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A New Method for Dual Detection of Magnetic and Dielectric Signals from Core/Shell Nanoparticles for Advanced Biodetection and Diagnostics
Advantages Simultaneously detects magnetic and dielectric signals from core/shell nanoparticles with high sensitivity. Provides rapid, real-time biodetection in microfluidic systems using minimal sample volumes. Accurately differentiates healthy and cancer cells through enhanced signal responsiveness. Easily integrates into scalable biomedical...
Published: 12/1/2025   |   Inventor(s): Manh-Huong Phan, Kee Young Hwang, T. Lee, Minh Nguyen, Supawitch Hoijang, Dakota Brown
Keywords(s): Biomarker, Nanotechnology, Sensors
Category(s): Technology Classifications > Electronics > Nanotechnology
A Biological Marker for Concussion
NU 2016-016 INVENTORS Nina Kraus* Trent Nicol Travis White-Schwoch SHORT DESCRIPTION This technology provides a method for objectively identifying non-penetrating brain injuries by analyzing the brain’s frequency following response (FFR) to an acoustic stimulus. It offers a non-invasive alternative that improves diagnostic precision and...
Published: 11/7/2025   |   Inventor(s):  
Keywords(s): Biomarker, Brain injury, Devices, Diagnostics, Electrophysiology, Health IT, Medical device, Neurologic disease, Research tool
Category(s): Life Sciences > Healthcare Devices, Tools & IT, Life Sciences > Biomarkers & Biomedical Research Tools
Spherical Nucleic Acids with Sheddable PEG Layers for Enhanced Tumor Targeting
NU 2017-169 INVENTORS Chad Mirkin* (Northwestern University, Weinberg College of Arts and Sciences, Department of Chemistry, Director of the International Institute for Nanotechnology (IIN)) Brian Meckes Wuliang Zhang SHORT DESCRIPTION For oncology applications, this invention offers spherical nucleic acids with an enzyme-cleavable PEG layer...
Published: 11/7/2025   |   Inventor(s):  
Keywords(s): Biologic, Biomarker, Biomedical, Cancer/Oncology, Chemicals, Diagnostics, Drug delivery, Nanoparticle, Nanotechnology, Personalized medicine, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Healthcare Devices, Tools & IT, Life Sciences > Biomarkers & Biomedical Research Tools
Reagents Targeting Neurodegenerative Diseases and Traumatic Brain Injury
Misfolding and aggregation of proteins, such as beta-amyloid (Aß), alpha-synuclein (a-syn), tau and TAR DNA-binding protein 43 (TDP-43), have been strongly correlated with early onset of neurodegenerative diseases such as Alzheimer's Disease (AD), Parkinson's Disease (PD), Frontotemporal Dementia (FTD), amyotrophic lateral sclerosis (ALS) and...
Published: 8/27/2025   |   Inventor(s): Michael Sierks, Stephanie Williams
Keywords(s): Alzheimer's Disease, Bioassay, biomarker, Neurodegenerative Disorders, Neurological Disorders
Category(s): Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Life Science (All LS Techs), Neurodegenerative Disease Technologies, Proteomic Assays/Reagents/Tools, Non-Cancer Therapeutics
Sweat as a Biofluid for Analysis and Disease Identification
Noninvasive sampling is critical for certain patient populations, such as hemophiliacs, neonates, elderly or immunocompromised individuals, especially if they require daily monitoring. Blood sampling is painful, inconvenient and often difficult and increases the risk of exposure to infectious agents, which can be devastating to immunocompromised populations....
Published: 8/27/2025   |   Inventor(s): Benjamin Katchman, Karen Anderson, Jennifer Blain Christen
Keywords(s): Antibiotic Resistant Bacteria, Antibodies, Autoantibody, biomarker, Defense/military, Diagnostics, Sweat
Category(s): Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Life Science (All LS Techs), Proteomic Assays/Reagents/Tools
Multi-Particle System for Capture and Detection of Cellular and Molecular Analytes (Case No. 2025-267)
Summary: UCLA researchers in the Department of Bioengineering have developed a novel multi-particle system that selectively confines cells and molecular reactions within cavities formed by interacting particles. Background: Screening and selecting cells with specific, beneficial traits has become a vital process in using cell-derived products...
Published: 10/20/2025   |   Inventor(s): Dino Di Carlo, Alyssa Arnheim, Michael Mellody, Yuta Nakagawa, Lily Shang
Keywords(s): Assay, B Cell, barcode, Bioassay, biological assays, Biomarker, biomarkers, Biomaterial, capping particles, CAR-T cell platform, CAR-T cell therapy, cavities, cavity-containing particles, Cell and tissue culture, cell encapsulation, cell engineering, cell imaging, cell mapping, cell sorting, cell type identification, cell-based therapy, centrifugation, confinement, Diagnostic Platform Technologies (E.G. Microfluidics), Digital Microfluidics, Drug, Drug Delivery, Drug Discovery, drug screening, high throughput, high throughput assays, high throughput testing, high-throughput analysis, High-Throughput Screening, Immunoassay, Immunoassay Sense (Molecular Biology), Microfluidics, Microfluidics And Mem's, Microfluidics Nanosphere, microparticles, moieties, Nanoparticle, single cell analysis, single cell analysis and testing, Single cell data, single-cell resolution, single-cell trapping
Category(s): Life Science Research Tools, Life Science Research Tools > Cell Counting And Imaging, Life Science Research Tools > Lab Equipment, Life Science Research Tools > Microscopy And Imaging, Life Science Research Tools > Microfluidics And Mems, Medical Devices, Platforms
Novel HPV Epitopes for Designing Cervical Cancer Immunotherapies
Advantages: Specific targeting of HPV epitopes from E2 and E6 proteins opens new avenues for cervical cancer immunotherapies. Correlation of high chemical complementarity scores between TCR CDR3 regions and HPV epitopes with improved overall and disease-free survival provides a reliable biomarker that complement traditional clinical factors. Whole...
Published: 4/24/2025   |   Inventor(s): George Blanck, Deo Rei Agnila, Rahul Jain, Michael Diaz, Tabitha Hudlock, Rachel Eakins, Andrea Chobrutskiy, Boris Chobrutskiy
Keywords(s): Biomarker, Cancer Treatment, Women’s Health
Category(s): Technology Classifications > Cancer > Cancer Diagnostics, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Womens Health
Interferon Activation Score Is a Biomarker for Immunotherapy in Malignant Glioma Patients (UCLA Case No. 2024-043)
UCLA researchers from the Department of Neurosurgery have characterized immune responses in malignant glioma patients receiving immunotherapy to develop a robust biomarker that will allow prediction of clinical outcomes following treatment. BACKGROUND: Malignant gliomas are the most common primary brain tumors in adults. No cures exist and most gliomas...
Published: 7/31/2025   |   Inventor(s): Robert Prins
Keywords(s): adjuvant therapy, Biomarker, Chemotherapy, Clinical Trial, dendritic cell vaccination, Glioblastoma, Glioma, immune response, Immunotherapy, interferon, malignant glioma
Category(s): Diagnostic Markers > Immunology, Diagnostic Markers > Cancer, Therapeutics > Inflammation And Inflammatory Diseases, Therapeutics > Oncology, Therapeutics > CNS and Neurology
Sensitive and Robust Biosensing Using Plasmonic Enhancement of Fluorescence by Rapid Thermal Annealed Silver Nanostructures
­Advantages: Enhances cancer biomarker sensitivity Scalable production methods Enables low-concentration detection Ideal for portable diagnostics Summary: In cancer diagnostics, a major challenge is the detection of biomarkers at extremely low concentrations, particularly at the nanogram per milliliter (ng/ml) level, which is crucial for...
Published: 11/19/2025   |   Inventor(s): Shuangming Li, Venkat Bhethanabotla
Keywords(s): Biomarker, Cancer Diagnostics
Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Electronics > Nanotechnology, Technology Classifications > Cancer > Cancer Diagnostics, Technology Classifications > Medical > Medical Nanotechnology, Technology Classifications > Medical > Medical Diagnostics
Therapy for non-alcoholic fatty liver disease
NU 2019-095 INVENTORS Grant Barish* Meredith Sommars Madhavi Senagolage SHORT DESCRIPTION Targeting B cell lymphoma protein 6 (BCL6) with small molecule inhibitors as a therapeutic strategy for non-alcoholic fatty liver disease. BACKGROUND Obesity is widely prevalent and linked to multiple comorbidities including metabolic dysfunction-associated...
Published: 11/6/2025   |   Inventor(s):  
Keywords(s): Biomarker, Research tool
Category(s): Life Sciences > Therapeutics
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