Search Results - platform+technology

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An iron oxide nanozyme formulation for augmenting the efficacy of oral care products.
A combinatory formulation for oral care products that enhances antimicrobial specificity, anti-plaque potency and prevents tooth decay. Problem: Tooth decay (dental caries), caused by the destruction of the outer layer (enamel) of teeth by bacteria in biofilms, affects nearly half of the global population and remains the most prevalent chronic disease...
Published: 4/25/2025   |   Inventor(s): Yue Huang, Hyun (Michel) Koo, David Cormode
Keywords(s): Bioengineering, Dentistry, Infectious Disease, Microbiome, Nanotechnology, Platform Technology
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Materials, Technology Classifications > Therapeutics
Reducing The Adverse Side Effects Of Using Native T-Cells To Destroy Cancer Cells
A Switchable Bispecific T-Cell Nanoengager (sBiTNE) to link T cells with cancer cells that can be reversed if off-tumor toxicity is detected. Problem: Compounds which link native T-cells with the surface antigens found on cancer cells have emerged as an effective treatment for blood malignancies and are currently being developed for solid tumors....
Published: 4/16/2025   |   Inventor(s): Michael Mitchell, Ningqiang Gong
Keywords(s): Bioengineering, Immunology, Immunoncology, Immunotherapy, Oncology, Platform Technology, Protein/Peptide (Non-Antibody), Small Molecule
Category(s): Technology Classifications > Therapeutics
Biocompatible And Low-Toxicity Lipid Nanoparticles (LNPs) For Selectively Delivering mRNA To The Bone Microenvironment
Ionizable LNPs with a rigid backbone of piperazine (PIP) linked to bisphosphonates (BPs) for the targeted delivery of mRNA to the bone. Problem: Available treatments for bone tissue related diseases provide only symptomatic relief and are associated with clinical challenges and potential side effects. Challenges persist in the delivery of therapeutic...
Published: 3/7/2025   |   Inventor(s): Michael Mitchell, Kyle Vining, Lulu Xue, Il-Chul Yoon
Keywords(s): Aging, Bioengineering, Drug Delivery, Gene Therapy, Orthopedics, Platform Technology, Women's Health
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Therapeutics
Anticancer IgG Against Multiple Epitopes on Live Tumors Upon Disruption of ‘Self’ Signaling by CD47
A method to combine two or three monoclonal antibodies (mABs) into one treatment to successfully bind to multiple cancer cell surface epitopes and promote targeted degradation by phagocytosis. Problem: Phagocytosis of ‘self’ cells is generally inhibited by a key macrophage checkpoint interaction between SIRPα on the macrophage and...
Published: 2/27/2025   |   Inventor(s): Dennis Discher, Jason Andrechak, Lawrence Dooling
Keywords(s): Antibody, Bioengineering, Cell Therapy, Drug Target, Immunology, Immunoncology, Immunotherapy, Oncology, Platform Technology
Category(s): Technology Classifications > Therapeutics
A Method for Promoting Structural and Functional Rescue of Photoreceptors in the Eye to Treat Advanced Retinal Degeneration.
Discovery and use of retina-specific promoters to rescue photoreceptor function specifically at clinically relevant, advanced stages of disease. Problem: Despite the fact that retinal gene therapy studies have shown promising results in animal models, treatment of advanced retinal degeneration with currently available gene therapies have not been successful....
Published: 1/24/2025   |   Inventor(s): Raghavi Sudharsan, William Beltran
Keywords(s): Bioengineering, Gene Therapy, Genetic Disorders, Ophthalmology, Orphan Disease, Platform Technology, Regenerative Medicine
Category(s): Technology Classifications > Therapeutics
Machine-Learning Foundation Model For The Early Detection Of Neurodegenerative Diseases
A machine learning technique that identifies biomarkers from neuroimaging data, allowing for identification and treatment of populations vulnerable to neurodegenerative diseases. Problem: Neurodegenerative diseases such as Alzheimer’s disease (AD) impact an estimated twenty-four million people worldwide, with prevalence increasing with global...
Published: 1/17/2025   |   Inventor(s): Saurabh Sihag, Alejandro Ribeiro
Keywords(s): Aging, Artificial Intelligence (AI) & Machine Learning, Neurodegenerative Diseases, Neurology, Platform Technology, Radiology
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Digital Health, Technology Classifications > Imaging
T-Cell-Activating Lipid Nanoparticles for Rapid Engineering of CAR T Cells
A method to streamline the process of generating chimeric antigen receptor (CAR) T cells for therapeutic applications. Problem: CAR T cell therapy has demonstrated clinical success in treating various forms of cancer. With more CAR T cell therapies projected to gain regulatory approval, manufacturing becomes increasingly important in the face of this...
Published: 12/20/2024   |   Inventor(s): Ann Metzloff, Margaret Billingsley, Michael Mitchell
Keywords(s): Bioengineering, Cell Therapy, Drug Delivery, Immunoncology, Immunotherapy, Oncology, Platform Technology
Category(s): Technology Classifications > Therapeutics
Prodrug Lipid Nanoparticles for Synergistic Cancer Immunotherapy
Prodrug lipid nanoparticle (LNP) with a mRNA encoding for a therapeutic cytokine for solid tumor immunotherapy.</brief> Problem: Approximately 2 million people are diagnosed with cancer each year in the United States. Messenger RNA (mRNA)-based cancer immunotherapy has emerged as a potential cancer treatment using cytotoxic T cells to eliminate...
Published: 1/7/2025   |   Inventor(s): Michael Mitchell, Qiangqiang Shi
Keywords(s): Bioengineering, Drug Delivery, Oncology, Platform Technology
Category(s): Technology Classifications > Therapeutics
Macrophage-Targeting Lipid Nanoparticles (MacLNPs) Deliver siRNA Intranasally to Treat Viral Pneumonia
siRNA-LNP knock-down of TAK1 delivered intranasally and to macrophages specifically prevents inflammation-induced pathology in a mouse model Problem: Macrophages are an important component of the innate immune system, but can mediate excessive inflammation and cause severe pathology if left unchecked. This poses a challenge for the treatment of acute...
Published: 12/19/2024   |   Inventor(s): Michael Mitchell, Lulu Xue, Andrew Vaughan, Gan Zhao
Keywords(s): Bioengineering, Drug Delivery, Gene Therapy, Immunology, Infectious Disease, Inflammation, Nanotechnology, Platform Technology
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Materials, Technology Classifications > Therapeutics, Technology Classifications > Vaccines
Targeted In Utero Therapeutics Delivery System for Precise Gene Editing
Targeted lipid nanoparticles (LNPs) that can deliver mRNA-based gene editing therapeutics to hematopoietic stem cells (HSCs) in utero Problem: Monogenic blood diseases, including sickle cell disease and / thalassemia, are among the most prevalent genetic conditions worldwide, causing significant pediatric morbidity with complications like painful...
Published: 1/2/2025   |   Inventor(s): Rohan Palanki, Michael Mitchell, William Peranteau
Keywords(s): Bioengineering, Gene Editing, Gene Therapy, Platform Technology
Category(s): Technology Classifications > Therapeutics
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