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Label-free Single-molecule Immunoassay Technique

Detection and quantification of low-abundance biomarkers is essential to early disease detection, monitoring and treatment. While many techniques, have been developed for measuring single molecules, all require signal amplification, via enzyme amplification, or fluorescence or gold nanoparticle probes, which come with their own unique drawbacks, including...

Published: 9/3/2024 | Inventor(s): Shaopeng Wang, Xiaoyan Zhou

Keywords(s):

Category(s): Bioanalytical Assays, Chemistries & Devices, Imaging, Life Science (All LS Techs), Medical Diagnostics/Sensors, Medical Devices

Microfluidic Digital Nanobiosensors for Point-of-Care Detection of Analytes

Detection, identification and quantification of molecular biomarkers, such as proteins, peptides, exosomes, hormones, neurotransmitters, metabolites and nucleic acids, are critical to disease diagnosis, progression monitoring, and management. While there are numerous approaches for analyzing biomarkers, the most validated and well-established is ELISA....

Published: 8/27/2024 | Inventor(s):

Keywords(s):

Category(s): Bioanalytical Assays, Chemistries & Devices, Cancer, Imaging, Life Science (All LS Techs), Medical Devices, Medical Diagnostics/Sensors

Novel Decoupling Technique for Multichannel RF Coil Arrays

Magnetic resonance imaging (MRI) is an important non-invasive imaging modality that produces detailed images of organs and tissues in a body. Using high fields, 1.5T, 3T, 7T, and above, provides higher signal-to-noise ratios (SNR), temporal resolutions and spatial resolution. MRI RF coils play a significant role in determining image quality. Surface...

Published: 8/19/2024 | Inventor(s): Sung-Min Sohn, Seyedamin Hashemi

Keywords(s):

Category(s): Advanced Materials/Nanotechnology, Imaging, Life Science (All LS Techs), Medical Imaging, Medical Devices

CoRAL: Collaborative Robotic Aquatic Laboratory

Continuous long-term observation of coral reefs is essential for gathering crucial data that helps determine the state of environmental health. Coral reefs support 25% of all marine species which makes it necessary that they be monitored for good health. Traditional methods of coral reef monitoring, such as diver-based surveys and airborne observatories,...

Published: 9/24/2024 | Inventor(s): Jnaneshwar Das, Rodney Staggers Jr., Aravind Saravanakumaran, Cole Brauer, Harish Anand, Yash Shethwala, Darwin Mick, Alex Goldman, Jason Achilles Mezilis, Sarah Bearman, Devin Keating, Ramon Arrowsmith, Elizabeth Trembath-Reichert, Roberta Martin, Greg Asner, Lakshmi Antervedi, Zhiang Chen

Keywords(s): Imaging, Oceanography, PS-Environmental, Robotics, Sensing, Sensors

Category(s): Environmental, Imaging, Physical Science

QuAD-FLIP: Quadrotor Aerial Delivery with Flipping for Limited-Access Inspection and Probing

Drones are garnering considerable interest for their capacity in autonomously transporting objects across diverse sectors. Their potential is poised to revolutionize the logistics realm by offering swifter, more cost-effective and efficient transportation solutions. This includes facilitating expedited delivery services for packages, transporting essential...

Published: 9/24/2024 | Inventor(s): Jnaneshwar Das, Saransh Jain, Yash Shethwala, Aravind Saravanakumaran, Zhiang Chen, Darwin Mick, Hariharan Ravichandran, Srikar Siddarth, Stephen Rees, Jason Achilles Mezilis, Amanda Clarke, Ramon Arrowsmith, Abdullah Masud

Keywords(s): Aerospace, Positioning, Robotics, Sensing, Sensors

Category(s): Imaging, Physical Science, Computing & Information Technology

Device to Hold and Image Cell Culture Flasks and Biodome Technologies

Labware receptacles, such as cell culture flasks or biodomes, are ubiquitous tools in cellular biology research which allow for growing as well as imaging cells. However, many labware receptacles face challenges when trying to image them, such as an inability to lay flat against the stage of a microscope, or to reproducibly place the receptacle in the...

Published: 7/29/2024 | Inventor(s): Barbara Smith, Ethan Marschall, Jarrett Eshima

Keywords(s):

Category(s): Bioanalytical Assays, Chemistries & Devices, Imaging, Life Science (All LS Techs), Manufacturing/Construction/Mechanical, Medical Devices

Inflammation Targeting Contrast Agent for MR Imaging

Atherosclerosis is characterized by the formation of fatty plaque deposits within the vasculature. With increasing plaque buildup, the affected arteries may harden and narrow leading to complications such as heart attack, stroke, aneurysm and other cardiovascular events. The complex nature of plaque makes lesion-targeting imaging, and subsequently early...

Published: 7/25/2024 | Inventor(s): Joshua Rousseau, Kuei-Chun Wang, Ting-Yun Wang

Keywords(s):

Category(s): Advanced Materials/Nanotechnology, Biomaterials, Imaging, Medical Imaging, Life Science (All LS Techs), Non-Cancer Therapeutics, Pharmaceuticals

UAV System with Vital Sign Sensing, Communications, and Positioning Estimation

When searching for missing persons, especially during emergency situations, such as catastrophic weather and infrastructure or geologic events, aerial reconnaissance can be an invaluable tool, particularly if the area is large and/or unstable. Unmanned aerial vehicles (UAVs) with thermal imaging capabilities can help detect heat signatures from victims,...

Published: 7/11/2024 | Inventor(s): Daniel Bliss, Alex Chiriyath, Arindam Dutta, Andrew Herschfelt, Yu Rong

Keywords(s):

Category(s): Intelligence & Security, Computing & Information Technology, Imaging, Life Science (All LS Techs), Wireless & Networking

Optical Imaging Platform for POC CAR T-Cell Therapy Assessment

Chimeric antigen receptor (CAR) T-cell therapy is a type of immunotherapy which uses altered T-cells to target cancer cells more effectively. As such, it has dramatically changed the treatment landscape for cancer patients. However, it has limitations including cytokine release syndrome (CRS), neurological events (NE), lack of response (which occurs...

Published: 8/27/2024 | Inventor(s): Shaopeng Wang, Nanxi Yu, Chao Chen, Xinyu Zhou, Januario Castro, Eider Moreno Cortes

Keywords(s):

Category(s): Medical Diagnostics/Sensors, Medical Devices, Life Science (All LS Techs), Imaging, Cancer, Bioanalytical Assays, Chemistries & Devices

Scalable Design and Manufacturing of Functional Metastructures and Metamaterials

Background Ultrathin photonic nanostructures, such as plasmonic and dielectric metamaterials and metasurfaces, have broad applications in electromagnetic wave manipulation, high resolution imaging, and computation. However, conventional production of these metastructures relies on precise nano-machining techniques that are difficult to manufacture...

Published: 4/23/2024 | Inventor(s): Chao Wang, Yu Yao, Shinhyuk Choi, Jiawei Zuo

Keywords(s):

Category(s): Advanced Materials/Nanotechnology, Imaging, Physical Science, Physics, Energy & Power

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