Search Results - cardiovascular

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Origami-Inspired And Remotely Adjustable Pediatric Heart Implant
Pediatric pulmonary artery band (PAB) using origami-inspired fabrication that is remotely adjustable after implantation. Problem: Congenital heart defects affect 1% of births in the United States and can lead to irregular blood flow through the main pulmonary artery (MPA). A pulmonary artery band (PAB) is an implant that can be placed on the MPA to...
Published: 11/18/2024   |   Inventor(s): Cynthia Sung, Gabriel Unger, Mark Fogel, Jonathan Chen, Brianna Leung
Keywords(s): Bioengineering, Cardiovascular, Pulmonary, Soft Materials, Surgery
Category(s): Technology Classifications > Medical Devices, Technology Classifications > Robotics
miRNA Nanoparticles for Targeted Enhancement of Thermogenic Adipocyte Generation
​ Introduction of a promising anti-obesity novel MiR-133a, Zipper nanoparticle treatment results in enhanced Prdm16 and Ucp1 expression, resulting in adipocyte browning. Invention Summary: Over 40% of adults are overweight and over 15% of adults are living with obesity. Obesity is a major contributor to various causes of mortality including...
Published: 11/12/2024   |   Inventor(s): Sarah Nevins, Ki-Bum Lee, Thanapat Pongkulapa, Sang Ah Yi
Keywords(s): Cardiovascular, Diabetes & Metabolic Disorders, Nanoparticles, Nanotechnology
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Nanotechnology
Synchronized Biventricular Heart Pacing Using Wirelessly Powered Leadless Pacemakers (Cases 2019-237 & 2020-401)
Summary: UCLA researchers in the department of electrical and computer engineering have developed a device for synchronized biventricular pacing. Background: Many patients with impaired cardiac function suffer from ventricular desynchrony, a condition that involves a lack of synchronization between the contractions of the left and right ventricles...
Published: 9/19/2024   |   Inventor(s): Aydin Babakhani, Hongming Lyu, Medhi Razavi, Mathews John, Allison Post
Keywords(s): acute myocardial infarction, cardiac cycle, Cardiac failure, cardiometabolic disease, cardiopulmonary illness, Cardiovascular, Cardiovascular Disease, cardiovascular diseases, cardiovascular modeling, cardiovascular monitoring, cardiovascular prediction, cardiovascular therapeutic solution, medical device cardiac monitoring, non-invasive cardiac monitoring, tachycardia
Category(s): Medical Devices, Medical Devices > Cardiac, Medical Devices > Monitoring And Recording Systems
Small Molecule Humanin Mimetics and Enhancers That Normalize Neuronal p-AKT as Novel Therapeutics for Alzheimer's Disease (UCLA Case No. 2023-230)
UCLA researchers in the Department of Neurology have discovered novel small molecule humanin mimetics for the treatment of Alzheimer's disease and other chronic conditions with dysregulated p-Akt. BACKGROUND: Alzheimer’s disease (AD) is the most common form of dementia accounting for 60-70% of all cases. Nearly 7 million Americans are living...
Published: 7/22/2024   |   Inventor(s): Varghese John
Keywords(s): Alzheimers disease, Cardiovascular, Cardiovascular Disease, Dementia, diabetes, mimetics, pAKT signaling, small molecules
Category(s): Therapeutics > CNS and Neurology, Therapeutics > Cardiovascular
Sleeve Adaptor for Connecting LVAD to Damaged Ventricle
to the heart and assisting it in pumping blood throughout the body until a donor heart becomes available. However, when implanting VADs the ventricular apex needs to be intact so that it may support the LVAD. Unfortunately, implantation is difficult and sometimes impossible in many patients due to concomitant weak, diseased, or calcified left ventricular...
Published: 6/26/2024   |   Inventor(s): Y. Joseph Woo, Pavan Atluri
Keywords(s): Cardiovascular
Category(s): Technology Classifications > Medical Devices
Predicting Post-Surgical Cardiovascular Events via Extracellular Vesicle Analysis
Flow cytometry-based method for predicting post-surgical cardiovascular events. Problem: Cardiovascular events that occur after non-cardiac vascular surgery are significantly associated with post-surgical mortality. In fact, the mortality rate of patients who experience heart attacks following non-cardiac vascular surgery is 65%. Additionally, one in...
Published: 6/17/2024   |   Inventor(s): Wade Rogers, Jonni Moore
Keywords(s): Cardiovascular
Category(s): Technology Classifications > Diagnostics
Deep Learning-Enhanced Paper-Based Vertical Flow Assay for High-Sensitivity Troponin Detection Using Nanoparticle Amplification (Case No. 2024-179)
Summary: UCLA researchers from the Departments of Electrical and Computer Engineering and Bioengineering have developed a novel assay for point-of-care testing for acute myocardial infarction. Background: Cardiovascular diseases are responsible for a substantial number of deaths and economic burdens. Acute myocardial infarction (AMI) is an event...
Published: 11/13/2024   |   Inventor(s): Aydogan Ozcan, Gyeo-Re Han, Artem Goncharov, Hyou-Arm Joung, Dino Di Carlo
Keywords(s): acute myocardial infarction, Assay, Bioassay, biological assays, cardiometabolic disease, cardiopulmonary illness, Cardiovascular, Cardiovascular Disease, Cardiovascular Disease Nephropathy, cardiovascular diseases, cardiovascular modeling, cardiovascular prediction, cardiovascular therapeutic solution, deep-learning analysis algorithms, Flow Device, heart disease mitigation, high-sensitivity cardiac troponin I, Immunoassay, Laminar flow, nanoparticle amplification chemistry, point-of-care testing, Targets And Assays, vertical flow assay
Category(s): Medical Devices, Medical Devices > Monitoring And Recording Systems, Platforms, Platforms > Diagnostic Platform Technologies, Diagnostic Markers, Diagnostic Markers > Targets And Assays
Enhanced Delivery and Efficacy of Antisense Drugs via Covalently Linked Nanodisc Scaffolds
Application A synthetic nanodisc (ND) scaffold for delivering antisense oligonucleotides (ASOs) for the treatment of disease. Key Benefits Improved cellular uptake and protein suppression using antisense oligos. Longer ASO half-life compared to other ASO delivery methods. Potential to overcome the delivery and efficacy challenges using ASOs for...
Published: 12/4/2024   |   Inventor(s): Khalid Salaita, Radhika Sharma
Keywords(s): Biomaterials, Cardiovascular, Chemistry, Oncology
Category(s): TechPub Algolia > Therapeutics, TechPub Algolia > Drug Discovery, TechPub Algolia > Micro and Nanotechnology
STAR-Echo: Software to Predict Cardiovascular Disease in Chronic Kidney Disease Patients
Application A novel software for prognosis of MACE in chronic kidney disease patients using spatiotemporal analysis and transformer-based radiomics models. Key Benefits Unique interpretable features – identifies novel features based on longitudinal changes in LVW shape (perimeter & sphericity) and texture (intensity variations) over a...
Published: 11/20/2024   |   Inventor(s): Rohan Dhamdhere, Sadeer Al-Kindi, Gourav Modanwal, Anant Madabhushi
Keywords(s): Artificial Intelligence, Cardiovascular, Nephrology
Category(s): TechPub Algolia > Software
Detection of Dicrotic Notch in Arterial Pressure and Photoplethysmography Signals Using Iterative Envelope Mean Filter (Case No. 2024-034)
Summary: UCLA Researchers in the Department of Anesthesiology have developed an iterative envelope mean (IEM) method for the detection of specific features in arterial pressure monitoring applications. Background: The cardiac cycle consists of the distinct systolic and diastolic phases. The transition from the contracted, systolic phase to the...
Published: 10/24/2024   |   Inventor(s): Maxime Cannesson, Ravi Pal, Akos Rudas, Jeffrey Chiang, Sungsoo (Danny) Kim
Keywords(s): arrhythmia, arterial blood pressure (ABP), cardiac cycle, Cardiac Electrophysiology, Cardiac failure, Cardiac Magnetic Resonance Imaging, cardiometabolic disease, cardiopulmonary illness, Cardiovascular, Cardiovascular Disease, Cardiovascular Disease Nephropathy, cardiovascular modeling, cardiovascular prediction, cardiovascular therapeutic solution, diastolic, diastolic phase peak, dicrotic notch, feature extraction tool, iterative envelope method (IEM), Medical Device, medical device cardiac monitoring, Medical Device Poly(Methyl Methacrylate), Medical Devices and Materials, non-invasive cardiac monitoring, photoplethysmography (PPG), Smart medical device, systolic, tachycardia, wearable medical device, wearable medical devices
Category(s): Medical Devices, Medical Devices > Monitoring And Recording Systems, Platforms, Platforms > Diagnostic Platform Technologies, Software & Algorithms, Diagnostic Markers > Targets And Assays, Diagnostic Markers
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