Search Results - drug+discovery

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Multi-Particle System for Capture and Detection of Cellular and Molecular Analytes (Case No. 2025-267)
Summary: UCLA researchers in the Department of Bioengineering have developed a novel multi-particle system that selectively confines cells and molecular reactions within cavities formed by interacting particles. Background: Screening and selecting cells with specific, beneficial traits has become a vital process in using cell-derived products...
Published: 7/29/2025   |   Inventor(s): Dino Di Carlo, Alyssa Arnheim, Michael Mellody, Yuta Nakagawa, Lily Shang
Keywords(s): Assay, B Cell, barcode, Bioassay, biological assays, Biomarker, biomarkers, Biomaterial, capping particles, CAR-T cell platform, CAR-T cell therapy, cavities, cavity-containing particles, Cell and tissue culture, cell encapsulation, cell engineering, cell imaging, cell mapping, cell sorting, cell type identification, cell-based therapy, centrifugation, confinement, Diagnostic Platform Technologies (E.G. Microfluidics), Digital Microfluidics, Drug, Drug Delivery, Drug Discovery, drug screening, high throughput, high throughput assays, high throughput testing, high-throughput analysis, High-Throughput Screening, Immunoassay, Immunoassay Sense (Molecular Biology), Microfluidics, Microfluidics And Mem's, Microfluidics Nanosphere, microparticles, moieties, Nanoparticle, single cell analysis, single cell analysis and testing, Single cell data, single-cell resolution, single-cell trapping
Category(s): Life Science Research Tools, Life Science Research Tools > Cell Counting And Imaging, Life Science Research Tools > Lab Equipment, Life Science Research Tools > Microscopy And Imaging, Life Science Research Tools > Microfluidics And Mems, Medical Devices, Platforms
Regenerative Extracellular Vesicle (EV) Therapy for Sarcopenia: A Cell-Free Solution for Muscle Aging
Advantages Rejuvenates aged muscle tissue: restoring to youthful state while enhancing muscle mass and strength. Reduces muscle fiber degeneration and inflammation: healthier and more effective muscle regeneration. Effectively reverses age-associated alterations in muscle stem cells (MuSCs), outperforming PBS treatment in aged mice models. Summary Sarcopenia...
Published: 7/23/2025   |   Inventor(s): Wanling Xuan
Keywords(s): Drug Discovery, Medical Pharmaceuticals, Therapeutics
Category(s): Technology Classifications > Medical, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals
Synapticflow Universal Scientific MPC/API Gateway (Case No. 2025-265)
Summary: UCLA researchers in the Department of Microbiology, Immunology, and Molecular Genetics have developed an advanced API gateway that leverages AI to autonomously process data requests with exceptional speed, reliability, and efficiency. Background: Application Programming Interface (API) infrastructures are universally employed to enable...
Published: 8/19/2025   |   Inventor(s): Lulan Wang
Keywords(s): AI, AI algorithms, Artifical Intelligence (Machine Learning, Data Mining), Coronavirus, Data Acquisition, Data Analytics, data security, Data Structure, Drug Discovery, drug screening, high speed, Medical diagnostics, Software, Software & Algorithms, Software Development Tools
Category(s): Software & Algorithms, Software & Algorithms > AI Algorithms, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Bioinformatics, Software & Algorithms > Data Analytics
Subgraph Matching for High-Throughput DNA-Aptamer Secondary Structure Classification and Machine Learning Interpretability (Case No. 2025-104)
Intro Sentence: UCLA researchers in the Department of Mathematics have developed machine learning methods to rapidly identify novel aptamer sequences for target binding to accelerate highly-accurate diagnostic and therapeutic development. Background: Aptamers are single-stranded nucleotide polymers that bind with high affinity to targets such as...
Published: 8/19/2025   |   Inventor(s): Andrea Bertozzi, Anne Andrews, Matthew Tyler, Paolo Climaco, Noelle Mitchell
Keywords(s): Advanced Computing / AI, advanced computing methods, Aptamers, Artifical Intelligence (Machine Learning, Data Mining), artificial intelligence/machine learning models, bioinformatics pipeline, cancer target, clustering, computational efficiency, computational efficiency and analysis, design software, DNA clustering, DNA oligomer, DNA Sequencing, Drug, Drug Delivery, Drug Development, Drug Discovery, drug screening, high throughput, high throughput assays, high throughput testing, high-throughput analysis, High-Throughput Screening, interpretability, pipeline, large-scale parallelization, Machine Learning, machine learning modeling, motif structures, open source, open source code, OpenAI, Pharmaceutical Drug, protein classification, secondary structure, SELEX, sequences of interest, single strand DNA sequences, Software, Software & Algorithms, Software Development Tools, Software-enabled learning, subgraph matching, target binding, target detection, Targeted Therapy, Targets And Assays, tissue targeting accuracy
Category(s): Software & Algorithms, Software & Algorithms > AI Algorithms, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Data Analytics, Life Science Research Tools, Life Science Research Tools > Research Methods, Life Science Research Tools > Screening Libraries, Platforms, Platforms > Drug Delivery, Diagnostic Markers > Targets And Assays, Diagnostic Markers, Software & Algorithms > Bioinformatics
Lab on a 3D Printer (Case No. 2025-094)
Summary: UCLA researchers in the Department of Bioengineering have developed a novel device capable of performing automated liquid handling to a great degree of precision on a miniaturized scale and with customizable features equipped for any laboratory task. Background: Automated liquid handling is essential in pharmaceutical and biotechnology research...
Published: 7/2/2025   |   Inventor(s): Dino Di Carlo, Shun Ye, Zixin Guan, Artem Goncharov, Vivek Rajasenan, Charlotte Rose McDonough, Tristan Lovely
Keywords(s): 3D biofabrication, 3D Printing, Automation, bioimaging, biomanufacturing, Biomaterial 3D Printing, Biomonitoring, Biosensor, Biotechnology, Drug Discovery, fluid mechanics, graphical user interface, Liquid tracking, mechanical durability, Robotic liquid handling
Category(s): Life Science Research Tools, Medical Devices, Diagnostic Markers, Life Science Research Tools > Lab Equipment, Mechanical
Methods To Generate Constrained Fluorinated Macrocycles (UCLA Case No. 2023-139)
UCLA researchers from the Department of Chemistry and Biochemistry have developed a novel method to generate fluorinated polycycles, which may be used for downstream drug discovery and development. BACKGROUND: A significant amount of research in the field of organic chemistry centers around generating increasingly complex molecules that cyclize, forming...
Published: 7/17/2025   |   Inventor(s): Patrick Harran
Keywords(s): Drug Discovery
Category(s): Chemical > Synthesis, Chemical > Catalysts
Method for Co-Localizing Two Proteins on the Inside of the Cell Membrane in Yeast
Advantages Localization of protein interactions at the cell membrane offers a more physiologically relevant model Improved screening by minimizing off-target interactions Broadly applicable and accessible tools Summary Protein-protein interactions involving membrane proteins are notoriously difficult to study under physiologically relevant conditions....
Published: 5/30/2025   |   Inventor(s): Lawrence Stern, Michael Nelson
Keywords(s): Drug Discovery
Category(s): Technology Classifications > Medical > Cell & Tissue Engineering, Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Biomaterials
Use of Quercetin and Related Flavonoids for the Treatment of Myotonic Dystrophy Types 1 and 2
A novel flavonoids-based therapeutic strategy for the treatment of myotonic dystrophy and potentially repeat expansion disorders. Background: Myotonic dystrophy (DM) is the most common form of adult muscular dystrophy. It is a multisystemic disorder affecting nearly all organs including muscles, brain, heart, eyes, and the GI tract, among others....
Published: 5/13/2025   |   Inventor(s): John Berglund, Subodh Mishra, Kaalak Reddy, John Cleary
Keywords(s): drug discovery, drug efficacy, myotonic dystrophy, RNA, Technologies
Category(s): Campus > University at Albany, Technology Classifications > Healthcare, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Therapeutics and Vaccines
A High-Throughput NMR Method for In-Membrane Ligand-Screening
Advantages: Maintains the original structural and functional properties of receptor proteins Enables high-throughput screening through automated NMR workflows with minimal sample quantities Enhanced Signal-to-Noise Ratio improves detection of ligand-receptor interactions (e.g. binding orientations, kinetics, and dynamics) Applicable to any membrane...
Published: 4/30/2025   |   Inventor(s): Libin Ye, Xudong Wang
Keywords(s): Drug Delivery and Nanomedicine, Drug Discovery
Category(s): Technology Classifications, Technology Classifications > Chemistry, Technology Classifications > Medical > Biotechnology
Small Molecule for Bladder Repair
NU 2021-153 INVENTORS Arun Sharma* Matthew Bury Natalie Fuller SHORT DESCRIPTION A small molecule to improve the regenerative outcomes of injured or diseased urinary bladder tissue ABSTRACT Northwestern researchers have identified a small molecule that facilitates the repair and restoration of damaged urinary bladder tissue following loss of...
Published: 8/5/2025   |   Inventor(s):  
Keywords(s): Drug discovery, Small molecule, Therapeutics, Urology
Category(s): Life Sciences > Therapeutics
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