Search Results - drug+discovery

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Precision Protein Repair Platform for Missense Mutations
Application This technology enables targeted chemical correction of missense mutations in proteins using a modular heterotrifunctional molecule platform. Key Benefits Restores protein function by chemically mimicking healthy amino acid side chains. Modular toolkit allows rapid customization for diverse protein targets. Validated across multiple...
Published: 11/7/2025   |   Inventor(s): Monika Raj
Keywords(s): Drug Discovery, Drug Target Identification, Enzyme and Protein Research, Protein and Peptide Therapeutics, Research Tools
Category(s): TechPub Algolia > Therapeutics
Gene Editing for Head and Neck Cancer Treatment
Application Method for delivering gene-editing therapeutic in head and neck cancers. Key Benefits CRISPR/CAS9-based gene editing mechanism targeting novel disease-modifying gene. Liquid nanoparticle encapsulation permitting in vivo delivery. Market Summary Head and neck cancers (HNC) are the 7th most common global cancer, accounting for 3%...
Published: 11/7/2025   |   Inventor(s): Yong Teng, Yamin Li
Keywords(s): Drug Discovery, Drug Target Identification, Gene Therapy and Editing, Nanoparticle Drug Delivery, Oncology Treatments, Reagents, Biomaterials, and Plasmids
Category(s): TechPub Algolia > Therapeutics
Anticancer Agent with N-Glycan Specificity
Application An engineered protein for targeting disease-associated N-glycans. Key Benefits High affinity, pH insensitive, no cofactors required. Applications in anticancer and antiviral therapeutics and research. Can aid in manufacturing monoclonal antibodies with desired N-glycosylation properties. Market Summary Glycosylation involves post-translation...
Published: 11/3/2025   |   Inventor(s): Eric J. Sundberg, Diego Sastre, Maros Huliciak
Keywords(s): Antibodies, Biologics, Biomarkers, Drug Discovery, Drug Target Identification, Enzyme and Protein Research, Microbiology and Infectious Disease Treatments, Oncology Treatments
Category(s): TechPub Algolia > Therapeutics
Treatment for Dengue Virus (DENV) Infection
Application Antiviral therapeutic for multiple Dengue virus serotypes. Key Benefits Targets conserved regions of DENV genomes, enabling efficacy across serotypes. Mitigates lethal infections with a single lipid nanoparticle (LNP) based dose in mice. Minimal off-target effects. Market Summary Despite 390+ million annual DENV infections, there...
Published: 10/30/2025   |   Inventor(s): Philip Santangelo, Daryll Vanover, Chiara Zurla, Lorena Carvalho de Souza Chaves
Keywords(s): DNA and RNA Vaccines, Drug Discovery, Drug Target Identification, Microbiology and Infectious Disease Treatments
Category(s): TechPub Algolia > Therapeutics
Combinatorial Therapy for Preserving Muscle Mass During Weight Loss
Application A combinatorial therapy to preserve muscle mass during semaglutide weight loss treatment. Key Benefits Preserves lean mass during semaglutide treatment in preclinical mouse models. Increases overall fat loss without affecting food/water intake during semaglutide treatment in preclinical mouse models. Market Summary The prevalence...
Published: 11/5/2025   |   Inventor(s): Todd Golde, Yong Ran, Eric Krause, Annette De Kloet, Karen Scott
Keywords(s): Antibodies, Biologics, Drug Discovery, Drug Target Identification, Metabolic Disease Treatments, Musculoskeletal Treatments, Personalized Medicine
Category(s): TechPub Algolia > Therapeutics
Use of Quercetin and Related Flavonoids for the Treatment of Myotonic Dystrophy Types 1 and 2
A novel flavonoids-based therapeutic strategy for the treatment of myotonic dystrophy and potentially repeat expansion disorders. Background: Myotonic dystrophy (DM) is the most common form of adult muscular dystrophy. It is a multisystemic disorder affecting nearly all organs including muscles, brain, heart, eyes, and the GI tract, among others....
Published: 10/24/2025   |   Inventor(s): John Berglund, Subodh Mishra, Kaalak Reddy, John Cleary
Keywords(s): drug discovery, drug efficacy, myotonic dystrophy, RNA, Technologies
Category(s): Campus > University at Albany, Technology Classifications > Healthcare, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Therapeutics and Vaccines
MKK3/MYC Protein-Protein Interaction Inhibitor Overcomes Resistant Non-Small Cell Lung Cancer
Application A therapeutic use for SGI-1027 in the treatment of Osimertinib-resistant non-small cell lung cancer (NSCLC). Key Benefits The MKK3/MYC protein-protein interaction inhibitor SGI-1027 effectively decreases MYC levels in Osimertinib-resistant NSCLC cell lines. The combination of SGI-1027 with Osimertinib offers synergistic benefits over...
Published: 10/15/2025   |   Inventor(s): Andrey Ivanov, Haian Fu, Shi-Yong Sun, Zhen Chen
Keywords(s): Drug Discovery, Oncology Treatments, Protein and Peptide Therapeutics
Category(s): TechPub Algolia > Therapeutics
Interactive Systems and Methods for Identifying Target Proteins in Drug Discovery (Case No. 2025-098)
Summary: UCLA researchers from the Department of Electrical and Computer Engineering have developed a novel computational system for target protein identification, enabling integrative drug discovery. Background: Target identification (Target ID) in drug discovery involves the identification and evaluation of protein candidates that could interact...
Published: 10/1/2025   |   Inventor(s): Xiang Chen, Youngseung Jeon, Christopher Hwang, Ziwen Li, Jesus Campagna, Varghese John, Whitaker Cohn, Eunice Jun
Keywords(s): AI-driven drug discovery, Alzheimer’s disease target discovery, Bioinformatics software platform, Drug, Drug Discovery, Functional annotation of proteins, High-throughput docking, large language models (LLMs), Ligand-protein docking, Mechanism-of-action prediction, Molecular docking simulation, Multi-criteria decision support, Neurodegenerative disease therapeutics, Pathway-centric drug targeting, personalized medicine, PPI-Comparator, PPI-Explorer, Protein structure prediction, Protein-protein interaction (PPI) analysis, Rational drug design, Retrieval-augmented generation (RAG), Semantic similarity modeling, Small molecule screening, Systems biology interface, Target identification (Target ID), Therapeutic impact modeling, User-guided AI exploration
Category(s): Software & Algorithms, Software & Algorithms > AI Algorithms, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Digital Health, Life Science Research Tools, Life Science Research Tools > Research Methods, Platforms, Platforms > Drug Delivery
Advancing In Vitro Intestine Models: Smart Polymer-Controlled Peristalsis
Advantages Replicates in vivo peristalsis without external pumps Electrically tunable frequency, amplitude, and waveform Compact, transparent design for real-time imaging Modular, scalable arrays using standard materials Summary Accurate in vitro intestinal models are essential for reliable drug screening, disease research, and microbiome studies,...
Published: 8/28/2025   |   Inventor(s): Rafsan Rashik, Nathan Gallant, Wenbin Mao
Keywords(s): Cell & Tissue Culture & Engineering, Drug Discovery
Category(s): Technology Classifications > Chemistry > Polymers, Technology Classifications > Medical > Cell & Tissue Engineering, Technology Classifications > Medical > Biomedical Engineering
A Novel Immunomodulatory Strategy for Treating Heart Failure in Aging Populations
Advantages Novel Mechanism of Action: Targets the Th17/IL17A signaling axis Validated Target: IL17A is already clinically validated in other inflammatory diseases (e.g., psoriasis, psoriatic arthritis), with FDA-approved therapies like secukinumab Strong Preclinical POC: transcriptomic, histological, and functional cardiac assessments showing reversal...
Published: 10/14/2025   |   Inventor(s): Wanling Xuan, Srinivas Tipparaju
Keywords(s): Cardiological Diseases Treatment, Cardiovascular Diseases, Drug Discovery
Category(s): zzCardiology, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Therapeutics
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