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Search Results - biomaterials
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Delivery of sustained local and systemic immunomodulation
Reducing treatment burden with continuous immune activation Background: Current immunotherapy approaches face significant limitations in both delivery and patient experience. Standard treatments rely on either systemic intravenous injections of antibodies or small molecules that require frequent clinic visits, or localized injections that provide...
Published: 6/13/2025
|
Inventor(s):
Srinivas Sridhar
,
Needa Brown
,
Jennifer Guerriero
,
Alexander Gottlieb
Keywords(s):
biocompatible
,
Biodegradable
,
Biomaterials
,
Cancer
,
Drug Delivery
,
Immunoengineering
,
immunotherapy
,
implant
,
Nanomedicine
Category(s):
Technology Classifications > 1. Life Science > Therapeutics
Methods for single-molecule amplification of nuclear RNA
Novel technique for sorting cells based on nuclear RNA expression that enhances detection sensitivity while maintaining high sensitivity Background: Single-molecule fluorescent in situ hybridization (smFISH) stands as the gold standard for RNA visualization and quantification in cellular studies. However, its application in high-throughput methods...
Published: 6/17/2025
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Inventor(s):
Sara Rouhanifard
,
Yifang Liu
Keywords(s):
Biology
,
Biomaterials
,
Fluorescence in situ hybridization (FISH)
,
Imaging Technology
,
RNA targetting
Category(s):
Technology Classifications > 1. Life Science > Bio-sensors
,
Technology Classifications > 1. Life Science > Chemistry
,
Technology Classifications > 1. Life Science > Biotechnology
Removing Per- and Polyfluorinated (PFAS) from the Environment
An effective, green, scalable, and sustainable approach for removing chemical contaminants from drinking water and groundwater. Background: Poly- and perfluoroalkyl substances (PFAS) are persistent manmade chemicals that have been widely used since the 1950s. Across the United States, hundreds of sites have been contaminated by these anthropogenic...
Published: 5/13/2025
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Inventor(s):
Yanna Liang
,
Weilan Zhang
Keywords(s):
biological materials
,
biomaterials
,
cleaning
,
cleaning technology
,
destruction
,
fluid management
,
hydrothermal liquefaction
,
PFAS
,
phytoremediation
,
Technologies
Category(s):
Technology Classifications > Materials and Chemicals
,
Campus > University at Albany
Customized Telodendrimer Nanocarriers for Targeted Drug Delivery for Disease Treatments
A suite of nanocarrier technologies that provide targeted drug delivery of hydrophobic and hydrophilic drugs to specific disease sites. Background: Delivery of therapeutic and diagnostic compounds is limited by the lack of efficient carriers to improve in vivo stability, selectivity as well as to reduce immunogenicity. Conventional nanocarrier design...
Published: 5/13/2025
|
Inventor(s):
Juntao Luo
,
Dandan Guo
,
Changying Shi
Keywords(s):
#SUNYresearch
,
affinity alkylating agent
,
autoimmune
,
autoimmune disease
,
bioactivity
,
biocompatible
,
biomaterials
,
chemical formulation
,
chemistry
,
cisplatin
,
combintorial conjugated dendrimer
,
dendritic drug delivery
,
drug delivery component
,
drug formulation
,
Featured
,
graft rejection
,
hydrophilic drug
,
hydrophobic drug
,
immune modulating
,
immunogenicity inflammation
,
inflammatory
,
inflammatory
,
inflammatory
,
inflammatory
,
inflammatory response
,
inflammatory response
,
intracellular delivery
,
methotrexate
,
moieties
,
nanocarriers
,
nanomedicine
,
nanoparticle
,
nanoparticle drug delivery
,
nanoparticle-enhanced delivery
,
nanotherapy
,
polyethylene glycol
,
polymyxin
,
targeted biologics delivery
,
targeted delivery
,
targeted drug delivery
,
targeted therapeutic delivery
,
targeting drug
,
Technologies
,
therapeutic drug
,
topoisomerase
,
vitamin E
Category(s):
Technology Classifications > Drug Delivery
,
Technology Classifications > Therapeutics and Vaccines
,
Technology Classifications > Healthcare
,
Campus > Upstate Medical University
Self-powered, bioresorbable drug release systems
NU 2023-045 INVENTORS John Rogers* Colin Franz* Yamin Zhang SHORT DESCRIPTION Northwestern and Shirley Ryan AbilityLab researchers have developed a novel, self-powered, bioresorbable drug delivery system that enables light-controlled, targeted drug release without the need for surgical removal post-treatment. BACKGROUND Current drug delivery systems...
Published: 6/19/2025
|
Inventor(s):
Keywords(s):
Biomaterials
,
Cancer/Oncology
,
Drug delivery
,
Infectious disease
,
Medical device
,
Therapeutics
Category(s):
Life Sciences > Healthcare Devices, Tools & IT
Sliding Bioactive Peptides for Therapeutic Delivery
NU 2023-142 INVENTORS Samuel I. Stupp* Federico Lancia Madison E. Strong Matias A. Alvarez-Saavedra SHORT DESCRIPTION This technology involves the design and engineering of peptide amphiphile nanofibers that deliver bioactive peptides both extra- and intra-cellularly. The bioactive peptides can slide along these structures...
Published: 6/10/2025
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Inventor(s):
Keywords(s):
Biomaterials
,
Drug delivery
Category(s):
Life Sciences > Therapeutics
Ion-Doped Supramolecular Nanostructures
NU 2023-006 INVENTORS Samuel Stupp* Zaida Alvarez Pinto Ivan Ramos Sasselli Nicholas Allen Sather Zois Syrgiannis SHORT DESCRIPTION This technology involves the development of ion-doped peptide amphiphiles (IDPAs) that form supramolecular nanostructures capable of enhancing neural development and membrane excitability...
Published: 6/10/2025
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Inventor(s):
Keywords(s):
Biomaterials
,
Drug delivery
,
Nanomaterials
Category(s):
Physical Sciences > Materials and Industrial Processes
Peptide Amphiphiles for Sonic Hedgehog Regulation of Pelvic Nerves for Treatment of Stress Urinary Incontinence and Erectile Dysfunction
NU 2018-075, 2018-076, 2018-077 INVENTORS Caroline Podlasek Kevin McVary Daniel Harrington Samuel Stupp* SHORT DESCRIPTION Novel peptide amphiphile (PA) nanofiber hydrogel is used to deliver sonic hedgehog (SHH) protein to nerves of the major pelvic ganglia and the rhabdospincter as a treatment for erectile dysfunction and urinary incontinence. ...
Published: 6/10/2025
|
Inventor(s):
Keywords(s):
Biomaterials
,
Drug delivery
,
Materials
,
Therapeutics
Category(s):
Life Sciences > Therapeutics
Aqueous Peptide Programming of Organic Ferroelectric Materials
NU2023-005 INVENTORS Samuel Stupp* Yang Yang SHORT DESCRIPTION Novel peptide material with precise nanoscale assembly, versatility in morphology, enhanced ferroelectric properties, high-temperature and electrochemical performance. BACKGROUND Poly(vinylidene fluoride) (PVDF) is the leading organic ferroelectric material with multiaxial ferroelectricity,...
Published: 6/10/2025
|
Inventor(s):
Keywords(s):
Biomaterials
,
Materials
Category(s):
Physical Sciences > Materials and Industrial Processes
Nanopatterning for control of cell cytoskeleton
NU 2018-027 INVENTORS Chad Mirkin* Milan Mrksich* Brian Meckes Maria Cabezas SHORT DESCRIPTION Polymer pen lithography (PPL) to spatially define locations where cells can adhere to a substrate in aniosotropic patterns. BACKGROUND Cells have unique shapes that play significant roles in their function; cell shape influences cellular processes...
Published: 6/19/2025
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Inventor(s):
Keywords(s):
Biomaterials
,
Therapeutics
Category(s):
Life Sciences > Therapeutics
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