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Search Results - life+science+research+tools
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Functional Enrichment and Purification of a Therapeutically Superior Population of Cells (Case No. 2024-024)
Summary: UCLA researchers in the Departments of Bioengineering and Biological Chemistry have developed a method for identifying and enriching therapeutically useful cell sub-populations based on their secretions (SEC-seq). Background: Cell function is defined by a myriad of biomolecules that they secrete; over 3 thousand proteins are estimated to...
Published: 9/11/2024
|
Inventor(s):
Dino Di Carlo
,
Kathrin Plath
,
Shreya Udani
,
Justin Langerman
Keywords(s):
Cell Surface Receptor
,
Cytometry
,
Flow Cytometry
,
Functional Genomics
,
High-Throughput Screening
,
hydrogel
,
Microfluidics
,
single cell analysis
,
Therapeutics
Category(s):
Therapeutics > Immunology And Immunotherapy
,
Therapeutics
,
Therapeutics > Oncology > Oncology Immunotherapy
,
Life Science Research Tools
,
Life Science Research Tools
> Research Methods
,
Diagnostic Markers > Targets And Assays
,
Therapeutics > Cell Therapy
Augmentations to Lentiviral Vectors to Increase Expression (UCLA Case No. 2019-616)
UCLA researchers in the Department of Microbiology, Immunology and Molecular Genetics have developed a novel method to produce short lentiviral vectors with tissue-specific expression, with a primary focus on lentiviral vectors for treating sickle cell disease and other disorders of hemoglobin. BACKGROUND: Sickle cell disease (SCD) is one of the...
Published: 8/14/2024
|
Inventor(s):
Donald Kohn
,
Roger Hollis
,
Richard Morgan
Keywords(s):
Category(s):
Therapeutics > Gene Therapy And Editing
,
Life Science Research Tools
,
Therapeutics > Genetic Diseases
Identifying Desirable T Lymphocytes by Change in Mass Responses (Case No. 2013-183)
Summary: UCLA researchers from the Department of Pathology and Lab Medicine have developed a novel method for the identification of T lymphocytes using live cell interferometry Background: The identification of T cell receptors (TCRs) that are specific to antigens is crucial for advancing various immunotherapies. Existing methods of characterizing...
Published: 8/15/2024
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Inventor(s):
Michael Teitell
,
Owen Witte
,
Thomas Zangle
,
Daina Burnes Linton
Keywords(s):
Category(s):
Therapeutics
,
Therapeutics > Immunology And Immunotherapy
,
Therapeutics > Autoimmune
,
Life Science Research Tools
,
Life Science Research Tools
> Research Methods
,
Life Science Research Tools
> Lab Equipment
Human T-Cell Receptors Targeting Tumor-Enhanced Splicing Epitopes on HLA-A for Small Cell Carcinoma (UCLA Case Nos. 2023-117, 2020-817)
UCLA Researchers in the Department of Microbiology, Immunology, & Molecular Genetics have utilized their previously developed computational method (IRIS), to process and capture small cell carcinoma-specific RNA splicing events in small cell cancer. These events and associated epitopes were then used as the basis for generating new T cell receptors...
Published: 5/16/2024
|
Inventor(s):
Owen Witte
Keywords(s):
alternative splicing
,
Cancer
,
prostate cancer
,
RNA splicing
,
small cell
,
small cell cancer
,
small cell lung cancer
,
small cell prostate cancer
,
Targets And Assays
Category(s):
Life Science Research Tools
Development of Novel Compounds to Suppress Neuronal Stress and Cross the Blood Brain Barrier (UCLA Case No. 2021-165)
SUMMARY: An interdisciplinary group of UCLA researchers have developed and validated a library of compounds that alleviate symptoms of Rett Syndrome and hold enormous therapeutic potential for the long-term treatment of other intellectual disability syndromes. BACKGROUND: Intellectual disability (ID) affects more than 100 million people globally and...
Published: 5/8/2024
|
Inventor(s):
William Lowry
,
Michael Jung
,
Xiaoguang Liu
,
Elena Korsakova
Keywords(s):
blood-brain barrier
,
Drug
,
intellectual disability
,
Organoids
,
senescence
Category(s):
Therapeutics > CNS and Neurology
,
Life Science Research Tools
,
Diagnostic Markers > Targets And Assays
1-Micron Frequency Comb OCT System (Case No. 2023-036)
Summary: UCLA researchers in the Department of Electrical and Computer Engineering have developed a new optical coherence tomography system for clinical imaging applications. Background: Optical coherence tomography (OCT) is a non-invasive imaging technique that is used in many clinical settings. OCT is used in ophthalmology to visualize layers...
Published: 3/20/2024
|
Inventor(s):
Chee Wei Wong
,
Tristan Melton
,
James McMillan
Keywords(s):
Category(s):
Electrical
,
Electrical > Imaging
,
Electrical > Electronics & Semiconductors
,
Life Science Research Tools
,
Life Science Research Tools
> Microscopy And Imaging
,
Life Science Research Tools
> Animal Imaging
,
Mechanical
,
Mechanical > Instrumentation
Targeted Delivery of IFN-gamma Using Antibody Fusion Proteins (UCLA Case No. 2017-543)
UCLA researchers in the Departments of Microbiology, Immunology & Molecular Genetics (MIMG) and Medicine have developed antibody–cytokine fusion proteins that enable the targeted delivery of active interferon-gamma (IFNγ) for cancer treatment. Interferon-gamma (IFNγ), a type II interferon, is a cytokine released by both natural...
Published: 2/26/2024
|
Inventor(s):
Sherie Morrison
,
John Timmerman
,
Kham (Ryan) Trinh
Keywords(s):
Antibody Delivery Platforms
,
Drug Delivery
,
Immunotherapy
,
Life Science Research Tools
,
Therapeutics & Vaccines
Category(s):
Therapeutics
,
Platforms > Drug Delivery
,
Platforms > Drug Delivery > Antibody Delivery Platforms
,
Life Science Research Tools
,
Therapeutics > Immunology And Immunotherapy
Antitumor activity of NKTR-214 alone or in combination with anti-PD-1 therapy in tumors resistant to anti-PD-1 (UCLA Case No. 2019-254)
UCLA researchers have discovered a therapy for anti-PD-1 resistant tumors in colon carcinoma patients. A small molecule therapeutic alone or in combination with immune-checkpoint blockade (ICB) therapy exhibits tumor remission even in sublines with mutated signalling pathways that have rendered them ICB resistant. BACKGROUND: Immunotherapy, the...
Published: 2/15/2024
|
Inventor(s):
Antoni Ribas
Keywords(s):
Colon carcinoma
,
Immune checkpoint blockade
,
Immunotherapy
,
Oncology
,
Oncology (Small Molecules, Peptides and Antibodies)
,
PD-1
,
PD-L1
,
Resistant tumors
,
Signaling pathways
,
Small molecule therapeutics
,
Tumor
Category(s):
Life Science Research Tools
,
Therapeutics > Oncology > Oncology Immunotherapy
,
Therapeutics > Oncology > Oncology (Small Molecules)
A Programming Language to Execute Biological Experiments (Command Line Biology/Biowrapper) (Case No. 2024-049)
Intro Sentence: UCLA researchers in the Department of Molecular and Medical Pharmacology have developed a programming language to automate biological experiments. Background: Manual labor is a common bottleneck in biological sciences, with automation technology still being unobtainable and impractical for most scientists in biomedical research....
Published: 9/3/2024
|
Inventor(s):
Robert Damoiseaux
,
Michael Mellody
,
Ronan Bennett
,
Alejandro Huerta
,
Rutu Shah
Keywords(s):
Artifical Intelligence (Machine Learning, Data Mining)
,
Artificial Intelligence
,
artificial intelligence augmentation
,
Artificial Neural Network
,
artificial-intelligent materials
,
Automation
,
generative artificial intelligence
,
Machine Learning
,
machine learning modeling
,
Medical artificial intelligence (AI)
,
Programmable Logic Device
Category(s):
Software & Algorithms
,
Software & Algorithms > Data Analytics
,
Software & Algorithms > Programs
,
Software & Algorithms > Artificial Intelligence & Machine Learning
,
Software & Algorithms > Image Processing
,
Life Science Research Tools
,
Life Science Research Tools
> Research Methods
Lip Protector for Preventing Oral Injuries During Intubation (Case No. 2018-171)
Summary: UCLA researchers in the David Geffen School of Medicine have designed a novel lip and tooth protector for intubation processes. Background: General anesthesia usually requires an artificial airway or breathing tube to be placed in a patient’s mouth or throat in order to help with proper breathing during medical procedure. Even with...
Published: 4/1/2024
|
Inventor(s):
Negar Motayagheni
Keywords(s):
Hospital Systems And Devices
,
Life Science Research Tools
,
Medical Devices and Materials
,
Surgical Tools
Category(s):
Life Science Research Tools
,
Medical Devices
,
Medical Devices > Surgical Tools
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