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Search Results - antibody
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Multiplexed Saliva-based Immunodiagnostics for Assessing Anti-flavivirus Immunity
An easy-to-use method for rapidly, accurately, and non-invasively assessing flavivirus immunity by measuring various
antibody
classes present in saliva. Background: Flaviviruses (including dengue virus) are the most common vector-borne human viral pathogens in the world. Nearly 40% of the world’s population are at risk of infection with dengue...
Published: 4/1/2025
|
Inventor(s):
Adam Waickman
,
Stephen Thomas
,
Frank Middleton
Keywords(s):
antibodies
,
antibody
,
infectious diseases
,
saliva
,
Technologies
,
viral immunology
Category(s):
Campus > Upstate Medical University
,
Technology Classifications
,
Technology Classifications > Biomedical Science and Engineering
,
Technology Classifications > Healthcare
,
Technology Classifications > Therapeutics and Vaccines
IgA Monoclonal Antibodies as a Prophylactic and Therapeutic Treatment for Dengue Virus Infection
Enables the prevention and treatment of dengue by avoiding the challenge of
Antibody
Dependent Enhancement. Background: Dengue virus is one of the most widespread vector-borne viral pathogens in the world. Nearly 400 million dengue virus infections occur each year, resulting in approximately 20,000 deaths. In addition, dengue-associated illness comprises...
Published: 4/1/2025
|
Inventor(s):
Adam Waickman
,
Adam Wegman
Keywords(s):
antibody
,
antibody
therapy
,
biologics
,
biomedical
,
disease prevention
,
immunotherapy
,
monoclonal
antibody
,
Technologies
,
viral immunology
,
viral pathogenesis
Category(s):
Technology Classifications > Therapeutics and Vaccines
,
Technology Classifications > Antibodies
,
Technology Classifications > Healthcare
,
Technology Classifications > Viral Vectors
,
Campus > Upstate Medical University
Anticancer IgG Against Multiple Epitopes on Live Tumors Upon Disruption of ‘Self’ Signaling by CD47
A method to combine two or three monoclonal antibodies (mABs) into one treatment to successfully bind to multiple cancer cell surface epitopes and promote targeted degradation by phagocytosis. Problem: Phagocytosis of ‘self’ cells is generally inhibited by a key macrophage checkpoint interaction between SIRPα on the macrophage and...
Published: 2/27/2025
|
Inventor(s):
Dennis Discher
,
Jason Andrechak
,
Lawrence Dooling
Keywords(s):
Antibody
,
Bioengineering
,
Cell Therapy
,
Drug Target
,
Immunology
,
Immunoncology
,
Immunotherapy
,
Oncology
,
Platform Technology
Category(s):
Technology Classifications > Therapeutics
A Novel Lymphocyte Stimulation Assay To Quantify Immune Responses (UCLA Case No. 2022-079)
UCLA researchers in the Department of Medicine have developed lymphocyte stimulation assays to evaluate immune responses, supporting various clinical applications such as adjusting immunosuppressant drug levels and advancing COVID-19 vaccine development. The assay systems are reliable, cost-effective, and easy-to-perform, providing accurate assessments...
Published: 2/14/2025
|
Inventor(s):
Yusaku Shino
Keywords(s):
Antibody
,
biomarkers
,
cytokines
,
Immunity (Medical)
,
immunosuppression
,
Organ Transplant
Category(s):
Life Science Research Tools > Antibodies
,
Therapeutics > Immunology And Immunotherapy
COMPOSITIONS AND METHODS RELATED TO CORONAVIRUS THERAPIES
COMPOSITIONS AND METHODS RELATED TO CORONAVIRUS THERAPIES Researchers at Stanford have developed fusion proteins, containing ACE2 domain linked to a fragment of non-neutralizing anti-SARS-CoV-2 spike protein
antibody
, with a greater breadth of protection than previously described similar fusion proteins. Coronaviruses are a large family of viruses...
Published: 11/6/2024
|
Inventor(s):
Peter Kim
,
Adrian Hugenmatter
,
Ashley Utz
,
Matthew Armbrust
Keywords(s):
ACE2
,
Antibody
,
Coronavirus
,
Neutralizing
,
Spike
Category(s):
Technology Classifications > Biology
METHODS AND COMPOSITIONS IN PROGRAMMABLE RECEPTOR FOR ANTIGEN DETECTION AND CUSTOMIZED CELL RESPONSES
METHODS AND COMPOSITIONS IN PROGRAMMABLE RECEPTOR FOR ANTIGEN DETECTION AND CUSTOMIZED CELL RESPONSES Researchers at Stanford have developed new methods to create programmable synthetic receptors (PAGER). The advent of programmable synthetic receptors represents a new era in cellular therapies and in biomedical science. There are currently tens...
Published: 12/5/2023
|
Inventor(s):
Nicholas Kalogriopoulos
,
Alice Ting
,
Matthew Ravalin
,
Reika Tei
Keywords(s):
Antibody
,
Fusion Protein
,
Receptor
Category(s):
Technology Classifications > Biology
ANTIBODY
COMPOSITIONS AND OPTIMIZATION METHODS
ANTIBODY
COMPOSITIONS AND OPTIMIZATION METHODS Researchers at Stanford have invented a method using directed evolution for predicting antibody improved antibody variants. Evolution searches across an immense space of possible sequences for rare mutations that improve fitness. In nature, this search is based on random mutation and recombination,...
Published: 9/14/2023
|
Inventor(s):
Brian Hie
,
Peter Kim
Keywords(s):
Antibody
,
Variant
Category(s):
Technology Classifications > Software
ANTIBODIES TO IL1RN AS MARKERS OF PRETERM BIRTH
ANTIBODIES TO IL1RN AS MARKERS OF PRETERM BIRTH Researchers at CZ Biohub SF and UCSF have discovered a novel biomarker of pre-term birth. Little is known about pre-term delivery risk and more specifically the immunological processes that allow for tolerance of a semi-allogenic fetus within the mother’s body. However, the processes that govern...
Published: 8/17/2023
|
Inventor(s):
Elze Rackaityte
,
Joseph DeRisi
Keywords(s):
Antibody
,
Biomarker
,
Preterm Delivery Risk
Category(s):
Technology Classifications > Biology
High-Affinity Mouse Monoclonal Antibodies to GPC-3 for Liver Cancer Research
Abstract: The National Cancer Institute Laboratory of Molecular Biology seeks parties for collaborative research to co-develop and commercialize
antibody
drug/toxin conjugates as liver cancer therapy and diagnostics. There is great interest and value in developing more sensitive and efficient agents for earlier detection of hepatocellular cancer (HCC). ...
Published: 5/21/2024
|
Inventor(s):
Mitchell Ho
,
Yen Phung
,
Wei Gao
,
Yifan Zhang
Keywords(s):
ANTIBODY
,
GLYCOPROTEIN
,
Glypican-3
,
GPC3
,
HCC
,
hepatocellular carcinoma
,
liver
,
monoclonal
Category(s):
Collaboration Sought > Collaboration
,
TherapeuticArea > Oncology
,
Application > Therapeutics
,
Collaboration Sought > Licensing
Anti-Py1235-Met Immunological Binding Reagent as Cancer Diagnostic
Abstract: This technology consists of highly specific rabbit monoclonal antibodies reactive with phosphorylated tyrosine located at amino acid 1235 in the human MET sequence. Binding to this pYl235 residue is independent of the phosphorylation of other tyrosines in the vicinity (1230 and 1234), does not cross-react with these nearby phosphotyrosine...
Published: 4/8/2024
|
Inventor(s):
Apurva Srivastava
,
Thomas Pfister
,
Mario Navas
,
James Doroshow
,
Ralph Parchment
Keywords(s):
ANTIBODY
,
Companion Diagnostic
,
diagnostic
,
MET
,
Rabbit Monoclonal
Antibody
,
tyrosine kinase inhibitor
Category(s):
Collaboration Sought > Licensing
,
Application > Diagnostics
,
Collaboration Sought > Collaboration
,
TherapeuticArea > Oncology
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