Search Results - lung

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Synthetic lipopeptide inhibitors of RAS oncoproteins
Abstract: It is well known that overactive Ras signaling is linked to many forms of cancer, and despite intensive efforts worldwide to develop effective inhibitors of Ras, to date there is no anti-Ras inhibitor in clinical use. Researchers at the NCI’s Cancer and Inflammation Program, in collaboration with scientists at Vanderbilt University and the...
Published: 6/11/2024   |   Inventor(s): Nadya Tarasova, Sergey Tarasov, Vadim Gaponenko, Joseph Kates, Michael Dean, Alla Ivanova
Keywords(s): COLON, LUNG, MULTIPLE MYELOMA, Pancreatic Cancer, RAS, THYROID CANCER
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology
Improved PE-based Targeted Toxins: A Therapeutic with Increased Effectiveness
Abstract: Targeted toxins (e.g., immunotoxins) are therapeutics that have at least two important components: (1) a toxin domain that is capable of killing cells and (2) a targeting domain that is capable of selectively localizing the toxic domain to only those cells which should be killed. By selecting a targeting domain that binds only to certain diseased...
Published: 5/21/2024   |   Inventor(s): Ira Pastan, Richard Beers, Masanori Onda
Keywords(s): Breast, HEAD, Hematological cancer, Immunotoxin, Ligand-targeted toxin, LUNG, NECK, OVARIAN, Toxin domain
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology, TherapeuticArea > Cardiology
Novel Cancer Immunotherapy: A T Cell Receptor That Specifically Recognizes Common KRAS Mutations
Abstract: Several malignancies associated with a poor prognosis such as lung, pancreatic and colorectal cancers frequently harbor constitutively active KRAS mutants, which play a pivotal role in oncogenesis.  Currently, there are no potentially curative treatments against most mutant KRAS harboring cancers once they become metastatic and unresectable. ...
Published: 4/8/2024   |   Inventor(s): Qiong Wang, James Yang, Zhiya Yu
Keywords(s): Colorectal, Immunotherapy, KRAS, LUNG, oncogenesis, PANCREAS, PROSTATE, T cell, TCR
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics
A Specialized Tissue Collection Device for the Preservation and Transportation of Needle Biopsies
Abstract: The ability to hold and transport tissue, especially needle biopsies in a pre-defined and controlled environment is critical for the preservation of biopsy samples in downstream analytic applications. Currently, tissue specimens are placed in open containers with variable, poorly controlled solutions applied to them, often in less than sterile...
Published: 4/8/2024   |   Inventor(s): Stephen Hewitt, Robert Star, Hiroshi Kijoma, Jeffrey Hanson, Armando Filie, Russell Bandle
Keywords(s): COLLECTION, DEVICE, FIXATION, Hewitt, KIDNEY, liver, LUNG, Needle Biopsy, PANCREAS, PRESERVATION, STERILE, Storage, Tissue, Transportation
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Medical Devices, Collaboration Sought > Collaboration, Application > Non-Medical Devices
Quantitative COVID-19 Scores Using High Resolution Computed Tomography (UCLA Case No. 2022-225)
Summary: UCLA researchers in the Department of Radiology have developed an innovation algorithm that measures lung damage associated with COVID-19 using computed tomography (CT) data. Background: Computed tomography (CT) scans are essential in diagnosing and monitoring different types of lung damage. At present, radiologist manually inspect CT scans...
Published: 7/19/2023   |   Inventor(s): Hyun (Grace) Kim, Jonathan Gerald Goldin, Fereidoun Abtin, Pang Yu Teng, Matthew Brown
Keywords(s): Angiogenesis Acute Lung Injury, Computer-Aided Design, Computer-Aided Diagnosis, Computerized Tomography scan (CT), COVID pneumonia, CT, HRCT, Lung, Lung Pulmonology, Pneumonia, Pulmonary fibrosis, Respiratory & Pulmonary, Software, Software & Algorithms
Category(s): Software & Algorithms, Medical Devices > Medical Imaging, Therapeutics > Infectious Diseases > COVID, Medical Devices > Medical Imaging > CT
Reducing Bloodstream Neutrophils as a Treatment for Lung Infection and Inflammation
During lung infection, bloodstream neutrophils (PMNs) responding to infection travel to the airspace lumen. Although successful arrival of microbicidal PMNs to the airspace is essential for host defense against inhaled pathogens, excessive accumulation of PMNs in the lung contributes to the pathogenesis of several prevalent lung disorders, including...
Published: 10/28/2024   |   Inventor(s): Carmen Williams, Wan-Chi Lin, Michael Fessler
Keywords(s): 2, BARRIER, DA1XXX, DA3XXX, DA4XXX, DAXXXX, DBXXXX, During, DXXXXX, Epithelial, Infection, Inflammation, INTEGRITY, LUNG, MEMBRANE, PROTECT, Protein, respiratory, Targeting, VJXXXX, VKXXXX, VLXXXX, VPXXXX, WBXXXX, WJXXXX, WKXXXX, XAXXXX, YAXXXX, YBXXXX, YCXXXX
Category(s): Collaboration Sought > Collaboration, ResearchProducts > Antibodies, Application > Diagnostics, Application > Therapeutics, TherapeuticArea > Ophthalmology, TherapeuticArea > Endocrinology, TherapeuticArea > Infectious Disease, TherapeuticArea > Cardiology, TherapeuticArea > Dental, TherapeuticArea > Immunology, TherapeuticArea > Oncology
Improved Acoustic Plethysmograph System for Noninvasive Measurement of Pulmonary Function
CDC researchers have developed a novel acoustic whole body plethysmograph (AWBP) that allows measurement of tidal volume in lab animals, independent of gas compression in the lung. This system provides particular advantages over the traditional whole body plethysmograph (WBP) when measuring model animals with increased gas compression due to increased...
Published: 10/28/2024   |   Inventor(s): David Frazer, Jeffrey Reynolds
Keywords(s): AA2XXX, AA5XXX, AAXXXX, AC1XXX, AC2XXX, AC3XXX, AC6XXX, Acoustic, ACXXXX, ADXXXX, AE1BXX, AE1XXX, AE3XXX, AE4XXX, AEXXXX, ANIMAL, Animal Model, ANIMAL welfare, ASTHMA, Breath, BREATHING, CDC Docket Import, CDC Docket Import CDC Prosecuting, DDXXXX, DEVICE, DEXXXX, DXXXXX, FUNCTION, IA3XXX, IA5XXX, ICXXXX, IDXXXX, LUNG, lung cancer, Lung Disease, LUNGS, Lung-Targeted, Measuring, NIOSH, NIOSH-HELD, Plethysmograph, Pulmonary, Pulmonary edema, PULMONARY FIBROSIS, research, RESEARCH TOOL, RESPIRABLE, Respiration, respiratory, Respiratory Diseases, respiratory INFECTION, Tool, VBXXXX, VJXXXX, VKXXXX, VLXXXX, VOXXXX, VPXXXX, WAXXXX, WBXXXX, WCXXXX, WGXXXX, WIXXXX, WMXXXX, XDXXXX, XHXXXX, XIXXXX, XJXXXX, YCXXXX, YEXXXX, YFXXXX
Category(s): Collaboration Sought > Licensing, Application > Software / Apps, Application > Medical Devices, Application > Diagnostics, TherapeuticArea > Pulmonology, TherapeuticArea > Immunology, Application > Research Materials, ResearchProducts > Research Equipment, TherapeuticArea > Cardiology, Application > Non-Medical Devices, TherapeuticArea > Ophthalmology, Application > Vaccines, Application > Therapeutics, Application > Occupational Safety and Health, TherapeuticArea > Infectious Disease, Application > Consumer Products, TherapeuticArea > Dental, TherapeuticArea > Endocrinology, ResearchProducts > Computational models/software, TherapeuticArea > Oncology
AAV5 Vector for Transducing Brain Cells and Lung Cells
The invention described and claimed in this patent application is related to the delivery of heterologous nucleic acids or genes to particular target cells. In particular, the application relates to methods of delivering a heterologous nucleic acid or gene of interest to particular target cells using an Adeno-Associated Virus of serotype 5 (AAV5)....
Published: 10/28/2024   |   Inventor(s): Beverly Davidson, Robert Kotin, Joseph Zabner, John (Jay) Chiorini
Keywords(s): AAV, AAV5, brain, CB2AXX, CBXXXX, CXXXXX, GB2A2X, GB2XXX, GENE THERAPY, IB4XXX, IBXXXX, IXXXXX, Listed LPM Reichman as of 4/15/2015, LUNG, NB1XXX, NBXXXX, NXXXXX, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, SACGHS DNA Patent Initial Set, USES, Vector, viral vector
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Pulmonology, TherapeuticArea > Oncology, TherapeuticArea > Neurology, Application > Research Materials, Application > Diagnostics, Application > Therapeutics
2020-810 Mechanical Ventilator With a Fixed Number of Orifice Plates to Generate Constant Flow Paths
Summary: UCLA researchers in the Department of Electrical and Computer Engineering & Bioengineering have developed a constant flow path mechanical ventilator used for the treatment of advanced respiratory diseases, such as acute respiratory distress syndrome (ARDS). Background: Respiratory failure leading to the need for respiratory support...
Published: 7/19/2023   |   Inventor(s): Glen Meyerowitz
Keywords(s): Angiogenesis Acute Lung Injury, Cellular Respiration, Cerebrospinal Fluid, Cerebrospinal Fluid Tetramer Retinol Binding Protein, Cerebrospinal Fluid Ventricular System Bleeding, Deoxygenation, Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Diagnostic Test, Digital Microfluidics, Ferrofluid, Flow Device, Fluid Dynamics, Fluidics, Half-Reaction Electrolysis Of Water Oxygen Evolution, Intensive-Care Unit Vital Signs, Lung, Lung Pulmonology, Mechanical, Mechanical Engineering, Mechanical Systems, Medical Device, Medical Device Poly(Methyl Methacrylate), Medical Devices and Materials, Microfluidics, Microfluidics And Mem's, Microfluidics Dielectrophoresis, Microfluidics Multi-Band Device, Microfluidics Nanosphere, Mouse Respiratory System, Oxygen, Oxygen Saturation, Reactive Oxygen Species, Respiratory & Pulmonary, Synovial Fluid
Category(s): Mechanical, Mechanical > Mechanical Systems, Therapeutics > Infectious Diseases > COVID
2021-092 FLOW REGULATION MECHANISM FOR COMPARTMENTALIZED LUNG VENTILATION
SUMMARY: UCLA researchers in the Department of Pulmonary and Clinical Care have developed a device capable of analyzing individual lungs in real-time to improve the quality of care for mechanically ventilated patients. BACKGROUND: Ventilators aid patients that have difficulty breathing by pressing positive air pressure into their lungs. Mechanical...
Published: 7/19/2023   |   Inventor(s):  
Keywords(s): Angiogenesis Acute Lung Injury, Diagnostic Test, Drug Delivery, Instrumentation, Lung, Lung Pulmonology, Medical Device, Medical Imaging, Monitoring And Recording Systems, Respiratory & Pulmonary, Sensors, Software
Category(s): Medical Devices, Medical Devices > Medical Imaging, Medical Devices > Monitoring And Recording Systems, Therapeutics > Infectious Diseases > COVID, Therapeutics > Respiratory And Pulmonary, Software & Algorithms > Programs
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