Search Results - neurodegenerative+diseases

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Modulating Molecular Chaperone DnaJB6b as a Novel Method to Regulate Tau Seeding and Propagation

Advantages: Semi-high throughput screening accelerates drug discovery by quickly identifying candidates, reducing time to market, and gaining a competitive edge. Molecular Chaperone reduces tau aggregation, preserving cognitive function and improving patient quality. Employs a precision medicine approach targeting tauopathy mechanisms, potentially...

Published: 9/11/2024 | Inventor(s): Abigail Esquivel, Laura Blair

Keywords(s): Alzheimer's Disease, Neurodegenerative Diseases

Category(s): Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Therapeutics

An Adaptive, Language-Agnostic, and Generalizable Method to Determine the Hearing Level and Speech Perception Abilities of a Patient

This hearing test is tuned to a patient’s hearing level and changes based on performance to accurately diagnose hearing ability Problem: Currently, no single hearing evaluation can determine multiple facets of an individual’s hearing ability. For example, some tests may determine hearing awareness at specific frequencies, but gather no data...

Published: 8/12/2024 | Inventor(s): Jason Brant, Tiffany Hwa

Keywords(s): Aging, Neurodegenerative Diseases, Software, Surgery

Category(s): Technology Classifications > Diagnostics, Technology Classifications > Testing & Measurement

Novel Helical Peptodomimetics that Prevent the Formation of Aβ Oligomerization in Alzheimer’s Disease (AD)

Advantages: Developed sulfonyl-γ-AA peptide helical peptidomimetics that can prevent the formation of neurotoxic Aβ oligomerization. High Specificity: The lead sulfonyl-γ-AApeptide helical foldamer, Ab-6, exhibits precise targeting to the central region of Aβ42 and induces α-helix conformation in Aβ. Sequence-Specific...

Published: 9/12/2024 | Inventor(s): Jianfeng Cai, Heng Liu

Keywords(s): Alzheimer's Disease, Biotechnology, Neurodegenerative Diseases

Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Neuroscience

New Device Material for a Flexible Chronic Implantable Neural Interface

Advantages: Superior biocompatibility reduces immune responses. Excellent electrical conductivity enhances signal transmission. Exceptional mechanical strength enables durable and flexible probes. Summary: Implantable neural interfaces (INIs) are devices configured to connect with the human nervous system through electrical means. Such...

Published: 9/3/2024 | Inventor(s): Stephen Saddow, Chenyin Feng, Christopher Frewin

Keywords(s): Drug Delivery and Nanomedicine, Medical Therapeutics Cell Therapy, Nanotechnology, Neurodegenerative Diseases

Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Biomaterials, Technology Classifications > Medical > Medical Devices, Technology Classifications > Medical > Neuroscience

Silencing of PRLΔE1 expression: a gene-agnostic treatment for retinal degenerations

Viral vector-mediated gene silencing of a novel short retinal isoform of Prolactin promotes photoreceptor survival. Problem: Age-related macular degeneration (AMD) and inherited retinal degeneration (IRDs) have extreme mutational heterogeneity, and many IRDs are orphan diseases. Developing individual gene therapies for each causative gene is impractical...

Published: 7/2/2024 | Inventor(s): William Beltran, Raghavi Sudharsan

Keywords(s): Drug Target, Gene Therapy, Genetic Disorders, Neurodegenerative Diseases, Ophthalmology, Orphan Disease

Category(s): Technology Classifications > Therapeutics

PET Radiotracers for Diagnosis and Patient Stratification of Neurodegenerative Disorders

Small molecules that bind to alpha-synuclein deposition and can be used for PET imagining in patients with synucleinopathies Problem: Imaging alpha-synuclein (αS) using noninvasive techniques such as positron emission tomography (PET) can help with the early diagnosis of synucleinopathies. Previous PET radiotracers suffer from low binding affinity...

Published: 6/6/2024 | Inventor(s): Robert Mach, E. James Petersson

Keywords(s): Imaging Agents, Neurodegenerative Diseases, Radiology, Small Molecule

Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Diagnostics, Technology Classifications > Imaging, Technology Classifications > Research Tools & Reagents

Secreted UBE3A for the Treatment of Neurological Disorders

Advantages: Novel vector, composition, and method of treating a neurological disorder with UBE3A deficiency. High fidelity to human Angelman syndrome. Facilitates comprehensive symptom representation for diverse treatment investigations. Allows innovative experiments for pioneering treatment development. Summary: Angelman...

Published: 1/2/2024 | Inventor(s): Kevin Nash

Keywords(s): Animal Models, Medical Therapeutics Gene Therapy, Neurodegenerative Diseases, Neuroscience

Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Neuroscience

Direct and Effective Method To Reverse The Effects of Fragile X Syndrome

A method of treating Fragile X syndrome by correcting the abnormal DNA clusters causing the characteristic symptoms. Problem: Fragile X syndrome (FXS) affects approximately 1 in 4,000 males and 1 in 8,000 females and is characterized by symptoms such as: Inherited Intellectual Disability Anxiety Attention Deficit Disorder (ADD) Skin, Ovaries...

Published: 3/8/2024 | Inventor(s): Jennifer Phillips-Cremins, Linda Zhou, Chunmin GE

Keywords(s): Bioengineering, Gene Therapy, Genetic Disorders, Neurodegenerative Diseases, Neurology

Category(s): Technology Classifications > Therapeutics, Technology Classifications > Vaccines

Investigating the Role of BIN1's SH3 Domain in Alzheimer's Desease

Advantages: The approach of targeting BIN1, a gene associated with AD increases the likelihood of finding effective therapeutic interventions. Determining the crystal structure of BIN1's SH3 domain provides detailed structural information which is crucial for designing small molecule inhibitors. The research reports promising preliminary...

Published: 1/23/2024 | Inventor(s): Gopal Thinakaran

Keywords(s): Medical Therapeutics Gene Therapy, Neurodegenerative Diseases, Neuroscience, Small Molecules

Category(s): Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Medical Diagnostics

Small Molecule Activators of Valosin-Containing Protein (VCP) as Therapeutics for Neurodegenerative Diseases with Ubiquitinated Protein Aggregates

Small molecule therapeutics that aid in clearing abnormal protein deposits observed in neurodegenerative diseases. Problem: Dementia, characterized by the impairment of at least two brain functions, such as memory loss and judgment, currently has no cure. Two common neurodegenerative diseases that cause dementia are Frontotemporal Dementia (FTD) and...

Published: 2/9/2024 | Inventor(s): Edward Lee, Benjamin Creekmore, Jessica Phan

Keywords(s): Aging, Genetic Disorders, Neurodegenerative Diseases, Neurology, Orphan Disease, Small Molecule

Category(s): Technology Classifications > Therapeutics

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