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Interferon Activation Score Is a Biomarker for Immunotherapy in Malignant Glioma Patients (UCLA Case No. 2024-043)
UCLA researchers from the Department of Neurosurgery have characterized immune responses in malignant glioma patients receiving immunotherapy to develop a robust biomarker that will allow prediction of clinical outcomes following treatment.
BACKGROUND: Malignant gliomas are the most common primary brain tumors in adults. No cures exist and most gliomas...
Published: 2/14/2025
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Inventor(s): Robert Prins
Keywords(s): adjuvant therapy, Biomarker, Chemotherapy, Clinical Trial, dendritic cell vaccination, Glioblastoma, Glioma, immune response, Immunotherapy, interferon, malignant glioma
Category(s): Diagnostic Markers > Immunology, Diagnostic Markers > Cancer, Therapeutics > Inflammation And Inflammatory Diseases, Therapeutics > Oncology, Therapeutics > CNS and Neurology
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Sensitive and Robust Biosensing Using Plasmonic Enhancement of Fluorescence by Rapid Thermal Annealed Silver Nanostructures
Advantages:
Enhances cancer biomarker sensitivity
Scalable production methods
Enables low-concentration detection
Ideal for portable diagnostics
Summary:
In cancer diagnostics, a major challenge is the detection of biomarkers at extremely low concentrations, particularly at the nanogram per milliliter (ng/ml) level, which is crucial for...
Published: 9/17/2024
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Inventor(s): Shuangming Li, Venkat Bhethanabotla
Keywords(s): Biomarker, Cancer Diagnostics
Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Electronics > Nanotechnology, Technology Classifications > Cancer > Cancer Diagnostics, Technology Classifications > Medical > Medical Nanotechnology, Technology Classifications > Medical > Medical Diagnostics
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Therapy for non-alcoholic fatty liver disease
NU 2019-095
INVENTORS
Grant Barish*
Meredith Sommars
Madhavi Senagolage
SHORT DESCRIPTION
Targeting B cell lymphoma protein 6 (BCL6) with small molecule inhibitors as a therapeutic strategy for non-alcoholic fatty liver disease.
BACKGROUND
Obesity is widely prevalent and linked to multiple comorbidities
including metabolic dysfunction-associated...
Published: 4/4/2025
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Inventor(s):
Keywords(s): Biomarker, Research tool
Category(s): Life Sciences > Therapeutics
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Field-Effect Transistor Biosensors Integrated With Porous Media (Case No. 2023-093)
Summary:
UCLA researchers in the Department of Electrical and Computer Engineering in collaboration with the University of Chicago have developed a new diagnostic biosensor by combining field-effect transistors with porous media.
Background:
Point-of-care (POC) and self-testing tools rely on the real-time monitoring of biomarkers in bodily fluids....
Published: 2/14/2025
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Inventor(s): Aydogan Ozcan, Hyouarm Joung, Hyun-June Jang, Junhong Chen
Keywords(s): Biomarker, biomarkers, Biomaterial, Biosensor, Computer-Aided Diagnosis, Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Diagnostic Test, Electrical, Electrical Engineering, electrically-mediated sensing, electrochemical sensors, enzyme functionalization, field-effect transistors (FETs), Medical diagnostics, multiplexed analysis, Point Of Care, point-of-care, porous media, sample matrix effects, transistors
Category(s): Electrical, Electrical > Sensors, Medical Devices, Medical Devices > Monitoring And Recording Systems, Diagnostic Markers, Diagnostic Markers > Targets And Assays, Platforms, Platforms > Diagnostic Platform Technologies
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Novel Method of Cancer Diagnosis by Label-Free Spectroscopic Imaging of Cell Membrane
Advantages
Utilizing rough aluminum substrates reduces expenses compared to traditional noble metals in cancer diagnostics.
Our method ensures safety by using biocompatible aluminum substrates, eliminating the toxicity of noble metals.
Atomic force microscopy (AFM) enhances precision, providing reliable Raman signal calibration for accurate...
Published: 3/5/2024
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Inventor(s): Dmitri Voronine, Phat Huynh, Dang Nguyen, Grace Binder, Sharad Ambardar
Keywords(s): Biomarker, Cancer Diagnostics, Spectroscopy
Category(s): Technology Classifications > Medical > Medical Devices, Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Cancer > Cancer Diagnostics, Technology Classifications > Electronics > Spectroscopy
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ANTIBODIES TO IL1RN AS MARKERS OF PRETERM BIRTH
ANTIBODIES TO IL1RN AS MARKERS OF PRETERM BIRTH
Researchers at CZ Biohub SF and UCSF have discovered a novel biomarker of pre-term birth.
Little is known about pre-term delivery risk and more specifically the immunological processes that allow for tolerance of a semi-allogenic fetus within the mother’s body. However, the processes that govern...
Published: 8/17/2023
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Inventor(s): Elze Rackaityte, Joseph DeRisi
Keywords(s): Antibody, Biomarker, Preterm Delivery Risk
Category(s): Technology Classifications > Biology
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A Viral Exposure Signature to Define and Detect Early Onset Hepatocellular Carcinoma
Abstract: Early detection of liver cancer, such as hepatocellular carcinoma (HCC), is key to improve cancer-related mortality. More than 800,000 people are diagnosed with this cancer each year throughout the world. Liver cancer is also a leading cause of cancer deaths worldwide, accounting for more than 700,000 deaths each year. Currently, millions...
Published: 4/8/2024
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Inventor(s): Xin Wei Wang, Jinping Liu, Wei Tang
Keywords(s): Biomarker, HCC, hepatocellular carcinoma, Liver cancer, viral infection, Wang
Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Oncology, Application > Diagnostics
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Tumor Tissues Harboring Mutations in cAMP-specific Phosphodiesterases
Abstract: The National Institute of Child Health and Human Development (NICHD), Division of Intramural Research, is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize clinical samples with genetic mutations associated with endocrine tumors.
Researchers at the...
Published: 4/8/2024
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Inventor(s): Constantine Stratakis, Anelia Horvath, Kit Man Tsang
Keywords(s): Biomarker, Clinical Samples, Endocrine Tumors, Phosphodiesterase Inhibitors, Research Tools
Category(s): TherapeuticArea > Oncology, Application > Research Materials, Collaboration Sought > Licensing
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Molecular Nanotags for Detection of Single Molecules
Abstract: Biological nanoparticles, like extracellular vesicles (EVs), possess unique biological characteristics making them attractive therapeutic agents, targets, or disease biomarkers. However, their use is hindered by the lack of tools available to accurately detect, sort, and analyze. Flow cytometers are used to sort and study individual cells....
Published: 4/8/2024
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Inventor(s): Jennifer Jones, William Telford
Keywords(s): Biological Nanoparticle, Biomarker, EVs, Extracellular Vesicles, flow cytometer, Jones, Nanoscale Molecular Tags, Nanotags
Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, Application > Research Materials, TherapeuticArea > Infectious Disease, TherapeuticArea > Endocrinology, TherapeuticArea > Oncology
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Anti-CD133 Monoclonal Antibodies as Cancer Therapeutics
Abstract: Most early work on CD133 was carried out using one of two monoclonal antibodies (mAbs), AC133 and AC141, which recognize an undefined glycosylated epitope of CD 133.
Researchers from NCI's Pharmacodynamic Assay Development and Implementation Section generated novel anti-human CD133 monoclonal antibodies from large extracellular domain loops...
Published: 4/8/2024
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Inventor(s): Thomas Pfister, Robert Kinders, Allison Marrero
Keywords(s): Anti-CD133, Biomarker, CANCER, Diagnostic Tool, Immunology, Rabbit Monoclonal Antibodies, screening
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Immunology, Application > Therapeutics, TherapeuticArea > Oncology
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