Search Results - drug+delivery

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Multifunctional Bioactive Dual-Layered Nanofibrous Matrix for Triple Negative Breast Cancer
​ Dual-Layered Nanofibrous Matrix designed for rapid-release and sustained-release of various therapeutics, leading to no tumor recurrence in triple negative breast cancer 4T1 tumor-resected mouse models. Invention Summary: Triple-negative breast cancer (TNBC), a particularly aggressive subtype of breast cancer which comprises 15-20% of all...
Published: 6/24/2025   |   Inventor(s): Sungyun Kim, Ki-Bum Lee, Hyun-Jong Cho
Keywords(s): Anti-cancer, Breast Cancer, Drug Delivery, Nanotechnology, Wound healing
Category(s): Technology Classifications > Cancer, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Nanotechnology
Delivery of sustained local and systemic immunomodulation
Reducing treatment burden with continuous immune activation Background: Current immunotherapy approaches face significant limitations in both delivery and patient experience. Standard treatments rely on either systemic intravenous injections of antibodies or small molecules that require frequent clinic visits, or localized injections that provide...
Published: 6/13/2025   |   Inventor(s): Srinivas Sridhar, Needa Brown, Jennifer Guerriero, Alexander Gottlieb
Keywords(s): biocompatible, Biodegradable, Biomaterials, Cancer, Drug Delivery, Immunoengineering, immunotherapy, implant, Nanomedicine
Category(s): Technology Classifications > 1. Life Science > Therapeutics
Bitter Taste Receptor Combination Therapies for Treatment of Head and Neck Squamous Cell Carcinoma and Other Cancers
A method of combining T2R agonists and GLUT1 inhibitors to treat head and neck cancers. Problem: Head and neck squamous cell carcinoma (HNSCC) is a significant health concern with a high incidence and mortality rate. Approximately half of patients succumb to disease within 5 years. Current treatments for HNSCC include surgery, radiation therapy, chemotherapy,...
Published: 5/21/2025   |   Inventor(s): Ryan Carey, Robert Lee, Zoey Miller
Keywords(s): Drug Delivery, Drug Target, Oncology, Surgery
Category(s): Technology Classifications > Therapeutics
Synthesis of Anticancer Agents Nannocystins and Their Analogs
Synthetic route to producing nannocystins, an anticancer agent that is typically found in myxobacteria. Background: Myxobacteria are some of the top producers of microbial secondary metabolites, a large portion of which have shown activity against human diseases. One of these metabolite groups are nannocystins, since they have shown excellent anticancer...
Published: 5/13/2025   |   Inventor(s): Zhang Wang, Jun Huang
Keywords(s): drug delivery, oncology
Category(s): Technology Classifications > Research Tools and Reagents, Campus > University at Albany
Self-powered, bioresorbable drug release systems
NU 2023-045 INVENTORS John Rogers* Colin Franz* Yamin Zhang SHORT DESCRIPTION Northwestern and Shirley Ryan AbilityLab researchers have developed a novel, self-powered, bioresorbable drug delivery system that enables light-controlled, targeted drug release without the need for surgical removal post-treatment. BACKGROUND Current drug delivery systems...
Published: 6/19/2025   |   Inventor(s):  
Keywords(s): Biomaterials, Cancer/Oncology, Drug delivery, Infectious disease, Medical device, Therapeutics
Category(s): Life Sciences > Healthcare Devices, Tools & IT
Sliding Bioactive Peptides for Therapeutic Delivery
NU 2023-142 INVENTORS Samuel I. Stupp* Federico Lancia Madison E. Strong Matias A. Alvarez-Saavedra SHORT DESCRIPTION This technology involves the design and engineering of peptide amphiphile nanofibers that deliver bioactive peptides both extra- and intra-cellularly. The bioactive peptides can slide along these structures...
Published: 6/10/2025   |   Inventor(s):  
Keywords(s): Biomaterials, Drug delivery
Category(s): Life Sciences > Therapeutics
Targeted, Enhanced Modification Of Lipid NanoparticlesTto Improve Tumor Therapeutic Efficacy
A method to inhibit small extracellular vesicles (sEVs) released by tumor cells to enhance lipid nanoparticle (LNP) accumulation in tumors. Problem: Lipid nanoparticles (LNPs) have shown promise as drug delivery systems for various diseases with several clinically approved products. However, their ability to deliver genes specifically to tumor cells...
Published: 4/11/2025   |   Inventor(s): Michael Mitchell, Ningqiang Gong, Wenqun Zhong, Wei Guo
Keywords(s): Bioengineering, Drug Delivery, Immunoncology, Oncology
Category(s): Technology Classifications > Therapeutics
Biocompatible And Low-Toxicity Lipid Nanoparticles (LNPs) For Selectively Delivering mRNA To The Bone Microenvironment
Ionizable LNPs with a rigid backbone of piperazine (PIP) linked to bisphosphonates (BPs) for the targeted delivery of mRNA to the bone. Problem: Available treatments for bone tissue related diseases provide only symptomatic relief and are associated with clinical challenges and potential side effects. Challenges persist in the delivery of therapeutic...
Published: 3/7/2025   |   Inventor(s): Michael Mitchell, Kyle Vining, Lulu Xue, Il-Chul Yoon
Keywords(s): Aging, Bioengineering, Drug Delivery, Gene Therapy, Orthopedics, Platform Technology, Women's Health
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Therapeutics
Engineered Lipid Tags for Extracellular Vesicle Loading
NU 2022-178 INVENTORS Neha Kamat* Joshua Leonard* Justin Alexander Peruzzi Taylor Gunnels SHORT DESCRIPTION This technology enhances the loading of protein cargo into extracellular vesicles (EVs) by directing protein association with membrane lipid rafts, utilizing engineered lipid tags for targeted delivery. BACKGROUND Extracellular...
Published: 6/10/2025   |   Inventor(s):  
Keywords(s): Biotechnology, Drug delivery, Nanoparticle, Synthetic biology
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
Leveraging Lipid-Protein Interactions to Engineer Spatial Organization in Cell-free Systems
NU 2021-231 INVENTORS Neha Kamat* Justin Alexander Peruzzi Jan Steinkuehler SHORT DESCRIPTION This innovative method enables the control of membrane protein location and distribution in synthetic lipid membranes using lipid-protein interactions, without chemical conjugation, facilitating the development of advanced cell-free systems. BACKGROUND Spatially...
Published: 6/10/2025   |   Inventor(s):  
Keywords(s): Biotechnology, Drug delivery, Nanoparticle, Synthetic biology
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools, Physical Sciences > Engineering & Technology
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