Search Results - immunotherapy

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Targeting CA19-9 with High-Specificity CAR-T Cells for Pancreatic Cancer

Chimeric antigen receptor (CAR) T cell therapy targeting CA19-9, an antigen over-expressed in several cancers, including 80-90% of pancreatic cancers. Problem: Pancreatic cancer is one of the deadliest common cancers and is now the sixth leading cause of cancer deaths worldwide, underscoring the need for better treatment options. One promising option...

Published: 7/8/2026 | Updated: 7/8/2026 | Inventor(s): Ben Stanger, Feiyan Mo

Keywords(s): Cell Therapy, Immunoncology, Immunotherapy, Oncology

Category(s): Technology Classifications > Therapeutics

Highly Selective, Bioengineered Cytokine Reduces Inflammation For Prevention Of Heart Failure After Heart Attack

Targeted delivery of an anti-inflammatory cytokine to prevent heart failure after myocardial infarction. Problem: Heart failure (HF) is one of the leading causes of death worldwide and is expected to affect more than eight million people in the US by 2030. Myocardial infarctions (MIs) are the leading cause of HF due to excessive inflammation caused...

Published: 7/1/2026 | Updated: 7/1/2026 | Inventor(s): Noor Momin, Emily Jacobs

Keywords(s): Bioengineering, Cardiovascular, Drug Delivery, Drug Target, Immunology, Immunotherapy, Inflammation, Protein/Peptide (Non-Antibody), Pulmonary

Category(s): Technology Classifications > Therapeutics

Polycomb Repressive Complex 1 (PRC1) Inhibitors to Restore Immune Response in B-Cell Lymphomas

SHORT DESCRIPTION A therapeutic approach that restores MHC-II expression using PRC1 inhibitors to reactivate anti-tumor immunity in B-cell lymphomas. INVENTORS Lu Wang* Zibo Zhao * Principal Investigator NU Tech ID: NU 2025-010 IP STATUS U.S. Provisional Patent Application has been filed. THERAPEUTICS...

Published: 6/25/2026 | Updated: 6/23/2026 | Inventor(s):

Keywords(s): Cancer/Oncology, Immunotherapy, Therapeutics

Category(s): Life Sciences > Therapeutics

Peptide Linkers for Modulating Antigen Immune Response in Cancer Vaccines

SHORT DESCRIPTION A novel non-biologically derived peptide linker technology enabling precise intracellular release of vaccine antigens to enhance immune activation. NU TECH ID NU 2024-124 INVENTORS Chad Mirkin* Weinberg College of Arts and Sciences, Department of Chemistry Tanner Fink *...

Published: 6/16/2026 | Updated: 6/16/2026 | Inventor(s):

Keywords(s): BIO2026, Cancer/Oncology, Immunology, Immunotherapy, Infectious disease, Therapeutics, Vaccine

Category(s): Life Sciences > Therapeutics

Biomimetic HDL Nanoparticles for Treatment of Cancer, Immune and Inflammatory Disorders, and Cardiovascular Disease

SHORT DESCRIPTION Self-assembling biomimetic high-density lipoprotein nanoparticle (HDL NP) platform technology with a soft organic core, designed to more closely replicate key functional properties of mature human HDL for therapeutic use in cardiovascular disease, cancer, and inflammatory/immune disorders. INVENTORS Colby Thaxton* Northwestern...

Published: 7/1/2026 | Updated: 6/16/2026 | Inventor(s):

Keywords(s): Atherosclerosis, Autoimmune disease, BIO2026, Breast cancer, Cancer/Oncology, Cardiology and Cardiovascular disease, Gene therapy, Immunology, Immunotherapy, Inflammation, Nanomaterials, Nanoparticle, Nanotechnology, Nucleic Acids, Platform technology, Prostate cancer, Research tool, Small molecule, Targeted therapy, Therapeutics

Category(s): Life Sciences > Biomarkers & Biomedical Research Tools, Life Sciences > Healthcare Devices, Tools & IT, Life Sciences > Therapeutics

Retargetable and Metabolically Tunable CAR Cell Platforms for Durable, Antigen‑Specific Cancer Therapy

SHORT DESCRIPTION A modular immunotherapy platform that combines hapten‑redirectable chimeric antigen receptor (CAR) constructs with itaconate‑programmed, memory‑like immune cells to deliver safer, more durable, and tunable antigen‑specific responses across hematologic and solid tumors. NU TECH ID NU 2023-021B INVENTORS Ashima...

Published: 7/8/2026 | Updated: 6/10/2026 | Inventor(s):

Keywords(s): Autoimmune disease, Cancer Treatment, Cancer/Oncology, Cell therapy, Immunology, Immunotherapy, Inflammation, Leukemia, Lymphoma, Targeted therapy, Therapeutics

Category(s): Life Sciences > Therapeutics

Open-Top Vascularized Tumor Microdevice

An open-top microfluidic chip enables transplantation of human solid tumor explants into vascularized 3D tissue for controlled CAR-T perfusion, imaging, and analysis. Tech Title: Technology: Technology: The invention includes an open-top microfluidic chip with a primary channel and adjacent side channel(s) separated by a barrier, plus apertures providing...

Published: 6/3/2026 | Updated: 5/29/2026 | Inventor(s): Dongeun (dan) Huh, Haijiao Liu

Keywords(s): Immunotherapy, Software

Category(s): Technology Classifications > Medical Devices, Technology Classifications > Research Tools & Reagents

A Method for treating TNF-α-driven pathologies via Fn14 inhibition

https://wsu.technologypublisher.com/files/sites/ncs_3618.pdf

Published: 5/12/2026 | Updated: 5/12/2026 | Inventor(s): Salah-uddin Ahmed, Farheen Shaikh

Keywords(s): anti-inflammatory, Immunotherapy, small molecule, Therapeutics

Category(s): Technologies > Health & Well-being > Chemistry

Precise, Efficient Delivery of mRNA Medicine to the Placenta

Using tiny lipid nanoparticles (LNPs) to improve mRNA medicine delivery and uptake in the placenta for healthier pregnancies Problem: The placenta is an important biological barrier that connects the mother and fetus while keeping their blood supplies separate, enabling nutrient and oxygen delivery and waste removal for healthy development. Abnormal...

Published: 5/8/2026 | Updated: 5/8/2026 | Inventor(s): Michael Mitchell, Hannah Safford, Kelsey Swingle, Hannah Geisler

Keywords(s): Bioengineering, Drug Delivery, Gene Therapy, Immunology, Immunotherapy, Women's Health

Category(s): Technology Classifications > Therapeutics

Targeted Nanoparticle-Mediated HIF Stabilization in Myeloid Cells for Enhanced Transplant Tolerance

SHORT DESCRIPTION A PEG-PPS nanoparticle technology for targeted delivery of roxadustat to myeloid cells to promote transplantation tolerance. INVENTORS Edward Thorp* Northwestern University Feinberg School of Medicine, Department of Pathology Evan Scott* McCormick School of Engineering, Department...

Published: 6/16/2026 | Updated: 5/7/2026 | Inventor(s):

Keywords(s): BIO2026, Drug delivery, Immunotherapy, Nanoparticle, Therapeutics, Tolerance induction, Transplantation

Category(s): Life Sciences > Therapeutics

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