Search Results - life+science+research+tools

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Functional Enrichment and Purification of a Therapeutically Superior Population of Cells (Case No. 2024-024)
Summary: UCLA researchers in the Departments of Bioengineering and Biological Chemistry have developed a method for identifying and enriching therapeutically useful cell sub-populations based on their secretions (SEC-seq). Background: Cell function is defined by a myriad of biomolecules that they secrete; over 3 thousand proteins are estimated to...
Published: 9/11/2024   |   Inventor(s): Dino Di Carlo, Kathrin Plath, Shreya Udani, Justin Langerman
Keywords(s): Cell Surface Receptor, Cytometry, Flow Cytometry, Functional Genomics, High-Throughput Screening, hydrogel, Microfluidics, single cell analysis, Therapeutics
Category(s): Therapeutics > Immunology And Immunotherapy, Therapeutics, Therapeutics > Oncology > Oncology Immunotherapy, Life Science Research Tools, Life Science Research Tools > Research Methods, Diagnostic Markers > Targets And Assays, Therapeutics > Cell Therapy
Augmentations to Lentiviral Vectors to Increase Expression (UCLA Case No. 2019-616)
UCLA researchers in the Department of Microbiology, Immunology and Molecular Genetics have developed a novel method to produce short lentiviral vectors with tissue-specific expression, with a primary focus on lentiviral vectors for treating sickle cell disease and other disorders of hemoglobin. BACKGROUND: Sickle cell disease (SCD) is one of the...
Published: 8/14/2024   |   Inventor(s): Donald Kohn, Roger Hollis, Richard Morgan
Keywords(s):  
Category(s): Therapeutics > Gene Therapy And Editing, Life Science Research Tools, Therapeutics > Genetic Diseases
Identifying Desirable T Lymphocytes by Change in Mass Responses (Case No. 2013-183)
Summary: UCLA researchers from the Department of Pathology and Lab Medicine have developed a novel method for the identification of T lymphocytes using live cell interferometry Background: The identification of T cell receptors (TCRs) that are specific to antigens is crucial for advancing various immunotherapies. Existing methods of characterizing...
Published: 8/15/2024   |   Inventor(s): Michael Teitell, Owen Witte, Thomas Zangle, Daina Burnes Linton
Keywords(s):  
Category(s): Therapeutics, Therapeutics > Immunology And Immunotherapy, Therapeutics > Autoimmune, Life Science Research Tools, Life Science Research Tools > Research Methods, Life Science Research Tools > Lab Equipment
Human T-Cell Receptors Targeting Tumor-Enhanced Splicing Epitopes on HLA-A for Small Cell Carcinoma (UCLA Case Nos. 2023-117, 2020-817)
UCLA Researchers in the Department of Microbiology, Immunology, & Molecular Genetics have utilized their previously developed computational method (IRIS), to process and capture small cell carcinoma-specific RNA splicing events in small cell cancer. These events and associated epitopes were then used as the basis for generating new T cell receptors...
Published: 5/16/2024   |   Inventor(s): Owen Witte
Keywords(s): alternative splicing, Cancer, prostate cancer, RNA splicing, small cell, small cell cancer, small cell lung cancer, small cell prostate cancer, Targets And Assays
Category(s): Life Science Research Tools
Development of Novel Compounds to Suppress Neuronal Stress and Cross the Blood Brain Barrier (UCLA Case No. 2021-165)
SUMMARY: An interdisciplinary group of UCLA researchers have developed and validated a library of compounds that alleviate symptoms of Rett Syndrome and hold enormous therapeutic potential for the long-term treatment of other intellectual disability syndromes. BACKGROUND: Intellectual disability (ID) affects more than 100 million people globally and...
Published: 5/8/2024   |   Inventor(s): William Lowry, Michael Jung, Xiaoguang Liu, Elena Korsakova
Keywords(s): blood-brain barrier, Drug, intellectual disability, Organoids, senescence
Category(s): Therapeutics > CNS and Neurology, Life Science Research Tools, Diagnostic Markers > Targets And Assays
1-Micron Frequency Comb OCT System (Case No. 2023-036)
Summary: UCLA researchers in the Department of Electrical and Computer Engineering have developed a new optical coherence tomography system for clinical imaging applications. Background: Optical coherence tomography (OCT) is a non-invasive imaging technique that is used in many clinical settings. OCT is used in ophthalmology to visualize layers...
Published: 3/20/2024   |   Inventor(s): Chee Wei Wong, Tristan Melton, James McMillan
Keywords(s):  
Category(s): Electrical, Electrical > Imaging, Electrical > Electronics & Semiconductors, Life Science Research Tools, Life Science Research Tools > Microscopy And Imaging, Life Science Research Tools > Animal Imaging, Mechanical, Mechanical > Instrumentation
Targeted Delivery of IFN-gamma Using Antibody Fusion Proteins (UCLA Case No. 2017-543)
UCLA researchers in the Departments of Microbiology, Immunology & Molecular Genetics (MIMG) and Medicine have developed antibody–cytokine fusion proteins that enable the targeted delivery of active interferon-gamma (IFNγ) for cancer treatment. Interferon-gamma (IFNγ), a type II interferon, is a cytokine released by both natural...
Published: 2/26/2024   |   Inventor(s): Sherie Morrison, John Timmerman, Kham (Ryan) Trinh
Keywords(s): Antibody Delivery Platforms, Drug Delivery, Immunotherapy, Life Science Research Tools, Therapeutics & Vaccines
Category(s): Therapeutics, Platforms > Drug Delivery, Platforms > Drug Delivery > Antibody Delivery Platforms, Life Science Research Tools, Therapeutics > Immunology And Immunotherapy
Antitumor activity of NKTR-214 alone or in combination with anti-PD-1 therapy in tumors resistant to anti-PD-1 (UCLA Case No. 2019-254)
UCLA researchers have discovered a therapy for anti-PD-1 resistant tumors in colon carcinoma patients. A small molecule therapeutic alone or in combination with immune-checkpoint blockade (ICB) therapy exhibits tumor remission even in sublines with mutated signalling pathways that have rendered them ICB resistant. BACKGROUND: Immunotherapy, the...
Published: 2/15/2024   |   Inventor(s): Antoni Ribas
Keywords(s): Colon carcinoma, Immune checkpoint blockade, Immunotherapy, Oncology, Oncology (Small Molecules, Peptides and Antibodies), PD-1, PD-L1, Resistant tumors, Signaling pathways, Small molecule therapeutics, Tumor
Category(s): Life Science Research Tools, Therapeutics > Oncology > Oncology Immunotherapy, Therapeutics > Oncology > Oncology (Small Molecules)
A Programming Language to Execute Biological Experiments (Command Line Biology/Biowrapper) (Case No. 2024-049)
Intro Sentence: UCLA researchers in the Department of Molecular and Medical Pharmacology have developed a programming language to automate biological experiments. Background: Manual labor is a common bottleneck in biological sciences, with automation technology still being unobtainable and impractical for most scientists in biomedical research....
Published: 9/3/2024   |   Inventor(s): Robert Damoiseaux, Michael Mellody, Ronan Bennett, Alejandro Huerta, Rutu Shah
Keywords(s): Artifical Intelligence (Machine Learning, Data Mining), Artificial Intelligence, artificial intelligence augmentation, Artificial Neural Network, artificial-intelligent materials, Automation, generative artificial intelligence, Machine Learning, machine learning modeling, Medical artificial intelligence (AI), Programmable Logic Device
Category(s): Software & Algorithms, Software & Algorithms > Data Analytics, Software & Algorithms > Programs, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Image Processing, Life Science Research Tools, Life Science Research Tools > Research Methods
Lip Protector for Preventing Oral Injuries During Intubation (Case No. 2018-171)
Summary: UCLA researchers in the David Geffen School of Medicine have designed a novel lip and tooth protector for intubation processes. Background: General anesthesia usually requires an artificial airway or breathing tube to be placed in a patient’s mouth or throat in order to help with proper breathing during medical procedure. Even with...
Published: 4/1/2024   |   Inventor(s): Negar Motayagheni
Keywords(s): Hospital Systems And Devices, Life Science Research Tools, Medical Devices and Materials, Surgical Tools
Category(s): Life Science Research Tools, Medical Devices, Medical Devices > Surgical Tools
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