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Search Results - drug+delivery
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New Lipiodol Formulation for Treating Hepatocellular Carcinoma with Transarterial Chemoimmunoembolization
NU 2021-148 INVENTORS Dong Hyun Kim* Heegon Kim SHORT DESCRIPTION A new Lipiodol formulation designed to improve the efficacy and safety of transarterial chemoembolization in combination with immunotherapy. BACKGROUND Transarterial chemoembolization...
Published: 9/4/2024
|
Inventor(s):
Keywords(s):
Cancer/Oncology
,
Drug delivery
,
Gastrointestinal and Hepatic disease
,
Immunotherapy
,
Therapeutics
Category(s):
Life Sciences > Therapeutics
Targeted Organ or Multiple Organ Delivery of mRNA with Ionizable Amphiphilic Janus Dendrimers
A library of easily synthesized ionizable amphiphilic Janus dendrimer (IAJD) compounds that deliver mRNA either to targeted organs or multiple organs, depending on the IAJD design. Problem: Four-component lipid nanoparticles (LNPs) are the benchmark synthetic vector for the delivery of mRNA. Despite their high biosafety, low toxicity, and immunogenicity,...
Published: 7/23/2024
|
Inventor(s):
Virgil Percec
,
Drew Weissman
,
Juncheng (Luke) Lu
,
Elena Atochina-Vasserman
,
Devendra Maurya
,
Dipankar Sahoo
Keywords(s):
Drug Delivery
,
Platform Technology
Category(s):
Technology Classifications > Chemical Processes and Synthesis
,
Technology Classifications > Vaccines
A
drug delivery
system tuned to the endogenous mechanical environment
Technology Overview: Tissues within the body experience mechanical perturbations across multiple force magnitudes and length scales, from mechanotransduction at the cell level to the dynamics of load-bearing joints. These forces not only maintain tissue homeostasis, but can also initiate degenerative processes when applied at supra-physiologic levels....
Published: 6/21/2024
|
Inventor(s):
Robert Mauck
,
George Dodge
,
Daeyeon Lee
Keywords(s):
Drug Delivery
Category(s):
Technology Classifications > Therapeutics
Strategies for Mitigating Acute Side Effects of Lung-Targeted Nanocarriers
Approaches and Design Techniques to Alleviate Coagulation-Related Acute Side Effects of Lung-Targeted Nanocarriers Problem: Lipid nanoparticles (LNPs) play a crucial role in
drug delivery
, enabling targeted drug administration to specific tissues. LNPs tailored for lung-specific delivery often incorporate cationic (positively charged) lipids. Unfortunately,...
Published: 6/26/2024
|
Inventor(s):
Jacob Brenner
,
Vladimir Muzykantov
,
Jacob Myerson
,
Oscar Marcos Contreras
,
Marco Zamora
,
Serena Omo-Lamai
Keywords(s):
Bioengineering
,
Drug Delivery
,
Gene Editing
,
Gene Therapy
,
Nanotechnology
,
Platform Technology
,
Pulmonary
Category(s):
Technology Classifications > Therapeutics
Immune Modulator Encoded Lipid Nanoparticle Formulation Improves T Cell Response to Vaccines
Researchers developed an LNP-mRNA-based vaccine that encodes different cytokine mRNAs, as a method to enhance CD8+ T cell responses and memory formation. Problem: Lipid nanoparticles (LNPs) are an emerging technique to deliver mRNA in vivo more efficiently. While recent progress in mRNA technology has allowed the rapid development of SARS-COV2 vaccines,...
Published: 7/2/2024
|
Inventor(s):
Christopher Hunter
,
Drew Weissman
,
Mohamad Alameh
,
Emily Aunins
,
Anthony Phan
Keywords(s):
Bioengineering
,
Drug Delivery
,
Immunology
,
Immunoncology
,
Immunotherapy
,
Infectious Disease
,
Nanotechnology
Category(s):
Technology Classifications > Therapeutics
,
Technology Classifications > Vaccines
A Stretch-Activated Adhesive Microcapsule For The Controlled Release of Drugs In Wound-Healing Dressings
An adhesive drug-loaded microcapsule which releases therapeutic cargo upon mechanical stretching. Problem: Medicated dressings can improve healing of open wounds and improve pain management in patients. However, drug-coated bandages lack stimuli-response release mechanisms, so therapeutics are not released in a controlled and sustained manner. Poor...
Published: 6/20/2024
|
Inventor(s):
Daeyeon Lee
,
Yun Kee Jo
,
Robert Mauck
,
George Dodge
Keywords(s):
Drug Delivery
,
Soft Materials
Category(s):
Technology Classifications > Materials
Targeted Delivery of IFN-gamma Using Antibody Fusion Proteins (UCLA Case No. 2017-543)
UCLA researchers in the Departments of Microbiology, Immunology & Molecular Genetics (MIMG) and Medicine have developed antibody–cytokine fusion proteins that enable the targeted delivery of active interferon-gamma (IFNγ) for cancer treatment. Interferon-gamma (IFNγ), a type II interferon, is a cytokine released by both natural...
Published: 2/26/2024
|
Inventor(s):
Sherie Morrison
,
John Timmerman
,
Kham (Ryan) Trinh
Keywords(s):
Antibody Delivery Platforms
,
Drug Delivery
,
Immunotherapy
,
Life Science Research Tools
,
Therapeutics & Vaccines
Category(s):
Therapeutics
,
Platforms >
Drug Delivery
,
Platforms >
Drug Delivery
> Antibody Delivery Platforms
,
Life Science Research Tools
,
Therapeutics > Immunology And Immunotherapy
Intelligent Stent System for Chronic On-Demand
Drug Delivery
(Case No. 2021-069)
Summary: UCLA researchers in the Department of Neurology have developed an intelligent stent system for chronic on-demand
drug delivery
, addressing the challenge of the blood-brain barrier hindering drug therapy in the central nervous system. Background: The blood-brain barrier poses a significant obstacle to effective drug delivery to the central...
Published: 7/9/2024
|
Inventor(s):
Jose Morales
,
Haotian Lu
,
Huachen Cui
,
Xiaoyu (Rayne) Zheng
Keywords(s):
blood flow management
,
blood-brain barrier
,
Drug
,
Drug Delivery
,
Drug monitoring
,
Invasiveness Of Surgical Procedures
,
MEMS
,
minimally invasive device
,
minimally invasive
drug delivery
systems
,
neural signals
,
neural stimulation
,
Neurocognitive
,
Neurodegeneration
,
neurological disorders
,
Neurology
,
neuro-oncology
,
Neuropathology
,
Neurosurgery
,
non-invasive
,
non-invasive drug monitoring
,
on-demand
drug delivery
,
Pharmaceutical Drug
,
piezoelectric ultrasound transducers
Category(s):
Platforms
,
Platforms >
Drug Delivery
,
Medical Devices
,
Therapeutics
,
Therapeutics > CNS and Neurology
,
Therapeutics > Oncology
,
Therapeutics > Musculoskeletal Disease
Biodegradable and Biocompatible Bioactive-based Polymers - Versatile Platform Technology
Invention Summary: The Uhrich group has developed various biodegradable polymers that chemically incorporate bioactive molecules, such as nonsteroidal anti-inflammatory drugs (e.g., salicylic acid), antioxidants (e.g., ferulic acid) and antimicrobials (e.g., carvacrol). Bioactive molecules are incorporated into polymer backbones through labile linkages,...
Published: 4/17/2024
|
Inventor(s):
Kathryn Uhrich
,
Jonathan Faig
,
Kervin Smith
Keywords(s):
Antibacterial
,
Bioengineering scaffolds
,
Biomaterials
,
Drug Delivery
,
Polymers & Composites
Category(s):
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Therapeutics
Topical LSD1 Inhibition for Treating Skin Diseases
Topical LSD1 inhibition can treat skin diseases that include cutaneous squamous cell carcinoma (cSCC), actinic keratoses, and viral warts. Problem: Current treatment options (i.e. cryotherapy, laser therapy, surgery, chemotherapy) for skin diseases such as cSCC, actinic keratoses, and viral warts are often non-targeted and destructive, and can cause...
Published: 2/12/2024
|
Inventor(s):
Brian Capell
,
Napasorn (Nina) Kuprasertkul
Keywords(s):
Dermatology
,
Drug Delivery
,
Drug Target
,
Immunoncology
,
Oncology
Category(s):
Technology Classifications > Therapeutics
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