Search Results - neurodegenerative+disease

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Cell-type specific disruption of M1 muscarinic acetylcholine receptor expression to alleviate Parkinson's disease
NU 2024-244 INVENTORS Dalton J. Surmeier Jr* Tatiana Tkatch Shenyu Zhai SHORT DESCRIPTION Gene therapy targeting M1 muscarinic receptor expression in striatal spiny projection neurons to enhance levodopa response and slow Parkinson’s Disease progression. BACKGROUND Parkinson’s Disease (PD) is the second most common age-related...
Published: 4/4/2025   |   Inventor(s):  
Keywords(s): Neurodegenerative disease, Neurologic disease
Category(s): Life Sciences > Therapeutics
Gene therapy for levodopa-induced dyskinesia
NU 2024-086 INVENTORS Dalton J. Surmeier Jr* Weixing Shen Shenyu Zhai Tatiana Tkatch Qiaoling Cui Zhong Xie SHORT DESCRIPTION Gene therapy targeting GRIN2B in striatal spiny projection neurons to treat levodopa-induced dyskinesia. BACKGROUND Parkinson’s Disease (PD) is the second most common age-related neurodegenerative disease...
Published: 4/4/2025   |   Inventor(s):  
Keywords(s): Neurodegenerative disease, Neurologic disease, Neurology, Parkinson's Disease
Category(s): Life Sciences > Therapeutics
Targeting Calcium Channels to treat Early-Stage Parkinson’s Disease
NU 2024-179 INVENTORS Dalton J. Surmeier Jr* Jack Nguyen SHORT DESCRIPTION Novel compounds to inhibit Cav1.3 calcium channels and slow the progression of Parkinson's Disease. BACKGROUND Parkinson’s Disease (PD) is the second most common age-related neurodegenerative disease after Alzheimer’s Disease, affecting nearly one million...
Published: 4/4/2025   |   Inventor(s):  
Keywords(s): Neurodegenerative disease, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
Therapeutic Intervention for ALS and Dementia
NU 2021-058 INVENTORS Evangelos Kiskinis* Juan Alberto Ortega Cano Marco Boccitto SHORT DESCRIPTION Design of an RNA-based oligonucleotide that protects from dipeptide repeat protein toxicity for the treatment of ALS and FTD. BACKGROUND Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are devastating neurodegenerative diseases...
Published: 3/3/2025   |   Inventor(s):  
Keywords(s): Neurodegenerative disease, Therapeutics
Category(s): Life Sciences > Therapeutics
TauSeeK: Disease Specific Tau Protein Fibrils & Seeding Proteins
NU2024-139 INVENTORS Austin Dubose Michael Vigers Andrew Longhini Vishnu Vijayan Kenneth Kosik Sam Lobo Peter C. Ryffel Songi Han* SHORT DESCRIPTION Compositions, kits, and methods for generating synthetic miniature tau peptides and fibrils, and synthetic full-length pathogenic tau fibrils. BACKGROUND A major hallmark of several neurodegenerative...
Published: 3/3/2025   |   Inventor(s):  
Keywords(s): Neurodegenerative disease, Research tool, Synthetic biology
Category(s): Life Sciences > Therapeutics
A peptidomimetic for LIMP-2 based activation of Glucocerebrosidase as a Gaucher/Parkinson’s Disease therapeutic
NU 2016-019 INVENTORS Dimitri Krainc* Michael Schwake SHORT DESCRIPTION LIMP-2-based peptidomimetic compounds to facilitate glucocerebrosidase activation in Gaucher and Parkinson’s Disease BACKGROUND Mutations in glucocerebrosidase (GCase) cause Gaucher Disease. Additionally, GCase mutations are a major risk factor in Parkinson’s Disease,...
Published: 10/17/2024   |   Inventor(s):  
Keywords(s): Neurodegenerative disease, Neurologic disease, Therapeutics
Category(s): Life Sciences > Therapeutics
Pharmacotherapy for Preventing Neurodegeneration
NU 2016-108 INVENTORS D. James Surmeier* Steven M. Graves SHORT DESCRIPTION Small molecule therapeutics to prevent neurological degeneration associated with other pharmaceutical treatments ABSTRACT Methamphetamine and amphetamine are pharmaceutical drugs sometimes used to treat attention definicity hyperactive disorder (ADHD), obesity, and narcolepsy....
Published: 4/4/2025   |   Inventor(s):  
Keywords(s): Neurodegenerative disease, Neurologic disease, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
Gene Therapy for Parkinson's Disease
NU 2021-039 INVENTORS D. James Surmeier* Michael Kaplitt Patricia Gonzalez Rodriguez SHORT DESCRIPTION A simple neurological procedure to treat late-stage Parkinson’s Disease patients BACKGROUND Approximately 60,000 Americans are diagnosed with Parkinson’s Disease (PD) each year. Although levodopa has been the gold-standard for symptomatic...
Published: 4/4/2025   |   Inventor(s):  
Keywords(s): Gene therapy, Neurodegenerative disease, Therapeutics
Category(s): Life Sciences > Therapeutics
Combination Treatment to Reduce Pathological Proteins in Neurodegenerative and Lysosomal Storage Diseases
NU 2021-206 INVENTORS Joseph Mazzulli* Iva Stojkovska SHORT DESCRIPTION A small molecule combination treatment to improve lysosomal function in neurodegenerative and lysosomal storage diseases BACKGROUND Many neurodegenerative disorders are characterized by a collapse in proteostasis, as shown by the accumulation of insoluble protein aggregates...
Published: 4/4/2025   |   Inventor(s):  
Keywords(s): Biomedical, Neurodegenerative disease, Small molecule
Category(s): Life Sciences > Therapeutics
Targeting specific neurons for personalized next-gen therapeutics
Technology summary Neurological and cognitive disorders such as epilepsy, pain, fear and anxiety, depression, addiction, apnea and tremors can result from aberrant activity of defined subsets of neurons, including an imbalance of excitatory versus inhibitory signaling. However, it is difficult to alter neuron function selectively in the brain for research...
Published: 11/1/2023   |   Inventor(s): Boris Zemelman
Keywords(s): Genetic engineering, Neurodegenerative disease, Neurology, Neurosciences
Category(s): Life sciences > Therapeutics > Gene therapy
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