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Search Results - daeyeon+lee
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Adhesive Microparticle Formulation For Localized And Sustained Drug Delivery
A hairy, water-in-oil-in-water microemulsion for prolonged delivery of one or more active ingredients while adhering to target tissues. Problem: Microparticles are promising drug delivery platforms due to their biocompatibility and stability. However, existing particle-based drug delivery systems are unable to fulfill the needs for prolonged delivery...
Published: 11/13/2024
|
Inventor(s):
Daeyeon Lee
,
Minjun Oh
,
Jaehyun Kim
,
Li-Wei Chang
,
Robert Mauck
,
George Dodge
,
Hyun (Michel) Koo
Keywords(s):
Bioengineering
,
Dentistry
,
Drug Delivery
,
Drug Target
Category(s):
Technology Classifications > Materials
Contactless, Reversible Material Deposition From Liquid Droplets To Solid Surfaces
A microfluidic device allowing spatiotemporal manipulation of droplets that can be applied to high-resolution analytical techniques. Problem: Electrowetting methods such as electrowetting-on-dielectric (EWOD) have been developed to support high-resolution analytical techniques such as mass spectrometry and atomic force microscopy. EWOD allows processing...
Published: 10/17/2024
|
Inventor(s):
Daeyeon Lee
,
Junhyong Kim
,
Paradorn Rummaneethorn
Keywords(s):
Microfluidics
Category(s):
Technology Classifications > Research Tools & Reagents
Photoactivated Selective Release (PHASR) of Droplets from Microwell Arrays
A photoresponsive polymer layer that can be integrated into microfluidic devices for selective release of unique droplets Problem: Droplet microfluidics are used for single molecule detection and analysis, such as isolation of protein biomarkers for monitoring of disease progression. Current techniques for recovering unique molecules or cells from droplet...
Published: 8/2/2024
|
Inventor(s):
Daeyeon Lee
,
Junhyong Kim
,
Yongwon Choi
,
Syung-Hun Han
Keywords(s):
Artificial Intelligence (AI) & Machine Learning
,
Microfluidics
,
Nanotechnology
Category(s):
Technology Classifications > Chemical Processes and Synthesis
,
Technology Classifications > Research Tools & Reagents
Single-Step Wettability Patterning for Microfluidic Generation of Emulsions
Method to transfer wettability properties of a mold to microfluidic devices, defining hydrophobic/hydrophilic regions through variable perfluoropolyether concentration. Problem: Current wettability patterning methods involve sequentially flowing chemicals into channels, blocking areas where treatment is not desired. These multi-step methods are labor...
Published: 7/23/2024
|
Inventor(s):
Daeyeon Lee
,
David Issadore
,
Jingyu Wu
Keywords(s):
Microfluidics
Category(s):
Technology Classifications > Chemical Processes and Synthesis
Effective Anti-Fouling Surface Coating of Microfluidic Mixing Devices for Robust mRNA Lipid Nanoparticles (LNP) Manufacturing
Employment of omniphobic, thin-layer perfluorocarbon (TLP) coating to prevent fouling and clogging in microfluidic mixing devices during mRNA LNP formulations. Problem: Lipid nanoparticle (LNP)-based delivery systems for mRNA and other therapeutics recently gained popularity because of their application in the Pfizer/BioNTech and Moderna COVID-19 vaccines....
Published: 7/15/2024
|
Inventor(s):
Daeyeon Lee
,
Yoon-Ho Hwang
,
David Issadore
Keywords(s):
Bioengineering
,
Microfluidics
Category(s):
Technology Classifications > Hardware & Components
,
Technology Classifications > Materials
A drug delivery system tuned to the endogenous mechanical environment
Technology Overview: Tissues within the body experience mechanical perturbations across multiple force magnitudes and length scales, from mechanotransduction at the cell level to the dynamics of load-bearing joints. These forces not only maintain tissue homeostasis, but can also initiate degenerative processes when applied at supra-physiologic levels....
Published: 6/21/2024
|
Inventor(s):
Robert Mauck
,
George Dodge
,
Daeyeon Lee
Keywords(s):
Drug Delivery
Category(s):
Technology Classifications > Therapeutics
Scalable and Eco-Friendly Manufacturing of Tunable Heterogeneous Nanoparticle Films
A scalable heterogeneous nanoparticle film with controllable manufacturing methods with tunable properties that could be useful for a variety of applications. Problem: Current techniques for manufacturing polymer-infiltrated nanoparticle films (PINFs) include immersion in polymer melts, capillary rise infiltration, and solvent-driven infiltration....
Published: 7/9/2024
|
Inventor(s):
Daeyeon Lee
,
Baek Min Kim
Keywords(s):
Nanotechnology
,
Soft Materials
Category(s):
Technology Classifications > Chemical Processes and Synthesis
,
Technology Classifications > Hardware & Components
,
Technology Classifications > Materials
A Stretch-Activated Adhesive Microcapsule For The Controlled Release of Drugs In Wound-Healing Dressings
An adhesive drug-loaded microcapsule which releases therapeutic cargo upon mechanical stretching. Problem: Medicated dressings can improve healing of open wounds and improve pain management in patients. However, drug-coated bandages lack stimuli-response release mechanisms, so therapeutics are not released in a controlled and sustained manner. Poor...
Published: 6/20/2024
|
Inventor(s):
Daeyeon Lee
,
Yun Kee Jo
,
Robert Mauck
,
George Dodge
Keywords(s):
Drug Delivery
,
Soft Materials
Category(s):
Technology Classifications > Materials
Modified Green Tea Polyphenol EGCG and EGCG-ester Inhibit Endospores
Modified Green Tea Polyphenol EGCG and EGCG-ester Inhibit EndosporesResearchers at Augusta University have invented skin-friendly compositions and methods for killing, inactivating, or otherwise reducing the bacterial endospores by using an effective amount of the green tea EGCG or its derivatives. EGCG research shows clear application for a hand sanitizer...
Published: 4/21/2023
|
Inventor(s):
Stephen Hsu
,
Lee Lee
,
Tin-Chun Chu
Keywords(s):
Category(s):
Therapeutics
Fabricating specialized oleosins: From surfactants to drug delivery to imaging
Technology Overview: The Hammer and Lee Labs have developed a method to produce oleosins and functionalized oleosins for a wide variety of applications from surfactants to a drug delivery vehicle to cancer cells. E. Coli can be can be transformed to fabricate oleosin or oleosin with additional molecules, including antibodies and GFP. Problem:...
Published: 10/16/2023
|
Inventor(s):
Daniel Hammer
,
Daeyeon Lee
Keywords(s):
Nanotechnology
Category(s):
Technology Classifications > Materials
,
Technology Classifications > Imaging
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