Search Results - cardiovascular

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Superoxide Dismutase-Loaded Porous Polymersomes As Highly Efficient Antioxidant Nanoparticles
Brief Description: Therapeutic compositions, comprising: an anti-reactive oxygen species agent and a pervious polymersome, the pervious polymersome encapsulating the anti-reactive oxygen species agent, and the pervious polymersome having therein channels defined by a channel diblock copolymer, the channels being arranged so as to retain at least some...
Published: 8/19/2025   |   Inventor(s): Zhiliang Cheng, Andrew Tsourkas, Ling Qin
Keywords(s): Cardiovascular, Drug Delivery
Category(s): Technology Classifications > Therapeutics
Intravascular cervical sympathetic nerve stimulation system
Brief Description: The disclosed subject matter provides techniques for treating a subject. An example method includes placing a lead in a vertebral vein of the subject, placing at least one electrode within the vertebral vein adjacent to an autonomic nerve, and modulating a cardiovascular system of the subject by supplying a predetermined amount...
Published: 8/19/2025   |   Inventor(s): Timothy Markman, Saman Nazarian
Keywords(s): Cardiovascular, Neurology
Category(s): Technology Classifications > Medical Devices
Method and Apparatus for Segmentation of Dense MR Images Using Deep Learning with Domain Adaptation (Case No. 2025-208)
Summary: UCLA researchers from the Department of Radiological Sciences have developed a deep learning-based segmentation framework that enables fully automated and reproducible analysis of left ventricular (LV) function in Displacement Encoding with Stimulated Echoes (DENSE) MRI. Background: Myocardial strain is a key metric for analyzing how much...
Published: 8/18/2025   |   Inventor(s): Xiaodong Zhong, Siyue Li, Kim-Lien Nguyen
Keywords(s): acute myocardial infarction, adjustable mount, aneurysm drainage, automatic leveling, bedside decisions, blood pressure monitoring, cardiac cycle, Cardiac Electrophysiology, Cardiac failure, Cardiac Magnetic Resonance Imaging, Cardiac MRI, Cardiovascular, Cardiovascular Disease, Cardiovascular Disease Nephropathy, cardiovascular diseases, cardiovascular monitoring, cerebrospinal fluid (CSF) drainage, Cine MRI, clamp, critical-care, CSF drainage, Deep learning MRI, DENSE MRI, laser alignment, Left ventricular segmentation, lumbar drains, Motion analysis, MRI, multiparametric MRI (mpMRI), Myocardial strain, non-invasive cardiac monitoring, operator variability, passive reflective target, phlebostatic axis measurement, Pseudo-labeling, radial MRI, Segment Anything Model (SAM), self-leveling system, transducer alignment, Unsupervised domain adaptation (UDA)
Category(s): Medical Devices > Cardiac, Electrical > Imaging, Software & Algorithms > AI Algorithms, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Image Processing, Therapeutics > Cardiovascular, Therapeutics > Radiology, Medical Devices > Medical Imaging > MRI, Medical Devices > Medical Imaging
An automated image analysis pipeline for diagnosing and predicting cardiac allograft vasculopathy
Docket # 22-9888 Patent Pending Check back for additional information once patent is published.
Published: 8/1/2025   |   Inventor(s): Eliot Peyster, Andrew Janowczyk, Abigail Swamidoss, Samhith Kethireddy
Keywords(s): Artificial Intelligence (AI) & Machine Learning, Cardiovascular
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Digital Health
Origami-Inspired And Remotely Adjustable Pediatric Heart Implant
Pediatric pulmonary artery band (PAB) using origami-inspired fabrication that is remotely adjustable after implantation. Problem: Congenital heart defects affect 1% of births in the United States and can lead to irregular blood flow through the main pulmonary artery (MPA). A pulmonary artery band (PAB) is an implant that can be placed on the MPA to...
Published: 11/18/2024   |   Inventor(s): Cynthia Sung, Gabriel Unger, Mark Fogel, Jonathan Chen, Brianna Leung
Keywords(s): Bioengineering, Cardiovascular, Pulmonary, Soft Materials, Surgery
Category(s): Technology Classifications > Medical Devices, Technology Classifications > Robotics
miRNA Nanoparticles for Targeted Enhancement of Thermogenic Adipocyte Generation
​ Introduction of a promising anti-obesity novel MiR-133a, Zipper nanoparticle treatment results in enhanced Prdm16 and Ucp1 expression, resulting in adipocyte browning. Invention Summary: Over 40% of adults are overweight and over 15% of adults are living with obesity. Obesity is a major contributor to various causes of mortality including...
Published: 8/12/2025   |   Inventor(s): Sarah Nevins, Ki-Bum Lee, Thanapat Pongkulapa, Sang Ah Yi
Keywords(s): Cardiovascular, Diabetes & Metabolic Disorders, Nanoparticles, Nanotechnology
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Nanotechnology
Synchronized Biventricular Heart Pacing Using Wirelessly Powered Leadless Pacemakers (Cases 2019-237 & 2020-401)
Summary: UCLA researchers in the department of electrical and computer engineering have developed a device for synchronized biventricular pacing. Background: Many patients with impaired cardiac function suffer from ventricular desynchrony, a condition that involves a lack of synchronization between the contractions of the left and right ventricles...
Published: 7/17/2025   |   Inventor(s): Aydin Babakhani, Hongming Lyu, Medhi Razavi, Mathews John, Allison Post
Keywords(s): acute myocardial infarction, cardiac cycle, Cardiac failure, cardiometabolic disease, cardiopulmonary illness, Cardiovascular, Cardiovascular Disease, cardiovascular diseases, cardiovascular modeling, cardiovascular monitoring, cardiovascular prediction, cardiovascular therapeutic solution, medical device cardiac monitoring, non-invasive cardiac monitoring, tachycardia
Category(s): Medical Devices, Medical Devices > Cardiac, Medical Devices > Monitoring And Recording Systems
Small Molecule Humanin Mimetics and Enhancers That Normalize Neuronal p-AKT as Novel Therapeutics for Alzheimer's Disease (UCLA Case No. 2023-230)
UCLA researchers in the Department of Neurology have discovered novel small molecule humanin mimetics for the treatment of Alzheimer's disease and other chronic conditions with dysregulated p-Akt. BACKGROUND: Alzheimer’s disease (AD) is the most common form of dementia accounting for 60-70% of all cases. Nearly 7 million Americans are living...
Published: 7/17/2025   |   Inventor(s): Varghese John
Keywords(s): Alzheimers disease, Cardiovascular, Cardiovascular Disease, Dementia, diabetes, mimetics, pAKT signaling, small molecules
Category(s): Therapeutics > CNS and Neurology, Therapeutics > Cardiovascular
Sleeve Adaptor for Connecting LVAD to Damaged Ventricle
to the heart and assisting it in pumping blood throughout the body until a donor heart becomes available. However, when implanting VADs the ventricular apex needs to be intact so that it may support the LVAD. Unfortunately, implantation is difficult and sometimes impossible in many patients due to concomitant weak, diseased, or calcified left ventricular...
Published: 7/25/2025   |   Inventor(s): Y. Joseph Woo, Pavan Atluri
Keywords(s): Cardiovascular
Category(s): Technology Classifications > Medical Devices
Predicting Post-Surgical Cardiovascular Events via Extracellular Vesicle Analysis
Flow cytometry-based method for predicting post-surgical cardiovascular events. Problem: Cardiovascular events that occur after non-cardiac vascular surgery are significantly associated with post-surgical mortality. In fact, the mortality rate of patients who experience heart attacks following non-cardiac vascular surgery is 65%. Additionally, one in...
Published: 8/15/2025   |   Inventor(s): Wade Rogers, Jonni Moore
Keywords(s): Cardiovascular
Category(s): Technology Classifications > Diagnostics
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