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Search Results - neurology
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Stimulation of Parvalbumin Neurons to Enhance Recovery After Stroke (UCLA Case No. 2024-131)
UCLA researchers from the Department of
Neurology
have discovered a molecular compound that promotes activation of parvalbumin neurons in the brain, enhancing behavioral recovery after stroke. BACKGROUND: Stroke is a leading cause of death and disability worldwide. According to the World Health Organization, approximately 15 million people suffer from...
Published: 8/28/2024
|
Inventor(s):
Stanley Carmichael
Keywords(s):
Cns
,
Neurology
,
neuroscience
,
parvalbumin neurons
,
spinal cord
,
Stroke
,
stroke rehabilitation
,
stroke therapeutics
Category(s):
Therapeutics > CNS and
Neurology
Low-Cost, Stable, and Easy-to-Use Guide for Accurate Intraventricular Access with Minimal Footprint
A single-use device which assists in stereotactic catheter placement into the cerebral ventricles and draining of cerebral spinal fluid (CSF) Problem: Hydrocephalus leads to increased intracranial pressure and an external ventricular drain (EVD) or ventricular-peritoneal shunt (VPS) is needed to drain excess CSF. However, the success of EVD/VPS requires...
Published: 6/26/2024
|
Inventor(s):
Rachel Blue
,
Michael Spadola
Keywords(s):
Neurology
,
Surgery
Category(s):
Technology Classifications > Medical Devices
Rapid manufacturing of soft, comfortable electrodes
Rapid, low-cost, and scalable production of comfortable electrode arrays suitable for measuring biosignals Problem: Medical electrodes convert ionic currents within the human body into electric currents used to diagnose and monitor diseases. The global medical electrode market is currently valued at over $1B and continues to grow in response to...
Published: 6/24/2024
|
Inventor(s):
Flavia Vitale
,
Nicolette Driscoll
,
Nicholas Apollo
,
Brian Litt
Keywords(s):
Neurology
Category(s):
Technology Classifications > Hardware & Components
A Precise, Analytical Model to Measure Visual Function and Monitor Retinal Disease
A model to estimate the change in photoreceptor outer segment length that occurs upon light stimulation – a biomarker of cone function in the retina. Problem: Vision relies on the isomerization of photopigments within photoreceptors (cones and rods) by light. Traditionally, researchers and clinicians have relied on functional assessments of photoreceptor...
Published: 3/6/2024
|
Inventor(s):
Jessica Morgan
,
David Brainard
,
Raymond Warner
Keywords(s):
Neurology
,
Ophthalmology
Category(s):
Technology Classifications > Imaging
,
Technology Classifications > Diagnostics
,
Technology Classifications > Testing & Measurement
Intelligent Stent System for Chronic On-Demand Drug Delivery (Case No. 2021-069)
Summary: UCLA researchers in the Department of
Neurology
have developed an intelligent stent system for chronic on-demand drug delivery, addressing the challenge of the blood-brain barrier hindering drug therapy in the central nervous system. Background: The blood-brain barrier poses a significant obstacle to effective drug delivery to the central...
Published: 7/9/2024
|
Inventor(s):
Jose Morales
,
Haotian Lu
,
Huachen Cui
,
Xiaoyu (Rayne) Zheng
Keywords(s):
blood flow management
,
blood-brain barrier
,
Drug
,
Drug Delivery
,
Drug monitoring
,
Invasiveness Of Surgical Procedures
,
MEMS
,
minimally invasive device
,
minimally invasive drug delivery systems
,
neural signals
,
neural stimulation
,
Neurocognitive
,
Neurodegeneration
,
neurological disorders
,
Neurology
,
neuro-oncology
,
Neuropathology
,
Neurosurgery
,
non-invasive
,
non-invasive drug monitoring
,
on-demand drug delivery
,
Pharmaceutical Drug
,
piezoelectric ultrasound transducers
Category(s):
Platforms
,
Platforms > Drug Delivery
,
Medical Devices
,
Therapeutics
,
Therapeutics > CNS and
Neurology
,
Therapeutics > Oncology
,
Therapeutics > Musculoskeletal Disease
Direct and Effective Method To Reverse The Effects of Fragile X Syndrome
A method of treating Fragile X syndrome by correcting the abnormal DNA clusters causing the characteristic symptoms. Problem: Fragile X syndrome (FXS) affects approximately 1 in 4,000 males and 1 in 8,000 females and is characterized by symptoms such as: Inherited Intellectual Disability Anxiety Attention Deficit Disorder (ADD) Skin, Ovaries...
Published: 3/8/2024
|
Inventor(s):
Jennifer Phillips-Cremins
,
Linda Zhou
,
Chunmin GE
Keywords(s):
Bioengineering
,
Gene Therapy
,
Genetic Disorders
,
Neurodegenerative Diseases
,
Neurology
Category(s):
Technology Classifications > Therapeutics
,
Technology Classifications > Vaccines
PennSorter: A software platform for rapid neural signal analysis.
PennSorter is a specialized "spike-sorting" software designed to facilitate the precise assignment of electrical signals to cells with enhanced accuracy and efficiency. Problem: Biomedical researchers, particularly those studying neurons and other electrically excitable cells like cardiac or muscle cells, frequently gather electrical data...
Published: 7/2/2024
|
Inventor(s):
William Beltran
,
Sergei Nikonov
,
Jean Bennett
,
Roman Nikonov
,
Puya Aravand
Keywords(s):
Neurology
,
Software
Category(s):
Technology Classifications > Research Tools & Reagents
Small Molecule Activators of Valosin-Containing Protein (VCP) as Therapeutics for Neurodegenerative Diseases with Ubiquitinated Protein Aggregates
Small molecule therapeutics that aid in clearing abnormal protein deposits observed in neurodegenerative diseases. Problem: Dementia, characterized by the impairment of at least two brain functions, such as memory loss and judgment, currently has no cure. Two common neurodegenerative diseases that cause dementia are Frontotemporal Dementia (FTD) and...
Published: 2/9/2024
|
Inventor(s):
Edward Lee
,
Benjamin Creekmore
,
Jessica Phan
Keywords(s):
Aging
,
Genetic Disorders
,
Neurodegenerative Diseases
,
Neurology
,
Orphan Disease
,
Small Molecule
Category(s):
Technology Classifications > Therapeutics
ONE GRAM PENNY-SIZED WIRELESS EEG RECORDING PATCH FOR LONG-TERM MENTAL HEALTH MONITORING
ONE GRAM PENNY-SIZED WIRELESS EEG RECORDING PATCH FOR LONG-TERM MENTAL HEALTH MONITORING Researchers at Stanford have developed a wearable patch that allows for continuous mental health monitoring via electroencephalogram (EEG) recording. EEG technology was developed during the advent of neuroscience nearly a century and a half ago. EEG technology...
Published: 8/17/2023
|
Inventor(s):
Ada Poon
,
Cheng Chen
,
Joonseok Yang
,
Hui Wang
Keywords(s):
EEG
,
Neurology
,
Wearable
Category(s):
Technology Classifications > Engineering
Xenon Biosensors Improve Early Breast Cancer Detection
A nuclear magnetic resonance (NMR) based enzyme-detection system comprising xenon (129Xe) biosensors complexed with an enzyme-specific peptide substrate. Problem: In 2023, about 298,000 American women will be diagnosed with breast cancer, with an estimated 43,700 deaths. Early cancer detection in the localized stage increases the five-year relative...
Published: 10/16/2023
|
Inventor(s):
Ivan Dmochowski
,
Qian Wei
,
Nicholas Kuzma
,
Aru Hill
Keywords(s):
Bioengineering
,
Imaging Agents
,
Neurology
,
Oncology
,
Radiology
,
Women's Health
Category(s):
Technology Classifications > Diagnostics
,
Technology Classifications > Chemical Processes and Synthesis
,
Technology Classifications > Imaging
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