Search Results - drug+discovery

52 Results Sort By:
Lab on a 3D Printer (Case No. 2025-094)
Summary: UCLA researchers in the Department of Bioengineering have developed a novel device capable of performing automated liquid handling to a great degree of precision on a miniaturized scale and with customizable features equipped for any laboratory task. Background: Automated liquid handling is essential in pharmaceutical and biotechnology research...
Published: 7/2/2025   |   Inventor(s): Dino Di Carlo, Shun Ye, Zixin Guan, Artem Goncharov, Vivek Rajasenan, Charlotte Rose McDonough, Tristan Lovely
Keywords(s): 3D biofabrication, 3D Printing, Automation, bioimaging, biomanufacturing, Biomaterial 3D Printing, Biomonitoring, Biosensor, Biotechnology, Drug Discovery, fluid mechanics, graphical user interface, Liquid tracking, mechanical durability, Robotic liquid handling
Category(s): Life Science Research Tools, Medical Devices, Diagnostic Markers, Life Science Research Tools > Lab Equipment, Mechanical
Methods To Generate Constrained Fluorinated Macrocycles (UCLA Case No. 2023-139)
UCLA researchers from the Department of Chemistry and Biochemistry have developed a novel method to generate fluorinated polycycles, which may be used for downstream drug discovery and development. BACKGROUND: A significant amount of research in the field of organic chemistry centers around generating increasingly complex molecules that cyclize, forming...
Published: 5/30/2025   |   Inventor(s): Patrick Harran
Keywords(s): Drug Discovery
Category(s): Chemical > Synthesis, Chemical > Catalysts
Method for Co-Localizing Two Proteins on the Inside of the Cell Membrane in Yeast
Advantages Localization of protein interactions at the cell membrane offers a more physiologically relevant model Improved screening by minimizing off-target interactions Broadly applicable and accessible tools Summary Protein-protein interactions involving membrane proteins are notoriously difficult to study under physiologically relevant conditions....
Published: 5/30/2025   |   Inventor(s): Lawrence Stern, Michael Nelson
Keywords(s): Drug Discovery
Category(s): Technology Classifications > Medical > Cell & Tissue Engineering, Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Biomaterials
Use of Quercetin and Related Flavonoids for the Treatment of Myotonic Dystrophy Types 1 and 2
A novel flavonoids-based therapeutic strategy for the treatment of myotonic dystrophy and potentially repeat expansion disorders. Background: Myotonic dystrophy (DM) is the most common form of adult muscular dystrophy. It is a multisystemic disorder affecting nearly all organs including muscles, brain, heart, eyes, and the GI tract, among others....
Published: 5/13/2025   |   Inventor(s): John Berglund, Subodh Mishra, Kaalak Reddy, John Cleary
Keywords(s): drug discovery, drug efficacy, myotonic dystrophy, RNA, Technologies
Category(s): Campus > University at Albany, Technology Classifications > Healthcare, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Therapeutics and Vaccines
A High-Throughput NMR Method for In-Membrane Ligand-Screening
Advantages: Maintains the original structural and functional properties of receptor proteins Enables high-throughput screening through automated NMR workflows with minimal sample quantities Enhanced Signal-to-Noise Ratio improves detection of ligand-receptor interactions (e.g. binding orientations, kinetics, and dynamics) Applicable to any membrane...
Published: 4/30/2025   |   Inventor(s): Libin Ye, Xudong Wang
Keywords(s): Drug Delivery and Nanomedicine, Drug Discovery
Category(s): Technology Classifications, Technology Classifications > Chemistry, Technology Classifications > Medical > Biotechnology
Small Molecule for Bladder Repair
NU 2021-153 INVENTORS Arun Sharma* Matthew Bury Natalie Fuller SHORT DESCRIPTION A small molecule to improve the regenerative outcomes of injured or diseased urinary bladder tissue ABSTRACT Northwestern researchers have identified a small molecule that facilitates the repair and restoration of damaged urinary bladder tissue following loss of...
Published: 6/10/2025   |   Inventor(s):  
Keywords(s): Drug discovery, Small molecule, Therapeutics, Urology
Category(s): Life Sciences > Therapeutics
Method for Repurposing FDA-approved Therapeutics & Composition for Treating Mesothelioma
The amount of time and money that goes into getting a drug from initial discovery to FDA approval is substantial, typically involving at least 10 years and hundreds of millions of dollars. Because of this, there has been a growing interest in repurposing drugs which have previously been approved for human use, particularly since their MOA as well as...
Published: 2/18/2025   |   Inventor(s): Chris Plaisier, Sierra Wilferd, Choung Hoang
Keywords(s): Cancer, Drug, Drug Discovery
Category(s): Pharmaceuticals, Cancer, Cancer Therapeutics, Artificial Intelligence/Machine Learning, Computing & Information Technology, Life Science (All LS Techs)
Compounds and methods of identifying novel E3 ligases for targeted protein degradation
NU 2023-096 INVENTORS Ananya Angela Basu Xiaoyu Zhang* SHORT DESCRIPTION A CRISPR-activation screen for discovering E3 ligases amenable to targeted protein degradation, and a novel PROTAC for FBXO22 BACKGROUND Traditional small molecule drugs function by directly interfering with the activities of proteins. However, many proteins lack suitable...
Published: 6/10/2025   |   Inventor(s):  
Keywords(s): Drug discovery, Proteomics, Small molecule
Category(s): Life Sciences > Therapeutics
Multifunctional Radical Quenchers for Mitochondrial Diseases
Mitochondrial diseases are a group of disorders associated with dysfunctional mitochondria, often caused by genetic mutations to mitochondrial DNA. Mitochondrial defects are damaging, particularly to tissues with high energy demands such as neural and muscle tissues. Energy effecting defects have been implicated in forms of movement disorders, cardiomyopathy,...
Published: 2/13/2025   |   Inventor(s): Sidney Hecht, Omar Khdour, Mohammad Alam, Sriloy Dey, Yana Chen, Arnaud Chevalier
Keywords(s): Alzheimer's Disease, Drug Discovery, Mitochondrial medicine, Neurodegenerative Disorders
Category(s): Life Science (All LS Techs), Pharmaceuticals, Non-Cancer Therapeutics
Nanopore and membrane protein dynamic multichannel measurement apparatus and fabrication method for same
INV-23089 Background: Nanopore sensing devices are integral to scientific research and applications such as DNA sequencing and protein detection. The dynamic of trans and cis user access to a membrane in such devices can, however, pose significant challenges. Fulfilling the need for multiplexed and scalable nanopore sensing systems, especially those...
Published: 10/15/2024   |   Inventor(s): Meni Wanunu, Ali Fallahi, Amr Makhamreh
Keywords(s): Biosensing, Drug Discovery, Microfluidics, Nanopores, Protein sequencing
Category(s): Technology Classifications > 2. Physical Science, Technology Classifications > 1. Life Science > Gene sequencing, Technology Classifications > 1. Life Science, Technology Classifications > 1. Life Science > Diagnostics
1 2 3 4 5 6