Search Results - neurology

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Novel 2-Imidazolyl-Pyrimidine Inhibitors for Neurodegenerative Disease Therapeutics

PROPOSED TITLE: Novel 2-Imidazolyl-Pyrimidine Inhibitors for Neurodegenerative Disease Therapeutics NU 2014-101 INVENTORS Richard Silverman* Paramita Mukherjee SHORT DESCRIPTION This invention introduces novel 2-imidazolyl-pyrimidine scaffolds that inhibit neuronal nitric oxide synthase. It offers potential for drug development targeting Parkinson’s...

Published: 11/18/2025 | Inventor(s):

Keywords(s): Biomedical, Materials, Neurodegenerative disease, Neurologic disease, Neurology, Small molecule, Therapeutics

Category(s): Physical Sciences > Materials and Industrial Processes

Potent and selective Cav1.3 negative allosteric modulators for use in Parkinson's Disease

NU 2010-105 and NU 2024-179 INVENTORS Richard Silverman* (Northwestern University, Weinberg College of Arts & Science, Department of Chemistry) Dalton Surmeier Jr.* (Northwestern University, Feinberg School of Medicine, Chair of the Department of Neuroscience) Garry Cooper Soosung Kang Jack Nguyen SHORT DESCRIPTION For pharmaceutical...

Published: 11/11/2025 | Inventor(s):

Keywords(s): Neurodegenerative disease, Neurologic disease, Neurology, PD - Parkinson's Disease

Category(s): Life Sciences > Therapeutics

Comprehensive Quantification of Animal Behavior at Ultra-High Resolution

Advantages: Behavior is the ultimate readout of nervous system function. We have developed a method for monitoring movement as well as the principal effectors of behavior, muscles, at unprecedented scale and resolution. Our approach is poised for widespread adoption and will enable new breakthroughs in both clinical and basic research. Problem: Behavioral...

Published: 8/11/2025 | Inventor(s): Timothy Machado, Jeffrey Gauthier, Michael Economo, Kate Hong

Keywords(s): Neurology, Optics & Photonics , Platform Technology

Category(s): Technology Classifications > Research Tools & Reagents, Technology Classifications > Testing & Measurement

Intranasally-Delivered Therapy for Treatment of Amyotrophic Lateral Sclerosis

Intranasal delivery of dantrolene nanoparticles can improve motor neuron function, muscle strength, and movement coordination and can offer therapeutic benefits for treatment of Amyotrophic Lateral Sclerosis (ASL). Problem: ALS a neurodegenerative disease with poor prognosis. ALS is categorized into the familial and sporadic types, with the former accounting...

Published: 9/30/2025 | Inventor(s): Huafeng Wei

Keywords(s): Genetic Disorders, Inflammation, Neurodegenerative Diseases, Neurology, Pulmonary, Small Molecule

Category(s): Technology Classifications > Therapeutics

High Quality, Differentiable, Imaging Method for Improving Computed Tomography (CT) Images

A method of CT imaging where the techniques of using non-circular orbits around the target and spectral imaging are combined resulting in fewer metal artifacts and higher image quality. Problem: Imaging techniques such as CT and Cone Beam Computed Tomography (CBCT) are highly susceptible to metal artifacts in interventional scenarios. Metal surgical...

Published: 8/1/2025 | Inventor(s): Jianan (Grace) Gang, Joseph Webster Stayman

Keywords(s): Neurology, Radiology, Software

Category(s): Technology Classifications > Diagnostics, Technology Classifications > Medical Devices

Intraoperative Neuromuscular Monitoring via Soft, Skin-Mounted Wireless Devices

NU 2017-108 INVENTORS John Rogers* SHORT DESCRIPTION This technology introduces a soft, wireless, skin-mounted device that enables non-invasive, real-time monitoring of neuromuscular function during surgical procedures, reducing patient discomfort and procedural complexity. BACKGROUND Conventional intraoperative neuromuscular monitoring relies...