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Restoration of motor function through delayed intraspinal delivery of mRNA-encoded IL-10 after spinal cord injury
Brief Description: Disclosed herein is a composition including a nucleoside-modified mRNA encapsulated in a lipid nanoparticle wherein the nucleoside-modified mRNA encodes IL10, IL-6, MIP1a, GDNF (glial cell line-derived neurotrophic factor), or a combination thereof. A method of treated spinal cord injury is also described. Image: Caption: Reference...
Published: 7/9/2025   |   Inventor(s): Norbert Pardi, Drew Weissman
Keywords(s): Bioengineering, Drug Delivery, Gene Therapy, Immunology, Neurology, Regenerative Medicine
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Vaccines