Search Results - bioengineering

72 Results Sort By:
Novel combination therapy for the treatment of EML4-ALK+ cancer
Brief Description: Described herein is a method of treating or ameliorating cancer in a subject in need thereof. The cancer includes a cytoplasmic RTK fusion protein aggregate. The method includes administering to the subject an inhibitor for the RTK fusion protein, and an inhibitor for matrix metalloprotease. Also described herein is a composition...
Published: 8/22/2025   |   Inventor(s): Lukasz Bugaj
Keywords(s): Bioengineering, Drug Target, Oncology
Category(s): Technology Classifications > Therapeutics
Stiffness Tunable Biomimetic Decellularized Extracellular Matrix-Based Material Systems
Brief Description: The present disclosure provides a tunable porous fibrous scaffold composition, comprising one or more modified glycosaminoglycans; and (ii) one or more extracellular matrix (ECM) proteins. The present disclosure also provides methods for preparing the tunable porous fibrous scaffold composition described herein. Intellectual Property...
Published: 8/21/2025   |   Inventor(s): Su Chin Heo, Se-Hwan Lee, Li (Molly) Zizhao
Keywords(s): Bioengineering, Orthopedics, Surgery
Category(s): Technology Classifications > Materials
Robotic Microcapsule Assemblies with Emergent Mobility for Targeted Treatment and Drug Delivery
Brief Description: The disclosed subject matter provides systems and methods for delivering a therapeutic agent for targeted treatments. The system can include at least one microcapsule and a magnetic system. The microcapsule can include the therapeutic agent and a layer of iron oxide nanoparticles (IONPs). The therapeutic agent can be encapsulated...
Published: 8/19/2025   |   Inventor(s): Hyun (Michel) Koo, Daeyeon Lee, Edward Steager, Hong-Huy Tran
Keywords(s): Bioengineering, Drug Delivery, Infectious Disease, Microfluidics, Neurodegenerative Diseases, Oncology, Platform Technology
Category(s): Technology Classifications > Robotics, Technology Classifications > Therapeutics
Bioengineered Models of Lung Development
Brief Description: A lung-on-a-chip microfluidic chip, comprising: a first region, the first region comprising a central channel and at least one side channel adjacent thereto, the central channel having therein a plurality of cells disposed in a matrix; and a second region, the second region comprising a vacuum chamber; and a membrane disposed between...
Published: 7/9/2025   |   Inventor(s): Dongeun (dan) Huh, Sunghee Estelle Park
Keywords(s): Bioengineering
Category(s): Technology Classifications > Research Tools & Reagents
Restoration of motor function through delayed intraspinal delivery of mRNA-encoded IL-10 after spinal cord injury
Brief Description: Disclosed herein is a composition including a nucleoside-modified mRNA encapsulated in a lipid nanoparticle wherein the nucleoside-modified mRNA encodes IL10, IL-6, MIP1a, GDNF (glial cell line-derived neurotrophic factor), or a combination thereof. A method of treated spinal cord injury is also described. Image: Caption: Reference...
Published: 7/9/2025   |   Inventor(s): Norbert Pardi, Drew Weissman
Keywords(s): Bioengineering, Drug Delivery, Gene Therapy, Immunology, Neurology, Regenerative Medicine
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Vaccines
Algorithm for Identifying Images of Fluorescently-Labeled Cells
Improves the ability to distinguish multiple fluorophores with overlapping emission spectra in biological images of labeled cells by a factor of two or more. Background: Cells (including normal and tumor cells), tissues, microbial communities, and other biological systems generally consist of multiple interacting components, especially proteins...
Published: 8/21/2025   |   Inventor(s): Alex Valm, Yunlong Feng
Keywords(s): bacterial cells, bacterial infection, bioengineering, biofilm control, bioinformatics, biomarker diagnostics, biomarkers, cancer, cell biology, computational biology, dental, diagnostics, digital image processing, fluorescence, fluorescence spectroscopy, gene expression analysis, image analysis, image processing, machine learning, medical imaging, microbial pathogenesis, personalized medicine, RNA, saliva, scanning microscopy, Technologies
Category(s): Campus > University at Albany, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare, Technology Classifications > Medical Imaging, Technology Classifications > Research Tools and Reagents, Technology Classifications > Therapeutics and Vaccines
An iron oxide nanozyme formulation for augmenting the efficacy of oral care products.
A combinatory formulation for oral care products that enhances antimicrobial specificity, anti-plaque potency and prevents tooth decay. Problem: Tooth decay (dental caries), caused by the destruction of the outer layer (enamel) of teeth by bacteria in biofilms, affects nearly half of the global population and remains the most prevalent chronic disease...
Published: 8/19/2025   |   Inventor(s): Yue Huang, Hyun (Michel) Koo, David Cormode
Keywords(s): Bioengineering, Dentistry, Infectious Disease, Microbiome, Nanotechnology, Platform Technology
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Materials, Technology Classifications > Therapeutics
Reducing The Adverse Side Effects Of Using Native T-Cells To Destroy Cancer Cells
A Switchable Bispecific T-Cell Nanoengager (sBiTNE) to link T cells with cancer cells that can be reversed if off-tumor toxicity is detected. Problem: Compounds which link native T-cells with the surface antigens found on cancer cells have emerged as an effective treatment for blood malignancies and are currently being developed for solid tumors....
Published: 4/16/2025   |   Inventor(s): Michael Mitchell, Ningqiang Gong
Keywords(s): Bioengineering, Immunology, Immunoncology, Immunotherapy, Oncology, Platform Technology, Protein/Peptide (Non-Antibody), Small Molecule
Category(s): Technology Classifications > Therapeutics
Targeted, Enhanced Modification Of Lipid NanoparticlesTto Improve Tumor Therapeutic Efficacy
A method to inhibit small extracellular vesicles (sEVs) released by tumor cells to enhance lipid nanoparticle (LNP) accumulation in tumors. Problem: Lipid nanoparticles (LNPs) have shown promise as drug delivery systems for various diseases with several clinically approved products. However, their ability to deliver genes specifically to tumor cells...
Published: 4/11/2025   |   Inventor(s): Michael Mitchell, Ningqiang Gong, Wenqun Zhong, Wei Guo
Keywords(s): Bioengineering, Drug Delivery, Immunoncology, Oncology
Category(s): Technology Classifications > Therapeutics
Methods and Sequences for mRNA and Other HIV Vaccine Development
Unique sequences eliciting broadly neutralizing antibodies (bNAbs) against human immunodeficiency virus (HIV) that could be used to develop effective mRNA-based and other types of HIV vaccine. Problem: Despite decades of research, there is currently no vaccine to prevent HIV infection. A major goal of HIV vaccine programs is to generate bNAbs, which...
Published: 8/1/2025   |   Inventor(s): George Shaw, Edward (Ted) Kreider, Beatrice Hahn, Ashwin Skelly, Hui Li, Drew Weissman
Keywords(s): Bioengineering, HIV/AIDS, Immunology, Infectious Disease, Protein/Peptide (Non-Antibody)
Category(s): Technology Classifications > Vaccines
1 2 3 4 5 6 7 8