Search Results - cns+-+central+nervous+system

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Cell-type specific disruption of M1 muscarinic acetylcholine receptor expression to alleviate Parkinson's disease
NU 2024-244 INVENTORS Dalton J. Surmeier Jr* Tatiana Tkatch Shenyu Zhai SHORT DESCRIPTION Gene therapy targeting M1 muscarinic receptor expression in striatal spiny projection neurons to enhance levodopa response and slow Parkinson’s Disease progression. BACKGROUND Parkinson’s Disease (PD) is the second most common age-related...
Published: 6/20/2025   |   Inventor(s):  
Keywords(s): CNS - Central Nervous System, Neurodegenerative disease, Neurologic disease, Neurology
Category(s): Life Sciences > Therapeutics
Gene therapy for levodopa-induced dyskinesia
NU 2024-086 INVENTORS Dalton J. Surmeier Jr* Weixing Shen Shenyu Zhai Tatiana Tkatch Qiaoling Cui Zhong Xie SHORT DESCRIPTION Gene therapy targeting GRIN2B in striatal spiny projection neurons to treat levodopa-induced dyskinesia. BACKGROUND Parkinson’s Disease (PD) is the second most common age-related neurodegenerative disease...
Published: 6/20/2025   |   Inventor(s):  
Keywords(s): CNS - Central Nervous System, Neurodegenerative disease, Neurologic disease, Neurology, Parkinson's Disease
Category(s): Life Sciences > Therapeutics
Targeting Calcium Channels to treat Early-Stage Parkinson’s Disease
NU 2024-179 INVENTORS Dalton J. Surmeier Jr* Jack Nguyen SHORT DESCRIPTION Novel compounds to inhibit Cav1.3 calcium channels and slow the progression of Parkinson's Disease. BACKGROUND Parkinson’s Disease (PD) is the second most common age-related neurodegenerative disease after Alzheimer’s Disease, affecting nearly one million...
Published: 6/20/2025   |   Inventor(s):  
Keywords(s): CNS - Central Nervous System, Neurodegenerative disease, Neurology, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
Therapeutic Intervention for ALS and Dementia
NU 2021-058 INVENTORS Evangelos Kiskinis* Juan Alberto Ortega Cano Marco Boccitto SHORT DESCRIPTION Design of an RNA-based oligonucleotide that protects from dipeptide repeat protein toxicity for the treatment of ALS and FTD. BACKGROUND Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are devastating neurodegenerative diseases...
Published: 6/26/2025   |   Inventor(s):  
Keywords(s): ALS - Amyotrophic Lateral Sclerosis, CNS - Central Nervous System, DPR - Dipeptide Repeat Proteins, FTD - Frontotemporal Dementia, Neurodegenerative disease, Neurology, RNA - Ribonucleic Acid, Therapeutics
Category(s): Life Sciences > Therapeutics
TauSeeK: Disease Specific Tau Protein Fibrils & Seeding Proteins
NU2024-139 INVENTORS Austin Dubose Michael Vigers Andrew Longhini Vishnu Vijayan Kenneth Kosik Sam Lobo Peter C. Ryffel Songi Han* SHORT DESCRIPTION Compositions, kits, and methods for generating synthetic miniature tau peptides and fibrils, and synthetic full-length pathogenic tau fibrils. BACKGROUND A major hallmark of several neurodegenerative...
Published: 6/20/2025   |   Inventor(s):  
Keywords(s): CNS - Central Nervous System, Neurodegenerative disease, Neurology, Research tool, Synthetic biology
Category(s): Life Sciences > Therapeutics
Human Spinal Cord Injury Organoids for Therapeutic Discovery
NU 2023-116 INVENTORS Nozomu Takata Nicholas Sather Samuel Stupp* SHORT DESCRIPTION A human organoid model to simulate spinal cord injury in vitro and test potential therapeutics. BACKGROUND Injury in organs triggers cellular and molecular rearrangements that induce intrinsic repair and regeneration, but the human central nervous system has...
Published: 6/20/2025   |   Inventor(s):  
Keywords(s): CNS - Central Nervous System, Neurology, Therapeutics
Category(s): Life Sciences > Therapeutics
Location-specific growth media for brain tumor organoids
LU 2023-082 INVENTORS Xiaonan Li* Milagros Suarez Palacios Yuchen Du SHORT DESCRIPTION Location-matched growth media formulations in brain tumor organoid models for biological and therapeutic applications BACKGROUND Brain cancer is the second most common type of childhood malignancy and the leading cause of death in children. Despite recent...
Published: 6/20/2025   |   Inventor(s):  
Keywords(s): Cancer/Oncology, CNS - Central Nervous System, Neurology
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
Immunomodulatory Nanoparticles for the Therapeutic Intervention of Traumatic Brain Injury
NU 2019-030 INVENTORS John Kessler Sripadh Sharma ABSTRACT There is no decisive treatment for traumatic brain injury (TBI). After the primary trauma, secondary injury, largely mediated by blood-borne immune cells called monocytes, takes place causing damage to surrounding healthy cells. Furthermore, cellular and whole brain swelling (edema) resulting...
Published: 6/20/2025   |   Inventor(s):  
Keywords(s): Autoimmune disease, Brain injury, CNS - Central Nervous System, Immunology, Neurology, Therapeutics
Category(s): Life Sciences > Therapeutics
Gene Therapy for Parkinson's Disease
NU 2021-039 INVENTORS D. James Surmeier* Michael Kaplitt Patricia Gonzalez Rodriguez SHORT DESCRIPTION A simple neurological procedure to treat late-stage Parkinson’s Disease patients BACKGROUND Approximately 60,000 Americans are diagnosed with Parkinson’s Disease (PD) each year. Although levodopa has been the gold-standard for symptomatic...
Published: 6/20/2025   |   Inventor(s):  
Keywords(s): CNS - Central Nervous System, Gene therapy, Neurodegenerative disease, Neurology, PD - Parkinson's Disease, Therapeutics
Category(s): Life Sciences > Therapeutics