Search Results - regenerative+medicine

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A New High-Throughput Cell Biology Method to Screen for Genes Critical for Cell Differentiation
A high-throughput method for identifying genes involved in the process of stem cell differentiation into specialized cells. Background: One of the many draws of stem cells is their potential for regenerating tissues, nerves, and other organs, but the differentiation potential of stem cells is highly regulated by genes. Therefore, the ability to...
Published: 7/11/2023   |   Inventor(s): Chunyu Liu
Keywords(s): cell culture, development, differentiation, high-throughput, neuroscience, regenerative medicine, screen
Category(s): Campus > Upstate Medical University, Technology Classifications > Gene Therapy
Accurate Blood Biomarkers for Early Diagnosis of Synovial Joint Disease in the Mucopolysaccharidoses
Ten candidate serum and synovial protein levels provide early indication of joint impairment in lysosomal storage disorders. Problem: The Mucopolysaccharidoses (MPS) group of lysosomal storage diseases occur once in every 25,000 births, all MPS subtypes share deficits in enzymatic degradation. Children with MPS suffer from a suite of variable and...
Published: 6/20/2024   |   Inventor(s): Lachlan Smith, Chenghao Zhang
Keywords(s): Bioengineering, Cell Therapy, Drug Target, Genetic Disorders, Inflammation, Orthopedics, Regenerative Medicine
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Testing & Measurement
Modified Lipid Nanoparticle Formulations with Improved Therapeutic Delivery to the Bone Microenvironment In-vivo
A library of bi-phosphonate ionizable lipids and LNP formulations to facilitate mRNA delivery to the bone microenvironment. Problem: The increasing prevalence of skeletal diseases such as osteoporosis, osteoarthritis and bone cancer have motivated efforts to target the bone microenvironment therapeutically. However, therapeutic agents must overcome...
Published: 2/7/2024   |   Inventor(s): Michael Mitchell, Lulu Xue
Keywords(s): Drug Delivery, Drug Target, Nanotechnology, Orthopedics, Platform Technology, Regenerative Medicine
Category(s): Technology Classifications > Vaccines, Technology Classifications > Therapeutics, Technology Classifications > Research Tools & Reagents
Ligand-Tethered Lipid Nanoparticles for Targeted RNA Delivery to Treat Liver Fibrosis
A new class of anisimide-functionalized lipids that enables targeted delivery of lipid nanoparticles (LNPs) to activated fibroblasts in the liver. Problem: Lipid nanoparticles (LNPs) have been successfully used in FDA-approved therapies to deliver messenger RNA (mRNA) and small interfering RNA (siRNA) . One of the biggest challenge in developing...
Published: 2/7/2024   |   Inventor(s): Michael Mitchell, Xuexiang Han
Keywords(s): Bioengineering, Drug Delivery, Gene Editing, Gene Therapy, Genetic Disorders, Immunology, Immunoncology, Platform Technology, Regenerative Medicine
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Vaccines
Myocardial In Vitro Platform for Drug Development and Cardiotoxicity Screening
This myocardial in vitro screening platform provides relevant physiological stimuli enabling analysis of output metrics with direct clinical relevance to cardiac function. While drug discovery is robust and well-funded, a very low percentage of experimental drug candidates reach the marketplace as FDA-approved therapies. This translates into billions...
Published: 8/14/2024   |   Inventor(s): William Richardson, Samuel Coeyman, Jonathan Heywood
Keywords(s): Analytical/Diagnostics/Instru./Sensors-Medical/Biological, Biomaterials - Cardiovascular, Cardiovascular, Diabetes, Drugs/Pharma - Antibiotics, Drugs/Pharma - Drug Delivery, Drugs/Pharma - HIV/Cancer/Other, Medical Device, Molecular Therapies, Oncology/Cancer, Regenerative Medicine, Tissue Engineering
Category(s): Biomedical Sciences
Differentiation of induced pluripotent stem cells into retinal progenitor cells and mature, functional human retinal ganglion cells
Simplified and reproducible two-step differentiation method optimized for efficient differentiation of human-induced pluripotent stem cells into retinal progenitor cells and functional retinal ganglion cells Problem: More than three million Americans live with glaucoma – a disease that can cause blindness resulting from optic nerve damage....
Published: 2/2/2024   |   Inventor(s): Venkata Chavali, Jason Mills, Joan O'Brien
Keywords(s): Cell Therapy, Ophthalmology, Regenerative Medicine
Category(s): Technology Classifications > Research Tools & Reagents
Encapsulation Strategy for Creating Engineered 3D Cellular Models
Cell culture is a fundamental research tool for countless biological applications from drug discovery to cancer research and regenerative medicine. While two-dimensional (2D) cell culture is ubiquitous in research settings, it fails to adequately consider the natural three-dimensional (3D) microenvironment of cells. As newer and better 3D cell culture...
Published: 2/23/2023   |   Inventor(s): Rajeshwar Nitiyanandan, Tanya Nanda, Kaushal Rege
Keywords(s): Drug Screening, Regenerative Medicine
Category(s): Advanced Materials/Nanotechnology, Biomaterials, Cancer Therapeutics, Life Science (All LS Techs), Medical Devices, Non-Cancer Therapeutics, Pharmaceuticals
Injectable Cell-Derived Therapeutic to Stimulate Tissue Regeneration or Healing
Delivers Therapeutically Active Enhanced Secretome to Damaged Tissue to Promote Tissue RegenerationThis injectable minimally invasive treatment delivers enhanced secretome harvested from electrically stimulated cells to damaged tissue, thereby promoting tissue regeneration noninvasively. Biological cells and tissues produce a variety of proteins and...
Published: 6/27/2021   |   Inventor(s): Christine Schmidt, Sahba Mobini
Keywords(s): electrical stimulation, Hydrogel, regenerative medicine, secretome, Therapeutic Application, Tissue Engineering
Category(s): Technology Classifications > Human Health Care > Therapeutics
Self-oxygen generating biomaterials for large tissue engineering
Organ transplantation continues to increase, with 34,770 transplants performed in the US in 2017. Currently, organ transplantation is limited by donor dependence, high costs, and, long-term use of immunosuppressive medications which, in turn, correlates with significant morbidity and mortality. To overcome these limitations, tissue engineering and transplantation...
Published: 3/5/2024   |   Inventor(s): Iman Noshadi
Keywords(s): Biomaterials, Electrolyte, Energy Storage, Hydrogels, Oxygenation, Regenerative Medicine, Scaffold, Stem Cells, Tissue Engineering , Transplant
Category(s): Human Health Care > Biomaterials
TGFβR3-based Biomaterial to Treat Bone Damage
Application PEG-MAL (Poly(ethylene glycol) methyl ether maleimide) polymer gel composition containing soluble TGFβ3R or embedded with modified TGFβ3R over-expressing cells for bone growth and repair therapy. Key Benefits Targets a non-BMP2 signaling pathway to improve BMP signaling. Avoids complications associated with BMP2. Market...
Published: 7/30/2024   |   Inventor(s): Steven Goudy
Keywords(s): Biomaterials, Musculoskeletal, Pediatrics, Regenerative Medicine
Category(s): TechPub Algolia > Drug Discovery
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