Search Results - assay

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Swabseq Universal Pathogen Diagnostic Platform (Case No. 2026-121)
Summary: UCLA researchers in the Department of Computer Science have developed a next-generation universal pathogen diagnostic platform combining scalable genomic sequencing, simplified laboratory workflows, and integrated logistics infrastructure to enable rapid, low-cost, high-throughput infectious disease detection. Background: The rise of pathogen-specific...
Published: 6/5/2026   |   Updated: 6/5/2026   |   Inventor(s): Eleazar Eskin, Valerie Arboleda, Chongyuan Luo, Taryn Jakub, Traci Toy
Keywords(s): AI-guided diagnostics, Assay, Computer-Aided Diagnosis, COVID-19, Diagnostic Markers & Platforms, diagnostic platforms, Diagnostic Test, diagnostics, Infectious Diseases, Infrastructure, Medical diagnostics, metagenomic diagnostic platform, Pathogen, platform technology, scalable platform
Category(s): Therapeutics > Infectious Diseases, Therapeutics > Infectious Diseases > COVID, Software & Algorithms > Digital Health, Software & Algorithms, Platforms > Diagnostic Platform Technologies, Platforms, Diagnostic Markers, Diagnostic Markers > Targets And Assays
Enzyme-Based Method for the Amplified Detection of Molecules on Particles (Case No. 2026-130)
Summary: UCLA researchers in the Department of Bioengineering have developed a novel enzyme-based particle platform that enables amplified molecular detection in fully aqueous systems for sensitive, multiplexed analysis of low-abundance analytes. Background: The detection of molecules and determination of enzymatic activity are foundational across...
Published: 6/5/2026   |   Updated: 6/5/2026   |   Inventor(s): Alyssa Arnheim, Dino Di Carlo
Keywords(s): Antibody, Aptamers, Assay, barcode, Biomarker, Biosensor, Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Drug Discovery, ELISA, enzyme functionalization, Enzyme Substrate (Biology), Flow Cytometry, Fluorescence, High-Throughput Screening, hydrogel, Immunoassay, Medical diagnostics, microparticles, Molecular Biology, multiplexed analysis, multiplexing, Nucleic Acids, protein, Signal-To-Noise Ratio
Category(s): Diagnostic Markers > Targets And Assays, Diagnostic Markers, Platforms > Diagnostic Platform Technologies, Chemical > Chemical Sensors, Life Science Research Tools > Antibodies
High Sensitivity and Specificity Biosensor
This sensor architecture enables signal amplification for detection of biomarkers and analytes at extremely low concentration Background Molecular diagnostics increasingly rely on sensitive detection of biomarkers such as nucleic acids, proteins, and cytokines in complex biological samples. Traditional biosensor probes often suffer from signal...
Published: 5/9/2026   |   Updated: 5/9/2026   |   Inventor(s): Li-Jing Cheng, Ye Liu
Keywords(s): analyte, assay, biomarkers, biosensor, diagnostic, immunoassay, magnetic nanoparticles, molecular diagnostics, molecular probe, multiplexed detection, nanoparticle, nanoparticles, plasmonics, raman system, sensor, signal amplification
Category(s): Diagnostics
Inclusion Body–Based Expression Platform for PTM-Preserved Proteins (PIInBody)
Enables high-yield production of unstable, post-translationally modified proteins by protecting them during expression and gentle release Background Intrinsically disordered proteins (IDPs), particularly those carrying labile post-translational modifications (PTMs), are difficult to produce recombinantly due to degradation, aggregation, and loss...
Published: 5/9/2026   |   Updated: 2/19/2026   |   Inventor(s): Richard Cooley, Cat Vesely, Ryan Mehl
Keywords(s): antibody, architecture, assay, assay development, bacterial, bacterial expression system, binders, cancer, code, denaturing, diagnostic, drug development, enzymatic, epitope, expression platform, expression system, fusion, homogeneous, inclusion, isotopic, isotopic labeling, mass spectrometry, neurodegeneration, post-translational, protein, purification, reagent, recombinant, screening assays, structural biology
Category(s): Biological Materials
Multi-Particle System for Capture and Detection of Cellular and Molecular Analytes (Case No. 2025-267)
Summary: UCLA researchers in the Department of Bioengineering have developed a novel multi-particle system that selectively confines cells and molecular reactions within cavities formed by interacting particles. Background: Screening and selecting cells with specific, beneficial traits has become a vital process in using cell-derived products...
Published: 10/20/2025   |   Updated: 7/29/2025   |   Inventor(s): Dino Di Carlo, Alyssa Arnheim, Michael Mellody, Yuta Nakagawa, Lily Shang
Keywords(s): Assay, B Cell, barcode, Bioassay, biological assays, Biomarker, biomarkers, Biomaterial, capping particles, CAR-T cell platform, CAR-T cell therapy, cavities, cavity-containing particles, Cell and tissue culture, cell encapsulation, cell engineering, cell imaging, cell mapping, cell sorting, cell type identification, cell-based therapy, centrifugation, confinement, Diagnostic Platform Technologies (E.G. Microfluidics), Digital Microfluidics, Drug, Drug Delivery, Drug Discovery, drug screening, high throughput, high throughput assays, high throughput testing, high-throughput analysis, High-Throughput Screening, Immunoassay, Immunoassay Sense (Molecular Biology), Microfluidics, Microfluidics And Mem's, Microfluidics Nanosphere, microparticles, moieties, Nanoparticle, single cell analysis, single cell analysis and testing, Single cell data, single-cell resolution, single-cell trapping
Category(s): Life Science Research Tools, Life Science Research Tools > Cell Counting And Imaging, Life Science Research Tools > Lab Equipment, Life Science Research Tools > Microscopy And Imaging, Life Science Research Tools > Microfluidics And Mems, Medical Devices, Platforms
Deep Learning-Enhanced Paper-Based Vertical Flow Assay for High-Sensitivity Troponin Detection Using Nanoparticle Amplification (Case No. 2024-179)
Summary: UCLA researchers from the Departments of Electrical and Computer Engineering and Bioengineering have developed a novel assay for point-of-care testing for acute myocardial infarction. Background: Cardiovascular diseases are responsible for a substantial number of deaths and economic burdens. Acute myocardial infarction (AMI) is an event...
Published: 2/14/2025   |   Updated: 6/5/2024   |   Inventor(s): Aydogan Ozcan, Gyeo-Re Han, Artem Goncharov, Hyouarm Joung, Dino Di Carlo
Keywords(s): acute myocardial infarction, Assay, Bioassay, biological assays, cardiometabolic disease, cardiopulmonary illness, Cardiovascular, Cardiovascular Disease, Cardiovascular Disease Nephropathy, cardiovascular diseases, cardiovascular modeling, cardiovascular prediction, cardiovascular therapeutic solution, deep-learning analysis algorithms, Flow Device, heart disease mitigation, high-sensitivity cardiac troponin I, Immunoassay, Laminar flow, nanoparticle amplification chemistry, point-of-care testing, Targets And Assays, vertical flow assay
Category(s): Medical Devices, Medical Devices > Monitoring And Recording Systems, Platforms, Platforms > Diagnostic Platform Technologies, Diagnostic Markers, Diagnostic Markers > Targets And Assays
Stain-Free, Rapid, and Quantitative Viral Plaque Assay Using Deep Learning and Holography (Case No. 2022-326)
Intro Sentence: UCLA researchers in the Department of Electrical and Computer Engineering have developed a rapid and stain-free quantitative assay using lens-free holography and deep learning to efficiently and cost-effectively determine the presence of viral plaque-forming units (PFUs) in samples. Background: A broad range of viruses have caused...
Published: 2/14/2025   |   Updated: 8/11/2023   |   Inventor(s): Aydogan Ozcan, Yuzhu Li, Tairan Liu
Keywords(s): Antiviral Drug, Artifical Intelligence (Machine Learning, Data Mining), Assay, Bioassay, Computer Aided Learning, Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Diagnostic Test, Digital Holography, Electrical, Electrical Brain Stimulation, Electrical Breakdown, Electrical Engineering, Electrical Impedance, Electrical Load, Electrical Load Equation Of State, Electrical Resistance And Conductance, Electrical Resistivity And Conductivity, Holography, Immunoassay, Immunoassay Sense (Molecular Biology), Lentivirus Viral Vector, Machine Learning, Machine Learning Autonomous Car Gradient Descent, Machine Learning Pain Management, Machine Learning Particulates Global Climate Model, Network Analysis (Electrical Circuits), Perceptual Learning, Plasmid Trabecular Meshwork Aqueous Humour Viral Vector, Targets And Assays, Transcutaneous Electrical Nerve Stimulation, Transfection Viral Vector, Unsupervised Learning , Viability Assay, Viral Delivery Systems, Viral Envelope, Viral Load
Category(s): Diagnostic Markers, Diagnostic Markers > Targets And Assays, Electrical, Life Science Research Tools, Life Science Research Tools > Research Methods, Life Science Research Tools > Other Reagents, Software & Algorithms > Artificial Intelligence & Machine Learning
A Sensitive, High Throughput Pseudovirus-Based Papillomavirus Neutralization Assay for HPV 16 and HPV 18
Abstract: Human Papilloma Viruses (HPV) is a very common virus; nearly 80 million people—about one in four—are currently infected in the United States. HPV is a group of more than 150 related viruses. Each HPV virus in this large group is given a number which is called its HPV type. HPV is named for the warts (papillomas) some that HPV types can cause....
Published: 4/22/2025   |   Updated: 8/2/2023   |   Inventor(s): John Schiller, Christopher Buck, Diana Pastrana, Douglas Lowy, Richard Roden
Keywords(s): assay, bovine papillomavirus, HPV, Human Papilloma Viruses
Category(s): TherapeuticArea > Infectious Disease, Application > Research Materials, TherapeuticArea > Oncology, Collaboration Sought > Licensing
A Rabbit Anti-pT1989 ATR Monoclonal Antibody for Use in Immunoassays
Abstract: Ataxia telangiectasia mutated and Rad3 Related (ATR) protein kinase is essential for regulating DNA damage checkpoints during the cell cycle. ATR, is phosphorylated at threonine 1989 site (T1989) in response to DNA damage and ATR activation leads to activation of downstream substrates, signaling cascades and cell cycle arrest. ATR is a potential...
Published: 4/22/2025   |   Updated: 8/2/2023   |   Inventor(s): Thomas Pfister, Allison Marrero, Ralph Parchment, James Doroshow, Robert Kinders
Keywords(s): ANTIBODY, assay, Ataxia telangiectasia mutated and Rad3-related kinase, CANCER, diagnostic, DNA checkpoint, monoclonal
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Diagnostics
Molecular Classification of Primary Mediastinal Large B Cell Lymphoma Using Formalin-Fixed, Paraffin-Embedded Tissue Specimens
Description of Technology: Primary mediastinal B-cell lymphoma (PMBCL) is an aggressive type of non-Hodgkin lymphoma that mostly occurs in people between the ages of 30-40. It accounts for 5-7% of all aggressive lymphomas. The diagnosis of PMBCL is challenging as the histological features of PMBCL overlap with diffuse large B-cell lymphoma (DLBCL),...
Published: 4/24/2026   |   Updated: 8/2/2023   |   Inventor(s): Louis Staudt, Lisa Rimsza, David Scott, George Wright, Anja Mottok, Christian Steid, Elaine Jaffe, Randy Gascoyne, Elias Guerri, Elias Guerri, Elias Guerri, Andreas Rosenwald, Kai Fu, Timothy Greiner, Erlend Smeland, Jan Delabie, Rita Braziel, Wing Chan, Joo Song, Dennis Weisenburger, German Ott, James Cook
Keywords(s): assay, Diffuse Large B Cell Lymphoma, DLBCL, FFPE, Formalin-fixed, GENE EXPRESSION, paraffin-embedded biopsies, PMBCL, Primary Mediastinal Large B Cell Lymphoma, Staudt
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Diagnostics
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