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Search Results - ki-bum+lee
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NanoScript & MitoScript – Nanoparticles for Modulation of Endogenous DNA at the Transcription Level
NanoScript (left) for the regulation of DNA transcription and MitoScript (right) for the regulation of mDNA transcription. Invention Summary: As of 2022, 1 in 4000 people are affected by mitochondrial disorders. Currently there are no cures for many mitochondrial disorders and treatment plans typically only address alleviating...
Published: 11/25/2024
|
Inventor(s):
Ki-Bum Lee
,
Sy-Tsong Chueng
,
Hyeon-Yeol Cho
,
Young Sup Yoon
Keywords(s):
Nanoparticles
Category(s):
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Nanotechnology
miRNA Nanoparticles for Targeted Enhancement of Thermogenic Adipocyte Generation
Introduction of a promising anti-obesity novel MiR-133a, Zipper nanoparticle treatment results in enhanced Prdm16 and Ucp1 expression, resulting in adipocyte browning. Invention Summary: Over 40% of adults are overweight and over 15% of adults are living with obesity. Obesity is a major contributor to various causes of mortality including...
Published: 11/12/2024
|
Inventor(s):
Sarah Nevins
,
Ki-Bum Lee
,
Thanapat Pongkulapa
,
Sang Ah Yi
Keywords(s):
Cardiovascular
,
Diabetes & Metabolic Disorders
,
Nanoparticles
,
Nanotechnology
Category(s):
Technology Classifications > Physical Sciences & Engineering
,
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Nanotechnology
Enhancing CAR Macrophage Efferocytosis via Surface Engineered Lipid Nanoparticles Targeting LXR Signaling
CAR-Macrophage efficiently uptakes apoptotic cell and cholesterol crystals via β-cyclodextrin, activating the LXR pathway and promoting cholesterol efflux Invention Summary: Atherosclerosis is considered the major cause of cardiovascular disease, leading to ischemic heart disease and ischemic strokes, the 1st and 5th largest causes of...
Published: 1/7/2025
|
Inventor(s):
Ki-Bum Lee
,
Skylar Chuang
Keywords(s):
Category(s):
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Physical Sciences & Engineering
,
Technology Classifications > Nanotechnology
Nanoparticles for Direct Regulation of Mitochondrial Gene Expression
Schematic representation of MitoScript and its components Invention Summary: Abnormal mitochondrial DNA (mtDNA) transcription has been associated with a multitude of human diseases that requires both an effective and dynamic approach to control mitochondrial DNA. While nanoparticle(NP)-mediated drug delivery systems (DDSs) have emerged as...
Published: 9/12/2024
|
Inventor(s):
Ki-Bum Lee
,
Letao Yang
Keywords(s):
Category(s):
Technology Classifications > Nanotechnology
,
Technology Classifications > Physical Sciences & Engineering
,
Technology Classifications > Healthcare & Life Sciences
Enhanced Intervertebral Disc Repair and Regeneration Using a Nano-Hybrid Gel
Nanomaterial (2D-Mn02)-embedded peptide hydrogel (NEPH) promotes cellular proliferation and tissue regeneration. Invention Summary: The limited capacity for regeneration, the presence of pro-inflammatory factors, and the complex extracellular matrix (ECM) microenvironment of degenerated intervertebral discs (IVD) remain significant issues...
Published: 9/12/2024
|
Inventor(s):
Ki-Bum Lee
,
Brian Conley
,
Inbo Han
Keywords(s):
Category(s):
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Medical Devices
,
Technology Classifications > Biomaterials
,
Technology Classifications > Physical Sciences & Engineering
Injectable Bioorthogonal Hydrogel for Intervertebral Disc Regeneration
IVD recovery imaging which demonstrates the efficacy and regeneration capability of the BIOGEL loaded with TGFB Invention Summary: Intervertebral disc degeneration (IVD) is the leading cause of back pain amongst humans and is a precursor to more severe conditions. To address this issue, a team led by Rutgers scientists have developed...
Published: 9/12/2024
|
Inventor(s):
Ki-Bum Lee
,
Jeffrey Luo
,
Inbo Han
Keywords(s):
Category(s):
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Medical Devices
,
Technology Classifications > Physical Sciences & Engineering
Spatial Dopant Separation using Core-Shell Architecture For Upconversion Luminescent Enhancement in the Erbium-Doped System
Invention Summary: Upconversion nanoparticles (UCNPs) have gained increasing attention for various biomedical applications due to their high photostability, low autofluorescent background, and deep tissue penetration; however, UCNPs also suffer from low emission intensities due to undesirable energy back-transfer. Further, the use of high-power density...
Published: 9/12/2024
|
Inventor(s):
Ki-Bum Lee
,
Hudifah Rabie
,
Nicholas Pasquale
Keywords(s):
Imaging
,
Sensors & Probes
Category(s):
Technology Classifications > Physical Sciences & Engineering
,
Technology Classifications > Nanotechnology
,
Technology Classifications > Medical Imaging
High-throughput Nanoarray Screening Platform for Multi-Cellular Applications
Scope of the combinatorial nanoarray cell screening platform – varying parameters can all be contained in the CBC array to match the complexity of natural ECMs and biophysical cues. Invention Summary: Biophysical cues mediated by natural or synthetic extracellular matrices (ECMs) play an essential role in cellular reprogramming. In nature,...
Published: 9/12/2024
|
Inventor(s):
Ki-Bum Lee
,
Letao Yang
Keywords(s):
Biosensor
Category(s):
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Nanotechnology
Versatile CRISPR-Cas9 Gene Editing System
Successful gene editing in neurons differentiated from patient-derived neural stem cells. Left panel, gene editing using control guide RNA; Right panel, gene editing using MeCP2 guide RNA. Invention Summary: CRISPR-Cas-mediated genome editing makes effective gene therapy of human disease feasible. Although viral delivery of CRISPR-Cas...
Published: 9/12/2024
|
Inventor(s):
Ki-Bum Lee
,
Hyeon-Yeol Cho
,
Myung-Sik Yoo
Keywords(s):
Gene editing
Category(s):
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Rare Disease
,
Technology Classifications > Therapeutics
Rapid Cell Assembly for 3D Culture
A. Schematic diagram showing the self-assembly of a spheroid. B. Schematic showing transplantation of spheroids for the repair/regeneration of spinal cord Invention Summary: 3D cell culture including organoid and spheroid cultures is at the center stage of biomedical research. It is widely applied in organ development research, disease modeling,...
Published: 9/12/2024
|
Inventor(s):
Ki-Bum Lee
,
Christopher Rathnam
,
Letao Yang
Keywords(s):
Bioengineering scaffolds
,
Tissue Engineering
Category(s):
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Physical Sciences & Engineering
,
Technology Classifications > Research Tools
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