Search Results - neurodegenerative+disease

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LIMP-2 based activation of Glucocerebrosidase
A peptidomimetic for LIMP-2 based activation of Glucocerebrosidase as a Gaucher/Parkinson’s Disease therapeutic NU 2016-019 INVENTORS Dimitri Krainc* Michael Schwake SHORT DESCRIPTION LIMP-2-based peptidomimetic compounds to facilitate glucocerebrosidase activation in Gaucher and Parkinson’s Disease BACKGROUND Mutations in glucocerebrosidase...
Published: 7/3/2024   |   Inventor(s):  
Keywords(s): Neurodegenerative disease, Neurologic disease, Therapeutics
Category(s): Life Sciences > Therapeutics
Pharmacotherapy for Preventing Neurodegeneration
NU 2016-108 INVENTORS D. James Surmeier* Steven M. Graves SHORT DESCRIPTION Small molecule therapeutics to prevent neurological degeneration associated with other pharmaceutical treatments ABSTRACT Methamphetamine and amphetamine are pharmaceutical drugs sometimes used to treat attention definicity hyperactive disorder (ADHD), obesity, and narcolepsy....
Published: 7/3/2024   |   Inventor(s):  
Keywords(s): Neurodegenerative disease, Neurologic disease, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
Gene Therapy for Parkinson's Disease
NU 2021-039 INVENTORS D. James Surmeier* Michael Kaplitt Patricia Gonzalez Rodriguez SHORT DESCRIPTION A simple neurological procedure to treat late-stage Parkinson’s Disease patients BACKGROUND Approximately 60,000 Americans are diagnosed with Parkinson’s Disease (PD) each year. Although levodopa has been the gold-standard for symptomatic...
Published: 7/3/2024   |   Inventor(s):  
Keywords(s): Gene therapy, Neurodegenerative disease, Therapeutics
Category(s): Life Sciences > Therapeutics
Combination Treatment to Reduce Pathological Proteins in Neurodegenerative and Lysosomal Storage Diseases
NU 2021-206 INVENTORS Joseph Mazzulli* Iva Stojkovska SHORT DESCRIPTION A small molecule combination treatment to improve lysosomal function in neurodegenerative and lysosomal storage diseases BACKGROUND Many neurodegenerative disorders are characterized by a collapse in proteostasis, as shown by the accumulation of insoluble protein aggregates...
Published: 7/3/2024   |   Inventor(s):  
Keywords(s): Biomedical, Neurodegenerative disease, Small molecule
Category(s): Life Sciences > Therapeutics
Targeting specific neurons for personalized next-gen therapeutics
Technology summary Neurological and cognitive disorders such as epilepsy, pain, fear and anxiety, depression, addiction, apnea and tremors can result from aberrant activity of defined subsets of neurons, including an imbalance of excitatory versus inhibitory signaling. However, it is difficult to alter neuron function selectively in the brain for research...
Published: 11/1/2023   |   Inventor(s): Boris Zemelman
Keywords(s): Genetic engineering, Neurodegenerative disease, Neurology, Neurosciences
Category(s): Life sciences > Therapeutics > Gene therapy
Production of Cholinergic Neurons From Stem Cells
NU 2009-173 Inventors Christopher Bissonnette John Kessler* Short Description Novel method for generating functional human cholinergic neurons from stem cellsAbstractNorthwestern researchers have developed a method to generate fully functional human basal forebrain cholinergic neurons (BFCNs) from stem cells, which holds promise for Alzheimer's Disease...
Published: 7/3/2024   |   Inventor(s):  
Keywords(s): Neurodegenerative disease, Platform technology, Stem cell
Category(s): Life Sciences > Therapeutics
Nanostructures for Diagnosis and Therapy of Alzheimer's Disease
NU 2009-169 Inventors Vinayak Dravid* Saurabh Sharma Kristen Viola William Klein* Short Description Novel magnetic nanostructures that recognize toxic beta-amyloid protein oligomers responsible for Alzheimer's disease progression Abstract Northwestern University researchers have developed a new magnetic nanostructure that can be used to detect and...
Published: 7/3/2024   |   Inventor(s):  
Keywords(s): Biomarker, Devices, Diagnostics, Health IT, Medical device, Nanoparticle, Neurodegenerative disease, Neurologic disease, Research tool, Therapeutics
Category(s): Life Sciences > Healthcare Devices, Tools & IT
Tau-7: Monoclonal Antibody Specific for the C-Terminus of Tau
NU 2008-109InventorLester BinderShort DescriptionTau-7 is a mouse monoclonal antibody (mAb) that binds to the carboxy terminal region of human tau. AbstractResearcher Lester Binder has created a series of useful antibodies that are specific for the human tau protein. This particular antibody, Tau-7 mAb, is of the IgG1 isotype and would be useful to...
Published: 7/3/2024   |   Inventor(s):  
Keywords(s): Antibody, Diagnostics, Imaging, Neurodegenerative disease, Research tool
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
A Genetic Marker for ALS
NU 2013-046 Inventors Faisal Fecto Teepu Siddique* Short Description Novel diagnostic biomarker for amyotrophic lateral sclerosis (ALS) Abstract Northwestern researchers have identified a novel gene, SQSTM1, for potential use in development of diagnostic tools for ALS. Presently, patients are diagnosed based on clinical, electrophysiological and...
Published: 7/3/2024   |   Inventor(s):  
Keywords(s): Biomarker, Diagnostics, Neurodegenerative disease, Research tool
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
Selective Human Sirtuin-2 Inhibitors, the Therapeutic Candidate for Huntington's Disease
NU 2012-145InventorsRichard Silverman*Hua WangMohammad KhanfarAleksey KazantsevShort DescriptionSelective human sirtuin-2 inhibitors for use in treating Huntington's diseaseAbstractNorthwestern researchers have discovered a new series of selective human sirtuin-2 inhibitors which show excellent neuronal protection in the Huntington's disease model....
Published: 7/3/2024   |   Inventor(s):  
Keywords(s): Neurodegenerative disease, Neurologic disease, Therapeutics
Category(s): Life Sciences > Therapeutics
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