Search Results - fluorescence

37 Results Sort By:
Algorithm for Identifying Images of Fluorescently-Labeled Cells
Improves the ability to distinguish multiple fluorophores with overlapping emission spectra in biological images of labeled cells by a factor of two or more. Background: Cells (including normal and tumor cells), tissues, microbial communities, and other biological systems generally consist of multiple interacting components, especially proteins...
Published: 4/1/2025   |   Inventor(s): Alex Valm, Yunlong Feng
Keywords(s): bacterial cells, bacterial infection, bioengineering, biofilm control, bioinformatics, biomarker diagnostics, biomarkers, cancer, cell biology, computational biology, dental, diagnostics, digital image processing, fluorescence, fluorescence spectroscopy, gene expression analysis, image analysis, image processing, machine learning, medical imaging, microbial pathogenesis, personalized medicine, RNA, saliva, scanning microscopy, Technologies
Category(s): Campus > University at Albany, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare, Technology Classifications > Medical Imaging, Technology Classifications > Research Tools and Reagents, Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Viral Vectors
DsDNA-templated Substrates as Fluorescent Probes for CRISPR-Cas12a-based Diagnostics
New design for CRISPR-based fluorescent probes improves disease diagnostics and sensing. Background: Scientists use the naturally occurring CRISPR-Cas12a gene editing system as a valuable tool for disease diagnostics. When Cas12a finds its target -- a sequence of double-stranded DNA -- it cuts it. In the process, it also cuts other nearby DNAs. Scientists...
Published: 4/1/2025   |   Inventor(s): Mehmet Yigit, Christopher Smith
Keywords(s): agriculture, biotechnology, Cas12a, Cas12a, CRISPR, CRISPR, detection, detection, DNA, DNA, fluorescence, fluorescence, RNA, RNA, sensor, sensor
Category(s): Technology Classifications > Diagnostics, Campus > University at Albany
DsDNA-templated Substrates as Fluorescent Probes for CRISPR-Cas12a-based Diagnostics
New design for CRISPR-based fluorescent probes improves disease diagnostics and sensing. Background: Scientists use the naturally occurring CRISPR-Cas12a gene editing system as a valuable tool for disease diagnostics. When Cas12a finds its target -- a sequence of double-stranded DNA -- it cuts it. In the process, it also cuts other nearby DNAs. Scientists...
Published: 4/1/2025   |   Inventor(s): Mehmet Yigit, Christopher Smith
Keywords(s): agriculture, biotechnology, Cas12a, Cas12a, CRISPR, CRISPR, detection, detection, DNA, DNA, fluorescence, fluorescence, RNA, RNA, sensor, sensor
Category(s): Technology Classifications > Diagnostics, Campus > University at Albany
Lentiviral Vectors with Dual Fluorescence/Luminescence Reporters
Abstract: The National Cancer Institute’s Protein Expression Laboratory seeks parties to co-develop dual luminescent/fluorescent cancer biomarkers. In research settings, visualization of  tumors or tumor cells is often done using either bioluminescence or fluorescence.  However, both of these methods have shortcomings: bioluminescence is not sensitive...
Published: 5/22/2024   |   Inventor(s): Dominic Esposito, Chi-Ping Day, Glenn Merlino
Keywords(s): Bioluminescence, Fluorescence, tumor visualization, vectors
Category(s): TherapeuticArea > Oncology, Application > Research Materials, Collaboration Sought > Licensing
Enhanced Tissue Clearing Solution, Clearing-Enhanced 3D (Ce3D), Compatible with Advanced Fluorescence Microscopy Imaging
NIH immunologists have created a solution, Clearing-enhanced 3D (Ce3D), that can be used to make entire organs extremely transparent (top right panel). This allows the tissue to be imaged using advanced fluorescence microscopy techniques (bottom panel). Unlike current tissue clearing solutions, the Ce3D tissue clearing solution is robustly compatible...
Published: 10/28/2024   |   Inventor(s): Michael Gerner, Weizhe Li, Ronald Germain
Keywords(s): 3D, AA3AXX, Ce3D:, Cellular, Clearing, Epitope, Fluorescence, histo-cytometry, IMAGING, imaging agent, Method, MICROSCOPY, REPORTER, Tissue
Category(s): Collaboration Sought > Collaboration
Microscopy System for Distinguishing Stimulated Emissions as a Means of Increasing Signal
The invention pertains to a system and method for distinguishing stimulated emissions as a means of enhancing signal strength of fluorescent markers in fluorescence microscopy applications. The system is arranged such that an excitation beam (e.g., laser beam) illuminates a sample along some axis exciting the fluorescent markers used in the sample....
Published: 10/28/2024   |   Inventor(s): Sanjay Varma, Andrew York
Keywords(s): AC1XXX, AC3XXX, AC4XXX, Distinguishing, Emission, Fluorescence, Increasing, MEANS, MICROSCOPY, Signal, STIMULATED, WMXXXX, XDXXXX, XFXXXX, XGXXXX, YAXXXX, YFXXXX
Category(s): Collaboration Sought > Collaboration, Application > Medical Devices, Application > Software / Apps, Application > Research Materials, Application > Diagnostics, Application > Non-Medical Devices, Application > Therapeutics, Application > Consumer Products
Simple, Field-Usable Fluorescence-Based Isothermal LAMP Assay for the On-Site Diagnosis of Malaria
CDC researchers have developed improved Loop-Mediated Isothermal Amplification (LAMP) assays for the nucleic acid-based diagnosis of malaria in field settings. The approach employs Plasmodium genus-specific LAMP primers and a portable tube scanner to run the LAMP reaction and measure fluorescence signal (e.g., SYBR green) as a measure of DNA amplification...
Published: 10/28/2024   |   Inventor(s): Allison Demas, Naomi Lucchi, Venkatachalam Udhayakumar
Keywords(s): assay, Based, CDC Docket Import, CDC Docket Import CDC Prosecuting, CDCRM, DA2XXX, DAXXXX, DDXXXX, DEVELOPING, Development, Diagnosis, diagnostic, DXXXXX, Field-usable, Fluorescence, Isothermal, ivd, LAMP, LIMITED-RESOURCE, LOW INPUT, Malaria, Mosquito, Mosquitoes, nucleic acid, NUCLEIC ACID DETECTION, PCR ALTERNATIVE, real time, REAL-TIME, SIMPLE, travel, traveler, travelers, VBXXXX, Vector-borne, Vector-borne diseases, VJXXXX, VKXXXX, VLXXXX, VOXXXX, WAXXXX, WBXXXX, WDXXXX, WFXXXX, WIXXXX, WMXXXX, YBXXXX, Zoonotic
Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, Application > Occupational Safety and Health, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Infectious Disease, Application > Consumer Products
Total Emission Detection System for Multi-Photon Microscopy
Available for licensing and commercial development is a novel two-photon microscope system, which would allow improved fluorescent light collection, the use of less excitation power and deeper penetration of tissue and isolated cells. Multi-photon fluorescence microscopy (MPFM) is an imaging technique that can investigate biological processes to sub-cellular...
Published: 10/28/2024   |   Inventor(s): Jay Knutson, Robert Balaban, Christian Combs
Keywords(s): AC3XXX, ACXXXX, AXXXXX, Detection, Fluorescence, MICROSCOPY, System, Two-photon, Wide-area
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing
Fluorescent Nanodiamonds as Fiducial Markers for Microscopy
The invention relates to fluorescent nanodiamonds (FNDs) and their uses as fiducial markers for microscopy. FNDs are bright fluorescent probes that do not blink or bleach and have broad fluorescence excitation and emission peaks. The fluorescence intensity can be readily controlled by the size of the FND, the number of fluorescent centers produced...
Published: 4/8/2024   |   Inventor(s): Han Wen, Jennifer Hong, Chang Yi, Ambika Bumb, Susanta Sarkar, Lawrence Samelson, Asit Manna, Keir Neuman
Keywords(s): AC2XXX, AC3XXX, AC4XXX, FIDUCIAL, Fluorescence, fluorescent, IMAGING, MICROSCOPY, Nanodiamonds, nanotechnology, PXXXXX, WIXXXX, XFXXXX, XGXXXX, XHXXXX, YBXXXX
Category(s): Collaboration Sought > Collaboration, Application > Non-Medical Devices, Application > Therapeutics, Application > Consumer Products, Application > Software / Apps, ResearchProducts > Research Equipment, Application > Medical Devices, Application > Research Materials, Application > Diagnostics
2022-140 Label-Free Virtual HER2 Immunohistochemical Staining of Breast Tissue Using Deep Learning
SUMMARY: UCLA researchers in the Departments of Bioengineering and Electrical and Computer Engineering have developed a deep learning-based algorithm that can detect and quantify the breast cancer marker human epidermal growth factor receptor 2 (HER2) in microscopic images without the need for time-consuming immunohistochemical staining (IHC). BACKGROUND:...
Published: 2/14/2025   |   Inventor(s): Aydogan Ozcan, Yair Rivenson, Bijie Bai, Hongda Wang
Keywords(s): Artifical Intelligence (Machine Learning, Data Mining), Biomarker, Bladder Cancer, Breast Cancer, Cancer, Cancer Immunotherapy, Computer Aided Learning, Diagnostic Markers & Platforms, Diagnostic Test, Fluorescence, Fluorescent Labelling, HER2/Neu, Histology, Immune System, Immunohistochemistry, Life Science Research Tools, Machine Learning, Optics, Research Methods, Unsupervised Learning
Category(s): Life Science Research Tools, Life Science Research Tools > Research Methods, Diagnostic Markers, Diagnostic Markers > Immunology, Medical Devices > Medical Imaging, Medical Devices > Medical Imaging > Fluorescence, Software & Algorithms > Artificial Intelligence & Machine Learning, Optics & Photonics
1 2 3 4