Search Results - cancer+therapeutics

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Method for Repurposing FDA-approved Therapeutics & Composition for Treating Mesothelioma
The amount of time and money that goes into getting a drug from initial discovery to FDA approval is substantial, typically involving at least 10 years and hundreds of millions of dollars. Because of this, there has been a growing interest in repurposing drugs which have previously been approved for human use, particularly since their MOA as well as...
Published: 1/8/2025   |   Inventor(s): Chris Plaisier, Sierra Wilferd, Choung Hoang
Keywords(s): Cancer, Drug, Drug Discovery
Category(s): Pharmaceuticals, Cancer, Cancer Therapeutics, Artificial Intelligence/Machine Learning, Computing & Information Technology, Life Science (All LS Techs)
Novel Human C3 Derivatives for Therapeutic Complement Depletion
The complement system is part of the immune system and is important in both innate and adaptive immunity. However, the complement system can also be a pathogenetic factor in many diseases including, rheumatoid arthritis, reperfusion injury, myasthenia gravis, and more. Complement has also been shown to be important for the development of antibodies...
Published: 11/11/2024   |   Inventor(s): Carl-Wilhelm Vogel, Paul Finnegan, Julie Rayes, Sebastien Lacroix-Desmazes
Keywords(s):  
Category(s): Cancer Therapeutics, Life Science (All LS Techs), Non-Cancer Therapeutics, Pharmaceuticals
RNA Sensor Platform for Targeting Cancer Fusion Genes and Transcripts
Many cancers have recurrent chromosomal translocations leading to the fusion of two genes. Often, said cancers are aggressive, have a poor prognosis with metastasis or recurrence, and do not have effective and targeted treatment. The challenge of many fusion-positive cancers is the lack of established targets downstream of the gene fusion despite years...
Published: 10/8/2024   |   Inventor(s): Albert Cheng, Ching Lau, Nathaniel Jilette, Jacqueline Jufen Zhu
Keywords(s):  
Category(s): Cancer, Cancer Therapeutics, Chemical/Biological Sensors, Genomic Assays/Reagents/Tools, Life Science (All LS Techs)
Accurate Tracking and Measurement of Intercellular Mitochondrial Transfer
Opportunity Mitochondria are commonly referred to as the powerhouse of the cell, and any change in mitochondrial function can drastically alter normal cell function. Diseases including neurodegeneration and cancer have been linked to changes in mitochondrial transfer between cells, which can weaken the functioning of healthy cells. Although studying...
Published: 3/14/2024   |   Inventor(s): Simon Grelet, Greg Hoover
Keywords(s):  
Category(s): All Technologies, Cancer Therapeutics, Research Tools, Screening Tests
Targeted Therapy for Triple-Negative Breast Cancer
Breast cancer is the second leading cause of death in women and is the most common cancer among women worldwide. There are four main breast cancer subtypes, luminal A, luminal B, HER2-positive and triple-negative. Triple-negative breast cancer (TNBC) is highly invasive and has higher rates of metastasis and a worse prognosis. Metastasis of cancer cells...
Published: 9/12/2023   |   Inventor(s): Shengxi Chen, Xiaojiang Cui, Yi Zhang, Sidney Hecht
Keywords(s):  
Category(s): Life Science (All LS Techs), Advanced Materials/Nanotechnology, Cancer, Cancer Therapeutics, Pharmaceuticals
CRISPR Platform & Portfolio
While genomic research has identified many genetic targets that have the potential to modify the course of a disease, there has been little translation of that into genetic therapies. However, the discovery of clustered regularly interspaced short palindromic repeat (CRISPR) segments and the subsequent development of CRISPR systems in 2011 revolutionized...
Published: 6/8/2023   |   Inventor(s): Radwa Ewaisha, Shayesteh Roshdi Ferdosi, Karen Anderson, Sri Krishna, Farzaneh Moghadam, Samira Kiani, Mo Reza Ebrahimkhani
Keywords(s):  
Category(s): Bioanalytical Assays, Chemistries & Devices, Cancer Therapeutics, Genomic Assays/Reagents/Tools, Life Science (All LS Techs), Non-Cancer Therapeutics, Pharmaceuticals
CRISPR Platform & Portfolio
While genomic research has identified many genetic targets that have the potential to modify the course of a disease, there has been little translation of that into genetic therapies. However, the discovery of clustered regularly interspaced short palindromic repeat (CRISPR) segments and the subsequent development of CRISPR systems in 2011 revolutionized...
Published: 6/8/2023   |   Inventor(s): Samira Kiani, Mo Reza Ebrahimkhani, Swechchha Pradhan, Farzaneh Moghadam
Keywords(s):  
Category(s): Life Science (All LS Techs), Pharmaceuticals, Non-Cancer Therapeutics, Genomic Assays/Reagents/Tools, Bioanalytical Assays, Chemistries & Devices, Cancer Therapeutics
Compounds to Modulate Retinoid X Receptors
The human retinoid X receptors (RXRs) function as transcriptional regulators, often in partnership with members of a larger nuclear receptor family of transcription factors. RXR agonists have been shown to modulate RXR transcription and activate or repress various biological pathways and effect therapeutic results for various conditions.There are a...
Published: 4/14/2023   |   Inventor(s): Carl Wagner, Peter Jurutka, Pamela Marshall
Keywords(s):  
Category(s): Cancer Therapeutics, Life Science (All LS Techs), Non-Cancer Therapeutics, Neurodegenerative Disease Technologies, Pharmaceuticals
Tumor-Targeted Killing with Aptamer-Nucleic Acid Nanostructures
Despite decades of research, cancer remains one of today’s most pressing health concerns. Traditional treatment approaches such as radiation therapy and chemotherapy can cause systemic toxicity and become ineffective when resistant tumors emerge. Recently, anticancer strategies have focused on drugs which specifically target tumor-related biological...
Published: 4/14/2023   |   Inventor(s): Yung Chang, Hao Yan
Keywords(s): Bio-Technology, Drug Screening, Therapeutics
Category(s): Life Science (All LS Techs), Cancer Therapeutics, Genomic Assays/Reagents/Tools
Creation of Multivalent Aptamers to Target Effector T Cells to Attack Tumor Cells
Despite decades of research effort, cancer remains one of today’s most pressing health concerns. Present day treatment methods tend to include debilitating side effects mainly due to low specificity of the treatments. Recently, some attempts have been made to augment tumor immunity by using bi-specific, hybrid antibodies that direct immune cells...
Published: 4/14/2023   |   Inventor(s): Yung Chang, Hao Yan
Keywords(s):  
Category(s): Life Science (All LS Techs), Cancer Therapeutics, Genomic Assays/Reagents/Tools, Pharmaceuticals
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