Search Results - drug+delivery

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Closed-Loop Implantable System for Automated Opioid Overdose Detection and Reversal
NU 2019-073 INVENTORS John Rogers (Northwestern University)* Robert Gereau (Washington University, St Louis)* SHORT DESCRIPTION This wireless device, the size of a pacemaker, is implanted to monitor oxygen levels. Below a specific threshold, it sends an alert to warning notification on a mobile app, then automatically releases naloxone to prevent...
Published: 11/7/2025   |   Inventor(s):  
Keywords(s): Drug delivery, Electronics & Circuits, Medical device, Microfluidics
Category(s): Life Sciences > Healthcare Devices, Tools & IT, Life Sciences > Therapeutics
Spherical Nucleic Acids with Sheddable PEG Layers for Enhanced Tumor Targeting
NU 2017-169 INVENTORS Chad Mirkin* (Northwestern University, Weinberg College of Arts and Sciences, Department of Chemistry, Director of the International Institute for Nanotechnology (IIN)) Brian Meckes Wuliang Zhang SHORT DESCRIPTION For oncology applications, this invention offers spherical nucleic acids with an enzyme-cleavable PEG layer...
Published: 11/7/2025   |   Inventor(s):  
Keywords(s): Biologic, Biomarker, Biomedical, Cancer/Oncology, Chemicals, Diagnostics, Drug delivery, Nanoparticle, Nanotechnology, Personalized medicine, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Healthcare Devices, Tools & IT, Life Sciences > Biomarkers & Biomedical Research Tools
Methods for assembling peptides into peptide amphiphile nanofibers
TITLE: Peptide Nanofiber Assembly for Enhanced Therapeutic Delivery NU 2020-081 SHORT DESCRIPTION This technology uses self-assembling peptide amphiphile nanofibers to protect and deliver therapeutic peptides. It reduces degradation and improves delivery efficiency for advanced treatment applications. BACKGROUND Peptide therapeutics offer promise...
Published: 11/6/2025   |   Inventor(s):  
Keywords(s): Drug delivery, Nanomaterials
Category(s): Life Sciences > Therapeutics
BDNF Mimetic Peptide Amphiphile for Enhanced Neurotrophic Signaling and Neuronal Regeneration
NU 2018-020 INVENTORS Samuel Stupp Alexandra Kolberg Zaida Alvarez Pinto SHORT DESCRIPTION This technology is an injectable, highly potent peptide amphiphile that mimics BDNF function via the TrkB pathway while providing extracellular support. It promotes neuronal growth and signaling for regenerative treatments in CNS injuries and diseases. BACKGROUND Current...
Published: 11/6/2025   |   Inventor(s):  
Keywords(s): CNS - Central Nervous System, Devices, Drug delivery, Health IT, Medical device
Category(s): Life Sciences > Healthcare Devices, Tools & IT
A Novel Combination Therapy for Parkinson’s Disease
NU 2013-149 INVENTORS Dalton Surmeier Jr. (Northwestern University, Feinberg School of Medicine, Chair of the Department of Neuroscience)* Daniel Galtieri Ema Ilijic Enrico Zampese Jaime Guzman-Lucero Javier Sanchez SHORT DESCRIPTION This technology uses a low-dose combination of two FDA-approved compounds to reduce oxidative stress in neurons...
Published: 11/6/2025   |   Inventor(s):  
Keywords(s): Biomedical, Drug delivery, Neurodegenerative disease, Neurologic disease, PD - Parkinson's Disease, Therapeutics
Category(s): Life Sciences > Therapeutics
Biomaterial-mediated Extracellular Vesicle Delivery CNS Regeneration
​ Reduction in cortical lesion volume post-TBI (a) and post-treatment (b); remyelination as shown by luxol fast blue-staining post-TBI (c) and post-treatment (d); and enhanced expression of occludin post treatment (f) as compared to post-TBI (e). Invention Summary: More than 3 billion people worldwide are affected by central nervous system...
Published: 10/3/2025   |   Inventor(s): Joshua Stein, Ki-Bum Lee, Inbo Han
Keywords(s): Bioengineering scaffolds, Biomaterials, Drug Delivery, Spinal Cord
Category(s): Technology Classifications > Biomaterials, Technology Classifications > Physical Sciences & Engineering
Gold Nanocluster-Based PROTAC Targeting pTau
​ Gold nanocluster binds both pTau and E3 ligase, initiating the ubiquitin-proteasome pathway and degrading pTau, as seen via immunostaining (Blue – Hoechst, red – TUJ1, green – pTau) Invention Summary: Hyperphosphorylated tau protein, a key clinical marker for various neurodegenerative diseases, leads to abnormal aggregation...
Published: 9/12/2025   |   Inventor(s): Sarah Nevins, Ki-Bum Lee
Keywords(s): Alzheimer’s, Drug Delivery, Inflammation, Nanoparticles
Category(s): Technology Classifications > Biomaterials, Technology Classifications > CNS Disorder, Technology Classifications > Nanotechnology, Technology Classifications > Physical Sciences & Engineering
Multi-Particle System for Capture and Detection of Cellular and Molecular Analytes (Case No. 2025-267)
Summary: UCLA researchers in the Department of Bioengineering have developed a novel multi-particle system that selectively confines cells and molecular reactions within cavities formed by interacting particles. Background: Screening and selecting cells with specific, beneficial traits has become a vital process in using cell-derived products...
Published: 10/20/2025   |   Inventor(s): Dino Di Carlo, Alyssa Arnheim, Michael Mellody, Yuta Nakagawa, Lily Shang
Keywords(s): Assay, B Cell, barcode, Bioassay, biological assays, Biomarker, biomarkers, Biomaterial, capping particles, CAR-T cell platform, CAR-T cell therapy, cavities, cavity-containing particles, Cell and tissue culture, cell encapsulation, cell engineering, cell imaging, cell mapping, cell sorting, cell type identification, cell-based therapy, centrifugation, confinement, Diagnostic Platform Technologies (E.G. Microfluidics), Digital Microfluidics, Drug, Drug Delivery, Drug Discovery, drug screening, high throughput, high throughput assays, high throughput testing, high-throughput analysis, High-Throughput Screening, Immunoassay, Immunoassay Sense (Molecular Biology), Microfluidics, Microfluidics And Mem's, Microfluidics Nanosphere, microparticles, moieties, Nanoparticle, single cell analysis, single cell analysis and testing, Single cell data, single-cell resolution, single-cell trapping
Category(s): Life Science Research Tools, Life Science Research Tools > Cell Counting And Imaging, Life Science Research Tools > Lab Equipment, Life Science Research Tools > Microscopy And Imaging, Life Science Research Tools > Microfluidics And Mems, Medical Devices, Platforms
Subgraph Matching for High-Throughput DNA-Aptamer Secondary Structure Classification and Machine Learning Interpretability (Case No. 2025-104)
Intro Sentence: UCLA researchers in the Department of Mathematics have developed machine learning methods to rapidly identify novel aptamer sequences for target binding to accelerate highly-accurate diagnostic and therapeutic development. Background: Aptamers are single-stranded nucleotide polymers that bind with high affinity to targets such as...
Published: 8/19/2025   |   Inventor(s): Andrea Bertozzi, Anne Andrews, Matthew Tyler, Paolo Climaco, Noelle Mitchell
Keywords(s): Advanced Computing / AI, advanced computing methods, Aptamers, Artifical Intelligence (Machine Learning, Data Mining), artificial intelligence/machine learning models, bioinformatics pipeline, cancer target, clustering, computational efficiency, computational efficiency and analysis, design software, DNA clustering, DNA oligomer, DNA Sequencing, Drug, Drug Delivery, Drug Development, Drug Discovery, drug screening, high throughput, high throughput assays, high throughput testing, high-throughput analysis, High-Throughput Screening, interpretability, pipeline, large-scale parallelization, Machine Learning, machine learning modeling, motif structures, open source, open source code, OpenAI, Pharmaceutical Drug, protein classification, secondary structure, SELEX, sequences of interest, single strand DNA sequences, Software, Software & Algorithms, Software Development Tools, Software-enabled learning, subgraph matching, target binding, target detection, Targeted Therapy, Targets And Assays, tissue targeting accuracy
Category(s): Software & Algorithms, Software & Algorithms > AI Algorithms, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Data Analytics, Life Science Research Tools, Life Science Research Tools > Research Methods, Life Science Research Tools > Screening Libraries, Platforms, Platforms > Drug Delivery, Diagnostic Markers > Targets And Assays, Diagnostic Markers, Software & Algorithms > Bioinformatics
Multifunctional Bioactive Dual-Layered Nanofibrous Matrix for Triple Negative Breast Cancer
​ Dual-Layered Nanofibrous Matrix designed for rapid-release and sustained-release of various therapeutics, leading to no tumor recurrence in triple negative breast cancer 4T1 tumor-resected mouse models. Invention Summary: Triple-negative breast cancer (TNBC), a particularly aggressive subtype of breast cancer which comprises 15-20% of all...
Published: 8/20/2025   |   Inventor(s): Sungyun Kim, Ki-Bum Lee, Hyun-Jong Cho
Keywords(s): Anti-cancer, Breast Cancer, Drug Delivery, Nanotechnology, Wound healing
Category(s): Technology Classifications > Cancer, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Nanotechnology
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