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Search Results - ki-bum+lee
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Biomaterial-mediated Extracellular Vesicle Delivery CNS Regeneration
Reduction in cortical lesion volume post-TBI (a) and post-treatment (b); remyelination as shown by luxol fast blue-staining post-TBI (c) and post-treatment (d); and enhanced expression of occludin post treatment (f) as compared to post-TBI (e). Invention Summary: More than 3 billion people worldwide are affected by central nervous system...
Published: 10/3/2025
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Inventor(s):
Joshua Stein
,
Ki-Bum Lee
,
Inbo Han
Keywords(s):
Bioengineering scaffolds
,
Biomaterials
,
Drug Delivery
,
Spinal Cord
Category(s):
Technology Classifications > Biomaterials
,
Technology Classifications > Physical Sciences & Engineering
Gold Nanocluster-Based PROTAC Targeting pTau
Gold nanocluster binds both pTau and E3 ligase, initiating the ubiquitin-proteasome pathway and degrading pTau, as seen via immunostaining (Blue – Hoechst, red – TUJ1, green – pTau) Invention Summary: Hyperphosphorylated tau protein, a key clinical marker for various neurodegenerative diseases, leads to abnormal aggregation...
Published: 9/12/2025
|
Inventor(s):
Sarah Nevins
,
Ki-Bum Lee
Keywords(s):
Alzheimer’s
,
Drug Delivery
,
Inflammation
,
Nanoparticles
Category(s):
Technology Classifications > Biomaterials
,
Technology Classifications > CNS Disorder
,
Technology Classifications > Nanotechnology
,
Technology Classifications > Physical Sciences & Engineering
Multifunctional Bioactive Dual-Layered Nanofibrous Matrix for Triple Negative Breast Cancer
Dual-Layered Nanofibrous Matrix designed for rapid-release and sustained-release of various therapeutics, leading to no tumor recurrence in triple negative breast cancer 4T1 tumor-resected mouse models. Invention Summary: Triple-negative breast cancer (TNBC), a particularly aggressive subtype of breast cancer which comprises 15-20% of all...
Published: 8/20/2025
|
Inventor(s):
Sungyun Kim
,
Ki-Bum Lee
,
Hyun-Jong Cho
Keywords(s):
Anti-cancer
,
Breast Cancer
,
Drug Delivery
,
Nanotechnology
,
Wound healing
Category(s):
Technology Classifications > Cancer
,
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Nanotechnology
Intervertebral Disc Repair Using a 3D Porous Hybrid Protein Nanoscaffold
Histological analysis of rat intervertebral disc tissue prior to (left) and post injury (center) compared to 6 weeks post treatment (right). Invention Summary: Degeneration of fibrocartilaginous tissues, such as intervertebral discs (IVD), knee menisci, and other tendon-bone junctions, can lead to debilitating pain. IVD degeneration is the...
Published: 8/12/2025
|
Inventor(s):
Ki-Bum Lee
,
Letao Yang
,
Inbo Han
Keywords(s):
Category(s):
Technology Classifications > Nanotechnology
,
Technology Classifications > Physical Sciences & Engineering
,
Technology Classifications > Biomaterials
Cell-Based Biosensor for Monitoring Neuronal Stem Cell Differentiation
Movement of fluorescent cargo (EGFP, green) from the cytoplasm to the nucleus (Hoechst, blue) as early as 10 minutes after stimulation with hippocalcin Invention Summary: Monitoring neuronal differentiation in stem cells is vital to advance regenerative stem cell therapies and our understanding of various neurodegenerative diseases. Traditional...
Published: 8/12/2025
|
Inventor(s):
Ki-Bum Lee
,
Youngeun Kwon
,
Euiyeon Lee
Keywords(s):
Category(s):
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Physical Sciences & Engineering
,
Technology Classifications > Diagnostics
,
Technology Classifications > Medical Devices
NanoScript & MitoScript – Nanoparticles for Modulation of Endogenous DNA at the Transcription Level
NanoScript (left) for the regulation of DNA transcription and MitoScript (right) for the regulation of mDNA transcription. Invention Summary: As of 2022, 1 in 4000 people are affected by mitochondrial disorders. Currently there are no cures for many mitochondrial disorders and treatment plans typically only address alleviating...
Published: 8/12/2025
|
Inventor(s):
Ki-Bum Lee
,
Sy-Tsong Chueng
,
Hyeon-Yeol Cho
,
Young Sup Yoon
Keywords(s):
Nanoparticles
Category(s):
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Nanotechnology
miRNA Nanoparticles for Targeted Enhancement of Thermogenic Adipocyte Generation
Introduction of a promising anti-obesity novel MiR-133a, Zipper nanoparticle treatment results in enhanced Prdm16 and Ucp1 expression, resulting in adipocyte browning. Invention Summary: Over 40% of adults are overweight and over 15% of adults are living with obesity. Obesity is a major contributor to various causes of mortality including...
Published: 8/12/2025
|
Inventor(s):
Sarah Nevins
,
Ki-Bum Lee
,
Thanapat Pongkulapa
,
Sang Ah Yi
Keywords(s):
Cardiovascular
,
Diabetes & Metabolic Disorders
,
Nanoparticles
,
Nanotechnology
Category(s):
Technology Classifications > Physical Sciences & Engineering
,
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Nanotechnology
Enhancing CAR Macrophage Efferocytosis via Surface Engineered Lipid Nanoparticles Targeting LXR Signaling
CAR-Macrophage efficiently uptakes apoptotic cell and cholesterol crystals via β-cyclodextrin, activating the LXR pathway and promoting cholesterol efflux Invention Summary: Atherosclerosis is considered the major cause of cardiovascular disease, leading to ischemic heart disease and ischemic strokes, the 1st and 5th largest causes of...
Published: 8/12/2025
|
Inventor(s):
Ki-Bum Lee
,
Skylar Chuang
Keywords(s):
Category(s):
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Physical Sciences & Engineering
,
Technology Classifications > Nanotechnology
Nanoparticles for Direct Regulation of Mitochondrial Gene Expression
Schematic representation of MitoScript and its components Invention Summary: Abnormal mitochondrial DNA (mtDNA) transcription has been associated with a multitude of human diseases that requires both an effective and dynamic approach to control mitochondrial DNA. While nanoparticle(NP)-mediated drug delivery systems (DDSs) have emerged as...
Published: 8/12/2025
|
Inventor(s):
Ki-Bum Lee
,
Letao Yang
Keywords(s):
Category(s):
Technology Classifications > Nanotechnology
,
Technology Classifications > Physical Sciences & Engineering
,
Technology Classifications > Healthcare & Life Sciences
Enhanced Intervertebral Disc Repair and Regeneration Using a Nano-Hybrid Gel
Nanomaterial (2D-Mn02)-embedded peptide hydrogel (NEPH) promotes cellular proliferation and tissue regeneration. Invention Summary: The limited capacity for regeneration, the presence of pro-inflammatory factors, and the complex extracellular matrix (ECM) microenvironment of degenerated intervertebral discs (IVD) remain significant issues...
Published: 8/12/2025
|
Inventor(s):
Ki-Bum Lee
,
Brian Conley
,
Inbo Han
Keywords(s):
Category(s):
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Medical Devices
,
Technology Classifications > Biomaterials
,
Technology Classifications > Physical Sciences & Engineering
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