP290-associated Ciliopathies and Unaffected Family Members
Abstract: Approximately one-third of non-syndromic retinal dystrophies involve a defect in a ciliary protein. Non-syndromic retinal ciliopathies include retinitis pigmentosa, cone dystrophy, cone-rod dystrophy, macular dystrophy, and Leber-congenital amaurosis (LCA). Many CEP290-LCA patients also exhibit auditory and olfactory defects. Induced pluripotent...
Published: 4/8/2024   |   Inventor(s): Anand Swaroop, Hiroko Shimada-Ishii, Yu Holly Chen, Milton English
Keywords(s): Anosmia, Cell therapy, Ciliopathies, Congenital Blindness, Drug Development, GENE THERAPY, hearing loss, iPS, National Eye Institute, NEI, Pluripotent Stem Cells, Primary Cilia, Retina, Retinal degeneration, Swaroop, VISION
Category(s): Application > Research Materials, Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Opthamology, TherapeuticArea > Eye / Ear / Nose / Throat
Combining Aminoglycoside Antibiotics and PKZ18 Analogs
Significantly enhances the efficacy of aminoglycosides drugs while reducing the risk of microbial drug resistance. Background: To increase drug efficacy and reduce the risk of the development of resistance to treatment, clinicians often prescribe multiple drugs of different classes in combination. For example, many topical creams use an aminoglycoside...
Published: 1/24/2024   |   Inventor(s): Ville Väre, Ryan Schneider
Keywords(s): antibiotics, antimicrobial, drug development, Staphylococcus aureus, synergistic interaction, Technologies
Category(s): Campus > University at Albany, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Drug Delivery, Technology Classifications > Healthcare, Technology Classifications > Therapeutics and Vaccines
2022-223 A Bioanalytics-Enabled and Hollow Microneedle-Based Wearable Technology for Personalized Medicine
­Summary: UCLA researchers in the Department of Electrical and Computer Engineering have developed a minimally-invasive wearable device that continuously monitors pharmaceutical concentrations in a user to optimize the drug’s dosage. Background: The annual cost of medication-related morbidity and mortality due to non-optimized pharmacotherapy...
Published: 7/19/2023   |   Inventor(s): Sam Emaminejad, Shuyu Lin
Keywords(s): Adverse Drug Reaction, Antibody-Drug Conjugate, Antiviral Drug, Biomonitoring, Blood Glucose Monitoring, Drug, Drug Carrier, Drug Delivery, Drug Delivery Microporous Material, Drug Development, Drug Development Feature Extraction, Drug Discovery, Drug monitoring, Drug Resistance, Drug-Eluting Stent, Extensively Drug-Resistant Tuberculosis, Fine-Needle Aspiration, Gene Combination Drug, Immunosuppressive Drug, interstitial fluid (ISF)-based information, Investigatioal New Drug, Management Of HIV/AIDS Psychoactive Drug, medical automation technology, Medical Device, Medical Devices and Materials, medication customization, medication efficacy, Microneedle array, minimally invasive device, Monitoring (Medicine), Monitoring And Recording Systems, Multiple Drug Resistance, Mutation Drug Design, Nanosensor, Nanostructure, Nanotechnology, non-invasive drug monitoring, personalized dose assessment, Pharmaceutical Drug, Pharmaceutical Drug Ethylene Glycol, Pharmaceutical Drug Opioid Dependence, Prescription Drug, real-time sensing/monitoring/tracking, remote monitoring, sample-to-answer devices, Smart medical device, Therapeutic Drug Monitoring, wearable medical device
Category(s): Mechanical, Mechanical > Sensors, Medical Devices, Medical Devices > Monitoring And Recording Systems, Platforms > Drug Delivery, Software & Algorithms > Bioinformatics, Software & Algorithms > Artificial Intelligence & Machine Learning, Electrical > Sensors, Materials > Nanotechnology
Improved drug delivery for solid tumors
A novel formulation paving the way for pancreatic cancer therapeutics Problem Pancreatic cancer therapeutics have a success rate of less than 8%. The solid nature of the tumor in pancreatic cancer renders the current standard of care, chemotherapy drugs, less effective. Unfortunately, the problem lies not with the drugs themselves, but with the drug...
Published: 11/1/2023   |   Inventor(s): Debadyuti Ghosh, Xinquan Liu
Keywords(s): Cancer, Drug delivery, Drug development, Drugs, Pharmaceuticals
Category(s): Life sciences > Therapeutics > Drug delivery, Life sciences > Therapeutics > Biologic
2022-222 A Wearable Aptamer Microneedle Patch for Continuous Minimally-Invasive Biomonitoring
Summary: UCLA researchers in the Department of Bioengineering have developed a novel wearable device for real-time, minimally-invasive medication monitoring. Background: Current medication dosing is determined by taking the average therapeutic dose of a small patient sample size. However, this is often inaccurate for many individuals and the recommended...
Published: 8/2/2024   |   Inventor(s): Sam Emaminejad, Shuyu Lin, Jialun Zhu, Xuanbing Cheng
Keywords(s): Biomonitoring, Drug, Drug Delivery, Drug Development, Drug Discovery, Drug Resistance, Invasiveness Of Surgical Procedures, Microneedle array, non-invasive drug monitoring, Personalized Pharmacotherapy, Pharmaceutical Drug, Pharmacokinetics, Pharmacology, Prescription Drug, Therapeutic Drug Monitoring, Therapeutics & Vaccines
Category(s): Life Science Research Tools, Medical Devices, Materials > Nanotechnology
Repurposing Tamoxifen to treat lethal E. coli infections
ProblemOver 100,000 people suffer from Shiga toxin-producing E. coli infections every year which cause gastrointestinal illness. In 5% to 15% of cases, these toxins enter the bloodstream, which can result in fatal renal disease. These infections are currently untreatable, as traditional antibiotics induce higher toxin concentrations and worsen illness....
Published: 11/1/2023   |   Inventor(s): Somshuvra Mukhopadhyay, Andrey Selyunin
Keywords(s): Antimicrobials, Digestive disease, Drug development, Drugs, Gastroenterology, Infectious disease, Kidney disease, Pharmaceuticals
Category(s): Life sciences > Therapeutics > Small molecule
Use of drug solvates in thermal processes to make solid dispersions at lower processing temperature
An improved manufacturing approach expands possibilities for poorly soluble drugs Description Increasing the solubility and bioavailability of poorly water-soluble drug candidates is critical to successful drug development and translation. While 90% of drug candidates in development and 40% of all marketed drugs exhibit poor solubility, this remains...
Published: 11/1/2023   |   Inventor(s): Robert Williams, Xiangyu Ma, Siyuan Huang
Keywords(s): Drug development, Drugs, Pharmaceuticals
Category(s): Life sciences > Therapeutics > Manufacturing platform
DosePlus: A pharmaceutical 3D-printing platform for flexible and precise dosages
Problem Innovations in 3D printing have caused a paradigm shift in the design and manufacture of pharmaceuticals. By allowing for on-demand production of custom dosages, 3D printing has the potential to transform the field of personalized medicine and the economics of pharmaceutical manufacturing.1 However, existing 3D printing techniques for drug manufacturing...
Published: 11/1/2023   |   Inventor(s): Mohammed Maniruzzaman, Jiaxiang Zhang, Rishi Thakkar
Keywords(s): 3D printing, Drug development, Pharmaceuticals
Category(s): Life sciences > Therapeutics > Manufacturing platform
High-throughput screening platform for skin penetration and permeability for dermal drugs and skin care products
Description The skin is one of the most readily accessible tissues for delivery of drugs and therapeutics. Improving skin permeation and retention is a major focus for new drugs and skin care products. In the development stage of transdermal drugs, it’s important to probe permeability and test delivery methods in a high-throughput, cost-effective,...
Published: 11/1/2023   |   Inventor(s): Hugh Smyth, Patricia Martins
Keywords(s): Drug development, Drug screening
Category(s): Life sciences > Research tools > Tool/assay/screening platform, Life sciences > Therapeutics > Drug screening
A Promoter Specifically Active in Newly Forming and Remodeling Arteries
Current State of the Art: Studies in angiogenesis link new blood vessel formation to both wound healing and pathologies in the human body. Angiogenesis can be stimulated during regeneration of diseased or damaged tissues as well as during tumor growth and metastasis, in order to gain access to oxygen and nutrients necessary for survival. Gene therapy...
Published: 9/2/2020   |   Inventor(s): Tsugio Seki
Keywords(s): Biomaterial, Drug Development, Gene Therapy, Research Tool, Targeting
Category(s): Therapeutics
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