Search Results - drug+delivery

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Rapid Synthesis of Amidine-Incorporated Degradable Lipids for Non-Liver mRNA delivery
One-pot combinatorial chemistry for fast and facile synthesis of amidine-incorporated degradable cationic lipids for lipid nanoparticle formulation and non-liver nucleic acid delivery. Problem: Messenger RNA (mRNA)-based therapeutics and vaccines have broad applications for a variety of diseases but require safe and efficient delivery mechanisms. Lipid...
Published: 2/10/2026   |   Inventor(s): Michael Mitchell, Xuexiang Han, Junchao Xu
Keywords(s): Bioengineering, Drug Delivery, Platform Technology
Category(s): Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics, Technology Classifications > Vaccines
Highly Miniaturized Closed-Loop Biosensing and Drug Delivery (Case No. 2025-276)
Summary: UCLA researchers in the Department of Electrical and Computer Engineering have developed an implantable closed-loop system that integrates electrochemical biosensing, wireless signal transmission, and programmable drug release. Background: Conventional disease management systems rely on single-point measurements and discrete interval drug...
Published: 2/5/2026   |   Inventor(s): Aydin Babakhani, Iman Habibagahi, Hamid Jafarisharemi, Roshan Mathews
Keywords(s): biomedical implantation, biomedical sensors, Drug Delivery, Drug monitoring, Implant (Medicine), implantable sensors, Medical Device, minimally invasive drug delivery systems, on-demand drug delivery, personalized dose assessment, Smart medical device, Therapeutics, wearable, wearable electronics, wearable medical device, wearable medical devices, wearable sensors, wearable sensors for health, Wireless, wireless communication
Category(s): Life Science Research Tools, Electrical, Medical Devices, Platforms > Diagnostic Platform Technologies, Platforms > Drug Delivery, Platforms
Lipid nanoparticles for targeted delivery of therapeutic agents in acute lung injury
This technology uses lung-targeting lipid nanoparticles to deliver a combination of anti-inflammatory and immune-modulating drugs directly to the lungs, offering a more effective and targeted treatment for acute lung injury and acute respiratory distress syndrome. Background: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS)...
Published: 1/29/2026   |   Inventor(s): Yamin Li, Yuqin Men, Robert Cooney, Qinghe Meng
Keywords(s): acute lung injury, anti-inflammatory therapeutic, drug delivery, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Drug Delivery
An Improved In Vivo Gene-Editing System Using Plug-and-Play Lipid Nanoparticles (LNPs) to Support CRISPR, Small Interfering RNA (siRNA), and Adenine Base Gene Editing Platforms
Simple, plug-and-play biodegradable lipids that form highly potent lipid nanoparticles (LNPs) for CRISPR mRNA delivery, outperforming benchmark gene-editing systems. Problem: CRISPR therapies can permanently correct disease-causing genes, but today's CRISPR delivery systems are either too risky or not potent enough. Viral vectors raise red flags...
Published: 1/14/2026   |   Inventor(s): Michael Mitchell, Xuexiang Han, Kelsey Swingle, Alex Hamilton
Keywords(s): Bioengineering, Drug Delivery, Gene Editing, Gene Therapy, Nanotechnology, Platform Technology, Protein/Peptide (Non-Antibody), Small Molecule
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Vaccines, Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Materials, Technology Classifications > Research Tools & Reagents
Sulfonium Lipid Nanoparticles for Intranasal mRNA Delivery to Lung Epithelial and Immune Cells
This technology uses specially designed sulfonium lipid nanoparticles to deliver mRNA directly to lung cells through the nose, offering a non-invasive, more effective and targeted treatment for pulmonary diseases like asthma and cystic fibrosis. Background: The field of pulmonary medicine faces significant challenges in the treatment of diseases...
Published: 1/29/2026   |   Inventor(s): Yamin Li, Yuqin Men
Keywords(s): active pharmaceutical ingredient, chemicals, drug delivery, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Drug Delivery
ACE2+ Exosomes for COVID-19 Decoy Therapy
PROPOSED TITLE: ACE2+ Exosomes for COVID-19 Decoy Therapy NU NUMBER NU 2020-145 INVENTORS Deyu Fang* Huiping Liu* Andrew Hoffmann Emma June Schuster Lamiaa El-Shennawy Nurmaa Dashzeveg SHORT DESCRIPTION This invention provides exosomes loaded with ACE2 protein or viral antigen-specific IgGs for treatment of COVID-19. BACKGROUND The COVID-19...
Published: 11/17/2025   |   Inventor(s):  
Keywords(s): COVID-19, Drug delivery, Infectious disease, Therapeutics
Category(s): Life Sciences > Therapeutics
Closed-Loop Implantable System for Automated Opioid Overdose Detection and Reversal
NU 2019-073 INVENTORS John Rogers (Northwestern University)* Robert Gereau (Washington University, St Louis)* SHORT DESCRIPTION This wireless device, the size of a pacemaker, is implanted to monitor oxygen levels. Below a specific threshold, it sends an alert to warning notification on a mobile app, then automatically releases naloxone to prevent...
Published: 12/9/2025   |   Inventor(s):  
Keywords(s): Drug delivery, Electronics & Circuits, Medical device, Microfluidics
Category(s): Life Sciences > Healthcare Devices, Tools & IT, Life Sciences > Therapeutics
Spherical Nucleic Acids with Sheddable PEG Layers for Enhanced Tumor Targeting
NU 2017-169 INVENTORS Chad Mirkin* (Northwestern University, Weinberg College of Arts and Sciences, Department of Chemistry, Director of the International Institute for Nanotechnology (IIN)) Brian Meckes Wuliang Zhang SHORT DESCRIPTION For oncology applications, this invention offers spherical nucleic acids with an enzyme-cleavable PEG layer...
Published: 12/9/2025   |   Inventor(s):  
Keywords(s): Biologic, Biomarker, Biomedical, Cancer/Oncology, Chemicals, Diagnostics, Drug delivery, Nanoparticle, Nanotechnology, Personalized medicine, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Healthcare Devices, Tools & IT, Life Sciences > Biomarkers & Biomedical Research Tools
Methods for assembling peptides into peptide amphiphile nanofibers
TITLE: Peptide Nanofiber Assembly for Enhanced Therapeutic Delivery NU 2020-081 SHORT DESCRIPTION This technology uses self-assembling peptide amphiphile nanofibers to protect and deliver therapeutic peptides. It reduces degradation and improves delivery efficiency for advanced treatment applications. BACKGROUND Peptide therapeutics offer promise...
Published: 1/9/2026   |   Inventor(s):  
Keywords(s): Brain injury, Drug delivery, Infectious disease, Nanomaterials, Neurodegenerative disease, Neurologic disease, Neurology, Neurovascular, Therapeutics
Category(s): Life Sciences > Therapeutics
BDNF Mimetic Peptide Amphiphile for Enhanced Neurotrophic Signaling and Neuronal Regeneration
NU 2018-020 INVENTORS Samuel Stupp Alexandra Kolberg Zaida Alvarez Pinto SHORT DESCRIPTION This technology is an injectable, highly potent peptide amphiphile that mimics BDNF function via the TrkB pathway while providing extracellular support. It promotes neuronal growth and signaling for regenerative treatments in CNS injuries and diseases. BACKGROUND Current...
Published: 12/9/2025   |   Inventor(s):  
Keywords(s): CNS - Central Nervous System, Devices, Drug delivery, Health IT, Medical device
Category(s): Life Sciences > Healthcare Devices, Tools & IT
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