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Search Results - neurology
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Instant, Calibration-Free Blood-Flow Measurement With A Single Optical Snapshot
A single-frame, multi-exposure time optical method enabling accurate extraction of absolute speckle decorrelation time and optimized for recovery of absolute deep-tissue blood flow. Problem: Accurately recovering absolute speckle decorrelation time without the use of calibration or complex instrumentation is challenging. For the use case of monitoring...
Published: 1/8/2026
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Inventor(s):
Arjun Yodh
,
Wesley Baker
,
Joseph Majeski
,
Rodrigo Menezes Forti
Keywords(s):
Bioengineering
,
Cardiovascular
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Electronic Materials
,
Gastroenterology
,
Internet of Things
,
Nephrology and Urology
,
Neurology
,
Oncology
,
Ophthalmology
,
Optics & Photonics
,
Platform Technology
,
Surgery
Category(s):
Technology Classifications > Computer Information Systems
,
Technology Classifications > Diagnostics
,
Technology Classifications > Digital Health
,
Technology Classifications > Hardware & Components
,
Technology Classifications > Imaging
,
Technology Classifications > Research Tools & Reagents
,
Technology Classifications > Medical Devices
,
Technology Classifications > Testing & Measurement
Novel 2-Imidazolyl-Pyrimidine Inhibitors for Neurodegenerative Disease Therapeutics
NU 2014-101 INVENTORS Richard Silverman* Paramita Mukherjee SHORT DESCRIPTION This invention introduces novel 2-imidazolyl-pyrimidine scaffolds that inhibit neuronal nitric oxide synthase. It offers potential for drug development targeting Parkinson’s and other neurodegenerative diseases. BACKGROUND Neurodegenerative disorders such as...
Published: 12/3/2025
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Inventor(s):
Keywords(s):
Biomedical
,
Materials
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Neurodegenerative disease
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Neurologic disease
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Neurology
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Small molecule
,
Therapeutics
Category(s):
Physical Sciences > Materials and Industrial Processes
Potent and selective Cav1.3 negative allosteric modulators for use in Parkinson's Disease
NU 2010-105 and NU 2024-179 INVENTORS Richard Silverman* (Northwestern University, Weinberg College of Arts & Science, Department of Chemistry) Dalton Surmeier Jr.* (Northwestern University, Feinberg School of Medicine, Chair of the Department of Neuroscience) Garry Cooper Soosung Kang Jack Nguyen SHORT DESCRIPTION For pharmaceutical...
Published: 11/11/2025
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Inventor(s):
Keywords(s):
Neurodegenerative disease
,
Neurologic disease
,
Neurology
,
PD - Parkinson's Disease
Category(s):
Life Sciences > Therapeutics
Methods for assembling peptides into peptide amphiphile nanofibers
TITLE: Peptide Nanofiber Assembly for Enhanced Therapeutic Delivery NU 2020-081 SHORT DESCRIPTION This technology uses self-assembling peptide amphiphile nanofibers to protect and deliver therapeutic peptides. It reduces degradation and improves delivery efficiency for advanced treatment applications. BACKGROUND Peptide therapeutics offer promise...
Published: 1/9/2026
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Inventor(s):
Keywords(s):
Brain injury
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Drug delivery
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Infectious disease
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Nanomaterials
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Neurodegenerative disease
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Neurologic disease
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Neurology
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Neurovascular
,
Therapeutics
Category(s):
Life Sciences > Therapeutics
Comprehensive Quantification of Animal Behavior at Ultra-High Resolution
Advantages: Behavior is the ultimate readout of nervous system function. We have developed a method for monitoring movement as well as the principal effectors of behavior, muscles, at unprecedented scale and resolution. Our approach is poised for widespread adoption and will enable new breakthroughs in both clinical and basic research. Problem: Behavioral...
Published: 8/11/2025
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Inventor(s):
Timothy Machado
,
Jeffrey Gauthier
,
Michael Economo
,
Kate Hong
Keywords(s):
Neurology
,
Optics & Photonics
,
Platform Technology
Category(s):
Technology Classifications > Research Tools & Reagents
,
Technology Classifications > Testing & Measurement
Intranasally-Delivered Therapy for Treatment of Amyotrophic Lateral Sclerosis
Intranasal delivery of dantrolene nanoparticles can improve motor neuron function, muscle strength, and movement coordination and can offer therapeutic benefits for treatment of Amyotrophic Lateral Sclerosis (ASL). Problem: ALS a neurodegenerative disease with poor prognosis. ALS is categorized into the familial and sporadic types, with the former accounting...
Published: 9/30/2025
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Inventor(s):
Huafeng Wei
Keywords(s):
Genetic Disorders
,
Inflammation
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Neurodegenerative Diseases
,
Neurology
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Pulmonary
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Small Molecule
Category(s):
Technology Classifications > Therapeutics
High Quality, Differentiable, Imaging Method for Improving Computed Tomography (CT) Images
A method of CT imaging where the techniques of using non-circular orbits around the target and spectral imaging are combined resulting in fewer metal artifacts and higher image quality. Problem: Imaging techniques such as CT and Cone Beam Computed Tomography (CBCT) are highly susceptible to metal artifacts in interventional scenarios. Metal surgical...
Published: 8/1/2025
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Inventor(s):
Jianan (Grace) Gang
,
Joseph Webster Stayman
Keywords(s):
Neurology
,
Radiology
,
Software
Category(s):
Technology Classifications > Diagnostics
,
Technology Classifications > Medical Devices
Intraoperative Neuromuscular Monitoring via Soft, Skin-Mounted Wireless Devices
NU 2017-108 INVENTORS John Rogers* SHORT DESCRIPTION This technology introduces a soft, wireless, skin-mounted device that enables non-invasive, real-time monitoring of neuromuscular function during surgical procedures, reducing patient discomfort and procedural complexity. BACKGROUND Conventional intraoperative neuromuscular monitoring relies...
Published: 11/6/2025
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Inventor(s):
Keywords(s):
Devices
,
Health IT
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Medical device
,
Neurology
Category(s):
Life Sciences > Healthcare Devices, Tools & IT
Sliding Bioactive Peptides for Therapeutic Delivery
NU 2023-142 INVENTORS Samuel I. Stupp* Federico Lancia Madison E. Strong Matias A. Alvarez-Saavedra SHORT DESCRIPTION This technology involves the design and engineering of peptide amphiphile nanofibers that deliver bioactive peptides both extra- and intra-cellularly. The bioactive peptides can slide along these structures...
Published: 1/9/2026
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Inventor(s):
Keywords(s):
Biomaterials
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CNS - Central Nervous System
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Drug delivery
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Neurologic disease
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Neurology
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Regenerative medicine
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SCI - Spinal cord injury
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Therapeutics
Category(s):
Life Sciences > Therapeutics
Printed Volatile Memristors for Neuromorphic Computing Hardware
NU 2025-007 INVENTORS Mark Hersam* Shreyash Hadke Vinod Sangwan SHORT DESCRIPTION This technology involves the development of printed volatile memristors designed for neuromorphic computing hardware. These memristors can be printed on flexible substrates, and mimic the complex spiking behavior of biological neurons. BACKGROUND Neuromorphic...
Published: 11/6/2025
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Inventor(s):
Keywords(s):
Neurology
,
Printed electronics
Category(s):
Physical Sciences > Materials and Industrial Processes
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