Search Results - nanotechnology

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High-Throughput Approach to Identify New Lipid Nanoparticle Formulations for Vaccine and Drug Delivery
High-throughput in vivo screening method to identify lipid nanoparticle (LNP) formulations for local and systemic delivery for mRNA vaccines and cancer immunotherapies. Problem: Nucleic acid delivery is an attractive and rapidly growing area of research, particularly for the development of vaccines and cancer immunotherapy. Historically, viral vectors...
Published: 12/20/2024   |   Inventor(s): Michael Mitchell, Alex Hamilton
Keywords(s): Bioengineering, COVID-19, Drug Delivery, Gene Therapy, Immunology, Immunoncology, Immunotherapy, Infectious Disease, Nanotechnology
Category(s): Technology Classifications > Testing & Measurement, Technology Classifications > Vaccines, Technology Classifications > Therapeutics
Macrophage-Targeting Lipid Nanoparticles (MacLNPs) Deliver siRNA Intranasally to Treat Viral Pneumonia
siRNA-LNP knock-down of TAK1 delivered intranasally and to macrophages specifically prevents inflammation-induced pathology in a mouse model Problem: Macrophages are an important component of the innate immune system, but can mediate excessive inflammation and cause severe pathology if left unchecked. This poses a challenge for the treatment of acute...
Published: 12/19/2024   |   Inventor(s): Michael Mitchell, Lulu Xue, Andrew Vaughan, Gan Zhao
Keywords(s): Bioengineering, Drug Delivery, Gene Therapy, Immunology, Infectious Disease, Inflammation, Nanotechnology, Platform Technology
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Materials, Technology Classifications > Therapeutics, Technology Classifications > Vaccines
Space Shuttle-Inspired Branched Lipid Nanoparticles As Potent mRNA Transporters
Lipid nanoparticles (LNPs) with reversibly attached branched lipid tails for the delivery of mRNA for gene therapy. Problem: Delivery of mRNA to target cells enables the expression of engineered proteins but mRNA is unstable and negatively charged, necessitating a delivery vehicle to ensure its entry into cells. LNPs can ferry mRNA across the cell...
Published: 11/26/2024   |   Inventor(s): Michael Mitchell, Xuexiang Han
Keywords(s): Bioengineering, Drug Delivery, Gene Therapy, Nanotechnology, Obesity Metabolic Disease and Diabetes, Platform Technology
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Therapeutics
Bilayer Solid-State Nanopores for the Tracking, Filtering and Guiding of DNA
A bilayered solid-state nanopore material that senses and guides DNA and other biomolecules into homogeneous configurations. Problem: Current methods of DNA sensing and sequencing typically involve short read lengths, chemical labeling, labor-intensive sample preparation, and lack of portability. To minimize these issues during DNA sequencing, protein-based...
Published: 11/25/2024   |   Inventor(s): Marija Drndic, Yung-Chien Chou, Dimitrios Monos, Chih-Yuan Lin
Keywords(s): Nanotechnology
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Materials, Technology Classifications > Research Tools & Reagents
Active Nematic Colloids For Microrobotics And Materials Assembly
A material mixture (active colloids immersed in nematic liquid crystals) that act as microrobots for directed assembly and micromanipulation of passive colloidal particles. Problem: Colloids interact with areas of distortion, such as with walls or with defects in the environment such as sharp edges and can become trapped along disclination lines in...
Published: 11/12/2024   |   Inventor(s): Tianyi Yao, Kathleen Stebe
Keywords(s): Nanotechnology, Platform Technology
Category(s): Technology Classifications > Robotics
miRNA Nanoparticles for Targeted Enhancement of Thermogenic Adipocyte Generation
​ Introduction of a promising anti-obesity novel MiR-133a, Zipper nanoparticle treatment results in enhanced Prdm16 and Ucp1 expression, resulting in adipocyte browning. Invention Summary: Over 40% of adults are overweight and over 15% of adults are living with obesity. Obesity is a major contributor to various causes of mortality including...
Published: 11/12/2024   |   Inventor(s): Sarah Nevins, Ki-Bum Lee, Thanapat Pongkulapa, Sang Ah Yi
Keywords(s): Cardiovascular, Diabetes & Metabolic Disorders, Nanoparticles, Nanotechnology
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Nanotechnology
Physical Neural Network for Fast, Scalable, and Power-Efficient Machine Learning Computation
A physical embodiment of a locally-learning neural network, which learns faster than current CPU-based nets. Problem: Machine learning is a ubiquitous tool that has found uses in engineering, science, and medicine. Neural networks are some of the most powerful machine learning algorithms, but they train very slowly when they become large. This hampers...
Published: 10/24/2024   |   Inventor(s): Samuel Dillavou, Douglas Durian, Andrea Liu, Menachem (Nachi) Stern, Marc Miskin
Keywords(s): Artificial Intelligence (AI) & Machine Learning, Data Science, Electronic Materials, Internet of Things, Nanotechnology, Software
Category(s): Technology Classifications > Computer Information Systems, Technology Classifications > Hardware & Components
An iron oxide nanozyme formulation for augmenting the efficacy of oral care products.
A combinatory formulation for oral care products that enhances antimicrobial specificity, anti-plaque potency and prevents tooth decay. Problem: Tooth decay (dental caries), caused by the destruction of the outer layer (enamel) of teeth by bacteria in biofilms, affects nearly half of the global population and remains the most prevalent chronic disease...
Published: 10/8/2024   |   Inventor(s): Yue Huang, Hyun (Michel) Koo, David Cormode
Keywords(s): Bioengineering, Dentistry, Infectious Disease, Microbiome, Nanotechnology, Platform Technology
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Materials, Technology Classifications > Therapeutics
Adjuvanted Lipid Nanoparticles (LNPs) Enhance Protective Immunity Imparted by SARS-CoV-2 mRNA Vaccine
A lipid nanoparticle formulation that elicits a strong innate immune response for improved vaccine protection Problem: Lipid nanoparticle (LNP)-formulated mRNA vaccines have revolutionized modern vaccinology through their ability to deliver mRNA vaccines with remarkable manufacturing flexibility. However, the modified (pseudouridylated) mRNA used in...
Published: 10/1/2024   |   Inventor(s): Michael Mitchell, Xuexiang Han, Drew Weissman, Mohamad Alameh
Keywords(s): Bioengineering, COVID-19, Drug Delivery, Immunology, Infectious Disease, Nanotechnology
Category(s): Technology Classifications > Materials, Technology Classifications > Vaccines
Nanoscale Metalbeating: Solid-State Transformation of 0D and 1D Gold or other metal Nanoparticles to Anisotropic 2D Morphologies
­Advantages: Consistent transformation of nanoparticles Scalable production method More efficient than traditional techniques Produces high-quality nanomaterials Summary: Efficient, scalable techniques to produce thin gold layers with controlled properties are essential for advanced applications in electronics, photonics, membrane filtration,...
Published: 10/16/2024   |   Inventor(s): Cai Mike Wang, Huijuan Zhao, Catherine Murphy, Md Rubayat-E Tanjil, Tanuj Gupta, Matthew Gole
Keywords(s): Nanotechnology
Category(s): Technology Classifications > Advance Materials > A/M Manufacturing, Technology Classifications > Engineering > Chemical Engineering, Technology Classifications > Electronics > Nanotechnology
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