Search Results - assay

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Deep Learning-Enhanced Paper-Based Vertical Flow Assay for High-Sensitivity Troponin Detection Using Nanoparticle Amplification (Case No. 2024-179)
Summary: UCLA researchers from the Departments of Electrical and Computer Engineering and Bioengineering have developed a novel assay for point-of-care testing for acute myocardial infarction. Background: Cardiovascular diseases are responsible for a substantial number of deaths and economic burdens. Acute myocardial infarction (AMI) is an event...
Published: 2/14/2025   |   Inventor(s): Aydogan Ozcan, Gyeo-Re Han, Artem Goncharov, Hyouarm Joung, Dino Di Carlo
Keywords(s): acute myocardial infarction, Assay, Bioassay, biological assays, cardiometabolic disease, cardiopulmonary illness, Cardiovascular, Cardiovascular Disease, Cardiovascular Disease Nephropathy, cardiovascular diseases, cardiovascular modeling, cardiovascular prediction, cardiovascular therapeutic solution, deep-learning analysis algorithms, Flow Device, heart disease mitigation, high-sensitivity cardiac troponin I, Immunoassay, Laminar flow, nanoparticle amplification chemistry, point-of-care testing, Targets And Assays, vertical flow assay
Category(s): Medical Devices, Medical Devices > Monitoring And Recording Systems, Platforms, Platforms > Diagnostic Platform Technologies, Diagnostic Markers, Diagnostic Markers > Targets And Assays
Stain-Free, Rapid, and Quantitative Viral Plaque Assay Using Deep Learning and Holography (Case No. 2022-326)
Intro Sentence: UCLA researchers in the Department of Electrical and Computer Engineering have developed a rapid and stain-free quantitative assay using lens-free holography and deep learning to efficiently and cost-effectively determine the presence of viral plaque-forming units (PFUs) in samples. Background: A broad range of viruses have caused...
Published: 2/14/2025   |   Inventor(s): Aydogan Ozcan, Yuzhu Li, Tairan Liu
Keywords(s): Antiviral Drug, Artifical Intelligence (Machine Learning, Data Mining), Assay, Bioassay, Computer Aided Learning, Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Diagnostic Test, Digital Holography, Electrical, Electrical Brain Stimulation, Electrical Breakdown, Electrical Engineering, Electrical Impedance, Electrical Load, Electrical Load Equation Of State, Electrical Resistance And Conductance, Electrical Resistivity And Conductivity, Holography, Immunoassay, Immunoassay Sense (Molecular Biology), Lentivirus Viral Vector, Machine Learning, Machine Learning Autonomous Car Gradient Descent, Machine Learning Pain Management, Machine Learning Particulates Global Climate Model, Network Analysis (Electrical Circuits), Perceptual Learning, Plasmid Trabecular Meshwork Aqueous Humour Viral Vector, Targets And Assays, Transcutaneous Electrical Nerve Stimulation, Transfection Viral Vector, Unsupervised Learning , Viability Assay, Viral Delivery Systems, Viral Envelope, Viral Load
Category(s): Diagnostic Markers, Diagnostic Markers > Targets And Assays, Electrical, Life Science Research Tools, Life Science Research Tools > Research Methods, Life Science Research Tools > Other Reagents, Software & Algorithms > Artificial Intelligence & Machine Learning
A Sensitive, High Throughput Pseudovirus-Based Papillomavirus Neutralization Assay for HPV 16 and HPV 18
Abstract: Human Papilloma Viruses (HPV) is a very common virus; nearly 80 million people—about one in four—are currently infected in the United States. HPV is a group of more than 150 related viruses. Each HPV virus in this large group is given a number which is called its HPV type. HPV is named for the warts (papillomas) some that HPV types can cause....
Published: 4/8/2024   |   Inventor(s): John Schiller, Christopher Buck, Diana Pastrana, Douglas Lowy, Richard Roden
Keywords(s): assay, bovine papillomavirus, HPV, Human Papilloma Viruses
Category(s): TherapeuticArea > Infectious Disease, Application > Research Materials, TherapeuticArea > Oncology, Collaboration Sought > Licensing
A Rabbit Anti-pT1989 ATR Monoclonal Antibody for Use in Immunoassays
Abstract: Ataxia telangiectasia mutated and Rad3 Related (ATR) protein kinase is essential for regulating DNA damage checkpoints during the cell cycle. ATR, is phosphorylated at threonine 1989 site (T1989) in response to DNA damage and ATR activation leads to activation of downstream substrates, signaling cascades and cell cycle arrest. ATR is a potential...
Published: 4/8/2024   |   Inventor(s): Thomas Pfister, Allison Marrero, Ralph Parchment, James Doroshow, Robert Kinders
Keywords(s): ANTIBODY, assay, Ataxia telangiectasia mutated and Rad3-related kinase, CANCER, diagnostic, DNA checkpoint, monoclonal
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Diagnostics
Molecular Classification of Primary Mediastinal Large B Cell Lymphoma Using Formalin-Fixed, Paraffin-Embedded Tissue Specimens
Abstract: Primary mediastinal B-cell lymphoma (PMBCL) is an aggressive type of non-Hodgkin lymphoma that mostly occurs in people between the ages of 30-40. It accounts for 5-7% of all aggressive lymphomas. The diagnosis of PMBCL is challenging as the histological features of PMBCL overlap with diffuse large B-cell lymphoma (DLBCL), another most common...
Published: 4/8/2024   |   Inventor(s): Louis Staudt, Lisa Rimsza, David Scott, George Wright, Anja Mottok, Christian Steid, Elaine Jaffe, Randy Gascoyne, Elias Guerri, Elias Guerri, Elias Guerri, Andreas Rosenwald, Kai Fu, Timothy Greiner, Erlend Smeland, Jan Delabie, Rita Braziel, Wing Chan, Joo Song, Dennis Weisenburger, German Ott, James Cook
Keywords(s): assay, Diffuse Large B Cell Lymphoma, DLBCL, FFPE, Formalin-fixed, GENE EXPRESSION, paraffin-embedded biopsies, PMBCL, Primary Mediastinal Large B Cell Lymphoma, Staudt
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Diagnostics
Genomics-based Diagnostic Assay for Cancer
Abstract: Molecular profiling with high throughput assays has gained utility in the management of select cancer patients and several gene expression-based assays are now marketed for improved prognostic accuracy for patients with cancer. This technology describes a genomics based diagnostic assay for the diagnosis and prognosis of cancer patients. ...
Published: 4/8/2024   |   Inventor(s): Steven Libutti, Mei He
Keywords(s): assay, CANCER, diagnostic, Genomics, PROGNOSIS
Category(s): Application > Diagnostics, TherapeuticArea > Oncology, Collaboration Sought > Licensing
DNA Methylation Based Non-invasive Blood Diagnostic Assay for Precision Cancer Detection and Classification
This technology includes a panel of 46 genomic loci of DNA methylation (represented by CpG dinucleotides on different chromosomes) with application in blood-based cancer screening. The markers robustly distinguish tumor from normal samples using 8 loci and classify 13 different tumor types. Using 39 loci, inventors were able to discriminate between...
Published: 10/28/2024   |   Inventor(s): Gennady Margolin, Laura Elnitski
Keywords(s): assay, Based, Blood, CANCER, CLASSIFICATION, Detection, diagnostic, DNA, Humans, Methylation, NON-INVASIVE, PRECISION, VCXXXX, WBXXXX, WIXXXX, XEXXXX
Category(s): Application > Research Materials, Application > Diagnostics, TherapeuticArea > Oncology, Application > Therapeutics
High-Throughput COVID-19 Diagnostic Test that Detects Both Viral and Host Nucleic Acid
The rapid worldwide spread and impact of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has created a need for accurate, reliable, and readily accessible testing on a massive scale. NIEHS researchers developed a massively paralleled multiplexed screening method using next generation sequencing (NGS). This method uses...
Published: 10/28/2024   |   Inventor(s): Brian Papa, Oswaldo Lozoya
Keywords(s): Acid, assay, DA4BXX, Diagnosis, HOST, Infection, Massively, Multi-patient, Nucleic, Paralleled, PATHOGENIC, PHYSIOLOGY, sequencing, Surveillance, VLXXXX, WBXXXX, XHXXXX, YAXXXX, YBXXXX, YFXXXX
Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Infectious Disease, ResearchProducts > Research Equipment, Application > Diagnostics
Real-Time PCR Assay for HIV-1 Subtype Diagnosis and Global Surveillance of Drug Resistance
CDC researchers have developed a patented set of RT-PCR and sequencing primers based on HIV-1 group M sequences. Evaluation of the primers using samples collected around the world demonstrated broad detection capacity for multiple HIV-1 group subtypes and predominant circulating recombinant forms. Commercially available HIV-1 drug resistance (HIVDR)...
Published: 10/28/2024   |   Inventor(s): Joshua Devos, Nicholas Wagar, Zhiyong Zhou, Chunfu Yang
Keywords(s): AIDS, assay, blood-borne, CDC Docket Import, CDC Docket Import CDC Prosecuting, CGH-DGHA, DA4AXX, DA4XXX, DAXXXX, DEVELOPING, Diagnosis, diagnostic, DRUG, drug resistance, drug resistant, DXXXXX, EMERGING, EPIDEMIOLOGIC, Genotype, Genotyping, Global, HIV, HIV-1, Listed LPM Houze as of 4/15/2015, PCR, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Resistance, RESISTANT, RT-PCR, Surveillance, therapeutic, tropical, viral, virus
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Diagnostics
West Nile/Zika Virus Chimeras for Inactivated Zika Vaccine and Diagnostic Assay Development
Zika virus (ZIKV) is a flavivirus primarily transmitted by infected Aedes mosquitoes. Infection with ZIKV during pregnancy can affect the fetus causing microcephaly, neurological complications, and other birth defects. Adults are also at risk of developing Guillain-Barre syndrome and other neurological disorders from ZIKV infection. In response to the...
Published: 10/28/2024   |   Inventor(s): Claire Kinney
Keywords(s): assay, Chimera, Development, INACTIVATED, NCEZID, NCEZID-DVBD, Neutralization, Nile/Zika, Vaccine, VLXXXX, WBXXXX, West, WIXXXX, WNXXXX, XEXXXX, XHXXXX, XKXXXX, YBXXXX, Zika
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Infectious Disease, Application > Diagnostics, Application > Research Materials, ResearchProducts > Research Equipment
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