Search Results - oncology

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T-Cell-Activating Lipid Nanoparticles for Rapid Engineering of CAR T Cells
A method to streamline the process of generating chimeric antigen receptor (CAR) T cells for therapeutic applications. Problem: CAR T cell therapy has demonstrated clinical success in treating various forms of cancer. With more CAR T cell therapies projected to gain regulatory approval, manufacturing becomes increasingly important in the face of this...
Published: 12/20/2024   |   Inventor(s): Ann Metzloff, Margaret Billingsley, Michael Mitchell
Keywords(s): Bioengineering, Cell Therapy, Drug Delivery, Immunoncology, Immunotherapy, Oncology, Platform Technology
Category(s): Technology Classifications > Therapeutics
Prodrug Lipid Nanoparticles for Synergistic Cancer Immunotherapy
Prodrug lipid nanoparticle (LNP) with a mRNA encoding for a therapeutic cytokine for solid tumor immunotherapy.</brief> Problem: Approximately 2 million people are diagnosed with cancer each year in the United States. Messenger RNA (mRNA)-based cancer immunotherapy has emerged as a potential cancer treatment using cytotoxic T cells to eliminate...
Published: 12/20/2024   |   Inventor(s): Michael Mitchell, Qiangqiang Shi
Keywords(s): Bioengineering, Drug Delivery, Oncology, Platform Technology
Category(s): Technology Classifications > Therapeutics
Method to Alleviate Side Effects of CAR T Cell Immunotherapies
CAR-T cells are PEGylated to block the interactions with monocytes and macrophages to reduce the side effects of CAR-T cell therapies (cytokine release syndrome and neurotoxicity). Problem: CAR-T cell therapies lead to many adverse side effects such as cytokine release syndrome (CRS) and neurotoxicity. It has been shown that 20-70% of patients receiving...
Published: 12/20/2024   |   Inventor(s): Michael Mitchell, Ningqiang Gong
Keywords(s): Bioengineering, Cell Therapy, Immunology, Immunoncology, Immunotherapy, Oncology
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Therapeutics
Novel RNA Binding Protein Targets to Treat Melanoma
Figure 1. RNA-binding proteins as novel oncological targets. (A) Unbiased screen on cell lines with increasing cancer aggressiveness​. (B) Specific inhibition of the RNA binding domain of one of the hit candidate RBPs affects tumoral cells viability. Novel antitumoral RNA-binding protein targets in melanoma identified by an unbiased screen. We are...
Published: 10/28/2024   |   Inventor(s): Fatima Gebauer, Neus Mestre Farras, Santiago Guerrero
Keywords(s): Melanoma, Oncology
Category(s): Drug Targets & Mechanisms, Therapeutics (Biologics & Compounds)
NudTx: Targeting Cancer Stem Cells
Small molecules hits, and companion diagnostic, selective for the ATP generating activity of NUDT5. We are developing lead compounds that eventually could be used to complement poly ADP-ribose polymerase therapy or as a treatment on itself as an alternative treatment option to treat primary and metastatic cancers. Technology: Recurrence and metastasis...
Published: 10/4/2024   |   Inventor(s): Miguel Beato, Roni Wright
Keywords(s): Metastasis, Oncology
Category(s): Drug Targets & Mechanisms, Therapeutics (Biologics & Compounds)
Novel Therapeutic Targets for DIPG
Various antitumoral targets identified from an unbiased multiomics screen on H3K27M mutated Diffuse Midline Glioma patient-derived material. We are finalizing target validation and developing high throughput small molecule screening assays to develop novel compounds that can be used to treat this devastating childhood cancer. Technology: Diffuse...
Published: 11/21/2024   |   Inventor(s): Luciano Di Croce, Maria Espejo Diaz
Keywords(s): Epigenetics, Oncology, Paediatric Disease
Category(s): Drug Targets & Mechanisms, Therapeutics (Biologics & Compounds)
Inhibitors of the N-terminal Domain of the Androgen Receptor (UCLA Case No. 2023-075)
Researchers at UCLA under the guidance of Drs. Matthew Rettig and Michael Jung have developed novel molecular compounds that reduce growth of prostate cancer cells. Dr. Jung in collaboration with Dr. Rettig have furthered the development of these compounds by synthesizing a new series of analogues that have similar inhibitory effects. BACKGROUND: Prostate...
Published: 9/23/2024   |   Inventor(s): Matthew Rettig, Michael Jung
Keywords(s): androgen receptor therapy, castration resistant prostate cancer, Oncology, Oncology (Small Molecules, Peptides and Antibodies), prostate cancer, small molecules
Category(s): Therapeutics > Oncology, Therapeutics > Oncology > Oncology (Small Molecules)
Assessment of Tumor Response to Treatment Using Level Set Clustering in PET Images
Application Tumor response algorithm that corrects for anatomical changes and robustly identifies local changes in serial PET images through a clustering algorithm. Key Benefits Robust to noise and outliers and can tolerate imperfections in data acquisition. Could be applicable to many other imaging modalities in radiation therapy. More accurately...
Published: 8/22/2024   |   Inventor(s): Timothy Fox, Eduard Schreibmann
Keywords(s): Imaging, Oncology
Category(s): TechPub Algolia > Medical Device, TechPub Algolia > Software
Dye-Loaded Micelles for Direct Visualization of Colorectal Cancer
A tissue-selective, biocompatible contrast agent enables the visual identification of tumors and tumor margins during procedures Problem: Dye-based chromoendoscopy (DBC) helps endoscopists visualize colorectal mucosa and identify inflammatory polyps that could progress toward colorectal cancer in patients with inflammatory bowel disease (IBD). However,...
Published: 8/2/2024   |   Inventor(s): Andrew Tsourkas, Ahmad Amirshaghaghi, Zhiliang Cheng, Karthik Sundaram, Yiran Tian
Keywords(s): Bioengineering, Imaging Agents, Nanotechnology, Oncology, Surgery
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Imaging, Technology Classifications > Materials
Methods and Compositions for Treating Melanoma (UCLA Case No. 2021-324)
The Graeber Laboratory at UCLA discovered a novel mechanism for treating melanoma using ferroptosis, a type of programmed cell death, that shows promise against therapy resistance. BACKGROUND: Melanoma is a highly aggressive skin cancer that spreads throughout the body and can be fatal if left untreated. Therapies for melanoma range from immunotherapy...
Published: 7/10/2024   |   Inventor(s): Thomas Graeber
Keywords(s): Cancer, ferroptosis, Immunotherapy, MAPK signaling, Melanoma, Oncology, Skin, tumor resistance
Category(s): Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy
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