Search Results - drug+discovery

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Compounds and methods of identifying novel E3 ligases for targeted protein degradation
NU 2023-096 INVENTORS Ananya Angela Basu Xiaoyu Zhang* SHORT DESCRIPTION A CRISPR-activation screen for discovering E3 ligases amenable to targeted protein degradation, and a novel PROTAC for FBXO22 BACKGROUND Traditional small molecule drugs function by directly interfering with the activities of proteins. However, many proteins lack suitable...
Published: 7/3/2024   |   Inventor(s):  
Keywords(s): Drug discovery, Proteomics, Small molecule
Category(s): Life Sciences > Therapeutics
Multifunctional Radical Quenchers for Mitochondrial Diseases
Mitochondrial diseases are a group of disorders associated with dysfunctional mitochondria, often caused by genetic mutations to mitochondrial DNA. Mitochondrial defects are damaging, particularly to tissues with high energy demands such as neural and muscle tissues. Energy effecting defects have been implicated in forms of movement disorders, cardiomyopathy,...
Published: 1/25/2024   |   Inventor(s): Sidney Hecht, Omar Khdour, Mohammad Alam, Sriloy Dey, Yana Chen, Arnaud Chevalier
Keywords(s): Alzheimer's Disease, Drug Discovery, Mitochondrial medicine, Neurodegenerative Disorders
Category(s): Life Science (All LS Techs), Pharmaceuticals, Non-Cancer Therapeutics
Nanopore and membrane protein dynamic multichannel measurement apparatus and fabrication method for same
INV-23089 Background: Nanopore sensing devices are integral to scientific research and applications such as DNA sequencing and protein detection. The dynamic of trans and cis user access to a membrane in such devices can, however, pose significant challenges. Fulfilling the need for multiplexed and scalable nanopore sensing systems, especially those...
Published: 9/10/2024   |   Inventor(s): Meni Wanunu, Ali Fallahi, Amr Makhamreh
Keywords(s): Biosensing, Drug Discovery, Microfluidics, Nanopores, Protein sequencing
Category(s): Technology Classifications > 2. Physical Science, Technology Classifications > 1. Life Science > Gene sequencing, Technology Classifications > 1. Life Science, Diagnostics
Novel Small Molecule Inhibitors Targeting Clostridioides Difficile Sporulation
­Advantages: The development of DBO compounds represents a novel therapeutic approach to tackling CDI. By inhibiting C. difficile sporulation, DBO compounds address a major cause of CDI recurrence, reducing the likelihood of patients experiencing repeated infections. DBO compounds improve the effectiveness of existing antibiotics used to treat...
Published: 10/2/2023   |   Inventor(s): Yu Chen, Michael Sacco, James Leahy, Elena Bray, Xingmin Sun, Xiujun Zhang
Keywords(s): Drug Discovery, Infectious Diseases Treatment
Category(s): Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Biotechnology
Development of a Novel Sub Picomolar Method for Microscale Thermophoresis
­Advantages: Cost-effective with minimal sample requirements. Label-free detection preserves native molecular states. Real-time analysis for dynamic interactions. Summary: Microscale thermophoresis (MST) is a method used to detect and analyze interactions between molecules. Current instrument detection limitations dictate that binding events...
Published: 2/9/2024   |   Inventor(s): William Lawless, Robert Sparks, Wayne Guida
Keywords(s): Autoimmune Diseases, Cancer, Drug Discovery
Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Pharmaceuticals
High-throughput Assay to Identify New Cancer Drugs
Abstract:  The National Cancer Institute seeks parties interested in collaborative research to evaluate or commercialize a diagnostic tool that can identify new drugs that increase chromosome instability.  Although chromosomal instability is generally thought of as a driver of tumor growth, a threshold level exists where CIN becomes a barrier to tumor...
Published: 4/8/2024   |   Inventor(s): Vladimir Larionov, William Earnshaw
Keywords(s): chromosome instability (CIN), drug discovery, green fluorescent protein labeled chromosome, high-throughput assay
Category(s): Application > Research Materials, TherapeuticArea > Oncology, Collaboration Sought > Licensing
y-AApeptide-based long-acting pan-coronavirus fusion inhibitor with dual targets in spike protein and oral bioavailability
­Advantages: S-20-1 demonstrates potent inhibitory action, this broad-spectrum activity suggests that S-20-1 could be effective against a wide range of coronaviruses, making it a valuable candidate for pandemic preparedness and management. The research provides insights into the mechanism of action of S-20-1, demonstrating its ability to bind...
Published: 9/25/2023   |   Inventor(s): Jianfeng Cai, Shibo JIANG, Lu LU, Songyi XUE, Xinling WANG, Lei WANG, Wei XU, Shuai XIA
Keywords(s): Drug Discovery, Immunology
Category(s): Technology Classifications > Medical > Biotechnology
Use of Quercetin and Related Flavonoids for the Treatment of Myotonic Dystrophy Types 1 and 2
A novel flavonoids-based therapeutic strategy for the treatment of myotonic dystrophy and potentially repeat expansion disorders. Background: Myotonic dystrophy (DM) is the most common form of adult muscular dystrophy. It is a multisystemic disorder affecting nearly all organs including muscles, brain, heart, eyes, and the GI tract, among others....
Published: 3/12/2024   |   Inventor(s): John Berglund, Subodh Mishra, Kaalak Reddy, John Cleary
Keywords(s): drug discovery, drug efficacy, myotonic dystrophy, RNA, Technologies
Category(s): Campus > University at Albany, Technology Classifications > Healthcare, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Therapeutics and Vaccines
Activation of E6Ap/Ube3A-Mediated Protein Ubiquitination and Degradation Pathways By A Cyclic G-Aa Peptide
Advantages By modulating E3 ligase activity, it is possible to regulate protein degradation pathways, gene activation, and other cellular functions. The research expands the therapeutic landscape by introducing the concept of E3 activators alongside E3 inhibitors, PROTACs, and molecular glues. Synthetic ligands, such as γ-AA peptides, offer...
Published: 4/18/2024   |   Inventor(s): Jianfeng Cai, Bo Huang, Jun Yin, Li Zhou, Ruochuan Liu
Keywords(s): Cancer Treatment, Drug Discovery, Neurodegenerative Diseases, Oncology
Category(s): Technology Classifications > Medical > Cell & Tissue Engineering, Technology Classifications > Medical > Neuroscience
Exercise Induced Myokines to Target Receptor Kinases and Chromatin Architecture
A Novel Myokine Oncology Therapeutic With Companion Drug Discovery Platform NU 2019-094 INVENTORS Hemant K. Roy Vadim Backman* SHORT DESCRIPTION Novel oncology drug discovery platform using contraction-induced myokine secretion BACKGROUND Colorectal cancer is the third most commonly diagnosed cancer and second most common cause of cancer...
Published: 7/3/2024   |   Inventor(s):  
Keywords(s): Cancer/Oncology, Drug discovery, Personalized medicine
Category(s): Life Sciences > Therapeutics
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