Search Results - cancer

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Targeting Protein Phosphatase-5 in Cancer

This technology introduces a novel approach to cancer treatment by targeting Protein Phosphatase 5 (PP5) to regulate apoptosis and inhibit tumor growth, particularly in clear cell renal cell carcinoma (ccRCC). Background: Cancer cells often evade programmed cell death, allowing tumors to grow unchecked. In clear cell renal cell carcinoma, dysregulation...

Published: 6/16/2026 | Updated: 6/16/2026 | Inventor(s): Mehdi Mollapour, Gennady Bratslavsky, John Chisholm, Dimitra Bourboulia, Mark Woodford

Keywords(s): cancer, cancer therapy, phosphorylation, Technologies

Category(s): Campus > Upstate Medical University, Technology Classifications > Gene Therapy

Targeting Hypoxia-inducible factor 2alpha in cancer

This technology offers a novel approach for new cancer treatments based on inhibiting HIF2α-related processes. Background: Hypoxia-inducible factor 2α (HIF2α) transcription factor is involved in the adaptation of cancer cells (including clear cell renal cell carcinoma (ccRCC)) to low oxygen conditions (hypoxia). It plays a role...

Published: 6/15/2026 | Updated: 6/15/2026 | Inventor(s): Mehdi Mollapour, Gennady Bratslavsky, Dimitra Bourboulia, Mark Woodford, John Chisholm

Keywords(s): cancer, cancer therapy, cell proliferation, regulation of transcriptional dynamics, Technologies

Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines

Bruton's Tyrosine Kinase as Anti-Cancer Drug Target

This technology identifies Bruton's Tyrosine Kinase (BTK) as a novel target in breast cancer therapy and provides methods for treatment and diagnosis by inhibiting a specific BTK variant. Background: Protein tyrosine kinases (PTKs) are essential enzymes involved in cellular communication and regulation, often playing a significant role in cancer...

Published: 5/5/2026 | Updated: 5/4/2026 | Inventor(s): Douglas Conklin, Antonis Kourtidis, Cheryl Eifert

Keywords(s): breast cancer, cancer, TAF, Technologies, therapeutic targets

Category(s): Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Biomedical Science and Engineering, Campus > University at Albany

Method and Apparatus for Implantable Tumor-Treating Field via Shape-Engineered Ultrasonic Powering Receiver

Advantages Enables battery-free, implantable tumor-treating field delivery directly at the tumor site Eliminates skull attenuation and cerebrospinal fluid shunting that limit conventional scalp-based TTF systems Fourfold higher ultrasonic-to-electric power conversion compared to standard cubic receivers Closed-loop field control maintains stable,...

Published: 6/1/2026 | Updated: 3/13/2026 | Inventor(s): Albert Kim, Sophia Selvarajan, Zeng-jie Yang, Silvia Valdes Rives

Keywords(s): Biotechnology, Cancer, Medical Devices, Medical Implants

Category(s): Technology Classifications > Medical > Medical Devices, Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Cancer, Technology Classifications > Energy & Environment > Energy Engineering

Inclusion Body–Based Expression Platform for PTM-Preserved Proteins (PIInBody)

Enables high-yield production of unstable, post-translationally modified proteins by protecting them during expression and gentle release Background Intrinsically disordered proteins (IDPs), particularly those carrying labile post-translational modifications (PTMs), are difficult to produce recombinantly due to degradation, aggregation, and loss...

Published: 5/9/2026 | Updated: 2/19/2026 | Inventor(s): Richard Cooley, Cat Vesely, Ryan Mehl

Keywords(s): antibody, architecture, assay, assay development, bacterial, bacterial expression system, binders, cancer, code, denaturing, diagnostic, drug development, enzymatic, epitope, expression platform, expression system, fusion, homogeneous, inclusion, isotopic, isotopic labeling, mass spectrometry, neurodegeneration, post-translational, protein, purification, reagent, recombinant, screening assays, structural biology

Category(s): Biological Materials

Dual Inhibition of RNA Polymerase I and III as a Novel Strategy for Targeting Ribosome Biogenesis in Cancer

A specially designed peptide blocks two key enzymes needed for ribosome production in cancer cells, shutting down their protein-making machinery and offering a new, more effective way to treat cancer and prevent drug resistance. Background: Ribosome biogenesis is a fundamental cellular process involving the coordinated synthesis of ribosomal RNA...

Published: 3/26/2026 | Updated: 2/19/2026 | Inventor(s): Haleigh Pascual, Bruce Knutson

Keywords(s): cancer, Technologies

Category(s): Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Therapeutics and Vaccines

HistoTME: an AI tool for prediction of the tumor microenvironment molecular composition from histopathology images

HistoTME is an AI software that predicts the tumor microenvironment’s molecular makeup from standard pathology images, helping identify lung cancer patients likely to benefit from immunotherapy without needing costly molecular tests. Background: The tumor microenvironment (TME) plays a crucial role in the progression and treatment response...

Published: 4/2/2026 | Updated: 2/3/2026 | Inventor(s): Tamara Jamaspishvili, Sushant Patkar, Alex Chen, Stephanie Harmon, Ismail Turkbey

Keywords(s): artificial intelligence, cancer, computational biology, digital image processing, disease diagnosis, Technologies

Category(s): Technology Classifications > Computer Software, Campus > Upstate Medical University, Technology Classifications > Medical Imaging

Profiling Chemically Modified DNA/RNA Units for Disease and Cancer Diagnosis

Diagnose a wide variety of conditions by analyzing DNA and RNA nucleotides/nucleosides. Background: In theory, RNA and DNA can be used to diagnose a broad range of diseases. Unfortunately, there are no existing technologies capable of providing comprehensive profiles of variant DNA/RNA components. Established approaches for the analysis/detection of...

Published: 1/30/2026 | Updated: 10/24/2025 | Inventor(s): Daniele Fabris, Rebecca Rose

Keywords(s): cancer, DNA modifications, epigenetics, genome-wide analysis, infection, oncology, RNA modifications, Technologies

Category(s): Technology Classifications > Diagnostics, Campus > University at Albany

OPTIMIZING CANCER CHEMOTHERAPY WITH THE GUT MICROBIOME

Researchers at UCSF have developed a novel innovation in harnessing the gut microbiome to alleviate severe side effects of chemotherapy. Dose-limiting toxicities remain a significant barrier in the advancement of drug therapies, particularly in oncology. Although decades of pharmacogenomic research have identified specific human genetic variants that...

Published: 4/15/2026 | Updated: 10/23/2025 | Inventor(s): Peter Turnbaugh, Chloe Atreya, Kidder Wesley, Kai Trepka

Keywords(s): Cancer, Diagnostics, Therapeutic

Category(s): Technology Classifications > Biology

METHODS, COMPOSITIONS, AND SYSTEMS TO DETECT NON-SMALL CELL LUNG CANCER

Researchers at CZ Biohub SF and UCSF have developed novel methods for the early detection of non-small cell lung cancer. Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related deaths in the U.S., with many cases diagnosed at an advanced stage, significantly reducing survival rates. Although low-dose chest CT (LDCT) scans are effective...

Published: 4/15/2026 | Updated: 10/23/2025 | Inventor(s): Chukwuka Didigu, Joseph DeRisi, David Jablons, Johannes Kratz, Andrew Kung

Keywords(s): Cancer, Diagnosis

Category(s): Technology Classifications > Biology

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