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Search Results - neurodegenerative+diseases
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Intranasally-Delivered Therapy For The Treatment Of Depression And Dementia
Intranasal nasal dantrolene nanoparticles alone, or in combination with lithium, can provide protection against depression and dementia with minimal or no side effects. Problem: Major depression disorder (MDD) affects 350 million patients in the world and about 16% of the population in USA. In addition, up to 50% of Alzheimer’s disease (AD)...
Published: 3/12/2025
|
Inventor(s):
Huafeng Wei
Keywords(s):
Aging
,
Immunology
,
Immunoncology
,
Infectious Disease
,
Inflammation
,
Neurodegenerative Diseases
Category(s):
Technology Classifications > Therapeutics
Intranasal Dantrolene Nanoparticle Use For Treatment Of Alzheimer's Disease
Intranasal delivering of dantrolene nanoparticles could potentially be used to inhibit memory loss and reduce amyloid plaques in patients with Alzheimer's disease. Problem: Alzheimer’s disease (AD) is a devastating neurodegenerative disease. The deficit in the development of new drugs targeting the amyloid pathology over the past several...
Published: 3/12/2025
|
Inventor(s):
Huafeng Wei
,
Qing Cheng Meng
,
Ge Liang
,
Maryellen Eckenhoff
Keywords(s):
Aging
,
COVID-19
,
Nanotechnology
,
Neurodegenerative Diseases
Category(s):
Technology Classifications > Animal Health
,
Technology Classifications > Chemical Processes and Synthesis
,
Technology Classifications > Food Science and Nutrition
,
Technology Classifications > Research Tools & Reagents
,
Technology Classifications > Therapeutics
YTH Domain-Containing Family Protein 1 (YTHDF1): A Novel Therapeutic Target for Alzheimer’s Disease
Advantages: A novel method for targeting m6A methylation via YTHDF1 offers a potential therapy for tauopathies and Alzheimer’s disease YTHDF1 reduces neuroinflammation in Alzheimer’s disease by downregulating pro-inflammatory genes like Ccl6 and Cst7 Enhance working memory and reduce hyperactivity in tauopathy, suggesting cognitive...
Published: 3/6/2025
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Inventor(s):
Gopal Thinakaran
,
Shuai Wang
Keywords(s):
Animal Models
,
Neurodegenerative Diseases
Category(s):
Technology Classifications > Medical > Neuroscience
,
Technology Classifications > Medical > Therapeutics
Machine-Learning Foundation Model For The Early Detection Of
Neurodegenerative Diseases
A machine learning technique that identifies biomarkers from neuroimaging data, allowing for identification and treatment of populations vulnerable to
neurodegenerative diseases
. Problem: Neurodegenerative diseases such as Alzheimer’s disease (AD) impact an estimated twenty-four million people worldwide, with prevalence increasing with global...
Published: 1/17/2025
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Inventor(s):
Saurabh Sihag
,
Alejandro Ribeiro
Keywords(s):
Aging
,
Artificial Intelligence (AI) & Machine Learning
,
Neurodegenerative Diseases
,
Neurology
,
Platform Technology
,
Radiology
Category(s):
Technology Classifications > Diagnostics
,
Technology Classifications > Digital Health
,
Technology Classifications > Imaging
Overcoming the Blood-Brain Barrier with Peptide-Functionalized Lipid Panoparticles
Peptide-functionalized lipid nanoparticles (pLNPs) for targeted messenger RNA (mRNA) delivery to the brain. Problem: Ionizable lipid nanoparticles (LNPs) have emerged as clinically advanced delivery vehicles for nucleic acids. However, as LNPs typically accumulate to the liver, tissue-specific delivery remains challenging, and systemic LNP delivery...
Published: 1/7/2025
|
Inventor(s):
Michael Mitchell
,
Emily Laura Han
Keywords(s):
Bioengineering
,
Drug Delivery
,
Neurodegenerative Diseases
Category(s):
Technology Classifications > Therapeutics
The First Curative Treatment of Phenylketonuria Using Genetic Engineering Approaches
The base editing of phenylalanine hydroxylase enzyme in the liver to restore phenylalanine metabolism and prevent neurotoxic effects. Problem: Phenylketonuria (PKU) is a severe disorder affecting approximately 1 in 10,000 U.S. newborns. PKU is marked by a genetic mutation in the phenylalanine hydroxylase enzyme (PAH), resulting in phenylalanine (Phe)...
Published: 10/28/2024
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Inventor(s):
Kiran Musunuru
,
Xiao Wang
,
Dominique Brooks
Keywords(s):
Gene Editing
,
Gene Therapy
,
Genetic Disorders
,
Neurodegenerative Diseases
,
Neurology
Category(s):
Technology Classifications > Therapeutics
Modulating Molecular Chaperone DnaJB6b as a Novel Method to Regulate Tau Seeding and Propagation
Advantages: Semi-high throughput screening accelerates drug discovery by quickly identifying candidates, reducing time to market, and gaining a competitive edge. Molecular Chaperone reduces tau aggregation, preserving cognitive function and improving patient quality. Employs a precision medicine approach targeting tauopathy mechanisms, potentially...
Published: 9/11/2024
|
Inventor(s):
Abigail Esquivel
,
Laura Blair
Keywords(s):
Alzheimer's Disease
,
Neurodegenerative Diseases
Category(s):
Technology Classifications > Medical > Neuroscience
,
Technology Classifications > Medical > Biotechnology
,
Technology Classifications > Medical > Therapeutics
An Adaptive, Language-Agnostic, and Generalizable Method to Determine the Hearing Level and Speech Perception Abilities of a Patient
This hearing test is tuned to a patient’s hearing level and changes based on performance to accurately diagnose hearing ability Problem: Currently, no single hearing evaluation can determine multiple facets of an individual’s hearing ability. For example, some tests may determine hearing awareness at specific frequencies, but gather no data...
Published: 8/12/2024
|
Inventor(s):
Jason Brant
,
Tiffany Hwa
Keywords(s):
Aging
,
Neurodegenerative Diseases
,
Software
,
Surgery
Category(s):
Technology Classifications > Diagnostics
,
Technology Classifications > Testing & Measurement
Novel Helical Peptodomimetics that Prevent the Formation of Aβ Oligomerization in Alzheimer’s Disease (AD)
Advantages: Developed sulfonyl-γ-AA peptide helical peptidomimetics that can prevent the formation of neurotoxic Aβ oligomerization. High Specificity: The lead sulfonyl-γ-AApeptide helical foldamer, Ab-6, exhibits precise targeting to the central region of Aβ42 and induces α-helix conformation in Aβ. Sequence-Specific...
Published: 2/19/2025
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Inventor(s):
Jianfeng Cai
,
Heng Liu
Keywords(s):
Alzheimer's Disease
,
Biotechnology
,
Neurodegenerative Diseases
Category(s):
Technology Classifications > Medical > Biomedical Engineering
,
Technology Classifications > Medical > Biotechnology
,
Technology Classifications > Medical > Neuroscience
New Device Material for a Flexible Chronic Implantable Neural Interface
Advantages: Superior biocompatibility reduces immune responses. Excellent electrical conductivity enhances signal transmission. Exceptional mechanical strength enables durable and flexible probes. Summary: Implantable neural interfaces (INIs) are devices configured to connect with the human nervous system through electrical means. Such...
Published: 9/3/2024
|
Inventor(s):
Stephen Saddow
,
Chenyin Feng
,
Christopher Frewin
Keywords(s):
Drug Delivery and Nanomedicine
,
Medical Therapeutics Cell Therapy
,
Nanotechnology
,
Neurodegenerative Diseases
Category(s):
Technology Classifications > Medical > Biomedical Engineering
,
Technology Classifications > Medical > Biomaterials
,
Technology Classifications > Medical > Medical Devices
,
Technology Classifications > Medical > Neuroscience
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