Search Results - cancer

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Profiling Chemically Modified DNA/RNA Units for Disease and Cancer Diagnosis
Diagnose a wide variety of conditions by analyzing DNA and RNA nucleotides/nucleosides. Background: In theory, RNA and DNA can be used to diagnose a broad range of diseases. Unfortunately, there are no existing technologies capable of providing comprehensive profiles of variant DNA/RNA components. Established approaches for the analysis/detection of...
Published: 10/24/2025   |   Inventor(s): Daniele Fabris, Rebecca Rose
Keywords(s): cancer, DNA modifications, epigenetics, genome-wide analysis, infection, oncology, RNA modifications, Technologies
Category(s): Technology Classifications > Diagnostics, Campus > University at Albany
OPTIMIZING CANCER CHEMOTHERAPY WITH THE GUT MICROBIOME
Researchers at UCSF have developed a novel innovation in harnessing the gut microbiome to alleviate severe side effects of chemotherapy. Dose-limiting toxicities remain a significant barrier in the advancement of drug therapies, particularly in oncology. Although decades of pharmacogenomic research have identified specific human genetic variants that...
Published: 10/23/2025   |   Inventor(s): Peter Turnbaugh, Chloe Atreya, Kidder Wesley, Kai Trepka
Keywords(s): Cancer, Diagnostics, Therapeutic
Category(s): Technology Classifications > Biology
METHODS, COMPOSITIONS, AND SYSTEMS TO DETECT NON-SMALL CELL LUNG CANCER
Researchers at CZ Biohub SF and UCSF have developed novel methods for the early detection of non-small cell lung cancer. Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related deaths in the U.S., with many cases diagnosed at an advanced stage, significantly reducing survival rates. Although low-dose chest CT (LDCT) scans are effective...
Published: 10/23/2025   |   Inventor(s): Chukwuka Didigu, Joseph DeRisi, David Jablons, Johannes Kratz, Andrew Kung
Keywords(s): Cancer, Diagnosis
Category(s): Technology Classifications > Biology
Physical Separation of Ultrashort Single-Stranded Cell-Free DNA in Biofluids Using Differential Filtration and Next-Generation Sequencing Pipeline to Detect Methylation Status of Ultrashort Single-Stranded Cell-Free DNA (UCLA 2023-077, 2023-082)
UCLA researchers in the Department of Dentistry have established novel extraction and bioinformatics pipeline of ultrashort single-stranded cell-free DNA for the use in liquid biopsy diagnostics. BACKGROUND: Liquid biopsy is a critical diagnostic tool for various human diseases. The rapid market growth of liquid biopsy is primarily driven by novel...
Published: 9/11/2025   |   Inventor(s): David Wong, Jordan Cheng
Keywords(s): Cancer, cell-free DNA, circulating DNA, Diagnostic Markers & Platforms, DNA methylation, liquid biopsy, next generation sequencing (NGS)
Category(s): Software & Algorithms > Bioinformatics, Life Science Research Tools > Research Methods, Platforms > Diagnostic Platform Technologies
Bioelectric Neuromodulation Methods for Hematopoiesis Regulation During Chemotherapy (Case No. 2020-382)
Summary: UCLA researchers in the Department of Bioengineering have developed an electrical neuromodulation method to accelerate recovery from deleterious chemotherapy side effects to improve patient outcome. Background: Chemotherapy works by targeting and killing fast-growing cancer cells using anti-cancer drugs. However, because these drugs lack...
Published: 10/21/2025   |   Inventor(s): Wentai Liu
Keywords(s): algorithmic cancer detection, Bladder Cancer, blood cancers, Brain cancer, Breast Cancer, Cancer, cancer antigen, cancer detection, Cancer Immunotherapy, cancer inhibition, cancer metabolism, Cancer stem cells, cancer target, castration resistant prostate cancer, Chemotherapy, head and neck cancer, lympathic cancers, lymphatic cancer, Mesenchymal Stem Cell Derived Cancer Cells, Neuromodulation, non-small cell lung cancer, Orthotopic cancer models, Pancreatic cancer, prostate cancer, small cell cancer, small cell lung cancer, small cell prostate cancer
Category(s): Medical Devices, Medical Devices > Neural Stimulation, Chemical, Electrical, Therapeutics, Therapeutics > Oncology
Pericellular oxygen-controlling cell culture incubator
Incubator system that directly measures and controls pericellular oxygen levels enabling precise regulation of the cellular microenvironment Background: Cell culture is a fundamental technique in biomedical research that aims to replicate physiological conditions for cellular studies. While oxygen is a critical factor affecting cell behaviour and...
Published: 9/3/2025   |   Inventor(s): Sidi Bencherif, Thibault Colombani, Zachary Rogers
Keywords(s): biomedical research, Cancer, Cell Culture, Hypoxia
Category(s): Technology Classifications > 1. Life Science > Bio-sensors
Delivery of sustained local and systemic immunomodulation
Reducing treatment burden with continuous immune activation Background: Current immunotherapy approaches face significant limitations in both delivery and patient experience. Standard treatments rely on either systemic intravenous injections of antibodies or small molecules that require frequent clinic visits, or localized injections that provide...
Published: 6/13/2025   |   Inventor(s): Srinivas Sridhar, Needa Brown, Jennifer Guerriero, Alexander Gottlieb
Keywords(s): biocompatible, Biodegradable, Biomaterials, Cancer, Drug Delivery, Immunoengineering, immunotherapy, implant, Nanomedicine
Category(s): Technology Classifications > 1. Life Science > Therapeutics
Analoging and SAR-Based Chemical Approach to Improve the Therapeutic Potency of Small-Molecule Inhibitors of Metastasis (UCLA Case No. 2024-116)
UCLA researchers in the Department of Molecular and Medical Pharmacology have developed an analoging and SAR-based chemical approach to generate novel, safe, and effective small-molecule inhibitors for preventing and treating cancer metastasis. BACKGROUND: The limited understanding of the biological mechanisms underlying metastasis in clear cell renal...
Published: 9/19/2025   |   Inventor(s): Lily Wu, Moe Ishihara, Robert Damoiseaux, Stuart Conway
Keywords(s): Cancer, Metastasis, Oncology (Small Molecules, Peptides and Antibodies), Small molecule therapeutics, small molecules
Category(s): Therapeutics > Oncology
Algorithm for Identifying Images of Fluorescently-Labeled Cells
Improves the ability to distinguish multiple fluorophores with overlapping emission spectra in biological images of labeled cells by a factor of two or more. Background: Cells (including normal and tumor cells), tissues, microbial communities, and other biological systems generally consist of multiple interacting components, especially proteins...
Published: 10/24/2025   |   Inventor(s): Alex Valm, Yunlong Feng
Keywords(s): bacterial cells, bacterial infection, bioengineering, biofilm control, bioinformatics, biomarker diagnostics, biomarkers, cancer, cell biology, computational biology, dental, diagnostics, digital image processing, fluorescence, fluorescence spectroscopy, gene expression analysis, image analysis, image processing, machine learning, medical imaging, microbial pathogenesis, personalized medicine, RNA, saliva, scanning microscopy, Technologies
Category(s): Campus > University at Albany, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare, Technology Classifications > Medical Imaging, Technology Classifications > Research Tools and Reagents, Technology Classifications > Therapeutics and Vaccines
KHK Inhibitors as Agents for the Treatment of Cancer and Metabolic Syndrome (UCLA Case No. 2021-222)
UCLA researchers in the Department of Chemistry and Biochemistry have synthesized novel KHK inhibitors that can result in anticancer drugs targeting cancer metabolism. BACKGROUND: Fructose is a naturally occurring sugar found in fruits and vegetables, and is an integral part of the human diet. In comparison to its functional isomer, glucose, which...
Published: 7/17/2025   |   Inventor(s): Heather Christofk, Michael Jung
Keywords(s): Cancer, cancer metabolism, metabolism, Oncology (Small Molecules, Peptides and Antibodies), small molecules
Category(s): Therapeutics > Oncology, Therapeutics > Metabolism And Endocrinology
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