Search Results - neurology

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Gene therapy for levodopa-induced dyskinesia
NU 2024-086 INVENTORS Dalton J. Surmeier Jr* Weixing Shen Shenyu Zhai Tatiana Tkatch Qiaoling Cui Zhong Xie SHORT DESCRIPTION Gene therapy targeting GRIN2B in striatal spiny projection neurons to treat levodopa-induced dyskinesia. BACKGROUND Parkinson’s Disease (PD) is the second most common age-related neurodegenerative disease...
Published: 4/4/2025   |   Inventor(s):  
Keywords(s): Neurodegenerative disease, Neurologic disease, Neurology, Parkinson's Disease
Category(s): Life Sciences > Therapeutics
Nanoparticles for Precise & Targeted Treatment of Neurological Conditions
Problem: Acute ischemic stroke (AIS) is the second leading cause of death worldwide, affecting around 600,000 Americans annually. However, pharmacological treatment of AIS is difficult due to ineffective and nonspecific targeting to blood brain barrier epitopes via intravenous administration. Over 100 drugs have been tried and failed in clinical trials...
Published: 2/20/2025   |   Inventor(s): Oscar Marcos Contreras, Jacob Brenner, Vladimir Muzykantov, Jia Nong, Patrick Glassman, Drew Weissman, Sahiley Reyes-Esteves
Keywords(s): Drug Delivery, Inflammation, Nanotechnology, Neurology
Category(s): Technology Classifications > Therapeutics
Positive Unlabeled Learning With Bias Mitigation for Fair Prediction of Undiagnosed Alzheimer’s Disease (Case No. 2025-113)
Summary: UCLA researchers in the Department of Neurology have developed a software to predict the diagnosis of Alzheimer’s Disease without racial or ethnic biases. Background: Alzheimer’s Disease (AD) represents a major health and economic challenge in the United States. Despite its prevalence, Alzheimer’s remains significantly...
Published: 2/14/2025   |   Inventor(s): Timothy Chang
Keywords(s): Alzheimers disease, artificial intelligence/machine learning models, electronic health records (EHR), medical bias reduction, Neurodegeneration Alzheimer's Disease Predictive Testing, neurological disorders, Neurology, personalized medicine
Category(s): Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Data Analytics, Software & Algorithms > Digital Health, Software & Algorithms > Image Processing, Software & Algorithms > Programs, Diagnostic Markers > Aging, Therapeutics > CNS and Neurology
Machine-Learning Foundation Model For The Early Detection Of Neurodegenerative Diseases
A machine learning technique that identifies biomarkers from neuroimaging data, allowing for identification and treatment of populations vulnerable to neurodegenerative diseases. Problem: Neurodegenerative diseases such as Alzheimer’s disease (AD) impact an estimated twenty-four million people worldwide, with prevalence increasing with global...
Published: 1/17/2025   |   Inventor(s): Saurabh Sihag, Alejandro Ribeiro
Keywords(s): Aging, Artificial Intelligence (AI) & Machine Learning, Neurodegenerative Diseases, Neurology, Platform Technology, Radiology
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Digital Health, Technology Classifications > Imaging
Electrical Stimulation for Acute Stroke (Case No. 2020-787)
Summary: Researchers at the UCLA Department of Neurology have developed an individualized method of delivering non-invasive electrical stimulation to treat acute human ischemic stroke. Background: Stroke is a leading cause of mortality and morbidity across the world. Over 80% of strokes are ischemic due to blockage of blood vessels, causing a low...
Published: 2/14/2025   |   Inventor(s): Mersedeh Bahr Hosseini, Jeffrey Saver, Marom Bikson
Keywords(s): Acute ischemic stroke, CNS Rehabilitation, Electrical, Electrical Engineering, Electrical stimulation, Neurocognitive, Neuroimaging, Neurointervention, neurological disorders, Neurology, Neuromodulation, Neuron, Neuropathology, Neuropsychological Test, neuroscience, Neurostimulation, Neurosurgery, soft electrical circuits, Stroke, Stroke Geriatrics Energy Accounting Local Area Network, stroke rehabilitation, stroke therapeutics, Transcutaneous Electrical Nerve Stimulation
Category(s): Electrical, Electrical > Flexible Electronics, Medical Devices, Medical Devices > Cardiac, Medical Devices > Hospital Systems
The First Curative Treatment of Phenylketonuria Using Genetic Engineering Approaches
The base editing of phenylalanine hydroxylase enzyme in the liver to restore phenylalanine metabolism and prevent neurotoxic effects. Problem: Phenylketonuria (PKU) is a severe disorder affecting approximately 1 in 10,000 U.S. newborns. PKU is marked by a genetic mutation in the phenylalanine hydroxylase enzyme (PAH), resulting in phenylalanine (Phe)...
Published: 10/28/2024   |   Inventor(s): Kiran Musunuru, Xiao Wang, Dominique Brooks
Keywords(s): Gene Editing, Gene Therapy, Genetic Disorders, Neurodegenerative Diseases, Neurology
Category(s): Technology Classifications > Therapeutics
Stimulation of Parvalbumin Neurons to Enhance Recovery After Stroke (UCLA Case No. 2024-131)
UCLA researchers from the Department of Neurology have discovered a molecular compound that promotes activation of parvalbumin neurons in the brain, enhancing behavioral recovery after stroke. BACKGROUND: Stroke is a leading cause of death and disability worldwide. According to the World Health Organization, approximately 15 million people suffer from...
Published: 2/14/2025   |   Inventor(s): Stanley Carmichael
Keywords(s): Cns, Neurology, neuroscience, parvalbumin neurons, spinal cord, Stroke, stroke rehabilitation, stroke therapeutics
Category(s): Therapeutics > CNS and Neurology
Low-Cost, Stable, and Easy-to-Use Guide for Accurate Intraventricular Access with Minimal Footprint
A single-use device which assists in stereotactic catheter placement into the cerebral ventricles and draining of cerebral spinal fluid (CSF) Problem: Hydrocephalus leads to increased intracranial pressure and an external ventricular drain (EVD) or ventricular-peritoneal shunt (VPS) is needed to drain excess CSF. However, the success of EVD/VPS requires...
Published: 6/26/2024   |   Inventor(s): Rachel Blue, Michael Spadola
Keywords(s): Neurology, Surgery
Category(s): Technology Classifications > Medical Devices
Rapid manufacturing of soft, comfortable electrodes
Rapid, low-cost, and scalable production of comfortable electrode arrays suitable for measuring biosignals Problem: Medical electrodes convert ionic currents within the human body into electric currents used to diagnose and monitor diseases. The global medical electrode market is currently valued at over $1B and continues to grow in response to...
Published: 6/24/2024   |   Inventor(s): Flavia Vitale, Nicolette Driscoll, Nicholas Apollo, Brian Litt
Keywords(s): Neurology
Category(s): Technology Classifications > Hardware & Components
A Precise, Analytical Model to Measure Visual Function and Monitor Retinal Disease
A model to estimate the change in photoreceptor outer segment length that occurs upon light stimulation – a biomarker of cone function in the retina. Problem: Vision relies on the isomerization of photopigments within photoreceptors (cones and rods) by light. Traditionally, researchers and clinicians have relied on functional assessments of photoreceptor...
Published: 3/6/2024   |   Inventor(s): Jessica Morgan, David Brainard, Raymond Warner
Keywords(s): Neurology, Ophthalmology
Category(s): Technology Classifications > Imaging, Technology Classifications > Diagnostics, Technology Classifications > Testing & Measurement
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