Search Results - drug+delivery

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Superoxide Dismutase-Loaded Porous Polymersomes As Highly Efficient Antioxidant Nanoparticles

Brief Description: Therapeutic compositions, comprising: an anti-reactive oxygen species agent and a pervious polymersome, the pervious polymersome encapsulating the anti-reactive oxygen species agent, and the pervious polymersome having therein channels defined by a channel diblock copolymer, the channels being arranged so as to retain at least some...

Published: 8/19/2025 | Inventor(s): Zhiliang Cheng, Andrew Tsourkas, Ling Qin

Keywords(s): Cardiovascular, Drug Delivery

Category(s): Technology Classifications > Therapeutics

Robotic Microcapsule Assemblies with Emergent Mobility for Targeted Treatment and Drug Delivery

Brief Description: The disclosed subject matter provides systems and methods for delivering a therapeutic agent for targeted treatments. The system can include at least one microcapsule and a magnetic system. The microcapsule can include the therapeutic agent and a layer of iron oxide nanoparticles (IONPs). The therapeutic agent can be encapsulated...

Published: 8/19/2025 | Inventor(s): Hyun (Michel) Koo, Daeyeon Lee, Edward Steager, Hong-Huy Tran

Keywords(s): Bioengineering, Drug Delivery, Infectious Disease, Microfluidics, Neurodegenerative Diseases, Oncology, Platform Technology

Category(s): Technology Classifications > Robotics, Technology Classifications > Therapeutics

Multi-Particle System for Capture and Detection of Cellular and Molecular Analytes (Case No. 2025-267)

Summary: UCLA researchers in the Department of Bioengineering have developed a novel multi-particle system that selectively confines cells and molecular reactions within cavities formed by interacting particles. Background: Screening and selecting cells with specific, beneficial traits has become a vital process in using cell-derived products...

Published: 7/29/2025 | Inventor(s): Dino Di Carlo, Alyssa Arnheim, Michael Mellody, Yuta Nakagawa, Lily Shang

Keywords(s): Assay, B Cell, barcode, Bioassay, biological assays, Biomarker, biomarkers, Biomaterial, capping particles, CAR-T cell platform, CAR-T cell therapy, cavities, cavity-containing particles, Cell and tissue culture, cell encapsulation, cell engineering, cell imaging, cell mapping, cell sorting, cell type identification, cell-based therapy, centrifugation, confinement, Diagnostic Platform Technologies (E.G. Microfluidics), Digital Microfluidics, Drug, Drug Delivery, Drug Discovery, drug screening, high throughput, high throughput assays, high throughput testing, high-throughput analysis, High-Throughput Screening, Immunoassay, Immunoassay Sense (Molecular Biology), Microfluidics, Microfluidics And Mem's, Microfluidics Nanosphere, microparticles, moieties, Nanoparticle, single cell analysis, single cell analysis and testing, Single cell data, single-cell resolution, single-cell trapping

Category(s): Life Science Research Tools, Life Science Research Tools > Cell Counting And Imaging, Life Science Research Tools > Lab Equipment, Life Science Research Tools > Microscopy And Imaging, Life Science Research Tools > Microfluidics And Mems, Medical Devices, Platforms

Subgraph Matching for High-Throughput DNA-Aptamer Secondary Structure Classification and Machine Learning Interpretability (Case No. 2025-104)

Intro Sentence: UCLA researchers in the Department of Mathematics have developed machine learning methods to rapidly identify novel aptamer sequences for target binding to accelerate highly-accurate diagnostic and therapeutic development. Background: Aptamers are single-stranded nucleotide polymers that bind with high affinity to targets such as...

Published: 8/19/2025 | Inventor(s): Andrea Bertozzi, Anne Andrews, Matthew Tyler, Paolo Climaco, Noelle Mitchell

Keywords(s): Advanced Computing / AI, advanced computing methods, Aptamers, Artifical Intelligence (Machine Learning, Data Mining), artificial intelligence/machine learning models, bioinformatics pipeline, cancer target, clustering, computational efficiency, computational efficiency and analysis, design software, DNA clustering, DNA oligomer, DNA Sequencing, Drug, Drug Delivery, Drug Development, Drug Discovery, drug screening, high throughput, high throughput assays, high throughput testing, high-throughput analysis, High-Throughput Screening, interpretability, pipeline, large-scale parallelization, Machine Learning, machine learning modeling, motif structures, open source, open source code, OpenAI, Pharmaceutical Drug, protein classification, secondary structure, SELEX, sequences of interest, single strand DNA sequences, Software, Software & Algorithms, Software Development Tools, Software-enabled learning, subgraph matching, target binding, target detection, Targeted Therapy, Targets And Assays, tissue targeting accuracy

Category(s): Software & Algorithms, Software & Algorithms > AI Algorithms, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Data Analytics, Life Science Research Tools, Life Science Research Tools > Research Methods, Life Science Research Tools > Screening Libraries, Platforms, Platforms > Drug Delivery, Diagnostic Markers > Targets And Assays, Diagnostic Markers, Software & Algorithms > Bioinformatics

Restoration of motor function through delayed intraspinal delivery of mRNA-encoded IL-10 after spinal cord injury

Brief Description: Disclosed herein is a composition including a nucleoside-modified mRNA encapsulated in a lipid nanoparticle wherein the nucleoside-modified mRNA encodes IL10, IL-6, MIP1a, GDNF (glial cell line-derived neurotrophic factor), or a combination thereof. A method of treated spinal cord injury is also described. Image: Caption: Reference...

Published: 7/9/2025 | Inventor(s): Norbert Pardi, Drew Weissman

Keywords(s): Bioengineering, Drug Delivery, Gene Therapy, Immunology, Neurology, Regenerative Medicine

Category(s): Technology Classifications > Therapeutics, Technology Classifications > Vaccines

Multifunctional Bioactive Dual-Layered Nanofibrous Matrix for Triple Negative Breast Cancer

Dual-Layered Nanofibrous Matrix designed for rapid-release and sustained-release of various therapeutics, leading to no tumor recurrence in triple negative breast cancer 4T1 tumor-resected mouse models. Invention Summary: Triple-negative breast cancer (TNBC), a particularly aggressive subtype of breast cancer which comprises 15-20% of all...

Published: 8/12/2025 | Inventor(s): Sungyun Kim, Ki-Bum Lee, Hyun-Jong Cho

Keywords(s): Anti-cancer, Breast Cancer, Drug Delivery, Nanotechnology, Wound healing

Category(s): Technology Classifications > Cancer, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Nanotechnology

Delivery of sustained local and systemic immunomodulation

Reducing treatment burden with continuous immune activation Background: Current immunotherapy approaches face significant limitations in both delivery and patient experience. Standard treatments rely on either systemic intravenous injections of antibodies or small molecules that require frequent clinic visits, or localized injections that provide...

Published: 6/13/2025 | Inventor(s): Srinivas Sridhar, Needa Brown, Jennifer Guerriero, Alexander Gottlieb

Keywords(s): biocompatible, Biodegradable, Biomaterials, Cancer, Drug Delivery, Immunoengineering, immunotherapy, implant, Nanomedicine

Category(s): Technology Classifications > 1. Life Science > Therapeutics

Synthesis of Anticancer Agents Nannocystins and Their Analogs

Synthetic route to producing nannocystins, an anticancer agent that is typically found in myxobacteria. Background: Myxobacteria are some of the top producers of microbial secondary metabolites, a large portion of which have shown activity against human diseases. One of these metabolite groups are nannocystins, since they have shown excellent anticancer...

Published: 5/13/2025 | Inventor(s): Zhang Wang, Jun Huang

Keywords(s): drug delivery, oncology

Category(s): Technology Classifications > Research Tools and Reagents, Campus > University at Albany

Self-powered, bioresorbable drug release systems

NU 2023-045 INVENTORS John Rogers* Colin Franz* Yamin Zhang SHORT DESCRIPTION Northwestern and Shirley Ryan AbilityLab researchers have developed a novel, self-powered, bioresorbable drug delivery system that enables light-controlled, targeted drug release without the need for surgical removal post-treatment. BACKGROUND Current drug delivery systems...

Published: 8/5/2025 | Inventor(s):

Keywords(s): Biomaterials, Cancer/Oncology, Drug delivery, Infectious disease, Medical device, Therapeutics

Category(s): Life Sciences > Healthcare Devices, Tools & IT

Sliding Bioactive Peptides for Therapeutic Delivery

NU 2023-142 INVENTORS Samuel I. Stupp* Federico Lancia Madison E. Strong Matias A. Alvarez-Saavedra SHORT DESCRIPTION This technology involves the design and engineering of peptide amphiphile nanofibers that deliver bioactive peptides both extra- and intra-cellularly. The bioactive peptides can slide along these structures...

Published: 8/5/2025 | Inventor(s):

Keywords(s): Biomaterials, Drug delivery

Category(s): Life Sciences > Therapeutics

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