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Search Results - neurology
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Comprehensive Quantification of Animal Behavior at Ultra-High Resolution
Advantages: Behavior is the ultimate readout of nervous system function. We have developed a method for monitoring movement as well as the principal effectors of behavior, muscles, at unprecedented scale and resolution. Our approach is poised for widespread adoption and will enable new breakthroughs in both clinical and basic research. Problem: Behavioral...
Published: 8/11/2025
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Inventor(s):
Timothy Machado
,
Jeffrey Gauthier
,
Michael Economo
,
Kate Hong
Keywords(s):
Neurology
,
Optics & Photonics
,
Platform Technology
Category(s):
Technology Classifications > Research Tools & Reagents
,
Technology Classifications > Testing & Measurement
Intranasally-Delivered Therapy for Treatment of Amyotrophic Lateral Sclerosis
Intranasal delivery of dantrolene nanoparticles can improve motor neuron function, muscle strength, and movement coordination and can offer therapeutic benefits for treatment of Amyotrophic Lateral Sclerosis (ASL). Problem: ALS a neurodegenerative disease with poor prognosis. ALS is categorized into the familial and sporadic types, with the former accounting...
Published: 9/30/2025
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Inventor(s):
Huafeng Wei
Keywords(s):
Genetic Disorders
,
Inflammation
,
Neurodegenerative Diseases
,
Neurology
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Pulmonary
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Small Molecule
Category(s):
Technology Classifications > Therapeutics
High Quality, Differentiable, Imaging Method for Improving Computed Tomography (CT) Images
A method of CT imaging where the techniques of using non-circular orbits around the target and spectral imaging are combined resulting in fewer metal artifacts and higher image quality. Problem: Imaging techniques such as CT and Cone Beam Computed Tomography (CBCT) are highly susceptible to metal artifacts in interventional scenarios. Metal surgical...
Published: 8/1/2025
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Inventor(s):
Jianan (Grace) Gang
,
Joseph Webster Stayman
Keywords(s):
Neurology
,
Radiology
,
Software
Category(s):
Technology Classifications > Diagnostics
,
Technology Classifications > Medical Devices
Intraoperative Neuromuscular Monitoring via Soft, Skin-Mounted Wireless Devices
NU 2017-108 INVENTORS John Rogers* SHORT DESCRIPTION This technology introduces a soft, wireless, skin-mounted device that enables non-invasive, real-time monitoring of neuromuscular function during surgical procedures, reducing patient discomfort and procedural complexity. BACKGROUND Conventional intraoperative neuromuscular monitoring relies...
Published: 10/3/2025
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Inventor(s):
Keywords(s):
Devices
,
Health IT
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Medical device
,
Neurology
Category(s):
Life Sciences > Healthcare Devices, Tools & IT
Printed Volatile Memristors for Neuromorphic Computing Hardware
NU 2025-007 INVENTORS Mark Hersam* Shreyash Hadke Vinod Sangwan SHORT DESCRIPTION This technology involves the development of printed volatile memristors designed for neuromorphic computing hardware. These memristors can be printed on flexible substrates, and mimic the complex spiking behavior of biological neurons. BACKGROUND Neuromorphic...
Published: 10/3/2025
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Inventor(s):
Keywords(s):
Neurology
,
Printed electronics
Category(s):
Physical Sciences > Materials and Industrial Processes
Artificial Extracellular Matrix for Enhanced Maturation of Human iPSCs-derived Neurons
Artificial Extracellular Matrix for Enhanced Maturation of Human iPSCs-derived Neurons NU 2018-157 Peptide amphiphile nanofibers enhance neuron maturation by promoting high mobility while reducing cell aggregation. INVENTORS Samuel I. Stupp Zaida Alvarez Pinto Juan Alberto Ortega Cano Kohei Sato Evangelos Kiskinis SHORT DESCRIPTION A...
Published: 10/3/2025
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Inventor(s):
Keywords(s):
Neurology
,
Research tool
Category(s):
Life Sciences > Biomarkers & Biomedical Research Tools
Cell-type specific disruption of M1 muscarinic acetylcholine receptor expression to alleviate Parkinson's disease
NU 2024-244 INVENTORS Dalton J. Surmeier Jr* Tatiana Tkatch Shenyu Zhai SHORT DESCRIPTION Gene therapy targeting M1 muscarinic receptor expression in striatal spiny projection neurons to enhance levodopa response and slow Parkinson’s Disease progression. BACKGROUND Parkinson’s Disease (PD) is the second most common age-related...
Published: 10/3/2025
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Inventor(s):
Keywords(s):
CNS - Central Nervous System
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Neurodegenerative disease
,
Neurologic disease
,
Neurology
,
PD - Parkinson's Disease
Category(s):
Life Sciences > Therapeutics
Gene therapy for levodopa-induced dyskinesia
NU 2024-086 INVENTORS Dalton J. Surmeier Jr* Weixing Shen Shenyu Zhai Tatiana Tkatch Qiaoling Cui Zhong Xie SHORT DESCRIPTION Gene therapy targeting GRIN2B in striatal spiny projection neurons to treat levodopa-induced dyskinesia. BACKGROUND Parkinson’s Disease (PD) is the second most common age-related neurodegenerative disease...
Published: 10/3/2025
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Inventor(s):
Keywords(s):
CNS - Central Nervous System
,
Neurodegenerative disease
,
Neurologic disease
,
Neurology
,
PD - Parkinson's Disease
Category(s):
Life Sciences > Therapeutics
Targeting Calcium Channels to treat Early-Stage Parkinson’s Disease
NU 2024-179 INVENTORS Dalton J. Surmeier Jr* Jack Nguyen SHORT DESCRIPTION Novel compounds to inhibit Cav1.3 calcium channels and slow the progression of Parkinson's Disease. BACKGROUND Parkinson’s Disease (PD) is the second most common age-related neurodegenerative disease after Alzheimer’s Disease, affecting nearly one million...
Published: 10/3/2025
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Inventor(s):
Keywords(s):
CNS - Central Nervous System
,
Neurodegenerative disease
,
Neurology
,
PD - Parkinson's Disease
,
Small molecule
,
Therapeutics
Category(s):
Life Sciences > Therapeutics
Collagen IV binding Vascular Endothelial Growth Factor (VEGF) Bioconjugates for Vascularization
NU2022-150 INVENTORS Kyle M. Koss* Yangxi Liu Jason A. Wertheim* SHORT DESCRIPTION Bioconjugates that localize and concentrate VEGF within scaffold structures to support long-term cell survival and promote vascularization in tissue engineering applications BACKGROUND The development of effective vascularization strategies is crucial for...
Published: 10/3/2025
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Inventor(s):
Keywords(s):
Cardiology and Cardiovascular disease
,
Hematology
,
Neurology
Category(s):
Life Sciences > Therapeutics
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