Search Results - bioengineering

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Dye-Loaded Micelles for Direct Visualization of Colorectal Cancer
A tissue-selective, biocompatible contrast agent enables the visual identification of tumors and tumor margins during procedures Problem: Dye-based chromoendoscopy (DBC) helps endoscopists visualize colorectal mucosa and identify inflammatory polyps that could progress toward colorectal cancer in patients with inflammatory bowel disease (IBD). However,...
Published: 8/2/2024   |   Inventor(s): Andrew Tsourkas, Ahmad Amirshaghaghi, Zhiliang Cheng, Karthik Sundaram, Yiran Tian
Keywords(s): Bioengineering, Imaging Agents, Nanotechnology, Oncology, Surgery
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Imaging, Technology Classifications > Materials
Biocompatible, Reversible, and Strong Multilayered Tape for Advanced Wound Care
A hydrogel-based adhesive with a hydrophobic backing layer protects it from exposure to water and offers painless removal and easy repositioning. Problem: Reversible adhesives have gained popularity in industries with a growing emphasis on reducing waste and improving sustainability. Previously, the inventors have developed a strong and reversible adhesive...
Published: 7/23/2024   |   Inventor(s): Shu Yang, Baohong Chen, Alexander Tucker
Keywords(s): Bioengineering, Hydrogels, Platform Technology, Soft Materials
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Materials
Effective Anti-Fouling Surface Coating of Microfluidic Mixing Devices for Robust mRNA Lipid Nanoparticles (LNP) Manufacturing
Employment of omniphobic, thin-layer perfluorocarbon (TLP) coating to prevent fouling and clogging in microfluidic mixing devices during mRNA LNP formulations. Problem: Lipid nanoparticle (LNP)-based delivery systems for mRNA and other therapeutics recently gained popularity because of their application in the Pfizer/BioNTech and Moderna COVID-19 vaccines....
Published: 7/15/2024   |   Inventor(s): Daeyeon Lee, Yoon-Ho Hwang, David Issadore
Keywords(s): Bioengineering, Microfluidics
Category(s): Technology Classifications > Hardware & Components, Technology Classifications > Materials
Deep Learning Model Discovers Antibiotic Drugs in Extinct Organisms Effective Against Drug-Resistant Superbugs
Antibiotic Peptide de-extinction (APEX) is a deep-learning AI solution that can unearth ancient antibiotics to effectively combat superbugs and tackle antibiotic resistance on a global scale. Problem: Escalating antibiotic resistance around the globe has emerged as one of the pressing problems of our time, with antibiotic-resistant infections causing...
Published: 6/27/2024   |   Inventor(s): Cesar de la Fuente-Nunez, Marcelo Der Torossian Torres, Fangping Wan
Keywords(s): Bioengineering, Infectious Disease, Platform Technology, Protein/Peptide (Non-Antibody)
Category(s): Technology Classifications > Therapeutics
Antimicrobial Peptides (AMPs) Mined from Human Gut Metagenome Are Effective Against Antibiotic Resistant Pathogens
The collective genomes of the human gut microbiome, known as the metagenome, encode peptides that are effective against antibiotic-resistant bacteria. Problem: Antimicrobial resistance poses a major threat to public health. The development of drug-resistance outpaces traditional drug discovery approaches. As a result, the supply of drugs available to...
Published: 6/26/2024   |   Inventor(s): Cesar de la Fuente-Nunez, Marcelo Der Torossian Torres, Ami Bhatt, Erin Brooks
Keywords(s): Artificial Intelligence (AI) & Machine Learning, Bioengineering, Infectious Disease, Microbiome, Protein/Peptide (Non-Antibody)
Category(s): Technology Classifications > Computer Information Systems, Technology Classifications > Therapeutics
Low-Cost, Point-of-Care Test for Rapid Visual Diagnosis of COVID-19
A rapid, low-cost, portable swab-based SARS-CoV-2 biosensor whose test result can be detected with naked eye Problem: COVID-19 has killed over 2.84 million people worldwide and has disproportionately affected people in lower-income and resource-limited geographies. High-frequency testing can prevent rapid virus spread and reduce COVID-19-related hospitalizations...
Published: 6/26/2024   |   Inventor(s): Cesar de la Fuente-Nunez, Marcelo Der Torossian Torres, Lucas Felipe de Lima, Andre Lopes Ferreira
Keywords(s): Bioengineering, COVID-19, Infectious Disease
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Medical Devices
Strategies for Mitigating Acute Side Effects of Lung-Targeted Nanocarriers
Approaches and Design Techniques to Alleviate Coagulation-Related Acute Side Effects of Lung-Targeted Nanocarriers Problem: Lipid nanoparticles (LNPs) play a crucial role in drug delivery, enabling targeted drug administration to specific tissues. LNPs tailored for lung-specific delivery often incorporate cationic (positively charged) lipids. Unfortunately,...
Published: 6/26/2024   |   Inventor(s): Jacob Brenner, Vladimir Muzykantov, Jacob Myerson, Oscar Marcos Contreras, Marco Zamora, Serena Omo-Lamai
Keywords(s): Bioengineering, Drug Delivery, Gene Editing, Gene Therapy, Nanotechnology, Platform Technology, Pulmonary
Category(s): Technology Classifications > Therapeutics
High-Throughput and Independent Temperature Regulation In Biological Samples
A device that provides independent thermal regulation for biological samples in a 96-well microwell plate. Problem: Thermal control of cellular processes allows for remote control through tissue or opaque media, allowing for precise targeting of therapies in the body as well as broad control of metabolic processes in bioreactors. However, current...
Published: 6/6/2024   |   Inventor(s): Lukasz Bugaj, Brian Chow, William Benman, Zikang (Dennis) Huang
Keywords(s): Bioengineering, Platform Technology
Category(s): Technology Classifications > Hardware & Components, Technology Classifications > Research Tools & Reagents, Technology Classifications > Testing & Measurement
A Stable Post-Pyloric Retention Gastrojejunal (GJ) Feeding Tube That Minimizes Dislodgement
The proposed invention is a gastric-jejunal (GJ) feeding tube that includes a retention device to maintain its position once placed in a patient. Problem: Enteral feeding devices, e.g., gastric (G) or gastrojejunal (GJ) feeding tubes, offer a safe and efficient means of delivering essential nutrition directly into the gastrointestinal tract. In particular,...
Published: 6/17/2024   |   Inventor(s): Scott Trerotola
Keywords(s): Bioengineering, Gastroenterology
Category(s): Technology Classifications > Medical Devices
Immune Modulator Encoded Lipid Nanoparticle Formulation Improves T Cell Response to Vaccines
Researchers developed an LNP-mRNA-based vaccine that encodes different cytokine mRNAs, as a method to enhance CD8+ T cell responses and memory formation. Problem: Lipid nanoparticles (LNPs) are an emerging technique to deliver mRNA in vivo more efficiently. While recent progress in mRNA technology has allowed the rapid development of SARS-COV2 vaccines,...
Published: 7/2/2024   |   Inventor(s): Christopher Hunter, Drew Weissman, Mohamad Alameh, Emily Aunins, Anthony Phan
Keywords(s): Bioengineering, Drug Delivery, Immunology, Immunoncology, Immunotherapy, Infectious Disease, Nanotechnology
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Vaccines
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