Search Results - daeyeon+lee

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Photoactivated Selective Release (PHASR) of Droplets from Microwell Arrays
A photoresponsive polymer layer that can be integrated into microfluidic devices for selective release of unique droplets Problem: Droplet microfluidics are used for single molecule detection and analysis, such as isolation of protein biomarkers for monitoring of disease progression. Current techniques for recovering unique molecules or cells from droplet...
Published: 8/2/2024   |   Inventor(s): Daeyeon Lee, Junhyong Kim, Yongwon Choi, Syung-Hun Han
Keywords(s): Artificial Intelligence (AI) & Machine Learning, Microfluidics, Nanotechnology
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Research Tools & Reagents
Single-Step Wettability Patterning for Microfluidic Generation of Emulsions
Method to transfer wettability properties of a mold to microfluidic devices, defining hydrophobic/hydrophilic regions through variable perfluoropolyether concentration. Problem: Current wettability patterning methods involve sequentially flowing chemicals into channels, blocking areas where treatment is not desired. These multi-step methods are labor...
Published: 7/23/2024   |   Inventor(s): Daeyeon Lee, David Issadore, Jingyu Wu
Keywords(s): Microfluidics
Category(s): Technology Classifications > Chemical Processes and Synthesis
Effective Anti-Fouling Surface Coating of Microfluidic Mixing Devices for Robust mRNA Lipid Nanoparticles (LNP) Manufacturing
Employment of omniphobic, thin-layer perfluorocarbon (TLP) coating to prevent fouling and clogging in microfluidic mixing devices during mRNA LNP formulations. Problem: Lipid nanoparticle (LNP)-based delivery systems for mRNA and other therapeutics recently gained popularity because of their application in the Pfizer/BioNTech and Moderna COVID-19 vaccines....
Published: 7/15/2024   |   Inventor(s): Daeyeon Lee, Yoon-Ho Hwang, David Issadore
Keywords(s): Bioengineering, Microfluidics
Category(s): Technology Classifications > Hardware & Components, Technology Classifications > Materials
A drug delivery system tuned to the endogenous mechanical environment
Technology Overview: Tissues within the body experience mechanical perturbations across multiple force magnitudes and length scales, from mechanotransduction at the cell level to the dynamics of load-bearing joints. These forces not only maintain tissue homeostasis, but can also initiate degenerative processes when applied at supra-physiologic levels....
Published: 6/21/2024   |   Inventor(s): Robert Mauck, George Dodge, Daeyeon Lee
Keywords(s): Drug Delivery
Category(s): Technology Classifications > Therapeutics
Scalable and Eco-Friendly Manufacturing of Tunable Heterogeneous Nanoparticle Films
A scalable heterogeneous nanoparticle film with controllable manufacturing methods with tunable properties that could be useful for a variety of applications. Problem: Current techniques for manufacturing polymer-infiltrated nanoparticle films (PINFs) include immersion in polymer melts, capillary rise infiltration, and solvent-driven infiltration....
Published: 7/9/2024   |   Inventor(s): Daeyeon Lee, Baek Min Kim
Keywords(s): Nanotechnology, Soft Materials
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Hardware & Components, Technology Classifications > Materials
A Stretch-Activated Adhesive Microcapsule For The Controlled Release of Drugs In Wound-Healing Dressings
An adhesive drug-loaded microcapsule which releases therapeutic cargo upon mechanical stretching. Problem: Medicated dressings can improve healing of open wounds and improve pain management in patients. However, drug-coated bandages lack stimuli-response release mechanisms, so therapeutics are not released in a controlled and sustained manner. Poor...
Published: 6/20/2024   |   Inventor(s): Daeyeon Lee, Yun Kee Jo, Robert Mauck, George Dodge
Keywords(s): Drug Delivery, Soft Materials
Category(s): Technology Classifications > Materials
Modified Green Tea Polyphenol EGCG and EGCG-ester Inhibit Endospores
Modified Green Tea Polyphenol EGCG and EGCG-ester Inhibit EndosporesResearchers at Augusta University have invented skin-friendly compositions and methods for killing, inactivating, or otherwise reducing the bacterial endospores by using an effective amount of the green tea EGCG or its derivatives. EGCG research shows clear application for a hand sanitizer...
Published: 4/21/2023   |   Inventor(s): Stephen Hsu, Lee Lee, Tin-Chun Chu
Keywords(s):  
Category(s): Therapeutics
Fabricating specialized oleosins: From surfactants to drug delivery to imaging
Technology Overview: The Hammer and Lee Labs have developed a method to produce oleosins and functionalized oleosins for a wide variety of applications from surfactants to a drug delivery vehicle to cancer cells. E. Coli can be can be transformed to fabricate oleosin or oleosin with additional molecules, including antibodies and GFP. Problem:...
Published: 10/16/2023   |   Inventor(s): Daniel Hammer, Daeyeon Lee
Keywords(s): Nanotechnology
Category(s): Technology Classifications > Materials, Technology Classifications > Imaging
Adhesive hydrogels for wet applications (Non-catechol based)
Biocompatible hydrogels exhibit robust adhesion in wet conditions to substrates with wide range of chemistries and moduli. Technology Overview: Recent interest in developing wet adhesion for biomedical and environmental applications have leveraged catechol-functionalized materials to achieve these results. However, catechol moieties can produce...
Published: 10/16/2023   |   Inventor(s): Laura Bradley, Daeyeon Lee, Kathleen Stebe
Keywords(s): Hydrogels
Category(s): Technology Classifications > Materials, Technology Classifications > Chemical Processes and Synthesis
Click-active Janus particles
Scalable synthesis and functionalization of clickable Janus particles via seeded emulsion polymerization Problem: Amphiphilic Janus particles are biphasic colloids, where each face has distinct chemical properties. Janus particles are useful for stabilizing multiphasic fluid mixtures, such as emulsions. Current methods make Janus particles rely...
Published: 10/16/2023   |   Inventor(s): Kathleen Stebe, Daeyeon Lee
Keywords(s):  
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Materials
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