Search Results - neurodegenerative+diseases

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Engineered Chimeric Antigen Receptor (CAR) Microglia-Like Cells for the Treatment of Neurodegenerative Disorders
Brief Description: Engineered stem cell/monocyte/macrophage/glia for the treatment and prevention of neurodegenerative disorders associated with misfolded proteins or glia dyshomeostasis. The present disclosure provides compositions and methods comprising chimeric antigen receptors (CARs) specific for amyloid beta (Aβ) and/or Tau. In certain...
Published: 8/19/2025   |   Inventor(s): Matias Porras Paniagua, Saar Gill, Frederick Christian Bennett
Keywords(s): Cell Therapy, Immunotherapy, Neurodegenerative Diseases
Category(s): Technology Classifications > Therapeutics
Robotic Microcapsule Assemblies with Emergent Mobility for Targeted Treatment and Drug Delivery
Brief Description: The disclosed subject matter provides systems and methods for delivering a therapeutic agent for targeted treatments. The system can include at least one microcapsule and a magnetic system. The microcapsule can include the therapeutic agent and a layer of iron oxide nanoparticles (IONPs). The therapeutic agent can be encapsulated...
Published: 8/19/2025   |   Inventor(s): Hyun (Michel) Koo, Daeyeon Lee, Edward Steager, Hong-Huy Tran
Keywords(s): Bioengineering, Drug Delivery, Infectious Disease, Microfluidics, Neurodegenerative Diseases, Oncology, Platform Technology
Category(s): Technology Classifications > Robotics, Technology Classifications > Therapeutics
M4 Foldamer Peptidomimetic: Targeting Amyloid-beta (Aβ) Aggregation to Restore Neuronal Function in Alzheimer’s Disease
Adantages Enhanced Blood-Brain Barrier (BBB) Penetration allows for efficient therapeutic targeting Superior serum stability enables a longer therapeutic window compared to conventional peptide therapeutics Multimodal therapeutic mechanism simultaneously addresses multiple pathological hallmarks of Alzheimer’s Disease (AD) Summary Alzheimer’s...
Published: 8/22/2025   |   Inventor(s): Jianfeng Cai, Heng Liu, Donghui Zhu, Firoz Akhter
Keywords(s): Alzheimer's Disease, Neurodegenerative Diseases, Therapeutics
Category(s): zzNeurodegenerative Diseases Treatment, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Therapeutics
Adaptive Recursive Self-feedback for Speech Production
Advantages Enables self-guided speech therapy with no need for a clinician Uses only the patient’s own voice for personalized feedback Adapts task difficulty automatically based on performance Works on smartphones for flexible, at-home use Showed improved speech fluency in early clinical testing Summary Millions of people suffer from...
Published: 8/22/2025   |   Inventor(s): Gerald Imaezue, Ofer Tchernichovski, Mira Goral
Keywords(s): Digital Healthcare, Neurodegenerative Diseases
Category(s): Technology Classifications > Medical > Therapeutics
Intranasally-Delivered Therapy for Treatment of Amyotrophic Lateral Sclerosis
Intranasal delivery of dantrolene nanoparticles can improve motor neuron function, muscle strength, and movement coordination and can offer therapeutic benefits for treatment of Amyotrophic Lateral Sclerosis (ASL). Problem: ALS a neurodegenerative disease with poor prognosis. ALS is categorized into the familial and sporadic types, with the former accounting...
Published: 7/15/2025   |   Inventor(s): Huafeng Wei
Keywords(s): Genetic Disorders, Inflammation, Neurodegenerative Diseases, Neurology, Pulmonary, Small Molecule
Category(s): Technology Classifications > Therapeutics
Fenchol: A Natural Therapeutic for Cognitive Health and Neurodegenerative Care
Advantages Targeting neuroinflammation and proteostasis Strong preclinical efficacy in cells, C. elegans, and Alzheimer’s mouse models GRAS-designated natural compound with excellent safety profile Multiple delivery formats: oral, nasal, buccal, topical, supplement Summary Neurodegenerative diseases such as Alzheimer’s Disease (AD)...
Published: 8/4/2025   |   Inventor(s): Hariom Yadav, Shalini Jain, Sidharth Mishra
Keywords(s): Neurodegenerative Diseases, Neuroscience, Nutrition / Diet Health
Category(s): Technology Classifications > Medical, Technology Classifications > Medical > Neuroscience
Cardiac Dysfunction in Friedreich’s Ataxia: Remodelling of the Cardiac Calcium Handling Machinery
Advantages: This study discovered a potential novel mechanism of cardiac dysfunction in Friedreich's ataxia (FA) by uncovering dysregulation in key calcium-handling proteins and mitochondrial dysfunction The study correlates data from an FA mouse model (FXN-KO) with human clinical manifestations, linking frataxin deficiency to cardiac dysfunction...
Published: 7/11/2025   |   Inventor(s): Bojjibabu Chidipi
Keywords(s): Neurodegenerative Diseases
Category(s): Technology Classifications > Medical > Neuroscience
Gamified Physical Therapy Rehabilitation System
Advantages: Turns muscle movement into gameplay using wearable EMG sensors Personalizes difficulty based on each user’s strength and ability Keeps patients engaged and motivated with real-time feedback and rewards Designed for at-home or clinical use, with easy setup and data tracking Summary: Physical therapy with a licensed physical...
Published: 6/6/2025   |   Inventor(s): Antonio Gonzalez, Gabriel Mozombite Gallegos, Ashley Pham, Nathan Schilaty, John Templeton, Voon Hee Lee
Keywords(s): Devices for Disabilities / Rehabilitation, Digital Healthcare, Human Computer Interfaces, Medical Devices, Neurodegenerative Diseases, Simulation Training Aid, Wearable Electronics
Category(s): Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Medical Devices
Binding Between TREM2 and Heparan Sulfate Delineates the Role of Microglia in AD and Reveals Novel Treatment Strategies
Advantages: Discovered novel structural interactions between HS and TREM2, associated with neurodegeneration High-affinity binding: TREM2 specifically interacts with Heparan Sulfate (HS) modified with 6-O-sulfation and iduronic acid, enabling precise microglial modulation compared to broad-spectrum anti-inflammatory strategies Defined structural...
Published: 8/12/2025   |   Inventor(s): Lianchun Wang, Ilayda McMillan
Keywords(s): Immunology, Neurodegenerative Diseases, Neuroscience
Category(s): zzNeurodegenerative Diseases Treatment, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Therapeutics
Intranasally-Delivered Therapy For The Treatment Of Depression And Dementia
Intranasal nasal dantrolene nanoparticles alone, or in combination with lithium, can provide protection against depression and dementia with minimal or no side effects. Problem: Major depression disorder (MDD) affects 350 million patients in the world and about 16% of the population in USA. In addition, up to 50% of Alzheimer’s disease (AD)...
Published: 8/1/2025   |   Inventor(s): Huafeng Wei
Keywords(s): Aging, Immunology, Immunoncology, Infectious Disease, Inflammation, Neurodegenerative Diseases
Category(s): Technology Classifications > Therapeutics
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