Search Results - drug+discovery

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Bioactive Supramolecular Peptide Amphiphile Platforms for CNS In Vitro Models, CNS Regeneration, and Neurotherapeutic Delivery
SHORT DESCRIPTION A suite of self‑assembling peptide amphiphile nanostructures and hydrogels that mimic key neurotrophic factors, modulate ionic and electrical microenvironments, and protect therapeutic peptides to enhance neural survival, maturation, and regeneration across CNS diseases and injuries INVENTORS Samuel I Stupp Weinberg...
Published: 6/16/2026   |   Updated: 6/16/2026   |   Inventor(s):  
Keywords(s): AD - Alzheimer’s Disease, ALS - Amyotrophic Lateral Sclerosis, BIO2026, Biomaterials, CNS - Central Nervous System, Drug delivery, Drug discovery, Drug screening, Hydrogel, In vitro models, Neurology, PD - Parkinson's Disease, Regenerative medicine, Research tool, Scaffold, SCI - Spinal cord injury, Smart/Functional materials, Therapeutics
Category(s): Life Sciences > Healthcare Devices, Tools & IT > Neurology, Life Sciences > Therapeutics
Enzyme-Based Method for the Amplified Detection of Molecules on Particles (Case No. 2026-130)
Summary: UCLA researchers in the Department of Bioengineering have developed a novel enzyme-based particle platform that enables amplified molecular detection in fully aqueous systems for sensitive, multiplexed analysis of low-abundance analytes. Background: The detection of molecules and determination of enzymatic activity are foundational across...
Published: 6/15/2026   |   Updated: 6/5/2026   |   Inventor(s): Alyssa Arnheim, Dino Di Carlo
Keywords(s): Antibody, Aptamers, Assay, barcode, Biomarker, Biosensor, Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Drug Discovery, ELISA, enzyme functionalization, Enzyme Substrate (Biology), Flow Cytometry, Fluorescence, High-Throughput Screening, hydrogel, Immunoassay, Medical diagnostics, microparticles, Molecular Biology, multiplexed analysis, multiplexing, Nucleic Acids, protein, Signal-To-Noise Ratio
Category(s): Diagnostic Markers > Targets And Assays, Diagnostic Markers, Platforms > Diagnostic Platform Technologies, Chemical > Chemical Sensors, Life Science Research Tools > Antibodies
Alpha Assay to Screen for Inhibitor Protein-Glycan Interactions in Neurodegeneration
RPI ID: 2024-030-201 Innovation Summary: This technology introduces a bead-based assay platform designed to screen for inhibitors of protein-glycan interactions implicated in neurodegenerative diseases. The assay utilizes functionalized beads to capture glycan-binding proteins and assess their interaction dynamics in the presence of candidate inhibitors....
Published: 3/10/2026   |   Updated: 3/10/2026   |   Inventor(s): Chunyu Wang, Shannon Faris
Keywords(s): AlphaScreen, Alzheimer's disease, Drug Discovery, heparan sulfate proteoglycan (HSPG), Heparin, tau, tauopathies
Category(s): Biotechnology and the Life Sciences
Method for the synthesis of heteroyohimbine natural products
NU 2015-009 INVENTORS Karl Scheidt* Herbert Meltzer Ashkaan Younai Bi-Shun Zeng SHORT DESCRIPTION Enantioselective synthetic methods for preparing heteroyohimbine alkaloid intermediates using a novel cooperative hydrogen bonding/enamine-catalyzed Michael addition reaction as a key step to access complex natural products, including alstonine...
Published: 2/24/2026   |   Updated: 2/23/2026   |   Inventor(s):  
Keywords(s): Drug discovery, Neurologic disease, Therapeutics
Category(s): Life Sciences > Therapeutics
Targeted Candidalysin Binders for Fungal Infection Control
Application A theranostic scaffold-derived protein that neutralizes candidalysin toxin. Key Benefits Different mechanism of action compared to current antifungal drugs, reducing the risk of resistance. Derived from human protein for lower immune response and produced cost-effectively in simple bacterial media. Small size improves tissue penetration...
Published: 4/27/2026   |   Updated: 1/20/2026   |   Inventor(s): Sohail Khoshnevis, Eric J. Sundberg, Maros Huliciak
Keywords(s): Diagnostics, Drug Discovery, Hydrogels, Protein and Peptide Therapeutics, Therapeutics
Category(s): TechPub Algolia > Therapeutics
Methioninase Inducing Virus for Anti-Cancer Therapy
Application A set of viral constructs that induce regulatable expression of methionine degrading enzyme for treatment of brain tumors. Key Benefits Built-in Tet-responsive element ensures precise regulation, preventing unwanted enzyme activity. IL-2 signal directs the enzyme for secretion, optimizing its therapeutic impact. Specific delivery...
Published: 6/15/2026   |   Updated: 12/9/2025   |   Inventor(s): Leon McSwain, Andrey Tikunov, Timothy R. Gershon
Keywords(s): Drug Discovery, Enzyme and Protein Research, Oncology Treatments, Therapeutics
Category(s): TechPub Algolia, TechPub Algolia > Therapeutics
Precision Protein Repair Platform for Missense Mutations
Application This technology enables targeted chemical correction of missense mutations in proteins using a modular heterotrifunctional molecule platform. Key Benefits Restores protein function by chemically mimicking healthy amino acid side chains. Modular toolkit allows rapid customization for diverse protein targets. Validated across multiple...
Published: 3/30/2026   |   Updated: 11/7/2025   |   Inventor(s): Monika Raj
Keywords(s): Drug Discovery, Drug Target Identification, Enzyme and Protein Research, Protein and Peptide Therapeutics, Research Tools
Category(s): TechPub Algolia > Therapeutics
Gene Editing for Head and Neck Cancer Treatment
Application Method for delivering gene-editing therapeutic in head and neck cancers. Key Benefits CRISPR/CAS9-based gene editing mechanism targeting novel disease-modifying gene. Liquid nanoparticle encapsulation permitting in vivo delivery. Market Summary Head and neck cancers (HNC) are the 7th most common global cancer, accounting for 3%...
Published: 5/22/2026   |   Updated: 11/7/2025   |   Inventor(s): Yong Teng, Yamin Li
Keywords(s): Drug Discovery, Drug Target Identification, Gene Therapy and Editing, Nanoparticle Drug Delivery, Oncology Treatments, Reagents, Biomaterials, and Plasmids
Category(s): TechPub Algolia > Therapeutics
Anticancer Agent with N-Glycan Specificity
Application An engineered protein for targeting disease-associated N-glycans. Key Benefits High affinity, pH insensitive, no cofactors required. Applications in anticancer and antiviral therapeutics and research. Can aid in manufacturing monoclonal antibodies with desired N-glycosylation properties. Market Summary Glycosylation involves post-translation...
Published: 5/22/2026   |   Updated: 11/3/2025   |   Inventor(s): Eric J. Sundberg, Diego Sastre, Maros Huliciak
Keywords(s): Antibodies, Biologics, Biomarkers, Drug Discovery, Drug Target Identification, Enzyme and Protein Research, Microbiology and Infectious Disease Treatments, Oncology Treatments
Category(s): TechPub Algolia > Therapeutics
Treatment for Dengue Virus (DENV) Infection
Application Antiviral therapeutic for multiple Dengue virus serotypes. Key Benefits Targets conserved regions of DENV genomes, enabling efficacy across serotypes. Mitigates lethal infections with a single lipid nanoparticle (LNP) based dose in mice. Minimal off-target effects. Market Summary Despite 390+ million annual DENV infections, there...
Published: 2/23/2026   |   Updated: 10/30/2025   |   Inventor(s): Philip Santangelo, Daryll Vanover, Chiara Zurla, Lorena Carvalho de Souza Chaves
Keywords(s): DNA and RNA Vaccines, Drug Discovery, Drug Target Identification, Microbiology and Infectious Disease Treatments
Category(s): TechPub Algolia > Therapeutics
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