Search Results - biomaterials

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Lipid nanoparticles for lung-targeted mRNA delivery

This technology is a new lipid nanoparticle system that can safely, specifically, and efficiently deliver mRNA to a patient’s lungs. Background: Therapeutics that deliver mRNA to a patient’s lungs offer significant potential for treating a broad spectrum of lung diseases. However, specifically and efficiently delivering mRNA to lung tissue...

Published: 6/22/2026 | Updated: 6/21/2026 | Inventor(s): Yamin Li, David Popoola, Zhi Cao, Yuqin Men

Keywords(s): biomaterials, chemistry, drug delivery, gene therapy, nanoparticle drug delivery, RNA, Technologies

Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines

Bioactive Supramolecular Peptide Amphiphile Platforms for CNS In Vitro Models, CNS Regeneration, and Neurotherapeutic Delivery

SHORT DESCRIPTION A suite of self‑assembling peptide amphiphile nanostructures and hydrogels that mimic key neurotrophic factors, modulate ionic and electrical microenvironments, and protect therapeutic peptides to enhance neural survival, maturation, and regeneration across CNS diseases and injuries INVENTORS Samuel I Stupp Weinberg...

Published: 6/16/2026 | Updated: 6/16/2026 | Inventor(s):

Keywords(s): AD - Alzheimer’s Disease, ALS - Amyotrophic Lateral Sclerosis, BIO2026, Biomaterials, CNS - Central Nervous System, Drug delivery, Drug discovery, Drug screening, Hydrogel, In vitro models, Neurology, PD - Parkinson's Disease, Regenerative medicine, Research tool, Scaffold, SCI - Spinal cord injury, Smart/Functional materials, Therapeutics

Category(s): Life Sciences > Healthcare Devices, Tools & IT > Neurology, Life Sciences > Therapeutics

GDNF-Mimetic Self-Assembling Supramolecular Nanostructure to Enhance Survival and Function of Dopaminergic Neurons for Treatment of Parkinson's Disease

NU 2024-175 SHORT DESCRIPTION A self-assembling bioactive matrix that presents GDNF-mimetic peptides to support the viability, maturation, and function of dopaminergic neurons in cell replacement therapy for treatment of Parkinson’s Disease. INVENTORS Samuel Stupp* Weinberg College of Arts and Sciences, Department...

Published: 6/16/2026 | Updated: 4/30/2026 | Inventor(s):

Keywords(s): BIO2026, Biologic, Biomaterials, Cell delivery, CNS - Central Nervous System, CVA - Cerebrovascular Accident, Nanomaterials, Neurodegenerative disease, Neurologic disease, Neurology, PD - Parkinson's Disease, Scaffold, SCI - Spinal cord injury, TBI - Traumatic brain injury, Therapeutics

Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools, Life Sciences > Healthcare Devices, Tools & IT > Neurology

Targeted Nanofiber Therapy for Atherosclerosis – Enhanced Plaque Regression via Precise Drug Delivery

SHORT DESCRIPTION Nanofiber-based drug delivery system that targets atherosclerotic plaque and delivers a therapeutic agent locally to induce plaque regression for management of cardiovascular disease. INVENTORS Samuel Stupp* Weinberg College of Arts and Sciences, Department of Chemistry * Principal Investigator NU...

Published: 6/16/2026 | Updated: 4/30/2026 | Inventor(s):

Keywords(s): Atherosclerosis, BIO2026, Biomaterials, Cardiology and Cardiovascular disease, Drug delivery, Nanomaterials, Nanotechnology, Self-assembly, Smart/Functional materials, Targeted therapy, Therapeutics

Category(s): Life Sciences > Therapeutics

Bioactive, Conductive, and Antioxidant Supramolecular Polymer Hydrogels for Neural Applications

SHORT DESCRIPTION Biomaterial scaffold for neural cell culture and therapeutic implants that harnesses bioactive, conductive, and antioxidant properties to boost neural cell viability and maturation. INVENTORS Samuel Stupp* Weinberg College of Arts and Sciences, Department of Chemistry Anna Metlushko Bo...

Published: 6/16/2026 | Updated: 4/30/2026 | Inventor(s):

Keywords(s): BIO2026, Biologic, Biomaterials, CNS - Central Nervous System, Implantable devices, Neurology, Regenerative medicine, Scaffold, SCI - Spinal cord injury, Smart/Functional materials

Category(s): Life Sciences > Biomarkers & Biomedical Research Tools, Life Sciences > Healthcare Devices, Tools & IT > Neurology, Life Sciences > Therapeutics

High-Efficiency Electrospray Deposition for Sub-Plume-Scale Surfaces

Schematic of the electrospray setup. (a) Schematic and (b) photograph of an electrospray deposition experiment. White dashed lines are provided as a guide to the eye of the plume. (c) Schematic of the improved spray system and process, highlighting different enhancements (E#). In stage 1, a negative polarity spray (E1) is sprayed directly at a large...

Published: 3/27/2026 | Updated: 3/27/2026 | Inventor(s): Jonathan Singer, Sarah Park

Keywords(s): Biomaterials

Category(s): Technology Classifications > COVID-19, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Medical Devices, Technology Classifications > Vaccine

Downregulation of Promoter Strength for Increased Production of Recombinant Biopolymers

RPI ID: 2021-070-401 Innovation Summary: Recombinant E. coli strains and synthetic protein sequence designs are used to produce disordered polypeptides such as spidroins and elastin-like peptides (ELPs). The system leverages genome engineering to suppress basal expression and redirect cellular resources toward target biopolymer synthesis. This approach...

Published: 3/10/2026 | Updated: 3/10/2026 | Inventor(s): Mattheos Koffas, Derek Nelson, Runye Zha, Alexander Connor

Keywords(s): Biomanufacturing, Biomaterials, Recombinant Protein Engineering, Sustainable Materials

Category(s): Biotechnology and the Life Sciences

Customizable Collagen-Mimetic Hydrogels for Precision Modeling and Bioscaffold Engineering

Synthesis of cysteine flanked collagen-mimetic peptides (CMPs) Invention Summary: Hydrogels are essential tools which can mimic extracellular matrix environments; however, current systems lack precise molecular-level control over crosslinking density and porosity. Conventional approaches utilize non-specific, generic biopolymers with statistical...

Published: 2/20/2026 | Updated: 12/2/2025 | Inventor(s): Sonal Gahlawat, David Shreiber

Keywords(s): Bioengineering scaffolds, Biomaterials, Peptides

Category(s): Technology Classifications > Biomaterials, Technology Classifications > Physical Sciences & Engineering

Protein Polymers for Organelle Engineering

Application Protein polymers enabling engineering of human membraneless organelles. Key Benefits Versatile applications across immunotherapy, cell therapy, and other therapeutic modalities. High biocompatibility with minimal reactivity with endogenous molecules. Deployable for organelle-level functionalization of human cells. Market Summary Proteins...

Published: 5/22/2026 | Updated: 11/7/2025 | Inventor(s): Felipe Quiroz, Ian Sicher, Spencer Hayes, Maria Giraldo-Castaño, Mariell Pascual, Alexa Avecilla

Keywords(s): Biomaterials, Cell Therapy, Immunotherapy, Protein and Peptide Therapeutics, Regenerative Medicine, Research Tools

Category(s): TechPub Algolia > Therapeutics

Biomaterial-mediated Extracellular Vesicle Delivery CNS Regeneration

Reduction in cortical lesion volume post-TBI (a) and post-treatment (b); remyelination as shown by luxol fast blue-staining post-TBI (c) and post-treatment (d); and enhanced expression of occludin post treatment (f) as compared to post-TBI (e). Invention Summary: More than 3 billion people worldwide are affected by central nervous system...

Published: 6/23/2026 | Updated: 10/3/2025 | Inventor(s): Joshua Stein, Ki-Bum Lee, Inbo Han

Keywords(s): Bioengineering scaffolds, Biomaterials, Drug Delivery, Spinal Cord

Category(s): Technology Classifications > Biomaterials, Technology Classifications > Physical Sciences & Engineering

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