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Novel Therapeutic Target to Promoting Cardiomyocyte Proliferation and Enhance Cardiac Regeneration for Myocardial Injury and Disease

Advantages: Identification of MRPS5 as a Therapeutic Target: Reduction of MRPS5 expression stimulates cardiomyocyte proliferation and enhances heart function Discovery of the MRPS5 signaling axis: Decreased MRPS5 enhances ATF4 and Knl1, which promote cardiomyocyte, boosting cardiac recovery after myocardial injury Improved Survival and Cardiac...

Published: 11/22/2024 | Inventor(s): Da-Zhi Wang, John Mably

Keywords(s): Biotechnology, Cardiological Diseases Treatment, Cell & Tissue Culture & Engineering, Medical Diagnostics, Pharmaceuticals

Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Cell & Tissue Engineering, Technology Classifications > Medical > Pharmaceuticals

Pyridinium-Based Cyclophanes as Synthetic Lectins and Their Use for Glucose Recognition and Sensing in Aqueous Solutions

Advantages: Highly sensitive glucose sensor with strong potential for use in biomedical diagnostics and continuous glucose monitoring. Flexible, adaptive binding pocket that selectively targets glucose’s functional groups, improving specificity and detection accuracy. Reversible, non-covalent binding to glucose, allowing real-time response...

Published: 11/8/2024 | Inventor(s): Wenqi Liu

Keywords(s): Biotechnology, Diabetes, Pharmaceuticals

Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical

Aesthetics and Wound Healing-related Technologies

NU2014-173; NU2014-168; NU2015-071; NU2015-101; NU2017-011; NU2018-071; NU2018-151; NU2020-033; NU2020-249; NU2022-016; NU2022-079; NU2024-094 Transform your wound care and tissue repair solutions with our portfolio of technologies that provide cutting-edge solutions for wound care, tissue engineering, and disease treatment. This includes hydrogels...

Published: 12/19/2024 | Inventor(s):

Keywords(s): Adhesive, Biomedical, Biotechnology, General surgery, Hydrogel, Wound Healing

Category(s): Life Sciences > Therapeutics, Life Sciences > Healthcare Devices, Tools & IT

Shoot Inducing Genes for Improved Production of Transgenic Plants

This invention, using Agrobacterium gene clusters, enables passive regeneration of transgenic cells without the need for plant hormones Background For plants which are recalcitrant (difficult) to transform, poor performance is usually associated with inadequate DNA delivery or difficult regeneration response. There is a need for improved methods...

Published: 12/12/2024 | Inventor(s): Greg Goralogia, Steven Strauss

Keywords(s): Agrobacterium, Biotechnology, gene transfer, gene-edited, transgenic

Category(s): Agricultural

Novel Helical Peptodomimetics that Prevent the Formation of Aβ Oligomerization in Alzheimer’s Disease (AD)

Advantages: Developed sulfonyl-γ-AA peptide helical peptidomimetics that can prevent the formation of neurotoxic Aβ oligomerization. High Specificity: The lead sulfonyl-γ-AApeptide helical foldamer, Ab-6, exhibits precise targeting to the central region of Aβ42 and induces α-helix conformation in Aβ. Sequence-Specific...

Published: 11/6/2024 | Inventor(s): Jianfeng Cai, Heng Liu

Keywords(s): Alzheimer's Disease, Biotechnology, Neurodegenerative Diseases

Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Neuroscience

Drill Guide/Suture Passer for Posterior Approach Total Hip Soft Tissue Repair

Combined drill guide and suture passer for use in assisting repair following posterior approach total hip arthroplasty. Background: The posterior approach to the hip for total hip replacement as well as trauma, pediatric orthopedic surgery, and tumors is the most common approach for total hip arthroplasties. However, the performance of this...

Published: 5/1/2024 | Inventor(s): Timothy Damron

Keywords(s): biomedical engineering, biotechnology, hardware, healthcare, medical devices, medical equipment, orthopedics, surgery, suturing technique, Technologies

Category(s): Campus > Upstate Medical University, Technology Classifications > Medical Devices

Drugs That Regulate Heparan Sulfate Expression for Cancer Treatment

Advantages: Developed a novel assay for identifying repurposed drugs targeting HS-related gene expression Revealed a dose-dependent inhibition of the HS-related gene EXT1 with Vitamin D/ Calcitriol EXT1 stable cell line with luciferase reporter ensures specificity in identifying EXT1 regulators, minimizing off-target effects Summary: Heparan...

Published: 11/25/2024 | Inventor(s): Lianchun Wang

Keywords(s): Biotechnology, Cancer Treatment, Medical Therapeutics Gene Therapy

Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals

Cold Shock Protein Scaffold for Engineering Non-Antibody Binding Proteins

Advantages: The small size of the TBP (<8 kDa) allows for superior tissue penetration, making it ideal for applications requiring effective targeting of specific sites. Derived from a hyperthermophilic bacteria, the TBP's stability in reducing conditions and absence of disulfide bonds ensure structural integrity in challenging environments. ...

Published: 4/16/2024 | Inventor(s): Jack Webster

Keywords(s): Biotechnology, Medical Imaging, Sensors

Category(s): Technology Classifications > Medical > Cell & Tissue Engineering

Controlling Bioluminescensce in Red Tide Algae

Advantages: Discovery of a novel GPCR signaling system which regulates bioluminescence in dinoflagellates, single-celled algae responsible for red tide blooms. Potential targeted interventions to mitigate red tide blooms by manipulating the BIR1 pathway. Potential method to target specific dinoflagellate species, with no cross-activity to...

Published: 9/3/2024 | Inventor(s): Libin Ye, Aidan McFarland

Keywords(s): Biotechnology, Environmental Sciences, Ocean / Marine Technology

Category(s): Technology Classifications > Energy & Environment > Agriculture, Technology Classifications > Medical > Biotechnology

Frequency Domain Diffuse Correlation Spectroscopy

Advantages: Robust simultaneous quantitative measurement of tissue blood flow and absorption, ensuring reliability and enabling easy cross-subject comparisons for versatility. Single source source-detector separation measurement, reducing the size of the optical probe significantly for portability. Simplifies electronics by eliminating the...

Published: 3/6/2024 | Inventor(s): Ashwin Parthasarathy, Sadhu Moka, Abdul Mohaimen Safi

Keywords(s): Biotechnology, Medical Diagnostics, Spectroscopy

Category(s): Technology Classifications > Medical > Cell & Tissue Engineering, Technology Classifications > Medical > Medical Imaging, Technology Classifications > Medical > Medical Devices, Technology Classifications > Electronics > Spectroscopy

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