Search Results - fluorescence

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Flexible Optical Biosensor for Point of Care Multi-Biomarker Detection
Fluorescence based point-of-care molecular diagnostic systems are ubiquitous in healthcare. However, many tests require that the sample be sent to a reference laboratory and read by trained medical staff which can be expensive and result in delayed analysis. Portable systems have been developed, however, detecting multiple biomarkers requires a different...
Published: 8/27/2025   |   Inventor(s): Joseph Smith, Jennifer Blain Christen, Karen Anderson, Benjamin Katchman
Keywords(s): Bioanalysis, Flexible electronics, Fluorescence
Category(s): Advanced Materials/Nanotechnology, Bioanalytical Assays, Chemistries & Devices, Chemical/Biological Sensors, Diagnostic Assays/Devices, Life Science (All LS Techs), Point of Care
Refractive Index-Corrected Light-Sheet Microscopy (Case No. 2025-176)
Summary: UCLA researchers from the Department of Medicine have developed a novel light-sheet fluorescence microscopy system that enables adaptive imaging across a range of refractive indices for enhanced biomedical imaging. Background: Light-sheet fluorescence microscopy (LSFM) has revolutionized biomedical imaging by allowing rapid and high-resolution...
Published: 8/15/2025   |   Inventor(s): Tzung Hsiai, Enbo Zhu
Keywords(s): bioimaging, cell imaging, Fluorescence, fluorescence lifetime, Fluorescence Microscope, fluorescence microscopy, Fluorescence-Lifetime Imaging Microscopy Leading Lights, Fluorescent Labelling, Hyperspectral Imaging, immunofluorescence, Microscope, Microscopy, Microscopy And Imaging, Near-Field Scanning Optical Microscope
Category(s): Medical Devices, Medical Devices > Medical Imaging, Medical Devices > Medical Imaging > Fluorescence, Optics & Photonics, Optics & Photonics > Microscopy, Life Science Research Tools, Life Science Research Tools > Microscopy And Imaging
Algorithm for Identifying Images of Fluorescently-Labeled Cells
Improves the ability to distinguish multiple fluorophores with overlapping emission spectra in biological images of labeled cells by a factor of two or more. Background: Cells (including normal and tumor cells), tissues, microbial communities, and other biological systems generally consist of multiple interacting components, especially proteins...
Published: 8/21/2025   |   Inventor(s): Alex Valm, Yunlong Feng
Keywords(s): bacterial cells, bacterial infection, bioengineering, biofilm control, bioinformatics, biomarker diagnostics, biomarkers, cancer, cell biology, computational biology, dental, diagnostics, digital image processing, fluorescence, fluorescence spectroscopy, gene expression analysis, image analysis, image processing, machine learning, medical imaging, microbial pathogenesis, personalized medicine, RNA, saliva, scanning microscopy, Technologies
Category(s): Campus > University at Albany, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare, Technology Classifications > Medical Imaging, Technology Classifications > Research Tools and Reagents, Technology Classifications > Therapeutics and Vaccines
DsDNA-templated Substrates as Fluorescent Probes for CRISPR-Cas12a-based Diagnostics
New design for CRISPR-based fluorescent probes improves disease diagnostics and sensing. Background: Scientists use the naturally occurring CRISPR-Cas12a gene editing system as a valuable tool for disease diagnostics. When Cas12a finds its target -- a sequence of double-stranded DNA -- it cuts it. In the process, it also cuts other nearby DNAs. Scientists...
Published: 5/13/2025   |   Inventor(s): Mehmet Yigit, Christopher Smith
Keywords(s): agriculture, biotechnology, Cas12a, Cas12a, CRISPR, CRISPR, detection, detection, DNA, DNA, fluorescence, fluorescence, RNA, RNA, sensor, sensor
Category(s): Technology Classifications > Diagnostics, Campus > University at Albany
DsDNA-templated Substrates as Fluorescent Probes for CRISPR-Cas12a-based Diagnostics
New design for CRISPR-based fluorescent probes improves disease diagnostics and sensing. Background: Scientists use the naturally occurring CRISPR-Cas12a gene editing system as a valuable tool for disease diagnostics. When Cas12a finds its target -- a sequence of double-stranded DNA -- it cuts it. In the process, it also cuts other nearby DNAs. Scientists...
Published: 5/13/2025   |   Inventor(s): Mehmet Yigit, Christopher Smith
Keywords(s): agriculture, biotechnology, Cas12a, Cas12a, CRISPR, CRISPR, detection, detection, DNA, DNA, fluorescence, fluorescence, RNA, RNA, sensor, sensor
Category(s): Technology Classifications > Diagnostics, Campus > University at Albany
Lentiviral Vectors with Dual Fluorescence/Luminescence Reporters
Abstract: The National Cancer Institute’s Protein Expression Laboratory seeks parties to co-develop dual luminescent/fluorescent cancer biomarkers. In research settings, visualization of  tumors or tumor cells is often done using either bioluminescence or fluorescence.  However, both of these methods have shortcomings: bioluminescence is not sensitive...
Published: 4/22/2025   |   Inventor(s): Dominic Esposito, Chi-Ping Day, Glenn Merlino
Keywords(s): Bioluminescence, Fluorescence, tumor visualization, vectors
Category(s): TherapeuticArea > Oncology, Application > Research Materials, Collaboration Sought > Licensing
Enhanced Tissue Clearing Solution, Clearing-Enhanced 3D (Ce3D), Compatible with Advanced Fluorescence Microscopy Imaging
NIH immunologists have created a solution, Clearing-enhanced 3D (Ce3D), that can be used to make entire organs extremely transparent (top right panel). This allows the tissue to be imaged using advanced fluorescence microscopy techniques (bottom panel). Unlike current tissue clearing solutions, the Ce3D tissue clearing solution is robustly compatible...
Published: 8/13/2025   |   Inventor(s): Michael Gerner, Weizhe Li, Ronald Germain
Keywords(s): 3D, AA3AXX, Ce3D:, Cellular, Clearing, Epitope, Fluorescence, histo-cytometry, IMAGING, imaging agent, Method, MICROSCOPY, REPORTER, Tissue
Category(s): Collaboration Sought > Collaboration
Microscopy System for Distinguishing Stimulated Emissions as a Means of Increasing Signal
The invention pertains to a system and method for distinguishing stimulated emissions as a means of enhancing signal strength of fluorescent markers in fluorescence microscopy applications. The system is arranged such that an excitation beam (e.g., laser beam) illuminates a sample along some axis exciting the fluorescent markers used in the sample....
Published: 10/28/2024   |   Inventor(s): Sanjay Varma, Andrew York
Keywords(s): AC1XXX, AC3XXX, AC4XXX, Distinguishing, Emission, Fluorescence, Increasing, MEANS, MICROSCOPY, Signal, STIMULATED, WMXXXX, XDXXXX, XFXXXX, XGXXXX, YAXXXX, YFXXXX
Category(s): Collaboration Sought > Collaboration, Application > Medical Devices, Application > Software / Apps, Application > Research Materials, Application > Diagnostics, Application > Non-Medical Devices, Application > Therapeutics, Application > Consumer Products
Simple, Field-Usable Fluorescence-Based Isothermal LAMP Assay for the On-Site Diagnosis of Malaria
CDC researchers have developed improved Loop-Mediated Isothermal Amplification (LAMP) assays for the nucleic acid-based diagnosis of malaria in field settings. The approach employs Plasmodium genus-specific LAMP primers and a portable tube scanner to run the LAMP reaction and measure fluorescence signal (e.g., SYBR green) as a measure of DNA amplification...
Published: 5/9/2025   |   Inventor(s): Allison Demas, Naomi Lucchi, Venkatachalam Udhayakumar
Keywords(s): assay, Based, CDC Docket Import, CDC Docket Import CDC Prosecuting, CDCRM, DA2XXX, DAXXXX, DDXXXX, DEVELOPING, Development, Diagnosis, diagnostic, DXXXXX, Field-usable, Fluorescence, Isothermal, ivd, LAMP, LIMITED-RESOURCE, LOW INPUT, Malaria, Mosquito, Mosquitoes, nucleic acid, NUCLEIC ACID DETECTION, PCR ALTERNATIVE, real time, REAL-TIME, SIMPLE, travel, traveler, travelers, VBXXXX, Vector-borne, Vector-borne diseases, VJXXXX, VKXXXX, VLXXXX, VOXXXX, WAXXXX, WBXXXX, WDXXXX, WFXXXX, WIXXXX, WMXXXX, YBXXXX, Zoonotic
Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, Application > Occupational Safety and Health, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Infectious Disease, Application > Consumer Products
Total Emission Detection System for Multi-Photon Microscopy
Available for licensing and commercial development is a novel two-photon microscope system, which would allow improved fluorescent light collection, the use of less excitation power and deeper penetration of tissue and isolated cells. Multi-photon fluorescence microscopy (MPFM) is an imaging technique that can investigate biological processes to sub-cellular...
Published: 10/28/2024   |   Inventor(s): Jay Knutson, Robert Balaban, Christian Combs
Keywords(s): AC3XXX, ACXXXX, AXXXXX, Detection, Fluorescence, MICROSCOPY, System, Two-photon, Wide-area
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing
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