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Methods and Sequences for mRNA and Other HIV Vaccine Development
Unique sequences eliciting broadly neutralizing antibodies (bNAbs) against human immunodeficiency virus (HIV) that could be used to develop effective mRNA-based and other types of HIV vaccine.
Problem:
Despite decades of research, there is currently no vaccine to prevent HIV infection. A major goal of HIV vaccine programs is to generate bNAbs, which...
Published: 3/31/2025
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Inventor(s): George Shaw, Edward (Ted) Kreider, Beatrice Hahn, Ashwin Skelly, Hui Li, Drew Weissman
Keywords(s): Bioengineering, HIV/AIDS, Immunology, Infectious Disease, Protein/Peptide (Non-Antibody)
Category(s): Technology Classifications > Vaccines
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Nanoparticles for Precise & Targeted Treatment of Neurological Conditions
Problem:
Acute ischemic stroke (AIS) is the second leading cause of death worldwide, affecting around 600,000 Americans annually. However, pharmacological treatment of AIS is difficult due to ineffective and nonspecific targeting to blood brain barrier epitopes via intravenous administration. Over 100 drugs have been tried and failed in clinical trials...
Published: 2/20/2025
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Inventor(s): Oscar Marcos Contreras, Jacob Brenner, Vladimir Muzykantov, Jia Nong, Patrick Glassman, Drew Weissman, Sahiley Reyes-Esteves
Keywords(s): Drug Delivery, Inflammation, Nanotechnology, Neurology
Category(s): Technology Classifications > Therapeutics
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Adjuvanted Lipid Nanoparticles (LNPs) Enhance Protective Immunity Imparted by SARS-CoV-2 mRNA Vaccine
A lipid nanoparticle formulation that elicits a strong innate immune response for improved vaccine protection
Problem:
Lipid nanoparticle (LNP)-formulated mRNA vaccines have revolutionized modern vaccinology through their ability to deliver mRNA vaccines with remarkable manufacturing flexibility. However, the modified (pseudouridylated) mRNA used in...
Published: 10/1/2024
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Inventor(s): Michael Mitchell, Xuexiang Han, Drew Weissman, Mohamad Alameh
Keywords(s): Bioengineering, COVID-19, Drug Delivery, Immunology, Infectious Disease, Nanotechnology
Category(s): Technology Classifications > Materials, Technology Classifications > Vaccines
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Targeted Organ or Multiple Organ Delivery of mRNA with Ionizable Amphiphilic Janus Dendrimers
A library of easily synthesized ionizable amphiphilic Janus dendrimer (IAJD) compounds that deliver mRNA either to targeted organs or multiple organs, depending on the IAJD design.
Problem:
Four-component lipid nanoparticles (LNPs) are the benchmark synthetic vector for the delivery of mRNA. Despite their high biosafety, low toxicity, and immunogenicity,...
Published: 7/23/2024
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Inventor(s): Virgil Percec, Drew Weissman, Juncheng (Luke) Lu, Elena Atochina-Vasserman, Devendra Maurya, Dipankar Sahoo
Keywords(s): Drug Delivery, Platform Technology
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Vaccines
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Immune Modulator Encoded Lipid Nanoparticle Formulation Improves T Cell Response to Vaccines
Researchers developed an LNP-mRNA-based vaccine that encodes different cytokine mRNAs, as a method to enhance CD8+ T cell responses and memory formation.
Problem:
Lipid nanoparticles (LNPs) are an emerging technique to deliver mRNA in vivo more efficiently. While recent progress in mRNA technology has allowed the rapid development of SARS-COV2 vaccines,...
Published: 7/2/2024
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Inventor(s): Christopher Hunter, Drew Weissman, Mohamad Alameh, Emily Aunins, Anthony Phan
Keywords(s): Bioengineering, Drug Delivery, Immunology, Immunoncology, Immunotherapy, Infectious Disease, Nanotechnology
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Vaccines
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Malaria mRNA vaccine
Nearly half of the world's population is at the risk of contracting malaria. According to the World Health Organization, Malaria remains a primary cause of childhood illness and death in sub-Saharan Africa. Recent studies provide evidence of the immunogenicity of mRNA vaccines against Plasmodium falciparum - the parasite responsible for most severe...
Published: 2/18/2025
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Inventor(s): Nirbhay Kumar, Drew Weissman, Clifford Thomas Holeski Hayashi, Yi Cao
Keywords(s):
Category(s): Technology Classifications > Therapeutics > Vaccines
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Hybrid Plasmonic Platform for Directing and Controlling Nanostructure Growth
Low-Heat, Bottom-Up Approach Can Produce Metal, Polymer or Bio-Molecule Structures for Catalysis, Biosensors, Electronic Devices and MoreThis surface plasmon mediated chemical solution deposition method uses surface plasmon resonance to deposit nanoparticles in the liquid phase at room temperature to direct and control nanostructure growth. Plasmonic...
Published: 6/27/2021
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Inventor(s): Wei Wei, Jingjing Qiu
Keywords(s): Catalysts, nanoparticle synthesis, Plasmonic, Thin Films
Category(s): Technology Classifications > Engineering > Chemical, Technology Classifications > Engineering > Materials
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14-3-3 Protein Overexpression to Enhance Plant Oil Production
Executive SummaryVegetable oils are used for nutrition, biofuel, industrial applications, cosmetics, and pharmaceuticals. To meet the growing demand for vegetable oils, production of oilseeds has increased steadily in recent years. Researchers at Michigan State University (MSU) have discovered a method to significantly increase the content of oil in...
Published: 2/17/2023
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Inventor(s): Christoph Benning, John Ohlrogge, Wei Ma, Que Kong
Keywords(s):
Category(s): Agriculture, Biotechnology
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Engineered WRINKLED1 Transcription Factor with Increased Stability and Enhanced Oil Production
IntroductionPlant oils, primarily seed oils, are major agricultural commodities. The world consumption of plant oils in 2013 was 165 million tonnes, which represents an increase of 100 million tonnes since 1995. The majority of vegetable oils are produced from just four crops, oil palm, soybeans, rapeseed, and sunflower, which together accounts for...
Published: 2/17/2023
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Inventor(s): John Ohlrogge, Christoph Benning, Wei Ma, Que Kong
Keywords(s): Agriculture Biotechnology, Biodiesel, Oil Crops
Category(s): Biotechnology, Agriculture
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