Search Results - single+cell+analysis

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Functional Enrichment and Purification of a Therapeutically Superior Population of Cells (Case No. 2024-024)
Summary: UCLA researchers in the Departments of Bioengineering and Biological Chemistry have developed a method for identifying and enriching therapeutically useful cell sub-populations based on their secretions (SEC-seq). Background: Cell function is defined by a myriad of biomolecules that they secrete; over 3 thousand proteins are estimated to...
Published: 9/11/2024   |   Inventor(s): Dino Di Carlo, Kathrin Plath, Shreya Udani, Justin Langerman
Keywords(s): Cell Surface Receptor, Cytometry, Flow Cytometry, Functional Genomics, High-Throughput Screening, hydrogel, Microfluidics, single cell analysis, Therapeutics
Category(s): Therapeutics > Immunology And Immunotherapy, Therapeutics, Therapeutics > Oncology > Oncology Immunotherapy, Life Science Research Tools, Life Science Research Tools > Research Methods, Diagnostic Markers > Targets And Assays, Therapeutics > Cell Therapy
Affinity and Functional Based Screening of T Cell Receptor Repertoire Using Nanovials (Case No. 2024-042)
Summary: Researchers in the Department of Bioengineering at UCLA have developed a hydrogel platform that measures single T cell secretions, aiding in the definition of T cell receptor repertoires for functional immunotherapy applications. Background: T cell immunotherapies, namely T cell receptor (TCR) therapies, have emerged as promising candidates...
Published: 9/20/2024   |   Inventor(s): Dino Di Carlo, Owen Witte, Doyeon Koo, Zhiyuan Mao
Keywords(s): Cancer Immunotherapy, CAR-T cell therapy, Flow Cytometry, hydrogel, Immunooncology, Immunotherapy, Peptide, single cell analysis, T Cell, T cell based therapy
Category(s): Diagnostic Markers > Immunology, Life Science Research Tools > Screening Libraries, Therapeutics > Immunology And Immunotherapy
DROPLET-ELECTROPHORESIS DEVICES AND RELATED METHODS
­DROPLET-ELECTROPHORESIS DEVICES AND RELATED METHODS Researchers at UC Berkeley have developed a novel method for comprehensively profiling the proteomes of single cells. Genomics (DNA) and transcriptomics (RNA) sequencing is one of the cornerstones of our modern-day understanding of the genetic blueprint of life. Furthermore, sequencing and...
Published: 4/22/2024   |   Inventor(s): Amy Herr, Yang Liu
Keywords(s): Microfluidics, Protein, Single Cell Analysis
Category(s): Technology Classifications > Engineering
Cell Type Scanner (UCLA Case No. 2021-115)
UCLA researchers in the Department of Chemistry and Biochemistry have developed a novel technology for spatial cell-type mapping in 2D and 3D tissue samples. BACKGROUND: Cell type mapping has become an integral component for many biomedical research studies and diagnostic technologies. However, a major challenge in single cell data is accurately...
Published: 4/8/2024   |   Inventor(s): Roy Wollman
Keywords(s): 3D tissue imaging, cell mapping, Principal component analysis, RNA imaging, single cell analysis, Single cell data
Category(s): Life Science Research Tools > Research Methods, Software & Algorithms > Data Analytics
Methods for Single Cell Analysis of the Epigenome, Transcriptome, and Genome
Abstract: There are currently no methodologies that allow for epigenome, genome and transcriptome analysis all in a single cell. In addition, there are currently no methodologies that permit repeating the results of these analyses on the same single cells. Scientists at the National Cancer Institute (NCI) Laboratory of Cellular Oncology have developed...
Published: 4/8/2024   |   Inventor(s): Giovanna Tosato, Hidetaka Ohnuki
Keywords(s): diagnostic, Epigenomic, Genomic, RESEARCH TOOL, Single Cell Analysis, Tosato, Transcriptomic
Category(s): Application > Diagnostics, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology
METHOD FOR COMBINED GENOME METHYLATION AND VARIATION ANALYSES
­METHOD FOR COMBINED GENOME METHYLATION AND VARIATION ANALYSES Researchers at Stanford have developed improved methods for combined analyses of epigenetics and nucleotide variation in single cells. Single cell genomic sequencing has allowed characterization of the diversity and evolution of cells within tissues. Recent advances in whole genome...
Published: 3/17/2023   |   Inventor(s): Veronica Gonzalez-Pena, Charles Gawad
Keywords(s): Biomolecules, Epigenetics, Methylation, Single Cell, Single Cell Analysis, Single Cell Genomics
Category(s): Technology Classifications > Biology
­SPATIAL GENOMICS WITH SINGLE CELL RESOLUTION
­SPATIAL GENOMICS WITH SINGLE CELL RESOLUTION Researchers at UCSF have developed methods for in situ labelling and sequencing to obtain spatial information and multiomics analysis at a single cell level. Single-cell sequencing has revealed unappreciated cellular diversity in many ostensibly homogeneous systems and led to an ongoing scientific...
Published: 7/5/2023   |   Inventor(s): Cyrille Delley, Adam Abate
Keywords(s): Single Cell, Single Cell Analysis, Single Cell Genomics, Single Cell RNA Sequencing, Single-cell Transcriptomics
Category(s): Technology Classifications > Biology
­QUANTIFICATION OF CELLULAR PROTEINS USING BARCODED BINDING MOIETIES
­QUANTIFICATION OF CELLULAR PROTEINS USING BARCODED BINDING MOIETIES Researchers at Stanford have developed a method enabling quantification of intracellular protein levels using oligonucleotide-barcoded antibodies. Multiplexing single cell technologies affords researchers the ability to characterize cell states and identify gene regulatory programs...
Published: 3/17/2023   |   Inventor(s): William Greenleaf, Amy Chen
Keywords(s): Affinity Reagent, Antibody, Biomolecules, Integrated Screening System, ScRNA-seq, Single Cell, Single Cell Analysis, Single Cell Genomics, Single Cell RNA Sequencing, Single-cell Transcriptomics
Category(s): Technology Classifications > Biology
MICROFLUIDIC CELL BARCODING AND SEQUENCING
MICROFLUIDIC CELL BARCODING AND SEQUENCING Researchers at UC Berkeley have developed µCB-seq, a microfluidic cell barcoding and sequencing platform for high-resolution imaging and sequencing of single cells. Single-cell RNA sequencing (scRNA-seq) enables the investigation of complex biological processes in multicellular organisms with high...
Published: 3/17/2023   |   Inventor(s): Aaron Streets, Tyler Chen, Anushka Gupta
Keywords(s): Fluorescence, Genetic Dissection, Microfluidics, ScRNA-seq, Single Cell, Single Cell Analysis, Single Cell Genomics, Single Cell RNA Sequencing, Single-cell Transcriptomics
Category(s): Technology Classifications > Biology
IMAGING AND SEQUENCING PROTEIN-DNA INTERACTIONS IN SINGLE CELLS USING INTEGRATED MICROFLUIDICS
IMAGING AND SEQUENCING PROTEIN-DNA INTERACTIONS IN SINGLE CELLS USING INTEGRATED MICROFLUIDICS Researchers at UC Berkeley have developed an integrated microfluidics method, µDamID (microfluidic DamID), capable of co-determining the cellular location and nucleotide sequence of DNA that is contacted by a protein of interest in a single cell. Genome...
Published: 3/17/2023   |   Inventor(s): Aaron Streets, Nicolas Altemose
Keywords(s): Fluorescence, Genetic Dissection, Microfluidics, Optical Probe, Single Cell, Single Cell Analysis
Category(s): Technology Classifications > Biology
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