Search Results - pd+-+parkinson%27s+disease

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Cell-type specific disruption of M1 muscarinic acetylcholine receptor expression to alleviate Parkinson's disease
NU 2024-244 INVENTORS Dalton J. Surmeier Jr* Tatiana Tkatch Shenyu Zhai SHORT DESCRIPTION Gene therapy targeting M1 muscarinic receptor expression in striatal spiny projection neurons to enhance levodopa response and slow Parkinson’s Disease progression. BACKGROUND Parkinson’s Disease (PD) is the second most common age-related...
Published: 8/5/2025   |   Inventor(s):  
Keywords(s): CNS - Central Nervous System, Neurodegenerative disease, Neurologic disease, Neurology, PD - Parkinson's Disease
Category(s): Life Sciences > Therapeutics
Gene therapy for levodopa-induced dyskinesia
NU 2024-086 INVENTORS Dalton J. Surmeier Jr* Weixing Shen Shenyu Zhai Tatiana Tkatch Qiaoling Cui Zhong Xie SHORT DESCRIPTION Gene therapy targeting GRIN2B in striatal spiny projection neurons to treat levodopa-induced dyskinesia. BACKGROUND Parkinson’s Disease (PD) is the second most common age-related neurodegenerative disease...
Published: 8/5/2025   |   Inventor(s):  
Keywords(s): CNS - Central Nervous System, Neurodegenerative disease, Neurologic disease, Neurology, PD - Parkinson's Disease
Category(s): Life Sciences > Therapeutics
Targeting Calcium Channels to treat Early-Stage Parkinson’s Disease
NU 2024-179 INVENTORS Dalton J. Surmeier Jr* Jack Nguyen SHORT DESCRIPTION Novel compounds to inhibit Cav1.3 calcium channels and slow the progression of Parkinson's Disease. BACKGROUND Parkinson’s Disease (PD) is the second most common age-related neurodegenerative disease after Alzheimer’s Disease, affecting nearly one million...
Published: 8/5/2025   |   Inventor(s):  
Keywords(s): CNS - Central Nervous System, Neurodegenerative disease, Neurology, PD - Parkinson's Disease, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
A peptidomimetic for LIMP-2 based activation of Glucocerebrosidase as a Gaucher/Parkinson’s Disease therapeutic
NU 2016-019 INVENTORS Dimitri Krainc* Michael Schwake SHORT DESCRIPTION LIMP-2-based peptidomimetic compounds to facilitate glucocerebrosidase activation in Gaucher and Parkinson’s Disease BACKGROUND Mutations in glucocerebrosidase (GCase) cause Gaucher Disease. Additionally, GCase mutations are a major risk factor in Parkinson’s Disease,...
Published: 8/5/2025   |   Inventor(s):  
Keywords(s): Neurodegenerative disease, Neurologic disease, PD - Parkinson's Disease, Therapeutics
Category(s): Life Sciences > Therapeutics
Gene Therapy for Parkinson's Disease
NU 2021-039 INVENTORS D. James Surmeier* Michael Kaplitt Patricia Gonzalez Rodriguez SHORT DESCRIPTION A simple neurological procedure to treat late-stage Parkinson’s Disease patients BACKGROUND Approximately 60,000 Americans are diagnosed with Parkinson’s Disease (PD) each year. Although levodopa has been the gold-standard for symptomatic...
Published: 8/5/2025   |   Inventor(s):  
Keywords(s): CNS - Central Nervous System, Gene therapy, Neurodegenerative disease, Neurology, PD - Parkinson's Disease, Therapeutics
Category(s): Life Sciences > Therapeutics
Combination Treatment to Reduce Pathological Proteins in Neurodegenerative and Lysosomal Storage Diseases
NU 2021-206 INVENTORS Joseph Mazzulli* Iva Stojkovska SHORT DESCRIPTION A small molecule combination treatment to improve lysosomal function in neurodegenerative and lysosomal storage diseases BACKGROUND Many neurodegenerative disorders are characterized by a collapse in proteostasis, as shown by the accumulation of insoluble protein aggregates...
Published: 8/5/2025   |   Inventor(s):  
Keywords(s): AD - Alzheimer’s Disease, Biomedical, Neurodegenerative disease, Neurology, PD - Parkinson's Disease, Small molecule
Category(s): Life Sciences > Therapeutics
Deep Learning Structural Analysis Of Cerebral Cortex Predicts Features From MRI Data
NU 2020-152 INVENTORS Pierre Alain Besson S. Kathleen Bandt* SHORT DESCRIPTION Graph convolutional neural networks (gCNNs) successfully predict patient age and sex from T1-weighted brain surface MRI data. BACKGROUND As clinical image-based data sets grow in resolution and size, the promise of machine learning greatly expedites image classification...
Published: 8/5/2025   |   Inventor(s):  
Keywords(s): AD - Alzheimer’s Disease, Artificial Intelligence & Machine Learning, Computer software, CVA - Cerebrovascular Accident, Data processing/analysis, Image/Signal processing, Neurologic disease, PD - Parkinson's Disease
Category(s): Life Sciences > Healthcare Devices, Tools & IT
Selective Human Sirtuin-2 Inhibitors, the Therapeutic Candidate for Huntington's Disease
NU 2012-145InventorsRichard Silverman*Hua WangMohammad KhanfarAleksey KazantsevShort DescriptionSelective human sirtuin-2 inhibitors for use in treating Huntington's diseaseAbstractNorthwestern researchers have discovered a new series of selective human sirtuin-2 inhibitors which show excellent neuronal protection in the Huntington's disease model....
Published: 8/5/2025   |   Inventor(s):  
Keywords(s): AD - Alzheimer’s Disease, Neurodegenerative disease, Neurologic disease, PD - Parkinson's Disease, Therapeutics
Category(s): Life Sciences > Therapeutics
Stable, Potent Compounds to Selectively Inhibit Neuronal Nitric Oxide Production
NU 2011-053 Inventors Haitao Mark Ji Richard B. Silverman* He Huang Abstract Nitric oxide (NO) is a critical neurotransmitter. Overproduction of NO has been implicated in a variety of neurological diseases, including Parkinson's, Alzheimer's, and Huntington's, as well as neuronal damage occurring in stroke patients. Inhibitors of the enzyme...
Published: 8/5/2025   |   Inventor(s):  
Keywords(s): AD - Alzheimer’s Disease, CVA - Cerebrovascular Accident, Neurologic disease, Neurology, PD - Parkinson's Disease, Research reagent, Research tool, Therapeutics
Category(s): Life Sciences > Therapeutics
MAP Kinase Targeted Therapeutics
NU 2006-087 InventorsLinda J. Van Eldik Daniel Martin Watterson* AbstractNorthwestern researchers have identified and validated a novel compound with significant potential in the treatment of neurological diseases. In addition to the specific compound, this invention includes medicinal chemistry refinement which improves the bioavailability of small...
Published: 8/5/2025   |   Inventor(s):  
Keywords(s): AD - Alzheimer’s Disease, Neurologic disease, PD - Parkinson's Disease, Therapeutics
Category(s): Life Sciences > Therapeutics