Search Results - microfluidics

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Contactless, Reversible Material Deposition From Liquid Droplets To Solid Surfaces
A microfluidic device allowing spatiotemporal manipulation of droplets that can be applied to high-resolution analytical techniques. Problem: Electrowetting methods such as electrowetting-on-dielectric (EWOD) have been developed to support high-resolution analytical techniques such as mass spectrometry and atomic force microscopy. EWOD allows processing...
Published: 10/17/2024   |   Inventor(s): Daeyeon Lee, Junhyong Kim, Paradorn Rummaneethorn
Keywords(s): Microfluidics
Category(s): Technology Classifications > Research Tools & Reagents
Functional Enrichment and Purification of a Therapeutically Superior Population of Cells (Case No. 2024-024)
Summary: UCLA researchers in the Departments of Bioengineering and Biological Chemistry have developed a method for identifying and enriching therapeutically useful cell sub-populations based on their secretions (SEC-seq). Background: Cell function is defined by a myriad of biomolecules that they secrete; over 3 thousand proteins are estimated to...
Published: 9/11/2024   |   Inventor(s): Dino Di Carlo, Kathrin Plath, Shreya Udani, Justin Langerman
Keywords(s): Cell Surface Receptor, Cytometry, Flow Cytometry, Functional Genomics, High-Throughput Screening, hydrogel, Microfluidics, single cell analysis, Therapeutics
Category(s): Therapeutics > Immunology And Immunotherapy, Therapeutics, Therapeutics > Oncology > Oncology Immunotherapy, Life Science Research Tools, Life Science Research Tools > Research Methods, Diagnostic Markers > Targets And Assays, Therapeutics > Cell Therapy
Photoactivated Selective Release (PHASR) of Droplets from Microwell Arrays
A photoresponsive polymer layer that can be integrated into microfluidic devices for selective release of unique droplets Problem: Droplet microfluidics are used for single molecule detection and analysis, such as isolation of protein biomarkers for monitoring of disease progression. Current techniques for recovering unique molecules or cells from droplet...
Published: 8/2/2024   |   Inventor(s): Daeyeon Lee, Junhyong Kim, Yongwon Choi, Syung-Hun Han
Keywords(s): Artificial Intelligence (AI) & Machine Learning, Microfluidics, Nanotechnology
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Research Tools & Reagents
Single-Step Wettability Patterning for Microfluidic Generation of Emulsions
Method to transfer wettability properties of a mold to microfluidic devices, defining hydrophobic/hydrophilic regions through variable perfluoropolyether concentration. Problem: Current wettability patterning methods involve sequentially flowing chemicals into channels, blocking areas where treatment is not desired. These multi-step methods are labor...
Published: 7/23/2024   |   Inventor(s): Daeyeon Lee, David Issadore, Jingyu Wu
Keywords(s): Microfluidics
Category(s): Technology Classifications > Chemical Processes and Synthesis
Effective Anti-Fouling Surface Coating of Microfluidic Mixing Devices for Robust mRNA Lipid Nanoparticles (LNP) Manufacturing
Employment of omniphobic, thin-layer perfluorocarbon (TLP) coating to prevent fouling and clogging in microfluidic mixing devices during mRNA LNP formulations. Problem: Lipid nanoparticle (LNP)-based delivery systems for mRNA and other therapeutics recently gained popularity because of their application in the Pfizer/BioNTech and Moderna COVID-19 vaccines....
Published: 7/15/2024   |   Inventor(s): Daeyeon Lee, Yoon-Ho Hwang, David Issadore
Keywords(s): Bioengineering, Microfluidics
Category(s): Technology Classifications > Hardware & Components, Technology Classifications > Materials
METHODS FOR ULTRA-HIGH-THROUGHPUT PROFILING OF NUCLEIC ACID BINDING OR MODIFYING PROTEINS
­METHODS FOR ULTRA-HIGH-THROUGHPUT PROFILING OF NUCLEIC ACID BINDING OR MODIFYING PROTEINS Researchers at Stanford have developed a novel method for the mapping of nucleic acid binding or modifying proteins in a massively multiplexed manner. Next generation sequencing (NGS) has allowed for sequence-agnostic sequencing and has revolutionized every...
Published: 4/22/2024   |   Inventor(s): Polly Fordyce
Keywords(s): High-Throughput, Microfluidics, Protein-DNA Interactions
Category(s): Technology Classifications > Engineering
DROPLET-ELECTROPHORESIS DEVICES AND RELATED METHODS
­DROPLET-ELECTROPHORESIS DEVICES AND RELATED METHODS Researchers at UC Berkeley have developed a novel method for comprehensively profiling the proteomes of single cells. Genomics (DNA) and transcriptomics (RNA) sequencing is one of the cornerstones of our modern-day understanding of the genetic blueprint of life. Furthermore, sequencing and...
Published: 4/22/2024   |   Inventor(s): Amy Herr, Yang Liu
Keywords(s): Microfluidics, Protein, Single Cell Analysis
Category(s): Technology Classifications > Engineering
Ultrasensitive, High-Throughput, Single-Scale Detection of Extracellular Vesicles
An optofluidic platform to detect extracellular vesicles (EVs) at the single-particle level by parallelizing droplet generation and analysis of EVs. Problem: Extracellular vesicles (EVs) are lipid bound nanomaterials carrying various molecular cargo that can be representative of their cells of origin. EVs play a critical role in intercellular communication...
Published: 2/26/2024   |   Inventor(s): David Issadore, Zijian Yang
Keywords(s): Bioengineering, Microfluidics, Optics & Photonics , Platform Technology
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Research Tools & Reagents, Technology Classifications > Testing & Measurement
Nanopore and membrane protein dynamic multichannel measurement apparatus and fabrication method for same
INV-23089 Background: Nanopore sensing devices are integral to scientific research and applications such as DNA sequencing and protein detection. The dynamic of trans and cis user access to a membrane in such devices can, however, pose significant challenges. Fulfilling the need for multiplexed and scalable nanopore sensing systems, especially those...
Published: 10/15/2024   |   Inventor(s): Meni Wanunu, Ali Fallahi, Amr Makhamreh
Keywords(s): Biosensing, Drug Discovery, Microfluidics, Nanopores, Protein sequencing
Category(s): Technology Classifications > 2. Physical Science, Technology Classifications > 1. Life Science > Gene sequencing, Technology Classifications > 1. Life Science, Diagnostics
Double Digital Assay for Isolation and Analysis of Single Extracellular Vesicles for Early Detection of Disease Biomarkers Including Cancer
An ultrasensitive diagnostic tool that isolates single extracellular vesicles (EVs) and measures their contents to single molecule resolution. Problem: EVs contain biomolecules that can identify a variety of disease states and, thus, have emerged as a promising source for diagnostics. Within the EV diagnostic field, there are two major challenges:...
Published: 10/16/2023   |   Inventor(s): Jina Ko, David Reynolds, Menghan Pan
Keywords(s): Bioengineering, Infectious Disease, Microfluidics, Oncology, Platform Technology
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Digital Health, Technology Classifications > Research Tools & Reagents, Technology Classifications > Hardware & Components, Technology Classifications > Testing & Measurement
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