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Search Results - ki-bum+lee
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Enhancing CAR Macrophage Efferocytosis via Surface Engineered Lipid Nanoparticles Targeting LXR Signaling
CAR-Macrophage efficiently uptakes apoptotic cell and cholesterol crystals via β-cyclodextrin, activating the LXR pathway and promoting cholesterol efflux Invention Summary: Atherosclerosis is considered the major cause of cardiovascular disease, leading to ischemic heart disease and ischemic strokes, the 1st and 5th largest causes of...
Published: 9/20/2024
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Inventor(s):
Skylar Chuang
,
Ki-Bum Lee
Keywords(s):
Category(s):
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Physical Sciences & Engineering
,
Technology Classifications > Nanotechnology
Nanoparticles for Direct Regulation of Mitochondrial Gene Expression
Schematic representation of MitoScript and its components Invention Summary: Abnormal mitochondrial DNA (mtDNA) transcription has been associated with a multitude of human diseases that requires both an effective and dynamic approach to control mitochondrial DNA. While nanoparticle(NP)-mediated drug delivery systems (DDSs) have emerged as...
Published: 9/12/2024
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Inventor(s):
Ki-Bum Lee
,
Letao Yang
Keywords(s):
Category(s):
Technology Classifications > Nanotechnology
,
Technology Classifications > Physical Sciences & Engineering
,
Technology Classifications > Healthcare & Life Sciences
Enhanced Intervertebral Disc Repair and Regeneration Using a Nano-Hybrid Gel
Nanomaterial (2D-Mn02)-embedded peptide hydrogel (NEPH) promotes cellular proliferation and tissue regeneration. Invention Summary: The limited capacity for regeneration, the presence of pro-inflammatory factors, and the complex extracellular matrix (ECM) microenvironment of degenerated intervertebral discs (IVD) remain significant issues...
Published: 9/12/2024
|
Inventor(s):
Ki-Bum Lee
,
Brian Conley
,
Inbo Han
Keywords(s):
Category(s):
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Medical Devices
,
Technology Classifications > Biomaterials
,
Technology Classifications > Physical Sciences & Engineering
Injectable Bioorthogonal Hydrogel for Intervertebral Disc Regeneration
IVD recovery imaging which demonstrates the efficacy and regeneration capability of the BIOGEL loaded with TGFB Invention Summary: Intervertebral disc degeneration (IVD) is the leading cause of back pain amongst humans and is a precursor to more severe conditions. To address this issue, a team led by Rutgers scientists have developed...
Published: 9/12/2024
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Inventor(s):
Ki-Bum Lee
,
Jeffrey Luo
,
Inbo Han
Keywords(s):
Category(s):
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Medical Devices
,
Technology Classifications > Physical Sciences & Engineering
Spatial Dopant Separation using Core-Shell Architecture For Upconversion Luminescent Enhancement in the Erbium-Doped System
Invention Summary: Upconversion nanoparticles (UCNPs) have gained increasing attention for various biomedical applications due to their high photostability, low autofluorescent background, and deep tissue penetration; however, UCNPs also suffer from low emission intensities due to undesirable energy back-transfer. Further, the use of high-power density...
Published: 9/12/2024
|
Inventor(s):
Ki-Bum Lee
,
Hudifah Rabie
,
Nicholas Pasquale
Keywords(s):
Imaging
,
Sensors & Probes
Category(s):
Technology Classifications > Physical Sciences & Engineering
,
Technology Classifications > Nanotechnology
,
Technology Classifications > Medical Imaging
High-throughput Nanoarray Screening Platform for Multi-Cellular Applications
Scope of the combinatorial nanoarray cell screening platform – varying parameters can all be contained in the CBC array to match the complexity of natural ECMs and biophysical cues. Invention Summary: Biophysical cues mediated by natural or synthetic extracellular matrices (ECMs) play an essential role in cellular reprogramming. In nature,...
Published: 9/12/2024
|
Inventor(s):
Ki-Bum Lee
,
Letao Yang
Keywords(s):
Biosensor
Category(s):
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Nanotechnology
Versatile CRISPR-Cas9 Gene Editing System
Successful gene editing in neurons differentiated from patient-derived neural stem cells. Left panel, gene editing using control guide RNA; Right panel, gene editing using MeCP2 guide RNA. Invention Summary: CRISPR-Cas-mediated genome editing makes effective gene therapy of human disease feasible. Although viral delivery of CRISPR-Cas...
Published: 9/12/2024
|
Inventor(s):
Ki-Bum Lee
,
Hyeon-Yeol Cho
,
Myung-Sik Yoo
Keywords(s):
Gene editing
Category(s):
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Rare Disease
,
Technology Classifications > Therapeutics
Rapid Cell Assembly for 3D Culture
A. Schematic diagram showing the self-assembly of a spheroid. B. Schematic showing transplantation of spheroids for the repair/regeneration of spinal cord Invention Summary: 3D cell culture including organoid and spheroid cultures is at the center stage of biomedical research. It is widely applied in organ development research, disease modeling,...
Published: 9/12/2024
|
Inventor(s):
Ki-Bum Lee
,
Christopher Rathnam
,
Letao Yang
Keywords(s):
Bioengineering scaffolds
,
Tissue Engineering
Category(s):
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Physical Sciences & Engineering
,
Technology Classifications > Research Tools
Modified Green Tea Polyphenol EGCG and EGCG-ester Inhibit Endospores
Modified Green Tea Polyphenol EGCG and EGCG-ester Inhibit EndosporesResearchers at Augusta University have invented skin-friendly compositions and methods for killing, inactivating, or otherwise reducing the bacterial endospores by using an effective amount of the green tea EGCG or its derivatives. EGCG research shows clear application for a hand sanitizer...
Published: 4/21/2023
|
Inventor(s):
Stephen Hsu
,
Lee Lee
,
Tin-Chun Chu
Keywords(s):
Category(s):
Therapeutics
Dual-Enhanced Raman Scattering-Based Nanoarray Biosensors
A schematic showing graphene-gold hybrid nanoarray for nucleic acid detection and cellular biosensing Invention Summary: Raman spectroscopy is a nondestructive, label-free technique that uses laser light to discriminate cell and tissue types. While Surface enhanced Raman scattering (SERS) has demonstrated great potential to analyze a variety of bio/chemical...
Published: 9/12/2024
|
Inventor(s):
Ki-Bum Lee
,
Letao Yang
Keywords(s):
Biosensor
Category(s):
Technology Classifications > Physical Sciences & Engineering
,
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Diagnostics
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