Search Results - infectious+disease

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Deep Learning Model Discovers Antibiotic Drugs in Extinct Organisms Effective Against Drug-Resistant Superbugs
Antibiotic Peptide de-extinction (APEX) is a deep-learning AI solution that can unearth ancient antibiotics to effectively combat superbugs and tackle antibiotic resistance on a global scale. Problem: Escalating antibiotic resistance around the globe has emerged as one of the pressing problems of our time, with antibiotic-resistant infections causing...
Published: 6/27/2024   |   Inventor(s): Cesar de la Fuente-Nunez, Marcelo Der Torossian Torres, Fangping Wan
Keywords(s): Bioengineering, Infectious Disease, Platform Technology, Protein/Peptide (Non-Antibody)
Category(s): Technology Classifications > Therapeutics
Antimicrobial Peptides (AMPs) Mined from Human Gut Metagenome Are Effective Against Antibiotic Resistant Pathogens
The collective genomes of the human gut microbiome, known as the metagenome, encode peptides that are effective against antibiotic-resistant bacteria. Problem: Antimicrobial resistance poses a major threat to public health. The development of drug-resistance outpaces traditional drug discovery approaches. As a result, the supply of drugs available to...
Published: 6/26/2024   |   Inventor(s): Cesar de la Fuente-Nunez, Marcelo Der Torossian Torres, Ami Bhatt, Erin Brooks
Keywords(s): Artificial Intelligence (AI) & Machine Learning, Bioengineering, Infectious Disease, Microbiome, Protein/Peptide (Non-Antibody)
Category(s): Technology Classifications > Computer Information Systems, Technology Classifications > Therapeutics
Low-Cost, Point-of-Care Test for Rapid Visual Diagnosis of COVID-19
A rapid, low-cost, portable swab-based SARS-CoV-2 biosensor whose test result can be detected with naked eye Problem: COVID-19 has killed over 2.84 million people worldwide and has disproportionately affected people in lower-income and resource-limited geographies. High-frequency testing can prevent rapid virus spread and reduce COVID-19-related hospitalizations...
Published: 6/26/2024   |   Inventor(s): Cesar de la Fuente-Nunez, Marcelo Der Torossian Torres, Lucas Felipe de Lima, Andre Lopes Ferreira
Keywords(s): Bioengineering, COVID-19, Infectious Disease
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Medical Devices
Immune Modulator Encoded Lipid Nanoparticle Formulation Improves T Cell Response to Vaccines
Researchers developed an LNP-mRNA-based vaccine that encodes different cytokine mRNAs, as a method to enhance CD8+ T cell responses and memory formation. Problem: Lipid nanoparticles (LNPs) are an emerging technique to deliver mRNA in vivo more efficiently. While recent progress in mRNA technology has allowed the rapid development of SARS-COV2 vaccines,...
Published: 7/2/2024   |   Inventor(s): Christopher Hunter, Drew Weissman, Mohamad Alameh, Emily Aunins, Anthony Phan
Keywords(s): Bioengineering, Drug Delivery, Immunology, Immunoncology, Immunotherapy, Infectious Disease, Nanotechnology
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Vaccines
Modified Antimicrobial Peptides For Enhanced Antibiotic Properties
Modified antimicrobial peptides with protein sequences for augmenting antimicrobial and antibiofilm properties. Problem: Antibiotic resistant bacteria are becoming more prevalent, while antibiotic innovation has slowed. Novel antimicrobial agents are needed to treat the 35,000 annual deaths from antibiotic resistant infections. While antimicrobial...
Published: 5/7/2024   |   Inventor(s): Cesar de la Fuente-Nunez, Marcelo Der Torossian Torres, Octavio Franco
Keywords(s): Bioengineering, Infectious Disease, Protein/Peptide (Non-Antibody)
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Vaccines
Hidden Antibiotics In The Human Proteome For The Treatment Of Antibiotic-Resistant Infections
Antimicrobial peptides computationally mined from the human proteome. Problem: Novel antibiotics are needed to counter the emergence of drug-resistant bacteria as traditional discovery approaches have not yielded new classes of antimicrobials for decades. Antimicrobial resistance (AMR) is a growing public health concern and, thus far, no significant...
Published: 1/5/2024   |   Inventor(s): Cesar de la Fuente-Nunez, Marcelo Der Torossian Torres, Marcelo Dos Reis Melo
Keywords(s): Bioengineering, Data Science, Infectious Disease, Protein/Peptide (Non-Antibody)
Category(s): Technology Classifications > Therapeutics
­DESIGN OF A UNIVERSAL INFLUENZA VACCINE CANDIDATES VIA ANTIGEN REORIENTATION
­DESIGN OF A UNIVERSAL INFLUENZA VACCINE CANDIDATES VIA ANTIGEN REORIENTATION Researchers at Stanford have developed a novel universal influenza vaccine candidate. Vaccines are a major feat of biomedical innovation. Successful vaccines produce broad humoral immunity to a pathogen to prevent subsequent infection. In this vein, adjuvants are compounds...
Published: 12/5/2023   |   Inventor(s): Duo Xu, Peter Kim
Keywords(s): Adjuvant, Alum, Infectious Disease, Vaccine
Category(s): Technology Classifications > Biology
Low Toxicity Antimicrobial Peptides To Overcome Antibiotic Resistance
Combining naturally occurring peptides by hybridizing them with known active peptides to synthesize effective antimicrobial peptides with minimal cytotoxicity. Problem: Antibiotic resistance is a significant concern that poses a potential risk of increased harm from future infectious diseases. Consequently, antimicrobial peptides (AMPs) are regarded...
Published: 11/3/2023   |   Inventor(s): Cesar de la Fuente-Nunez, Ravi Radhakrishnan, Vani Xavier de Oliveira Junior, Marcelo Der Torossian Torres, Yiming Wang, Cibele Nicolaski Pedron
Keywords(s): Infectious Disease, Protein/Peptide (Non-Antibody)
Category(s): Technology Classifications > Chemical Processes and Synthesis
Double Digital Assay for Isolation and Analysis of Single Extracellular Vesicles for Early Detection of Disease Biomarkers Including Cancer
An ultrasensitive diagnostic tool that isolates single extracellular vesicles (EVs) and measures their contents to single molecule resolution. Problem: EVs contain biomolecules that can identify a variety of disease states and, thus, have emerged as a promising source for diagnostics. Within the EV diagnostic field, there are two major challenges:...
Published: 10/16/2023   |   Inventor(s): Jina Ko, David Reynolds, Menghan Pan
Keywords(s): Bioengineering, Infectious Disease, Microfluidics, Oncology, Platform Technology
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Digital Health, Technology Classifications > Research Tools & Reagents, Technology Classifications > Hardware & Components, Technology Classifications > Testing & Measurement
­IMMUNOGENIC EBOLAVIRUS FUSION PROTEINS AND RELATED METHODS
­IMMUNOGENIC EBOLAVIRUS FUSION PROTEINS AND RELATED METHODS Researchers at Stanford have developed a novel vaccine strategy for ebolavirus using fusion proteins composed of the virus’ glycoprotein. Hemorrhagic fevers have become a major public health issue in Africa, the most notable of which being Ebola. Ebola has a notably high mortality...
Published: 10/6/2023   |   Inventor(s): Peter Kim, Duo Xu, Abigail Powell
Keywords(s): Ebola Virus, Infectious Disease, Vaccine
Category(s): Technology Classifications > Biology
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