Search Results - neurodegenerative+disease+technologies

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Biofeedback Device for Speech Modulation
Neurodegenerative diseases, such as Parkinson’s Disease (PD), affect many of the body’s functions such as balance and movement. They can also have a profound effect on communication abilities, with the majority of patients suffering from some form of vocal impairment, usually a difficulty in modulating vocal intensity. These speech difficulties...
Published: 12/12/2024   |   Inventor(s): Nithish Kumar Saravanan, Kirthik Roshan Nagaraj, Ezhilan Veluchami, Ramprakash Sridharan, Tyler Hulson, Zane Reynolds, Tara Chay, Maura Rhodes
Keywords(s):  
Category(s): Life Science (All LS Techs), Manufacturing/Construction/Mechanical, Medical Devices, Neurodegenerative Disease Technologies, Artificial Intelligence/Machine Learning
Formulations to Prevent Neurological Diseases and Disorders, including TBI
Traumatic brain injury (TBI) is a major source of death and long-term physical, cognitive and mental disability worldwide, with roughly 27 million new cases each year. In the U.S. alone, this results in almost 70,000 deaths, annually. Although TBIs can affect people of all ages, the risk of getting a TBI is greatest in adolescents, young adults and...
Published: 11/4/2024   |   Inventor(s): Abhinav Acharya, Sarah Stabenfeldt
Keywords(s):  
Category(s): Vaccines/Antimicrobials, Pharmaceuticals, Non-Cancer Therapeutics, Neurodegenerative Disease Technologies, Life Science (All LS Techs)
Implantable Electrode for Coordinated Reset Neuromodulation
Excessive synchronization of populations of neurons has been implicated in several neurological conditions. Coordinated reset neuromodulation, is a method which takes advantage of neuroplasticity to counteract excessive synchronization and reset the phase and change connection strengths of neurons. As such, it may be used to treat these neurological...
Published: 5/6/2024   |   Inventor(s): Derek Smetanick, Shaun Victor, Ashley Tse, Dhrasti Dalal, Alan Ramsey, David Lott, Juergen Neubauer, Jitendran "jit" Muthuswamy
Keywords(s):  
Category(s): Medical Devices, Life Science (All LS Techs), Neurodegenerative Disease Technologies
Diagnostic and Prognostic Biomarkers for ALS
Amyotrophic Lateral Sclerosis (ALS) is a terminal neurodegenerative disease defined by the progressive loss of motor neuron function. Despite intense research efforts, clinical outcomes in ALS patients have remained limited. Because there are no diagnostic or prognostic biomarkers for ALS, patients are classified based on the site of symptom onset,...
Published: 4/18/2024   |   Inventor(s): Jarrett Eshima, Barbara Smith, Chris Plaisier
Keywords(s):  
Category(s): Diagnostic Assays/Devices, Life Science (All LS Techs), Medical Diagnostics/Sensors, Neurodegenerative Disease Technologies
Laser Capture Microdissection (LCM) Microfluidic Platform for Single-Cell Proteomic Analysis
Single-cell proteomics is an emerging field for proteomic analyses of individual cells. Single-cell genomic analyses have greatly expanded our understanding of cell heterogeneity and disease progression; however, protein identification and quantitative cell-to-cell variation provide a deeper level of understanding of the biological regulators in the...
Published: 6/28/2023   |   Inventor(s): Alexandra Ros, Jorvani Cruz Villarreal, Ana Egatz-Gomez, Todd Sandrin, Paul Coleman
Keywords(s):  
Category(s): Proteomic Assays/Reagents/Tools, Neurodegenerative Disease Technologies, Life Science (All LS Techs), Bioanalytical Assays, Chemistries & Devices
Reagents Targeting Neurodegenerative Diseases and Traumatic Brain Injury
Misfolding and aggregation of proteins, such as beta-amyloid (Aß), alpha-synuclein (a-syn), tau and TAR DNA-binding protein 43 (TDP-43), have been strongly correlated with early onset of neurodegenerative diseases such as Alzheimer's Disease (AD), Parkinson's Disease (PD), Frontotemporal Dementia (FTD), amyotrophic lateral sclerosis (ALS) and...
Published: 4/19/2023   |   Inventor(s): Michael Sierks, Stephanie Williams
Keywords(s): Antibodies, Antigen-specific Therapies, Bioassay, biomarker, ELISA, Mental Disorders, Traumatic Brain Injury
Category(s): Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Life Science (All LS Techs), Neurodegenerative Disease Technologies, Non-Cancer Therapeutics, Proteomic Assays/Reagents/Tools
Compounds to Modulate Retinoid X Receptors
The human retinoid X receptors (RXRs) function as transcriptional regulators, often in partnership with members of a larger nuclear receptor family of transcription factors. RXR agonists have been shown to modulate RXR transcription and activate or repress various biological pathways and effect therapeutic results for various conditions.There are a...
Published: 4/14/2023   |   Inventor(s): Carl Wagner, Peter Jurutka, Pamela Marshall
Keywords(s):  
Category(s): Cancer Therapeutics, Life Science (All LS Techs), Non-Cancer Therapeutics, Neurodegenerative Disease Technologies, Pharmaceuticals
Recombinant Antibody Fragments that Selectively Target Oligomeric Tau Aggregates
Alzheimer's disease (AD) is one of the most prevalent and feared neurodegenerative diseases associated with aging, characterized by progressive neuronal loss and cognitive dysfunction. AD affects nearly 5 million Americans, and unfortunately, there is no cure as of yet. Numerous studies have implicated oligomeric amyloid beta (Aß) aggregates as...
Published: 4/19/2023   |   Inventor(s): Michael Sierks, Huilai Tian, James Moe, Eliot Davidowitz
Keywords(s): Antibodies, Antibody Therapeutics, Antigen-specific Therapies, Bioassay, Dementias, Diagnostics, Human aging, Protein, Therapeutics
Category(s): Life Science (All LS Techs), Neurodegenerative Disease Technologies, Non-Cancer Therapeutics, Diagnostic Assays/Devices, Medical Diagnostics/Sensors, Proteomic Assays/Reagents/Tools
Selective Clearance of Beta-Amyloid Using Bispecific Recombinant Antibody fragments
Alzheimer’s disease (AD) is one of the most prominent and feared neurodegenerative diseases associated with aging. A hallmark of this disease is the formation of extra-cellular amyloid plaques in the brain. The principle component of these extracellular plaques is amyloid-ß protein (Aß). Though the mechanisms underlying Alzheimer’s...
Published: 4/19/2023   |   Inventor(s): Michael Sierks, Yong Shen
Keywords(s):  
Category(s): Pharmaceuticals, Life Science (All LS Techs), Neurodegenerative Disease Technologies, Non-Cancer Therapeutics
Bi-specific Antibodies as a Therapeutic for Alzheimer’s Disease
Alzheimer’s disease (AD) is one of the most prominent and feared neurodegenerative diseases associated with aging. A hallmark of this disease is the formation of extra-cellular amyloid plaques in the brain. The principle component of these extracellular plaques is amyloid-ß protein (Aß). Though the mechanisms underlying Alzheimer’s...
Published: 4/19/2023   |   Inventor(s): Michael Sierks, Shanta Boddapati, Srinath Kasturirangan
Keywords(s): Bio-Technology, Therapeutics
Category(s): Life Science (All LS Techs), Neurodegenerative Disease Technologies, Non-Cancer Therapeutics, Pharmaceuticals
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