Search Results - bioengineering

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3D Printing Filaments for Customizable Iodine-Infused Spectral CT Phantoms
3D printing filaments for 3D printing phantoms with controlled iodine concentrations for precise, adjustable spectral CT imaging research and calibration. Problem: Traditional CT imaging phantoms act as physical proxies for human tissue and anatomy, but they are expensive, rigid, and limited in both achievable iodine concentrations and geometric complexity....
Published: 5/20/2026   |   Updated: 5/20/2026   |   Inventor(s): Anatoliy Popov, Peter Noel, Franz Englbrecht
Keywords(s): Bioengineering, Imaging Agents, Radiology
Category(s): Technology Classifications > Materials, Technology Classifications > Imaging, Technology Classifications > Research Tools & Reagents
Continuous Bicontinuous Interfacially Jamming Emulsion Gels (Bijel) Fabrication For Complex, Three-Dimensional Structures
Adaptation of emulsion precursor materials to enable three-dimensional printing of bijels via direct ink writing (DIW) and co-solvent vaporization. Problem: Previously developed bijel fabrication methods produce structures with limited macroscale morphologies, such as fibers, particles, and other simple 2D structures. This restriction limits the applicability...
Published: 5/15/2026   |   Updated: 5/15/2026   |   Inventor(s): Daeyeon Lee, Kathleen Stebe, Jordan Raney, Philip Iaccarino, Damilola Lawal
Keywords(s): Bioengineering, Hydrogels, Platform Technology, Soft Materials
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Energy, Technology Classifications > Materials, Technology Classifications > Medical Devices
Highly Efficient Approach for Developing Biocompatible and Potent Lipid Nanoparticles
Enhancing the biocompatibility and potency of lipid nanoparticles (LNPs) by refining the structure of ionizable lipids through an iterative method. Problem: Ionizable lipids play a crucial role in determining the potency and biocompatibility of LNPs. Current approaches, medicinal chemistry, and combinatorial chemistry, each have limitations. Medicinal...
Published: 5/8/2026   |   Updated: 5/8/2026   |   Inventor(s): Michael Mitchell, Xuexiang Han, Rohan Palanki
Keywords(s): Bioengineering, Drug Delivery, Nanotechnology, Platform Technology
Category(s): Technology Classifications > Therapeutics
Precise, Efficient Delivery of mRNA Medicine to the Placenta
Using tiny lipid nanoparticles (LNPs) to improve mRNA medicine delivery and uptake in the placenta for healthier pregnancies Problem: The placenta is an important biological barrier that connects the mother and fetus while keeping their blood supplies separate, enabling nutrient and oxygen delivery and waste removal for healthy development. Abnormal...
Published: 5/8/2026   |   Updated: 5/8/2026   |   Inventor(s): Michael Mitchell, Hannah Safford, Kelsey Swingle, Hannah Geisler
Keywords(s): Bioengineering, Drug Delivery, Gene Therapy, Immunology, Immunotherapy, Women's Health
Category(s): Technology Classifications > Therapeutics
An All-In-One “Swiss Army Knife” Tool To Edit Genes And Regulate Their Expression Without Off-Target Effects And Toxicity
A flexible toolkit for human gene editing, activation, and repression that can be applied in orthogonally and in various disease models. Problem: There is increasing demand for technologies that can simultaneously edit the genome and regulate the transcriptome without relying on toxic double-stranded breaks. Currently, treating complex diseases such...
Published: 5/5/2026   |   Updated: 5/5/2026   |   Inventor(s): Xue Sherry Gao, Tyler Daniel, Hongzhi Zeng, Qichen Yuan
Keywords(s): Bioengineering, Cell Therapy, Gene Editing, Genetic Disorders, Neurodegenerative Diseases, Obesity Metabolic Disease and Diabetes, Oncology, Orphan Disease, Pulmonary
Category(s): Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics
Microfluidic Lung Chip For Development Modeling
A microfluidic lung chip applies controlled mechanical forces to hydrogel-embedded lung cells or organoids to model lung development in vitro. Problem: Developing lung tissues experiences dynamic mechanical forces during organogenesis. How these forces influence later-stage lung development remains poorly understood. Existing models have not adequately...
Published: 5/4/2026   |   Updated: 5/1/2026   |   Inventor(s): Dongeun (dan) Huh, Sunghee Estelle Park
Keywords(s): Bioengineering, Pulmonary
Category(s): Technology Classifications > Medical Devices, Technology Classifications > Research Tools & Reagents
Tool to Reduce Intrauterine Device Expulsion in Postpartum Women
Placement device for inserting intrauterine devices (IUD) into the postpartum uterus. Problem: An IUD is a small T-shaped device that is placed into the uterus and provides a highly effective method of long-acting reversible contraception. IUDs can be conveniently placed immediately after delivery to prevent unintended pregnancies. A challenge associated...
Published: 4/29/2026   |   Updated: 4/29/2026   |   Inventor(s): Eileen Wang, Gabriel Arenas
Keywords(s): Bioengineering, Women's Health
Category(s): Technology Classifications > Materials, Technology Classifications > Medical Devices
Device For Rapid, Tunable, And Scalable Generation Of Lipid Nanoparticle Formulations
Microfluidic device for generation of large, precisely-defined, diverse lipid nanoparticle libraries for screening LNP formulations. Problem: Lipid nanoparticles (LNPs) have broad applications such as delivery agents for gene editing cargo, immunotherapies, and many clinical applications. The structures of the lipid components of an LNP, their relative...
Published: 4/17/2026   |   Updated: 4/17/2026   |   Inventor(s): Michael Mitchell, David Issadore, Andrew Hanna
Keywords(s): Bioengineering, Drug Delivery, Gene Editing, Gene Therapy, Immunology, Immunotherapy, Microfluidics, Nanotechnology
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Hardware & Components, Technology Classifications > Robotics
An Accessible and Automated Device to Diagnose Nerve and Muscle Disorders
A device consisting of electrode patches, a control box, and software for automated nerve conduction studies. Problem: Nerve conduction studies are essential tools in the diagnosis and management of nerve and muscle disorders. However, current diagnostic tools rely heavily on trained physicians, manual testing protocols, and the precise placement of...
Published: 4/8/2026   |   Updated: 4/8/2026   |   Inventor(s): Josh Baxter, Flavia Vitale, Margaret (Maggie) Wagner, Quinn Tate
Keywords(s): Artificial Intelligence (AI) & Machine Learning, Bioengineering, Neurodegenerative Diseases, Neurology, Orthopedics, Software
Category(s): Technology Classifications > Hardware & Components, Technology Classifications > Diagnostics, Technology Classifications > Medical Devices, Technology Classifications > Testing & Measurement
Rapid Synthesis of Amidine-Incorporated Degradable Lipids for Non-Liver mRNA delivery
One-pot combinatorial chemistry for fast and facile synthesis of amidine-incorporated degradable cationic lipids for lipid nanoparticle formulation and non-liver nucleic acid delivery. Problem: Messenger RNA (mRNA)-based therapeutics and vaccines have broad applications for a variety of diseases but require safe and efficient delivery mechanisms. Lipid...
Published: 2/10/2026   |   Updated: 2/10/2026   |   Inventor(s): Michael Mitchell, Xuexiang Han, Junchao Xu
Keywords(s): Bioengineering, Drug Delivery, Platform Technology
Category(s): Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics, Technology Classifications > Vaccines
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