Search Results - als+-+amyotrophic+lateral+sclerosis

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Pyrimidine-2,4,6-Trione Derivatives Preparation and Their Use for the Treatment of Amyotrophic Lateral Sclerosis (ALS) ALS Therapy
NU 2009-072 INVENTORS Richard Morimoto* Richard Silverman* Gavin Guoyao Xia SHORT DESCRIPTION This invention discloses novel pyrimidine-2,4,6-trione derivatives (PYT compounds) that prevent abnormal protein aggregation associated with ALS, offering a promising new therapeutic approach for neurodegenerative diseases. BACKGROUND Amyotrophic...
Published: 11/18/2025   |   Inventor(s):  
Keywords(s): ALS - Amyotrophic Lateral Sclerosis, Neurodegenerative disease, Therapeutics
Category(s): Life Sciences > Therapeutics
Therapeutic Intervention for ALS and Dementia
NU 2021-058 INVENTORS Evangelos Kiskinis* Juan Alberto Ortega Cano Marco Boccitto SHORT DESCRIPTION Design of an RNA-based oligonucleotide that protects from dipeptide repeat protein toxicity for the treatment of ALS and FTD. BACKGROUND Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are devastating neurodegenerative diseases...
Published: 11/6/2025   |   Inventor(s):  
Keywords(s): ALS - Amyotrophic Lateral Sclerosis, CNS - Central Nervous System, DPR - Dipeptide Repeat Proteins, FTD - Frontotemporal Dementia, Neurodegenerative disease, Neurology, RNA - Ribonucleic Acid, Therapeutics
Category(s): Life Sciences > Therapeutics