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Search Results - oncology
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Inhibitors of the N-terminal Domain of the Androgen Receptor (UCLA Case No. 2023-075)
Researchers at UCLA under the guidance of Drs. Matthew Rettig and Michael Jung have developed novel molecular compounds that reduce growth of prostate cancer cells. Dr. Jung in collaboration with Dr. Rettig have furthered the development of these compounds by synthesizing a new series of analogues that have similar inhibitory effects. BACKGROUND: Prostate...
Published: 9/23/2024
|
Inventor(s):
Matthew Rettig
,
Michael Jung
Keywords(s):
androgen receptor therapy
,
castration resistant prostate cancer
,
Oncology
,
Oncology
(Small Molecules, Peptides and Antibodies)
,
prostate cancer
,
small molecules
Category(s):
Therapeutics >
Oncology
,
Therapeutics >
Oncology
> Oncology (Small Molecules)
Assessment of Tumor Response to Treatment Using Level Set Clustering in PET Images
Application Tumor response algorithm that corrects for anatomical changes and robustly identifies local changes in serial PET images through a clustering algorithm. Key Benefits Robust to noise and outliers and can tolerate imperfections in data acquisition. Could be applicable to many other imaging modalities in radiation therapy. More accurately...
Published: 8/22/2024
|
Inventor(s):
Timothy Fox
,
Eduard Schreibmann
Keywords(s):
Imaging
,
Oncology
Category(s):
TechPub Algolia > Medical Device
,
TechPub Algolia > Software
Dye-Loaded Micelles for Direct Visualization of Colorectal Cancer
A tissue-selective, biocompatible contrast agent enables the visual identification of tumors and tumor margins during procedures Problem: Dye-based chromoendoscopy (DBC) helps endoscopists visualize colorectal mucosa and identify inflammatory polyps that could progress toward colorectal cancer in patients with inflammatory bowel disease (IBD). However,...
Published: 8/2/2024
|
Inventor(s):
Andrew Tsourkas
,
Ahmad Amirshaghaghi
,
Zhiliang Cheng
,
Karthik Sundaram
,
Yiran Tian
Keywords(s):
Bioengineering
,
Imaging Agents
,
Nanotechnology
,
Oncology
,
Surgery
Category(s):
Technology Classifications > Diagnostics
,
Technology Classifications > Imaging
,
Technology Classifications > Materials
Methods and Compositions for Treating Melanoma (UCLA Case No. 2021-324)
The Graeber Laboratory at UCLA discovered a novel mechanism for treating melanoma using ferroptosis, a type of programmed cell death, that shows promise against therapy resistance. BACKGROUND: Melanoma is a highly aggressive skin cancer that spreads throughout the body and can be fatal if left untreated. Therapies for melanoma range from immunotherapy...
Published: 7/10/2024
|
Inventor(s):
Thomas Graeber
Keywords(s):
Cancer
,
ferroptosis
,
Immunotherapy
,
MAPK signaling
,
Melanoma
,
Oncology
,
Skin
,
tumor resistance
Category(s):
Therapeutics >
Oncology
,
Therapeutics > Immunology And Immunotherapy
Temporal Transcriptomic Characterization of Small Cell Neuroendocrine Prostate Cancer (UCLA Case No. 2023-268)
The laboratory of Dr. Thomas Graeber at UCLA developed a novel in vivo model that can characterize mechanisms of the trans-differentiation of prostate cancer into small cell neuroendocrine cancer. BACKGROUND: Prostate cancer is one of the most common cancers among men worldwide, with an estimated 288,300 new cases in the U.S. last year. Among many...
Published: 7/10/2024
|
Inventor(s):
Thomas Graeber
Keywords(s):
neuroendocrine
,
Oncology
,
prostate cancer
,
small cell cancer
,
transdifferentiation
Category(s):
Therapeutics >
Oncology
> Oncology (Small Molecules)
,
Platforms > Diagnostic Platform Technologies
Multi-Phasic Therapeutic Delivery System (UCLA Case No. 2020-396)
Researchers in the Department of Radiological Sciences at UCLA have conceived a new methodology to overcome obstacles arising after the treatment of tumors by accessing their vascular supply by 1) targeting tumor vessels 2) delivering antineoplastic agents (e.g., chemotherapy or immunotherapy) and 3) delivering anti-angiogenic therapy to reduce blood...
Published: 7/10/2024
|
Inventor(s):
Antoinette Gomes
Keywords(s):
Anti-Angiogenics
,
Multiphasic and Multitemporal
,
Oncology
,
Therapeutics
,
Vascular therapy
Category(s):
Therapeutics >
Oncology
,
Medical Devices
Treatment of viral induced cancers
Docket Number: Docket# S4039 Tech Title: Technology Technology: Epstein-Barr virus (EBV) and Kaposi’s sarcoma-associated herpesvirus(KSHV) are human γ-herpesviruses associated with a broad spectrum of B-cell lymphomas typically in immune-compromised populations. There are no drugs which can specifically target EBV/KSHV-associated B-cell...
Published: 6/21/2024
|
Inventor(s):
Erle Robertson
Keywords(s):
Oncology
Category(s):
Technology Classifications > Therapeutics
Universal cancer vaccine targeting tumor vasculature
A DNA vaccine targeting tumor endothelial marker 1 (TEM1) that allows to prevent and delay tumor progression without adverse effect on physiologic angiogenesis Technology Overview: Immunization against antigens specifically expressed on tumor vasculature is a very attractive immunotherapy options due to its ability to prevent solid tumor growth....
Published: 6/21/2024
|
Inventor(s):
George Coukos
Keywords(s):
Oncology
Category(s):
Technology Classifications > Vaccines
Tumor Suppression by Retinoic Acid Pathway Inhibition
Targeting retinoic acid (RA) synthesizing enzymes or RA receptors with small molecules boosts the immune system towards a tumor rejection response Problem: Hepatocellular carcinoma (HCC) is the most common liver cancer globally. In the US alone, 33 000 patients are diagnosed yearly, 27 000 of which will die. Once metastasized, HCC shows...
Published: 6/21/2024
|
Inventor(s):
Malay Haldar
,
Ganesha Rai Bantukallu
Keywords(s):
Cell Therapy
,
Drug Target
,
Immunology
,
Immun
oncology
,
Oncology
,
Small Molecule
Category(s):
Technology Classifications > Therapeutics
Early Detection of Pancreatic Cancer
A 2-protein panel blood test for early detection of pancreatic ductal adenocarcinoma. Problem: Pancreatic cancer is the third leading cause of cancer related death in the US and is predicted to become the second leading cause of cancer mortality by 2020. Most pancreatic ductal adenocarcinoma (PDAC) patients are diagnosed at an advanced stage of disease,...
Published: 6/21/2024
|
Inventor(s):
Kenneth Zaret
Keywords(s):
Oncology
Category(s):
Technology Classifications > Diagnostics
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