Search Results - yvonne+chen

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Engineered T Cells Capable of Simultaneous Tumor Targeting and Alteration of Tumor Microenvironment Through Vasculature Normalization (UCLA Case No. 2023-264)
UCLA researchers in the Department of Microbiology, Immunology and Molecular Genetics have built a series of chimeric antigen receptor (CAR)-T cells that target different antigens and secrete different anti-angiogenic proteins. Additionally, researchers also constructed bispecific CARs that respond to tumor antigen and pro-angiogenic molecules. BACKGROUND:...
Published: 6/27/2024   |   Inventor(s): Yvonne Chen
Keywords(s): Cancer, Cancer Immunotherapy, CAR-T cell therapy, immunosuppression, Immunosuppressive Drug, Immunotherapy, solid tumors, Tumor microenvironment, tumor vasculature, VEGF
Category(s): Therapeutics > Oncology
Novel Anti-mesothelin CAR for Use in Engineered Cell Therapies (UCLA Case No. 2023-281)
UCLA researchers in the Department of Microbiology Immunology and Molecular Genetics have developed a nanobody-based CAR T cell platform with increased stability and cross-immunogenicity between human and mouse antigens. BACKGROUND: Chimeric antigen receptor (CAR) T-cell therapy makes use of reengineered T cells to target and clear cancer cells....
Published: 6/28/2024   |   Inventor(s): Yvonne Chen
Keywords(s): Cancer, CAR-T cell platform, CAR-T cell therapy, cell engineering, Immunotherapy, Mesothelin, nanobody, Nanoparticle
Category(s): Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy
2022-190 Pharmacological Modulation of Chimeric Antigen Receptor (CAR)-T Cell Signaling Pathways to Improve Tumor-Killing Efficacy
SUMMARY: UCLA researchers in the Department of Microbiology, Immunology and Molecular Genetics have developed a novel chimeric antigen receptor (CAR)-T cell manufacturing process to prevent premature CAR-T cell dysfunction and enhance CAR-T cell durability and potency. BACKGROUND: Chimeric antigen receptor (CAR)-T cell therapy is an emerging pillar...
Published: 8/20/2023   |   Inventor(s): Yvonne Chen
Keywords(s):  
Category(s): Therapeutics, Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology > Oncology Immunotherapy
2019-839 Self-Modulating T Cells with Robust Anti-Tumor Efficacy and Reduced Propensity for Triggering Severe Cytokine Release Syndrome
SUMMARY: Researchers from UCLA’s Department of Microbiology, Immunology and Molecular Genetics have developed methods for generating self-modulating CAR-T cells which retain robust anti-tumor function whilst having reduced adverse side effects relating to cytokine release syndrome. BACKGROUND: The immunotherapy approach of T-cell engineering...
Published: 9/11/2023   |   Inventor(s): Yvonne Chen
Keywords(s):  
Category(s): Therapeutics, Therapeutics > Oncology, Therapeutics > Autoimmune, Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology > Oncology Immunotherapy
Novel Multi-Omics Aging Clock
­A multi-omics clock analyzes multiple layers of omics data with machine learning to predict remaining lifespan of mammals, particularly for animal model studies. Large omics data sets may be used from combinations of genomics, proteomics, lipids, etc. available from blood or other simple sample collection. This tool can robustly capture changes...
Published: 3/12/2024   |   Inventor(s): George Sutphin, Samuel Freitas, Megha Padi, Chen Chen
Keywords(s):  
Category(s): Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Simulators and Modeling Tools
Autonomous Drone for railroad track inspection
Reference #: 01564 The University of South Carolina is offering licensing opportunities for Autonomous Drone for railroad track inspection Background: The current practices suffer from three main drawbacks: 1) Human pilot cost is significant. The schedule of the drone-based track inspection is contingent on the pilot’s availability rather than...
Published: 3/15/2023   |   Inventor(s): Yu Qian, Yi Wang, Chen Chen
Keywords(s): autonomous drone, flight control, image processing, railroad track inspection, self-navigation
Category(s): Engineering and Physical Sciences
2015-671 Underground Shafts for Hydrogen Storage
SummaryResearchers at UCLA have developed an underground drilled shaft concept for storage of hydrogen or other gases.BackgroundOne challenge in creating a hydrogen economy is developing hydrogen gas storage solutions. Increased interest has helped the global hydrogen storage market grow to $2.6 billion in 2016, and it is expected to reach over $5...
Published: 7/19/2023   |   Inventor(s): Adrienne Lavine, Hossein Kavehpour, Dante Simonetti, Richard Wirz, Chen Chen, Gabriela Bran, Gopinath Warrier, Hamarz Aryafar, Jonathon Kennedy, Joshua Jordan, Keith Lovegrove
Keywords(s): Energy & Water
Category(s): Energy & Environment > Energy Generation > Solar, Energy & Environment > Energy Storage
IL-6 Receptor Alpha-Binding Protein and its Use In Controlling Cytokine Release Syndrome In Immunotherapy (UCLA Case No. 2017-453)
SUMMARY UCLA researchers in the Department of Chemical and Biomolecular Engineering have developed a novel protein that binds to and inhibits human IL-6 receptor alpha (IL-6Rα), which can be used to modulate and/or prevent cytokine release syndrome in immunotherapy. BACKGROUND Severe cytokine release syndrome (CRS), or a sudden and dramatic...
Published: 8/31/2023   |   Inventor(s): Yvonne Chen, Meng-Yin Lin
Keywords(s): Immunotherapy, Life Science Research Tools, Oncology Immunotherapy
Category(s): Life Science Research Tools, Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology > Oncology Immunotherapy
2015-390 Bispecific, OR-Gate Chimeric Antigen Receptor Responsive to CD19 and CD20
Bispecific, Or-Gate Chimeric Antigen Receptor Responsive To CD19 And CD20SUMMARYUCLA research have developed a CD19‐OR‐CD20 chimeric antigen receptor (CAR) that can trigger T‐cell activation upon detection of CD19 or CD20.BACKGROUNDConventional T‐cell therapy utilizes single‐input anti‐CD19 CAR-T cells. Multiple clinical trials have reported remarkable...
Published: 9/18/2023   |   Inventor(s): Yvonne Chen, Eugenia Zah, Michael Jensen, Anne Deepika Silva-Benedict
Keywords(s): Immunotherapy, Oncology Immunotherapy
Category(s): Therapeutics, Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology > Oncology Immunotherapy