Search Results - drug+delivery

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New Lipiodol Formulation for Treating Hepatocellular Carcinoma with Transarterial Chemoimmunoembolization
NU 2021-148 INVENTORS Dong Hyun Kim* Heegon Kim SHORT DESCRIPTION A new Lipiodol formulation designed to improve the efficacy and safety of transarterial chemoembolization in combination with immunotherapy. BACKGROUND Transarterial chemoembolization...
Published: 9/4/2024   |   Inventor(s):  
Keywords(s): Cancer/Oncology, Drug delivery, Gastrointestinal and Hepatic disease, Immunotherapy, Therapeutics
Category(s): Life Sciences > Therapeutics
Targeted Organ or Multiple Organ Delivery of mRNA with Ionizable Amphiphilic Janus Dendrimers
A library of easily synthesized ionizable amphiphilic Janus dendrimer (IAJD) compounds that deliver mRNA either to targeted organs or multiple organs, depending on the IAJD design. Problem: Four-component lipid nanoparticles (LNPs) are the benchmark synthetic vector for the delivery of mRNA. Despite their high biosafety, low toxicity, and immunogenicity,...
Published: 7/23/2024   |   Inventor(s): Virgil Percec, Drew Weissman, Juncheng (Luke) Lu, Elena Atochina-Vasserman, Devendra Maurya, Dipankar Sahoo
Keywords(s): Drug Delivery, Platform Technology
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Vaccines
A drug delivery system tuned to the endogenous mechanical environment
Technology Overview: Tissues within the body experience mechanical perturbations across multiple force magnitudes and length scales, from mechanotransduction at the cell level to the dynamics of load-bearing joints. These forces not only maintain tissue homeostasis, but can also initiate degenerative processes when applied at supra-physiologic levels....
Published: 6/21/2024   |   Inventor(s): Robert Mauck, George Dodge, Daeyeon Lee
Keywords(s): Drug Delivery
Category(s): Technology Classifications > Therapeutics
Strategies for Mitigating Acute Side Effects of Lung-Targeted Nanocarriers
Approaches and Design Techniques to Alleviate Coagulation-Related Acute Side Effects of Lung-Targeted Nanocarriers Problem: Lipid nanoparticles (LNPs) play a crucial role in drug delivery, enabling targeted drug administration to specific tissues. LNPs tailored for lung-specific delivery often incorporate cationic (positively charged) lipids. Unfortunately,...
Published: 6/26/2024   |   Inventor(s): Jacob Brenner, Vladimir Muzykantov, Jacob Myerson, Oscar Marcos Contreras, Marco Zamora, Serena Omo-Lamai
Keywords(s): Bioengineering, Drug Delivery, Gene Editing, Gene Therapy, Nanotechnology, Platform Technology, Pulmonary
Category(s): Technology Classifications > Therapeutics
Immune Modulator Encoded Lipid Nanoparticle Formulation Improves T Cell Response to Vaccines
Researchers developed an LNP-mRNA-based vaccine that encodes different cytokine mRNAs, as a method to enhance CD8+ T cell responses and memory formation. Problem: Lipid nanoparticles (LNPs) are an emerging technique to deliver mRNA in vivo more efficiently. While recent progress in mRNA technology has allowed the rapid development of SARS-COV2 vaccines,...
Published: 7/2/2024   |   Inventor(s): Christopher Hunter, Drew Weissman, Mohamad Alameh, Emily Aunins, Anthony Phan
Keywords(s): Bioengineering, Drug Delivery, Immunology, Immunoncology, Immunotherapy, Infectious Disease, Nanotechnology
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Vaccines
A Stretch-Activated Adhesive Microcapsule For The Controlled Release of Drugs In Wound-Healing Dressings
An adhesive drug-loaded microcapsule which releases therapeutic cargo upon mechanical stretching. Problem: Medicated dressings can improve healing of open wounds and improve pain management in patients. However, drug-coated bandages lack stimuli-response release mechanisms, so therapeutics are not released in a controlled and sustained manner. Poor...
Published: 6/20/2024   |   Inventor(s): Daeyeon Lee, Yun Kee Jo, Robert Mauck, George Dodge
Keywords(s): Drug Delivery, Soft Materials
Category(s): Technology Classifications > Materials
Targeted Delivery of IFN-gamma Using Antibody Fusion Proteins (UCLA Case No. 2017-543)
UCLA researchers in the Departments of Microbiology, Immunology & Molecular Genetics (MIMG) and Medicine have developed antibody–cytokine fusion proteins that enable the targeted delivery of active interferon-gamma (IFNγ) for cancer treatment. Interferon-gamma (IFNγ), a type II interferon, is a cytokine released by both natural...
Published: 2/26/2024   |   Inventor(s): Sherie Morrison, John Timmerman, Kham (Ryan) Trinh
Keywords(s): Antibody Delivery Platforms, Drug Delivery, Immunotherapy, Life Science Research Tools, Therapeutics & Vaccines
Category(s): Therapeutics, Platforms > Drug Delivery, Platforms > Drug Delivery > Antibody Delivery Platforms, Life Science Research Tools, Therapeutics > Immunology And Immunotherapy
Intelligent Stent System for Chronic On-Demand Drug Delivery (Case No. 2021-069)
Summary: UCLA researchers in the Department of Neurology have developed an intelligent stent system for chronic on-demand drug delivery, addressing the challenge of the blood-brain barrier hindering drug therapy in the central nervous system. Background: The blood-brain barrier poses a significant obstacle to effective drug delivery to the central...
Published: 7/9/2024   |   Inventor(s): Jose Morales, Haotian Lu, Huachen Cui, Xiaoyu (Rayne) Zheng
Keywords(s): blood flow management, blood-brain barrier, Drug, Drug Delivery, Drug monitoring, Invasiveness Of Surgical Procedures, MEMS, minimally invasive device, minimally invasive drug delivery systems, neural signals, neural stimulation, Neurocognitive, Neurodegeneration, neurological disorders, Neurology, neuro-oncology, Neuropathology, Neurosurgery, non-invasive, non-invasive drug monitoring, on-demand drug delivery, Pharmaceutical Drug, piezoelectric ultrasound transducers
Category(s): Platforms, Platforms > Drug Delivery, Medical Devices, Therapeutics, Therapeutics > CNS and Neurology, Therapeutics > Oncology, Therapeutics > Musculoskeletal Disease
Biodegradable and Biocompatible Bioactive-based Polymers - Versatile Platform Technology
Invention Summary: The Uhrich group has developed various biodegradable polymers that chemically incorporate bioactive molecules, such as nonsteroidal anti-inflammatory drugs (e.g., salicylic acid), antioxidants (e.g., ferulic acid) and antimicrobials (e.g., carvacrol). Bioactive molecules are incorporated into polymer backbones through labile linkages,...
Published: 4/17/2024   |   Inventor(s): Kathryn Uhrich, Jonathan Faig, Kervin Smith
Keywords(s): Antibacterial, Bioengineering scaffolds, Biomaterials, Drug Delivery, Polymers & Composites
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
Topical LSD1 Inhibition for Treating Skin Diseases
Topical LSD1 inhibition can treat skin diseases that include cutaneous squamous cell carcinoma (cSCC), actinic keratoses, and viral warts. Problem: Current treatment options (i.e. cryotherapy, laser therapy, surgery, chemotherapy) for skin diseases such as cSCC, actinic keratoses, and viral warts are often non-targeted and destructive, and can cause...
Published: 2/12/2024   |   Inventor(s): Brian Capell, Napasorn (Nina) Kuprasertkul
Keywords(s): Dermatology, Drug Delivery, Drug Target, Immunoncology, Oncology
Category(s): Technology Classifications > Therapeutics
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